Kugadzirira "Divigel": kuongorora, tsanangudzo, kushanda

Gel transdermal yekushanda "Divigel", inongororwa iyo yakawanda kwazvo, inorwisa anti-climacteric yakagadzirwa nemishonga yakagadzirirwa zviratidzo zvekushaya isrogen yakaoma. Muchidimbu chayo, ndiyo nzira yehomoni inotsiva-shandiswa, nokuti inoshandiswa-inoshandiswa-yakagadzirwa nesradiol-inokonzera uye inowanzoenderana nehupenyu hwemadzimai evanhukadzi.

Mushonga we "Divigel", iyo inongororwa inonyanya kunaka, inobatsira kwazvo munguva refu kana kuti kubhejira kwevakadzi munguva yekuenda-kumwedzi. Pamusana pekushaya kuchengeteka kweesrogen muchikamu chino, zvirwere zvakasiyana-siyana zvemuviri zvinoonekwa, zvinoratidzirwa nehutano hwekurara, kusagadzikana kwevasomotor, kufambira mberi kwechirwere chemajitourinary system uye kazhinji osteoporosis yepamusoro. Kushanda nesimba, zvakafanana nekuita kwemahomoni chaiwo, uye kukurudzira kufambisa kwevakadzi, fallopian tubes uye chiberekero, kugadzirira "Divigel" (kuongororodza izvi kusimbisa) kunopedza zvachose kana zvakanyanya kuderedza izvi zviratidzo.

Ma pharmodynamics ejeri iyi ndeyotevera. Mumasero ayo chiito chekugadzirisa "Divigel" inotungamirirwa, synthetic estradiol inopinda mukambani yemakemikari nemamwe mapepa, inogadzira pamwe ne-receptor-ligand yakaoma uye inobatanidza ne estrogen-effector zvikamu zvejenome, uyewo nemapuroteni anonzi intracellular. Izvi zvinokonzera kuiswa kwe-I-RNA synthesis uye kusunungurwa kwemaktokines akasiyana-siyana.

Nokudaro, transdermal "Divigel" inokurudzira kuregererwa kwekupedzisira kwe endometrium uye kuchenesa ropa nguva dzose. Mushonga mukuru wemishonga unogona kukurudzira kukura kwe endometrial hyperplasia, kubviswa kwe lactation, kuvharwa kwefupa resorption, uye kukurudzira kushandiswa kwemamwe mapuroteni ekutakura (thyroxin-binding globulin, transcortin, transferrin).

Kushandiswa kwekunze kwe "Divigel" (kubvunzurudza kunopupurira izvi) zvinenge zvisingabatsiri zvakadai sokuwedzera kweropa. Izvi, zvechokwadi, inobatsira zvikuru mukuenzanisa nemarudzi akasiyana esradiol-ane muromo wemishonga.

Shanduro ye "transigermal" inonzi "Divigel" neAVF inorayirwa kana inotarisirwa kuti ichengetedze huwandu hunodiwa hweedradiol. Nhamba yacho ndeyega uye inosarudzwa nevanyanzvi vekliniki uko ino inoitwa. Zvidzidzo zvechipatara zvekugadzirira "Divigel" dzakagadzirisa hutano hwekuenderana kwayo nekushandana nemimwe mishonga. Saka, yakazozivikanwa kuti iyo inoshandiswa inogona kuderedza kushanda kwemishonga inorwisa antihypertensive, antidiabetic uye anticoagulants. Iko kushandiswa panguva imwe chete kwechirwere ichi uye magadzirira ane inducers uye hepatic enzyme (barbiturates, "carbamazepine", "griseofulvin", "rifampicin" nevamwe), zvinogona kukonzera kuderera kuduku mu estradiol muropa remuropa.

Iyo nzira yekurapa nemishonga "Divigel", mutengo waro wakanyatsonaka, inofanira kuendeswa neongororo dzenguva dzose. Chiremba anogadzirisa nguva uye maitiro ehutano maererano nezvinodiwa nemakiriniki emuviri wega wega. Asi, sekutonga, mammamiro anorayirwa muhuwandu hwemhosva.

Sezvo murairo uchitaura, mushonga we "Divigel" unopesana nezvimwe. Kunyanya, akaongororwa kana kuti akambofungidzirwa oncology yemakumbo emakumbo, maitiro emakumbo emakumbo (uterine myoma, cervical, vulvar, ovarian, nezvimwewo), endometrial hyperplasia, zvinogadzirisa mishonga yakasiyana-siyana, hutachiona hunokonzera hutachiona, hutachiona hwechiropa, hwechiropa uye hwepituiti, kuputsa Kupararira kweperesi, chirwere cheshuga mellitus nezvimwe zvirwere. Saka, tora ichi chinodhaka chinofanira kungorongedzerwa nachiremba uye zvakanyatsorongedzerwa.