Makenduru "Flex": richitungamirira, ongororo, mitengo, analogs

"FLEX" makenduru ndivo mishonga boka NSAIDs (non-steroidal Anti-anogumbura nevamiririri). Rine Anti-anogumbura, antipyretic, unonyaradza marwadzo uye antiagregatsionnoe chiito. Nechipiriso zvinodhaka kutigumbura ari enzayemu basa (cyclooxygenases 1 uye 2) uye prostaglandin usage. Izvi zvinoita kuti paumbwe anogumbura nevamiririri uye kuchititadzisa pakuonekwa leukotrienes.

Makenduru "FLEX" antibradikininovuyu zviratidzwa basa, dzikamisa lysosomal biomembrane, chikonzero chinovhiringidza kuti neutrophil basa pavarwere vane chirwere kuti "dzinonzi rheumatoid arthritis". Tunodzivisa platelet aggregation. The unonyaradza marwadzo nezvinozoitika nokuda zvose nechepakati uye peripheral zvigadziriswe. vanachiremba vakawanda kuti kurwadziwa uye yemajoini kurapwa ushandiswe "Flex" (makenduru). Mutengo zvinodhaka zvinoita kuti tikwanise kuwana kuti zvakasiyana Mapato wevarwere. Reviews pamusoro medicament zvinopupurira ayo yakakwirira kunyatsoshanda uye kuchengeteka utano achiita zvaidiwa kunenge.

Mirayiridzo kushandiswa kwezvinodhaka iri zvakanaka nyore, uye wongororo kusimbisa pachena kuchirapa mugumisiro. Kuti chikamu zvinodhaka? Chii ehupfumi izvozvo ane? Pane ngozi nemishonga? Mhinduro dzemibvunzo iyi vari kutsvaka varwere vakawanda.

The makemikari anoumba zvinodhaka

The gadziriro iri kunzwisisa kuti bioactive zvinhu uye Excipients:

• Ketoprofen (zvinhu bioactive remubatanidzwa);
• wakisi;
• hydrogenated mafuta muriwo;
• colloidal nesilicon yakasviba;
• yavaibvisa ethyl parahydroxybenzoate;
• sorbitol;
• gelatin;
• mafuta muriwo;
• glycerol;
• Sou lecithin;
• titanium yakasviba;
• yavaibvisa propyl parahydroxybenzoate.

"FLEX" makenduru analogues

In kuchirapa tsika vanachiremba asi vachishingaira kushandisa analogues wemagazini yambotaurwa Pfungwa:

• "Artrozilen".
• "Ketonal navaviri".
• "Artrum".
• "Bystrumgel".
• "Valusal".
• "Bystrumkaps".
• "Ketonal".
• "Oruvel".
• "Febrofit".
• "Flamaks".
• "Profenid".
• "Ketonal uno".

kubatsira zvinodhaka

The chikuru kubatsira zvinodhaka kunofanira kusanganisira zvinotevera indices:

• kufadza kuchirapa chaizvoizvo;
• soro bioavailability zvinodhaka ichienzaniswa vezera ayo.

zvazvakashatira zvinodhaka

The chikuru zvipi "Flex" kunofanira kusanganisira zvinotevera nzira:

• mutengo Akakwirira zvinodhaka zvichienzaniswa vezera;
• haana kuwanikwa daily (mazhinji) kusunungurwa siyana.

Pharmacokinetics

Bondability bioactive zvinhu zvinodhaka pamwe mapuroteni mu plasma iri 99 muzana. Makenduru "FLEX" vanoonekwa ne mukuru bioavailability (90%). Kuchirapa wevasungwa "Flex" muropa anodzokororwa kwemaawa 6. Main metabolic cleavage zvinodhaka unowanikwa hepatocytes kubudikidza glyukorirovaniya. The hafu-upenyu maawa anenge maviri. The mushonga hauna cumulated, rinobva kazhinji itsvo uye kuburikidza muura.

"Flex" (makenduru): mirayiridzo kushandiswa, mutengo

The pamusoro medicament akava navanopinda chakarondedzera kuchirapa chiito. "FLEX" makenduru kazhinji nezvaro kurapwa tsika kuti kurapa kurwadziwa uye anogumbura vamwe siyana mavambo. Kushandisa mishonga pachii zvinotevera pathologies:

• migraine;
• psoriatic chearthritis;
• tenosynovitis;
• renal colic;
• gouty chearthritis;
• bursitis;
• dorsalgia;
• myalgia;
• dzinonzi rheumatoid arthritis;
• otitis nhau;
• chemajoini zvakasiyana localization;
• polymyalgia rheumatica;
• pfupa marwadzo;
• Sciatica;
• phlebitis;
• ankylosing spondylitis;
• neuralgia;
• thrombophlebitis;
• Sciatica;
• adnexitis;
• Zvokurwara ari lumbosacral plexus;
• Sciatica;
• algodismenorei;
• postoperative uye mushure mokumuka Kunetseka chirwere ;
• lymphangitis;
• kurwadziwa kenza pathologies.

Kutenga mushonga "Flex", mutengo iyo kunosiyana-siyana zviri kuwanda 200-300 rubles, kana uine mushonga chero chemishonga. Uyewo kucherechedza ndechokuti makenduru "Flex" iri Gynecology iri zvakaenzanirana unowanzoshandiswa dzavo nachiremba ovarian chikofu. Maererano nouchapupu varwere vakawanda, mishonga inoshanda zvinobudirira. vanachiremba vakawanda vanoti kuti mushure kurapwa "Fleksenom" mazuva 10 uye gamuchirai mamwe zvinodhaka chikofu nokupera.

Contraindications

Kana ukasarudza kushandisa "Flex" (makenduru), kudzidziswa Chinyorwa chinoratidza kuti zvinodhaka izvi hazvifaniri kushandiswa zvinotevera nyaya:

• ropa ari nemudumbu;
• runoratidzwa itsvo uye chiropa dysfunction;
• pamuviri uye lactation nguva;
• hypersensitivity vasiri-steroidal Anti-anogumbura zvinodhaka;
• Mamota;
• "Asipurini" asima;
• Zvirwere ropa pakugwamba ;
• proctitis;
• zera pasi pemakore 15;
• dysfunction of hematopoietic ino (leukopenia, coagulation zvirwere, thrombocytopenia, hemophilia);
• bowel chirwere exacerbation.

mirayiridzo Special

"FLEX" (makenduru) gwaro anoratidza kushandiswa nokungwaririra pavarwere vane renal dysfunction, chiropa, zvomudumbu turakiti, Árbol asima, udhakwa, rhinitis, panguva polyps ari nasal mucosa, kupera muviri, urticaria, kusvuta, cirrhosis, hyperbilirubinemia, zvirwere ropa sepsis, chirwere cheshuga, musana pathologies, vanhu vakwegura. Panguva kurapwa pamwe akati medicament kunoda enderana richiona nezvezvabuda renal nerevane chiropa. Kana "Flex" makenduru vakagadzwa anorenda pamwe anticoagulants (heparin), mikana yakawanda ropa. Long kuchirapa kosi zvinogoneka chete mumamiriro ezvinhu ane chipatara. Panguva kurapwa, kusatora doro.

divi kushanda

Awakapiwa "Flex" (makenduru)? Mirayiridzo Use haadi haabatanidzi kukura nemishonga. Ivo:

• kwazvo nomusoro;
• svoto;
• chirungurira;
• dzungu;
• kurutsa;
• kurasikirwa havi;
• kushaya hope;
• gastrointestinal ropa;
• asthenia;
• hope;
• conjunctivitis;
• xerophthalmia;
• kutya;
• kupatira;
• tinnitus;
• kukanganwa;
• madzerere;
• chiropa;
• kunzwa kurasikirwa;
• vertigo;
• peripheral neuropathy;
• gastralgia;
• tachycardia;
• vavanongogara dysuria;
• Flushing;
• eczema;
• cystitis;
• nephrotic urwere;
• urethritis;
• fotodermatit;
• laryngeal edema;
• hematuria;
• erythema;
• renal dysfunction;
• edema chirwere ;
• itchy ganda;
• ganda Kurwara;
• kuwedzera transaminases (alanine aminotransferase uye aspartate aminotransferase) muropa serum;
• kupfupika mweya;
• rhinitis;
• nosebleeds;
• bronchospasm;
• anaphylactic kuvhunduka.

Kushandiswa suppositories kukonzerawo manyoka, tenesmus uye inopisa manyawi.

Zviratidzo zviri ovhadhozi

Makenduru "FLEX" aiendeswa rectal kushandiswa - 1 suppository (100 MG) 1-2 kanomwe pazuva. Kufadza zvinobvumidzwa dose zuva nezuva ketoprofen - 300 MG. Zvinotevera Zviratidzo zvinochengetwa pakuparwa ovhadhozi:

• dysfunction chiropa uye itsvo;
• hope;
• svoto;
• ropa;
• kurwadziwa ari epigastric nharaunda;
• kurutsa.

Kana Detective pamusoro apa zviri basa symptomatic kurapa. Hapana chaizvo mushonga. Somunhu adsorbent neactivated charcoal, "Sorbeks", "Medetopek" kana "Neointestopan". Dialysis, kumanikidzwa diuresis - sashanda kurapa. Ipa alkalizing yomuchipatara kuti zviite chikamu alimentary mugero zviratidzo. glucocorticoids zvinogona kushandiswa kana zvakakodzera. In renal insufficiency, hemodialysis. In nokugwinha kugadza "Diazepam" benzodiazepanovye kana zvimwe zvinodhaka anticonvulsant; kwazvo hypotension zvinowedzera plasma raitongwa ( "Reopoligljukin", "Poliglyukin", "Enterodez", "Polidez", "Hemodez"). Murwere kunoda kugara pakuongorora kwemazuva mashomanana, sezvo pane ngozi kuratidzwa akazotevera zvimwe zvirwere gastrointestinal (ropa, ulceration).

Kudyidzana nevamwe zvinodhaka

It runogonesa kuitwa anticoagulants, fibrinolytics, panyaya iyi, antiplatelet vamiririri, akazoita mugumisiro peripheral vasodilators, spironolactone, kushanda zvakanaka mishonga uricosuric, Pharmaceuticals uye hypotensive diuretics. Kumusoro vakapa mishonga zvaisaenderana "Tramadol." Kushandiswa kwose "Flex" nevamwe vasiri steroidal Anti-anogumbura vamiririri, ethyl doro, corticosteroids, corticotropin chinokurwadzai nokuumbwa nemaronda uye kukura gastrointestinal kubuda ropa. Antacids kuderedza kunyatsoshanda pakati Absorção de Água zvinodhaka. Mazuva maviri asati chokuendesa Analyses pamusoro zviri 17-ketosteroids zvinodhaka Akawisira.

"FLEX" anowedzera hypoglycemic mugumisiro jekiseni uye kunanzvana zvinodhaka hypoglycemic. zvinodhaka Myelotoxic kuwedzera mashoko gematotoksichnosti zvinodhaka. Inductors microsomal biooxidation ari chiropa ( "phenylbutazone", panyaya iyi, tricyclic antidepressants, "Phenytoin", "Rifampicin" barbiturates) simba iri biosynthesis kuti basa hydroxylated metabolites. Mawa Chikumbiro "FLEX" ne "yavaibvisa valproate" rinoita kuvhiringidza platelet aggregation.

Reviews kugadzirira

Varwere vakawanda vanofarira wokuti chii chaizvoizvo ndiyo makenduru "FLEX". Mirayiridzo kushandiswa, mari zvinodhaka, zviratidzo uye contraindications - zviri, Chokwadi, huru. Kunyange zvakadaro, vanofanira vazive pachavo pamwe maonero nyanzvi uye varwere panyaya iyi. vanachiremba vakawanda vanodavira kuti yakanakisisa unonyaradza marwadzo uye Anti-anogumbura mumiririri - "FLEX" (makenduru). Mhinduro Varwere kakawanda (80 kusvika 90%) akanaka, nokuda kudunhu kunyatsoshanda zvinodhaka, kurwadziwa hwakavimbika siyana etiology uye localization, inogara kushanda uye nyore. A zvakwakanakira anogona kuonekwa kubvira pamazuva kubvuma rokutanga chairo. Negative wongororo pamusoro gadziriro ainyanya chokuita nechitarisiko nemishonga yayo cost, asi nezvayakaipira izvi kurapwa havagoni kufukidza dzakakwirira kunyatsoshanda kwayo.

Mamiriro ezvinhu nerubatsiro Pharmacies

The mushonga ari muchimiro suppositories uye capsules vakasunungurwa kunoparirwa mushonga. A medicament muchimiro gel chinogona kupiwa pasina mushonga.

chengetedzo mamiriro

Ramba pasigasvikirwi vana ari tembiricha hapana kupfuura 25-30 ° C. The wainyatsotaura tembiricha siyana anoreva kwose kusunungurwa. The musi wazvinenge pamusoro pasuru. Mishonga havafaniri kutorwa mushure expiry musi!