Short peptides uye polypeptides sorutivi mitambo kudya kunovaka. Chii kusarudza?

Peptides tiri dzakakurumbira nzira iyo rinoshandiswa hurongwa mukugadzirwa yemitambo zvokudya kuti vatambi mumutambo mudzidzi uye nyanzvi [3]. peptides All - Sports kudya zvinoriumba - unogona kukamurwa 2 mapoka: pfupi (diki) peptides uye polypeptides ( "guru"). The peptides akaumbwa nyore zvinoriumba - amino acids. Kana peptide ine vashomanana amino acids Somuenzaniso 3 kana 4, - ndiko pfupi peptide. Kana peptide iri 20-30 amino acids, uye zvakawanda - ndiko polypeptide. Polypeptides - iri rinenge zvakafanana mapuroteni - kiyi mamorekuru mumuviri wedu. Sei zvichikosha kuti weboka kupinda pfupi peptides uye polypeptides? Kubva Kureba peptide zvinoenderana nokuda kwayo basa, kushanda zvakanaka uye kuchengeteka kana inoshandiswa mumitambo kudya kunovaka.

Parizvino nevakawanda sezvo mutambo kudya zvinoriumba vari polypeptides kuti pave mafuta pomoto, kuwedzera kwetsandanyama, kuwedzera kutapata, kuvandudza kunopindirana utano. Zvisinei, vane zvinokosha zvainovhiringidzawo. Polypeptides, kunyanya peptide mahormone, zvingava zvaisaenderana mumwe, kuvhiringa dzinongoitika mahormone mumuviri. Uyezve, vose peptides "guru" vari vatorwa kuna muviri uye unogona kukonzera neutachiona. High kurovedza muviri kuti nguva dzose anoedza mutambi, kazhinji pave vasanyanye kutapata, mamwe anowedzera rutivi neutachiona kushandisa polypeptides. Sezvo polypeptides kazhinji kure mhuka muviri [2, 3, 9], zvaipesana rokuchenesa michina ivo ingasanganisira tsvina inokuvadza - mapuroteni vatorwa, DNA zvimedu, nemavhairasi, prions, idzo nhaka immunogenicity (kukwanisa kufurira chisimbwa) uye anogona kutungamirira kukudziri- zvirwere.

Zvinoita kudaro, kuti uchengete anobatsira ehupfumi ose bioregulatory polypeptides uye panguva imwecheteyo kubvisa kukanganisa kwavo? Hongu, zvino yava zvichibvira. Somugumisiro makore tsvakurudzo, kwakaonekwa kuti mumwe polypeptide une muzinda - kuti chikamu chiduku payo, izvo basa kushanda peptide. Inobva Kuongorora Zvinoumba polypeptides maererano zvigadzirwa chaiyo Ideal Pharma GmbH pfupi peptides zvakasikwa, zvinosanganisira 2, 3 kana 4 amino asidhi residues [5, 6, 7]. peptides kwakadaro pfupi haumanikidzwi chokubvisa kubva munyama mhuka, uye vanogona synthesized mishonga. Zviri nani nokuti chakaita zvokugadzirwa peptides dzisina zvinhu kuti anokonzera Kurwara. In ichi pfupi peptides IPH kwaro mamiriro akafanana zvachose dzinongoitika vanoshingaira (dzichipfekeka) polypeptide mamorekuru nzvimbo uye havasi panoonekwa muviri sezvo dzimwe zvinhu. Zvakakosha kuziva kuti pfupi peptides IPH, kuva chaizvoizvo "basa" imwe polypeptide Morekuru inoshandiswa mumitambo zvokudya panguva zvese kuvatumwa "peptides makuru."

Chimwe chakanakira anokosha IPH pfupi peptides kukwanisa yavo nani yokuita zvinoitwa muviri kufananidzwa polypeptides. Izvi zvinoitika sei? Mapuroteni uye polypeptides, achipinda muviri nezvokudya anopinda mudumbu uye ura. Ikoko vari uchibatsirwa dzinokosha makemikari (peptidases) "akacheka" mu zvimedu zvidiki - pfupi peptides rinoumbwa 2 kana 3 amino asidhi residues. Zvadaro pfupi peptides kupinda ropa uye kuendeswa kune tsandanyama uye dzimwe nhengo uye munyama, vane pamutemo kushanda. Vazhinji polypeptides, izvo isu tinogamuchira sechikamu mitambo zvokudya vachava "kugurwa" peptidase uye haambovi zvinozoita, kana mugumisiro achava simba. In IPH ichi pfupi peptides inhengo mitambo zvokudya vachatitaka pakarepo kubva mudumbu uye ura kupinda muropa uye munyama, pasina nokuputsa. Pari Ideal Pharma GmbH akagadzira uye synthesized akatevedzana pfupi peptides, akadana IPH, nokuti naiyowo zvokudya, zvizorwa uye zvemitambo maindasitiri, izvo zvinoita masoja, huta uye kwemakemikari anobudiswa enyika, vane antioxidant ehupfumi, Activate muviri uye vashumire nokuda kudzivirira kenza uye vakawedzera hurefu [5, 6, 7, 8]. Zvinofanira kucherechedzwa kuti polypeptides hakusi kuziva chaiyo mashandiro ose zvipenyu basa, asi kuti pfupi peptides IPH zvidzidzo zvakadaro kunze nyore zvikuru uye tinogona kusvika majini kuronda kuti mashandiro chiito pamusoro peptide [1, 5, 6, 7, 8, 10 ]. Izvi zvinobvumira kuti nechivimbo kugadzirira efficacy uye kuchengeteka pfupi peptides IPH, zvinoberekwa Ideal Pharma GmbH (Germany).

Saka, pfupi peptides IPH, ane zvose zvipenyu anokonzerwa polypeptides, njodzi, dzisiri immunogenic, vane mashandiro chiito nesayenzi nezveBhaibheri uye ndiyo yakanakisisa yokupedza sechinhu chezvinonhuwira muviri mitambo [4] uye Vector kuti kukura pharmacology ano uye mushonga samolecular.

Sources asimbise efficacy uye kuchengeteka pfupi peptides

1. Ashapkin VV, Linkov NS, Havinson VH, Vanyushin BF Epigenetic zvigadziriswe peptidergic mutemo Gene okuti mune vakwegura mumasero dzevanhu // kudzidza nezvezvinhu zvipenyu. - 2015. - V. 80, Issue. 3. - P. 374-388.
2. Zilov IS Protein zvinoumba mu kushandiswa zvokudya nokuda sportsmen // Nutrition. - 2014. - T.83, №53. - C. 133.
3. Mezenova NY, vertuhaya VV, Volkov VV, Baydalinova Ls Mezenova OJ Kutsunga kwesayenzi parameters pakati Nezvakakuyiwa ose vanoshingaira peptides kubva mafunurwa hove sechikamu bio-chigadzirwa kune zvemitambo kudya // Proceedings ari kuyunivhesiti. Zvakarurama Chemistry uye hwokushandura zvinhu zvipenyu. - 2016. - №2 (17). - S. 104-114.
4. Havinson VH, Trofimova SV, Trofimov AV, Kachan EY, Wiener Usmanov IA Terekhina Rn, Kryuchek ES, ea Pyrozhkov Nzira hwakavakirwa achiwedzera padanho kugadzirira yakakwirira mukirasi gymnasts vanoshandisa anokosha mumuviri kurovedza uye peptide bioregulators. // Guidelines. - St. Petersburg: St. Petersburg Bio-murau Gerontology Institute.. - 2013. - 44 p.
5. Khavinson V.Kh., Polyakova Võ, Linkova NS, Dudkov AV, Kvetnoy IM Peptides chengetedza Cortical Thymocytes Kusiyanisa, Kuwanda, uye Apoptosis // Journal of Amino Acids. 2011. ArticleID 517137. P. 1-5.
6. Khavinson V.Kh., Tendler SM, Rfsyanenko NA, Tarnovskaya SI, Linkova NS, Ashapkin VV, Yakutseni PP, Vanyushin BF Tetrapeptide KEDW Interacts pamwe DNA uye inodzora Gene Rwekutaura // American Journal of anorapa achishandisa mitemo Sciences. - 2015. - Vol. 7, N3. - P. 156-169. Khavinson V.Kh., Tendler SM, Vanyushin BF, Kasyanenko NA, Kvetnoy IM, Linkovan.S., Ashapkin VV, Polyakova Võ, Basharina VS, Bernaotte A. Peptide Regulation kuti Gene Rwekutaura uye Protein reongororo muna Árbol Epithelium // Lung. - 2014. - Vol. 192. - P. 781-791.
7. Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova? Lv The peptide semax kunokanganisa kutaura majini chokuita zvirwere uye vascular enyika ari gonzo uropi zvatichiri ischemia: genome yose transcriptional pachisara // BMC Genomics . - 2014. - Vol. 15. - P. 228.
8. Stadnik J., Kęska P. Meat uye yakavira nyama zvigadzirwa seinokonzera bioactive peptides // ActaSci Pol .Technol. Aliment. - 2015. - Vol. 14, N 3. - P. 181-190.
9. Sweetwyne MT, Pippin JW, Eng dg, Hudkins KL, Chiao Ya, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ The mitochondrial-zvakanangwa peptide, SS-31, anovandudza glomerular architecture makonzo okukwegura // Kidney Int. 2017. S0085-2538 (16) 30652-4.