HIV mushonga kuchabatsira kuti pave antibodies mune mombe

Mhou anogona kuita basa rinokosha mukurwisa HIV. In dzinotevedzana kuedza, vaongorori vakawana kuti pazvipfuwo anokwanisa nokukurumidza kuva antibodies kuti utachiwana, zvinogona kubatsira kubudisa mushonga kuti tikunde chirwere ichi kwaiparadza.

Mwero antibody

Basa rinoitwa US National Institutes of Health, kwakaratidza kuti mombe HIV maantigen, akatanga kubudisa antibodies rinozivikanwa bNAb (broadly neutralizing antibodies) kuti sunga kuna chete rakazaruka pamusoro antigen. Pashure pemazuva 42 chete, masayendisiti akawana kuti antibodies mu mombe vanogona neutralize 20 muzana kwakaedzwa okuva HIV, uye mukati memazuva 381 nhamba yakawedzera kusvika 96 muzana.

"Mhinduro idzi here isu zvakashamisa, - akati Dr. Devin Soklt. - Ivo kunyange zvakaoma kudavira, sezvo muviri vanhu vatange antibodies, tiri kutaura nezvazvo, zvinotora matatu namashanu. Izvi zvinokosha chaizvo nokuti muviri wedu haagoni zvakadaro pfupi kutsungirira kuchikosha basa iri. Ndiani angadai akafunga kuti mhou achaita rakakura pakurwisa HIV? ".

Unique zviri rokuzvidzivirira mhou

Mombe havagoni kuti HIV takasununguka, sezvo utachiwana rakavapo pane primates uye nechinangwa, kurwisa masero dzevanhu. Zvisinei, vanotsvakurudza vanofarira kuziva kuti mhou muviri vachaita sei utachiwana nokuti rokuzvidzivirira mombe ane nemamwe zvinhu izvo maererano masayendisiti, anogona kutenga kubudisa antibodies simba semhinduro chirwere.

Vatsvakurudzi jekiseni nemavhairasi maantigen 117 nemhuru kudzidza kwaiita muviri. Zvisinei, kumhanya kwaiita rokuzvidzivirira mhuka yakarohwa nevatsvakurudzi. Kamuka kuti nokuti zvomudumbu mamiriro mhou akazara utachiona kuti kugaya uswa, dziviriro yezvirwere mumuviri mhuka vakagamuchira kukwanisa kukurumidza kubereka antibodies kuchengeta utachiona izvi pasi pesimba.

Mune zvisingawanzoitiki Muzviitiko, vamwe vanhu vane simbawo sezvingatarisirwa kubereka antibodies dzakadaro, asi sezvo zvinotora nguva refu pashure chirwere, utachiona anokwanisa mutate uye kuakunda. Zvisinei, mombe bNAb yakabereka mukati shomanana.

Kukosha tsvakurudzo itsva

"Our zvakabudiswa vari chinozikamwa nekuti mombe, sokuti unobereka antibodies bNAb ari pfupi nguva. Kusiyana antibodies kwevanhu mune mombe angangorema nemamwe zvinhu uye ane paanopfuura kunzwisisa immunogens HIV ", - akatsanangura Dennis R. Burton, uyo akatungamirira kuongorora.

Kunyange zvazvo kuwanikwa ichi zvinokosha, vatsvakurudzi vanonyevera kuti antibodies havagoni zvakananga kushandisa mukurwisa HIV muvanhu. Zvisinei, izvi zvinogona kuva nhano inokosha pagadzirwe dzimwe inowirirana nhengo pamusoro antibodies yevanhu, izvo zvinozoita inogona kuchinjwa kuva mushonga.