Purotoni pombi FIs: mashandiro chiito uye chikumbiro mune zvokurapa

By hwepurotoni Pombi FIs ndiyo boka pharmacological yomuchipatara kuti kuderedza mwero secretion ose hydrochloric asidhi mudumbu. Kuva rakananga zvainoita secretory canaliculi, ivo zvinobudirira anonamata kutsvakwa kuchirapa mugumisiro maronda, erosive gastritis, Gerd. The boka rinosanganisira muzvizhinji zvinodhaka kwemakemikari mamiriro zvakafanana, asi tine zvakasiyana pharmacodynamic parameters, i.e. anoita zvakafanana zvinodhaka vanoita pamusoro secretory masero, asi kudaro kuwanda siyana uye aimhanya zvakasiyana.

Purotoni pombi FIs: samolecular zvinhu simba kugadzirira

Purotoni pombi chinhu chisinganzwisisiki mapuroteni mamiriro Dare kupinda rehydrogen ions ari gastric lumen. Inoitwa maviri mishonga dissimilar okunze, zvimwe kunzi subunits. The wokutanga chete mapuroteni uye inovakwa kubva amino acids. Muna Kamudzira sero stuffer nayo haazvibati neimwe nzira, akayambuka 10 nguva, zvinoita kuti paumbwe 5-secretory mugero zvishwe. Nomunyika mhango pakati ions kuwira mukati gastric lumen uye kupa acidification pamusoro svikiro uye akawira rehydrogen indekisi. Muchiitiko ichi chiri mune rimwe muzvishwe ndiwo basa pakati puroteni - kutevedzana kwezviitiko 800 amino acids, izvo catalyzes Kuparara ATP, chikuru simba sero substrate.

Other subunit chinhu puroteni kunzwisisa kuti rinoumbwa polypeptide kutevedzana ukuwo mumwe akarayira marongerwo uye glycoprotein ngetani. Hunoshamisa Chikamu morekuru kunze cytoplasm, uye zvimwe chikamu glycoprotein riri ekstratsitoplazmaticheskim Kanotokonya yakaoma kuti otora chiratidzo pakati activation yacho enzayemu H + \ K + -ATPase. Panyaya iyi puroteni chikamu Morekuru chinoyambuka Kamudzira kamwe, zvichireva kukosha kwayo sechinhu unobva chinhu pakati wokunze uye wokutanga Kanotokonya subunit basa pakuitisa CATALYTIC maitiro kwetunhu protons.

Saizvozvowo, sechivako Purotoni pombi secretory tubules masero parietal anogona kugumisa sei nyore kunogona kudzvinyirira secretion pakati H + vakapinda muviri mhango. Chinonyanya kururamiswa musimboti - ndiko chinovhiringidza of enzayemu anokonzera kwetunhu kuti hwepurotoni pombi FIs.

Kushandisa FIs mu zvekuchipatara tsika

In mushonga, hwepurotoni pombi FIs anoshandiswa nevakawanda, kunyanya mu gastroenterology, riri chokuita kugona kwavo kuderedza ari acidity pakati gastric secretion, uye nokudaro kuderedza kukuvadza kunoita pamusoro mudumbu porusvingo, riri kunyanya kukosha kana rirwadze. Panyaya iyi kuchirapa nezvinozoitika yakazvimirira etiology pakati kushoma, sezvazvakanyorwa yabviswa ne hasha simba kwezvakatipoteredza kuvimbika muviri. Uyewo chakarondedzera pathologies izvo pakurapa kwokushandisa hwepurotoni pombi FIs chakaramba chichiwedzera ne gastric urikanwi uye duodenal urikanwi, erosive uye asiri erosive Gerd siyana.

Pakati rakajairika mishonga zvinosanganisira hwepurotoni pombi FIs pamwe mazita anotevera Generic omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, uye vamwe. Pakati pavo vane mazita zvokutengeserana kumira kunze, yakadai se "Omez". Medicines zvinowanikwa Kamudzira fomu. Ivo vanobviswa nomuromo mune ramakanzi chipimo chemushonga ane nyanzvi, iyo dzinosiyana-siyana zvichienderana chaiwo Chirwere. Nepo kubvumira kuzvicheka-kutarisira sezvo pane boka varwere chokunyunyuta pamusoro pamwaka exacerbation echirwere gastric kana duodenal maronda. Mune zvimwe zviitiko, mabiko iri nekambani nachiremba panguva rubvumo.