Wegamma-interferon: basa uye kukosha mumuviri womunhu

Kudzivirira vanhu muviri kubva kukuvadza anokonzerwa utachiona - nemavhairasi, pane mashandiro ari zvirwere, ichipa kudzora zvirwere. Zviri firimu masero, akadai T-lymphocytes zvimwe zvinhu, rimwe riri wegamma-interferon. Achiumba ari zvirwere, kubatana anoita somunhu cellular kuzvidzivirira. Sei zvichikosha sezvakaita mufananidzo, uye chii maererano anofanira kuvimbika muviri wedu - mibvunzo iyi ichapindurwa munyaya ino.

Makemikari mamiriro uye kugamuchira

Hwaro nefuma - a glycoprotein - chokuita peptide carbohydrate. Biochemists dzinounzwa kaviri zvakasiyana amino iine acid sezvamunoita 139 uye wokutanga monomer iri polypeptide cheni. Dzinonzi wegamma-interferon 1a uye 2a. The paavhareji samolecular kurema sezvakarayirwa 20 - 25 kDa. Kuumbwa pakupindurwa kupinda pakati munyama uye masero ane pathogenic mumiririri aimiririra nemavhairasi inoramba. Ezvokunambira kunze kwomuviri waamai fuma yaunganidzwa hwokushandura zvinhu zvipenyu uye majini ouinjiniya kushandisa utachiona hunokonzera Escherichia coli coli, mumwe plasmid rine majini kuti interferon kwevanhu. Izvi wegamma-interferon inonzi recombinant ndiye chikamu kugadzirira: "Immuneron" "Ingaron" "Immunnomaks".

The mashandiro kuti masoja mhinduro

The pakuonekwa muviri womutorwa virulent utachiona nguva dzose pamwe kwegadziriro anodzivirira urongwa, rimwe riri kuzvimba. It anoshumira chiratidzo, zvichiratidza kutanga zvose chirwere uye mhinduro sero pakupindura maantigen pakati nayo utachiona. Pane kunzwisisa kusakarongeka pakati pezvokuvamba utachiona zvinyama kana nenyere. Kwakavakirwa zvinhu zvinoberekwa masero ari lymphoid zvinyama: cytokines (lymphokines). Somuenzaniso, masero yevanhu interferon-wegamma, interleukin 2 nokukurudzira Kamudzira mukukurukurirana vasina utachiona kutanga kwetunhu antibodies, uye vanotova achipa chiratidzo mapurotini. Ngationgororei navo zvizere.

ehupfumi lymphokines

munhu The chromosome 6 peya yaiva locus dzine chine majini, vakatakura ruzivo pamusoro antigenic ehupfumi pakati plasma Kamudzira nemamwe cellular organelles: musimboti, mitochondria, etc. Lymphokines pachavo havagoni zvakananga kupesvedzera maantigen ose nemavhairasi, asi nokukurumidza budisa ruzivo pamusoro kuvapo dzimwe zvinhu kubva muchitokisi chimwe. Somuenzaniso, Kanotokonya ari antigen-mubatsiri masero uye T-lymphocytes gate induces ane intracellular chiratidzo, vaviri zvakananga simba mapuroteni. Uyezve munzvimbo iri lymphoid zvinyama kunosimudzirwa mitotic nokupesana hadzichatori - kuwanda uye sero-yairevererwa kutapata ichiwedzerwa kwazvo. Kufanana nevamwe lymphokines, interferon-wegamma kuchititadzisa ari dzinotsanagura transcription pakati nemavhairasi nucleic acid, uye zvakare kuchititadzisa paungano mashandiro mapuroteni mamorekuru utachiona hwakakura. Tinogona kutaura kuti mapuroteni yeimwe, runoonekwa nesu, tiri hwaro humoral kutapata.

dziviriro yezvirwere mumuviri sei

Thymus, node nodes, tonsils, okuwedzera - nzvimbo lymphocyte inotungamirwa. masero Protective pave antibodies kuti tunodzivisa kukura muviri pazvirwere mavambo. Mukutanga zvokukura kukura zvirwere masero anonzi mano, haagoni arambe dzimwe maantigen, mabhakitiriya uye wanda. Vanofanira kukura uye kuva immunocompetent - richiwanika munyika thymus. The gadziriro nhengo kuti unobereka kudzivirira pachake masero vose: macrophages, T masero, muurayi masero, uyewo-siyana wegamma-interferon aidzorwa dzakanga cortical nzvimbo wouropi.

basa rayo riri nokudzorwa adrenal omumuviri, pituitary shwanu uye hypothalamus. Psycho-mupfungwa zvinetso, murombo muviri uye netsika dzakaipa kuderedza zvirwere maitiro muviri, kazhinji izvi kuitika tikafunga chisingaperi mupfungwa. Sezvo kwaiita muviri ndiwo mugumisiro zviito zvose dzemuviri, chero zvaipesana homeostasis masoja hwakazara kukundikana uye utano murombo.

Antibodies kuvanhu interferon wegamma

In okurapa sechinhu prophylactic uye dzokurapwa mumiririri akashandisa zvinhu ane anodzivirira mapuroteni zvinoberekwa majekiseni anodzivirira mhuka pamwe recombinant interferon. Antibody mamorekuru kunokurumidziswa kubva serum ropa, Yakanatswa uye kushandiswa antiviral zvinodhaka. It anogona kuwedzera basa pachavo yeimwe anodzivirira muviri, semuenzaniso, wegamma-globulins, uyewo kuderedza zviratidzo kufema noutachiona: rhinitis uye nasal kuzara, chikosoro.

The kuchirapa mugumisiro interferon

Unodzivirira glycoprotein kuchititadzisa ari chokuwanziridza pakati nemavhairasi uye zvinosimudzira muchitokisi makemikari, akadai mapuroteni kinase adenilatsintetazu uye kupa kudzvinyirira pamusoro kwetunhu nucleic acids uye mapuroteni ari nemavhairasi hamvuropu. The fuma anokwanisa kupesvedzera nehanya kuti Kamudzira mapuroteni kuti sero lymphokines, t. E. Is immunomodulators. Wegamma-interferon vana uye vakuru rinoshandiswa kuti kudzivirirwa uye Mabatirwo yokuSpain uye kufema zvirwere, zvakanaka ivhu kuvapo Koch kuti bacillus mumuviri. The kuchirapa mumiririri ukasunungurwa muchimiro mapiritsi, mafuta okuzora, suppositories uye majekiseni.

Kushandisa zvinodhaka chairayirwa chiremba, vana vanogona kutanga kubva 6 mwedzi, vakapiwa kushaya mwana neutachiona uye zvakakomba pathologies pakati kumwoyo. Contraindication kuti kurapwa wevakadzi pamuviri uye chisimbwa. Current mishonga kunyanya kushandiswa Pediatrics, ane rokudzivirira recombinant mapuroteni dzakakwirira kuchena uye kusavapo polypeptide zvimedu rakakwana.