Isoniazid. Mirayiridzo

Mushonga we "Isoniazid" unowanikwa nenzira yehupfu, mahwendefa, suppositories (rectal). Iyo inoshandiswa inoshandiswa isonicotinic acid hydrazide.

Isoniazid inorondedzerwa sechirwere chinopesana nehutachiona chero ipi zvayo chirwere chacho. Chirwere ichi, pamwe nemishonga iyi "Streptomycin", "Cycloserin" nevamwe, inoshandiswa semishonga inodhaka. I "Isoniazid" mishonga inobvumira vana nevakuru kuti vashandise mirayiridzo. Zvimwe zvinoreva kushanda kwehutano hwechirwere mumatambudziko akaoma uye ekutanga kwechirwere cheshuga.

Mishonga inoratidzirwa kune maitiro ekudzivirira kwebronchoadenitis. Isoniazid inorayirirwa kuti ive mamiriyadhi uye inobvumirana nehumatogenically inopararira chirwere chemapupa, kuwedzera kwefibrous-cavernous maitiro echirwere chisingaverengeki, kunyanya kudhakwa uye lupus, chirwere chetachiva, marashi mumuromo, chirwere chemuviri, serous membranes, urongwa hwehuroyi, maziso, mapfupa.

Iko hakuna chirevo chekurapa kwehutano kune varwere vane chirwere chekare cheprhotic.

Kurapa kwehutano hwakasiyana-siyana hwehutachiona, mushonga we "Isoniazid" unorayira kurayirirwa kunyoreswa pamwe chete nemafanana anokwana sulfonamides uye antibiotics.

Mushonga wacho unotorwa katatu pazuva nokuda kwe2 gramu mushure mekudya. Mukana wekutsungirira kwakanaka, kuwedzerwa kwemuti kusvika ku9 gm pazuva (kanaro 0.3 gramu pazuva) kunobvumirwa. Nechiremera chemuviri zvisingasviki 50 kg, hapana kudarika 0.15 gm inokurudzirwa katatu pazuva.

Maximum zuva nezuva akabvumirwa kutora 0.9 gmm, pamusana pokugamuchira - 0.6 gramu. Majekiseni emishonga uye suppository anoshandiswa mumatomu akafanana, inopera zvinyorwa ne 0,01-0,015 g / kg nenzira ye 0.2m solution.

Contraindicated kune varwere vanowanzosangana nemamiriro ezvinhu akaoma, chirwere chevascular, chirwere chepfungwa, uyewo kuva nekukuvadza kwechiphilita kune hurongwa hweshungu.

Ngwarira pakurondedzera mushonga we "Isoniazid" mirayiridzo inokurudzira kuti murwere ane kukanganisa kwechiropa, itsvo, nherera ye peripheral system, optic nerve.

Zvinokonzerwa nemigumisiro inoshandiswa pakushandisa chiremba inofanira kusanganisira polyneuritis, paresthesia, kukanganwa kwepfungwa, kusuruvara, euphoria, kusagadzikana, musoro. Mukuwedzera, pane dzimwe nguva pane musumutsi twitchings, chirungu, kunetseka. Kune maitiro asina kunaka pakushandisa mishonga iyi "Isoniazid" murayiridzo unosanganisira ataxia, fever, stupor, yakaoma muromo, kuputika, hepatitis, nekuchengetedza urinary (mumarume). Kazhinji anemia, pellagra, jaundice, eosinophilia inoitika.

Mukati remishonga, semitemo, mushonga wekurapa unotarisirwa pakutenga kwekugadzirira "Izoniazid".

Zviito zvakakurudzirwa zvezvinetso uye chepfu

Kuti abvise migumisiro yekutora "Isoniazid" mishonga (kusanganisira mumatomu akakwirira), chiremba "Pyridoxine hydrochloride" inorayirwa. Nheyo inoitwa intravenously. Muyero we "Pyridoxine hydrochloride" unoiswa pachiyero chegamu rimwe pa gram ye "Isoniazid" kugadzirira. Kana zvikazogadziriswa zvekupedzisira zvisinganzwisisi, fungai magiramu mashanu emudhaka "Pyridoxine hydrochloride" uye makumi mashanu magamu e isotonic sodium chloride solution. Mhinduro yakadaro inogadzirirwa kwemaminitsi mashanu mukati, uye zvakare shure mushure memakumi maviri kusvika makumi matatu emaminitsi, kusvikira pfungwa dzidzoka uye mamiriro ekutora ari kubviswa.

Kana pane chepfu kana kuti kudarika, gastric rinopisa rinorayirwa nekusimudzirwa kwekatebhoni kana kushungurudzwa kwemarutsiro echimiro. Saline laxative inoratidzwa . Kufuridzirwa kwepfungwa kunoshandiswa. Ipa mishonga "Prednisolone", madhiragi ekuwedzerwa, kugovera mukati mega " Sodium Hydrocarbonate" (3-5%) yemakumi mashanu nemamiriyoni zana. Kuti abvise kugunun'una, zvishoma nezvishoma injected "Sibazon" (zvichida hypersensitivity) kana kuti mabhakitiriri ekutsvaga kwenguva pfupi. Kugadzirira "Cyanocobalamin", "Methionine", "Thiamin" inoratidzwa.

Kugadzirwa kwemishonga "Isoniazid" ine zvirevo zvinotevera: "Tubazid", "Rimicid", "Zonazid", "Kotinazin", "Ditubin" nevamwe.