"Theophylline": mirayiridzo kushandiswa. "Theophylline": zvairatidza kuti kushandiswa analogues

Kana munhu anotambura yemweya mhingaidzo, ichi zvingaratidza pamberi chisingaperi obstructive pulmonary chirwere (COPD). chirwere ichi iwayo akakurumbira. Kazhinji panowanikwa chirwere ichi kuonekwa vanosvuta. Kukura chirwere ichi kunokonzerwa chirwere raparadza, kana chii nevamwe kukuvara yemapapu. Munhu ane kufema constriction hakugoni exhale. Somugumisiro, huru zviratidzo ndivo zvinoratidza chirwere dyspnea, chikosoro, uye sputum kugadzirwa. Zvakakosha kuziva. Rakajairika ndiyo kukura mamwe COPD. chinowanikwazve Iri asima, chisingaperi bronchitis, emphysema, bronchiectasis. In kurapwa nedzimwe zvirwere izvi uye vazhinji chichabatsira mushonga akadai "Theophylline". Mirayiridzo kushandiswa kwezvinodhaka ichashandwa murugwaro urwu. Mamwe mashoko pamusoro peizvi.

tsananguro

"Theophylline", uyo akafanana achaiswa kurondedzerwa pazasi, iri chena crystalline upfu. Zviri zvishoma soluble mumvura inotonhora (mu nhamba 1: 180), asi ari nyore zvazvichanyungudutswa mvura inopisa (ari nhamba 1:85). Zvinoitawo urwa mu alkalis uye acids.

mamiriro

In Pfungwa iyi huru vanoshingaira chirungiso ndiyo theophylline. napano zvinosanganisira zvimwe ebetsero zvinoriumba. Zvinoti - lactose monohydrate, magnesium stearate, talc, methacrylic acid.

kusunungurwa Form

Kune mhando dzakawanda panyaya iyi. "Theophylline" kugadzirwa sezvo mahwendefa wakatsigira-kusunungurwa (0.1 g, 0.25 g), capsules (0.125 g, 0.5 g), uye suppositories (0.2 g).

pharmacological zviito

Functionality ose akati Pfungwa iri multi-faceted. "Theophylline", wongororo zvacho zvakanaka, kutandara anoratidza tsandanyama zviri principales, ane muviri uye vasodilator chiito. gadziriro iyi kunovimbisa kunowanzoitika nokushanda kufema centre. Kubvisa marwadzo ari diaphragm uye kuvandudza kushanda intercostal tsandanyama kunoitawo kuti "Theophylline". kushandiswa kwaro kwenzombe akazoita ndingangokuvara kuoneka neutachiona munyika kufema ino mhando miviri. Akati gadziriro rinogona diuretic kushanda. Kuvapo yezviri zvinhu zviri medicament anokurudzira normalization pakati kufema basa, kuderedza nenhanho carbon dioxide inobvisa uye kwakawedzera kufefetedza. "Theophylline" zvinobudirira anowedzera coronary riparadzirwe. asiwo kunobatsira kuderedza mataurire nhumbi uropi, itsvo uye mwoyo. Kana tichiita refu kurapwa kuri kuwedzera biliary turakiti, normalization microcirculation uye erythrocyte kuramba deformation inowedzerawo. In varwere vanenge hypotension, ungave BP. Implementation yokugamuchira imwe gadziriro yakadaro "theophylline", pamwe Beta-blockers, uye mishonga inorwisa mabhakitiriya kunotungamirira mikana yakawanda nemishonga.

zvairatidza

Rongera akati mushonga pa panowanikwa Árbol asima, asthmatic chinzvimbo, obstructive bronchitis, pulmonary emphysema. Uyewo rinoshandiswa sechinhu chinoyamura vachangoberekwa vacheche pamwe kufema. Shandisa "Theophylline" zvikurukuru somunhu bronchodilator. Uyewo, ivo kurishandisa somunhu mwero cardiotonic (anowedzera simba mwoyo sunga) uye diuretic (diuretic) zvinodhaka nokuda congestive kuratidzwa renal uye cardiac mavambo. Dzimwe nguva chinotarisirwa pamwe nevamwe anogumbura uye bronchodilators.

rondedzero pamusoro chakarondedzera akati Pfungwa

Pakutanga, pakurapa COPD ndiyo basa bronchodilators. Vanotakura kuburitsa Airways. Mumwe zvinodhaka izvi, sezvo kare ambotaurwa, kugadzirira kwakadaro se "theophylline". Mirayiridzo kushandiswa ndozvavava rive bronchodilator zvinodhaka, izvo anoita vanonzi ichivharira kuti purine receptors. Kuvapo akadaro kukanganisa mashandiro chendangariro kubviswa kurwadza kwacho vari anotsvedzerera tsandanyama pakati principales, kubviswa kurwadziwa diaphragm, activation reokisijeni kuti mapapu, kuvandudza basa intercostal netsandanyama. Somugumisiro, mashoko Airways zarurai, munhu kufema nyore.

It ane chaicho zvinobatsira, "Theophylline". Mirayiridzo dzokushandisa kunoratidza kuti zvinodhaka izvi kunogona tinzwe kwete chete pane kufema turakiti, asiwo vamwe hurongwa muviri. mushonga uyu unobatsira kuwedzera coronary uye peripheral nemidziyo ropa, KUNOTADZISA chirongwa platelet adhesion, ari munyoro diuretic chiito. Inopa dzishande kuchekerera basa pomwoyo (myocardium), yakaderera BP, uyewo sei musimboti tsinga chinobatsira. Somugumisiro, mushonga anokwanisa kuita ichiita mabasa akawanda, panguva imwe chete rine antiasthmatic, bronchodilator, diuretic, spasmolytic, vasodilatory uye cardiotonic zvivako.

"Theophylline": mirayiridzo kushandiswa

Kuti tizive chipimo chemushonga, pane zvakawanda zvinodiwa. "Theophylline", maererano nemirayiridzo, unofanira kutora vana makore 14 uye vakuru, 300 MG pazuva 2-3 nguva. Panyaya iyi, mushonga vanofanira kunwa mvura yakawanda. Kana zvakakodzera, kuti dose anogona ngazviwedzerwe 500 MG 2 kanomwe pazuva, kana ndakarumbidzwa nachiremba wako. Kana murwere ane uremu muviri asingasviki 60 makirogiramu, kuti chipimo chemushonga inofanira kuva 100 MG 2 kanomwe pazuva. Panyaya iyi, dzakatarwa mangwanani uye manheru womuchato rokugadzirira ichi se "Theophylline". Instruction inoti kuti mushonga zvinokosha kutanga mishonga diki uye zvishoma nezvishoma zvinowedzera kuti. mushonga uyu zvinofanira kuitwa panguva nenguva. Vanofanira kuva mazuva 2-3. Maererano mirayiridzo iyi, kana kurapa kwacho zvinokosha kuti kuitisa dzose chirwere dzokuvhiya. Kureva - Implementation kuti ongororo ropa, BP nekuyera, X-ray, ECG, kuziva padanho remafuta akawandisa uye hemoglobin. Kuratidzwa kuchirapa mugumisiro vakati nzira anouya pashure pemazuva maviri. Zvakakosha kuziva. In Joint negashiro mushonga chete antispasmodics kunge kuwedzera kunyatsoshanda ari kurapwa kwacho. "Theophylline" akazoita chiito mishonga antidiarrheal nevamiririri. Kupodzwa nguva vanofanira kungwarira kuita chero caffeinated zvinhu uye antidepressants.

Kutora zvinodhaka panguva yepamuviri uye achiyamwa

"Theophylline" zvainoita azvarwa pasi category "C" by FDA. The chishandiso kupinda munharaunda yacho placental chipingamupinyi. Vakadzi vane pamuviri zvinogona vati zvinodhaka chete zviitiko apo akatarisirwa vabatsirwe kuna mai kupfuura zvingakanganisa azvarwa. Munguva I trimester uye okupedzisira vhiki pamuviri vanofanira kutora mushonga, kuchengeta yakaoma zviratidzo. Zvakakosha kuyeuka.

Hwakawanda zvaanorumbidza dzinoti theophylline Clearance munguva III trimester akazvitakura ipfupi. Izvi kungada kakawanda Kutsunga wevasungwa rimwe fuma muropa uye zvichibvira rutapudzo of dose.

Achiyamwa "Theophylline" muwisira mukaka uye zvingakonzera zviratidzo kushatirwa mune vacheche kana zvimwe zviratidzo toxicity. Zvakakosha kuziva. Kuwanda akati fuma iri mukaka ndiko anenge yakaenzana ayo kugutsikana mune ropa serum pakati mai. Uyewo, izvi zvinoreva yekudyidzana kuchititadzisa uterine sunga.

Contraindications

"Theophylline" mirayiridzo kushandiswa zvatsanangurwa pamusoro, ari contraindicated kana paine:

• Idiosyncrasy.
• Hyperthyroidism.
• Chenjera myocardial infarction.
• Subaortic stenosis. Ichi asiri anogumbura chirwere rworuboshwe ventricle mwoyo tsandanyama tishu. It kunoratidzwa kutaura unopinza aienda kwaro mhango.
• Arrythmia.
• Pfari nezvimwe zvirwere convulsive.
• Pregnancy.

With kutarisira zvakafanira kuita negashiro zvinodhaka panguva kuratidzwa maronda chirwere mudumbu uye duodenum.

chaizvo zvinodiwa

Kusvuta yekudyidzana kunokanganisa kunhaka kuti muviri uye excretion vakadai zvinhu zvakadai theophylline. Zvinofanira kurangarirwa. Persons uyo aisvuta 1-2 packs it fodya rimwe zuva, kuva akaderedza hafu-upenyu kumwedzi. In varwere hepatic, cardiac kana kufema kukundikana akaratidza, uyewo kutapukirwa noutachiona uye hyperthermia kunoitika deceleration kubviswa yezviri fuma. Negashiro doro caffeine-mhando uye zvigadzirwa anewo chinokosha zvainoita muviri kuti theophylline.

kudyidzana

The mushonga "Theophylline" chinosimudzira potentiation mugumisiro β2-agonists. Kungawedzerawo tremor, izvo yakakonzerwa sympathomimetic zvinodhaka mhando uye anokwanisa tunodzivisa chirongwa Absorção de Água kuti phenytoin. Slow kubviswa nzira unowanikwa kudyidzana dzaro "erythromycin" uye "phenobarbital." Rinoreva "Theophylline" rinopa kuwedzera renal excretion kuti lithium. Panyaya iyi, kuti mishonga nepakati akashatirwa Varwere vari unoenderana munyu. The mushonga "cimetidine" zvinobatsira kuti wevasungwa muropa theophylline yomuropa, uye anowedzera nguva yaro kurega. Mishonga yakafanana migumisiro zvichabviswa pasi apa.

Kuvapo nemishonga

Kana muchigamuchira akati mishonga vangava zvakasiyana chaisava zviratidzo. zvinoti:

• Unogona kuona zviratidzo dzungu, kushaya hope, kutemwa nomusoro, kufenda, kufunganya, tremor, kuvhiringidzika, netsviyo.
• In kumwoyo - arrhythmia, tachycardia, venhema angina, kungoerekana kuderera BP, angina pectoris.
• Kubva zvomudumbu hurongwa - the kwaita kuda kurutsa, kurutsa, chirungurira, manyoka, flatulence, colitis, gastritis.
• Kana basa nokugamuchirwa nzira inogona kuchengetwa zvimwe kuratidzwa neutachiona muchimiro yakafunuka, nokutsva, urticaria, dermatitis, nefivhiri, vangadikitira uye ganda rashes.

ovhadhozi

Muchiitiko chino, pane mamwe zviratidzo. Under kuratidzwa izvi zvinosanganisira:

- nokusagadzikana;

- kuvhiringidzika;

- nokugwinha;

- tachycardia;

- arrhythmia;

- hypotension;

- svoto;

- manyoka;

- kurutsa ane admixture ropa;

- hyperglycemia;

- metabolic acidosis.

Kana zviratidzo izvi zviri basa imwe kurapwa. Kureva, kuitwa:

• Maratya nzira.
• Kudiridza nharaunda bowel mubatanidzwa munyu uye polyethylene glycol mhinduro.
• Intravenous kugamuchira "MCP" kana "Ondansetron" pamwe anozivikanwa zviratidzo svoto uye kurutsa.
• Kugamuchirwa "benzodiazepines", "Phenobarbital" (kana thiopental yavaibvisa) uye peripheral tsandanyama relaxants panguva panowanikwa pfari.

"Theophylline": dzomuzana

Pane mishonga akawanda akasiyana izvi mhando. Panyaya iyi, funga zvinotevera mishonga:

- "Teobiolong" ( "Theobilongum").

- "Spofillinretard" "(Spophillin kutadzisa").

- "Perfillon" ( "PerphyUon").

- "Neoefrodal" ( "Neo-Efrodal").

- "Franol" ( "Franol").

chengetedzo

The Nezvakakuyiwa uye mahwendefa ( "theophylline") akachengetwa ari murima, nzvimbo yakaoma. Hwavo pasherefu upenyu huri makore mashanu. Storage makenduru zvinofanira kuitwa mufiriji. Panguva iyoyo irege chando. Hwavo pasherefu-upenyu makore mana.

mugumisiro

Pashure pokuverenga apa, munhu anogona kufungidzira mushonga akadai "theophylline", mutengo chiri zvinogamuchirika (mukati 70-160 kwiza.). Uyewo murugwaro urwu akaudza pamusoro mirayiridzo kushandiswa kwezvinodhaka uye kudyidzana kwayo pamwe nedzimwe nzira.