HCG vavo mabasa

Makemikari raznostrukturnyh Organic zvinhu anogona kukanganisa kushanda kunoita muviri. Gonadotropic mahormone chokuita basa dzokubereka nadzo. Ivo synthesized mune Anterior pituitary shwanu uye kubva ipapo vari secreted kupinda ropa.

The mahormone of Anterior pituitary

The pituitary shwanu iri muzvikamu zviviri: mberi neshure. Zvakananga pamberi hormone synthesized uye secreted kupinda muropa. The posterior akafukidza pituitary shwanu, vachibva hypothalamus uye secreted kupinda ropa chete zvadai.

Gonadotropic pituitary mahormone inotokonya dzepabonde mumasero. Idzi dzinosanganisira:

• FSH - follicle-mutange kemikari. Zvinokurudzira oogenesis uye spermatogenesis. Chinhu chisinganzwisisiki mapuroteni (glycoprotein) iro rinoumbwa amino acids anonamatirana makabhohaidhiretsi.
• LH - luteinizing kemikari. Zvinokurudzira kusunungurwa zai kubva ovary kunokanganisa secretion dzepabonde mahormone (estrogen, progesterone) nevanhu kunokonzera secretion pakati androgens. Huwandu kemikari kunosiyana-siyana panguva imwe kumwedzi, pane Proportional uye synchronous secretion imwe yakawanda FSH uye LH.

kemikari Kugadzirwa rinoitwa mu gonadotropah (basophilic masero) adenohypophysis. Vanoumba anenge 15% vose masero ose Anterior akafukidza.

Pregnancy kemikari - HCG

Kana pakusangana uye muchibereko zviri ovum iri uterine pamadziro mumuviri mukadzi anotanga kubudisa chaizvo pituitary gonadotropic mahormone akauya chorionic gonadotropin.

Kemikari basa iri kuramba mashoko corpus luteum mbeu basa (pakusarudza inonzi estrogen uye progesterone) zvizere kuibvisa kuti placenta. Inopa yakakwirira luteinizing zvainoita muviri, izvo zvikuru akapfuudza FSH uye LH.

Structural zviri mahormone

The chaivo basa mahormone inopa rakasiyana marongerwo zvinosanganisira subunits maviri. Chokutanga, a-subunit, ane anenge kufanana chivako mune gonadotropins zvose, apo b-subunit inopa rakasiyana kuona kemikari.

Somunhu mumwe nomumwe, subunits izvi regai kutakura chero kuchinja nhengo, asi kana vari zvakabatanidzwa, akapa basa kwavakabva uye kuchinja kunokosha pezvakaitwa ane muviri, kunyanya dzokubereka nadzo. Saka, gonadotropic mahormone vane chinokosha zvazvinoita kwete chete pane zvepabonde bhora, asiwo kwemakemikari anobudiswa pezvakaitwa uye mutemo hormone nemwero.

Sezvo mahormone sei muviri

Kubvira munguva dzekare, masayendisiti vakaedza kudzidza zvipenyu basa hormone zvazvinoita pane dzemuviri. Gonadotropic mahormone vane simba guru pamusoro pezvakaitwa womunhu muviri. Naizvozvo, kudzidza kwavo mashandiro chiito kunokosha zvikuru uye zvinofadza mubvunzo. In vachiitisa tsvakurudzo pamwe akanzi kemikari akawanikwa kuti masero anogona kuziva zvimwe hormone kusungira chete masero chaizvo.

Muitiro tichisunga kuti sero rinoitwa nokuita Kamudzira kana masero mukati puroteni Morekuru - Kanotokonya. Intracellular kugamuchira chokuita steroid mahormone, sezvo avanotarisira dawo mumakamuri uye kuchinja pasi basa rake. Kamudzira kugamuchirwa mamirire mapuroteni mahormone kuti vasunge kuti sero Kamudzira unhani.

Nokusungwa kemikari Kanotokonya mapuroteni inosimudzira paumbwe zvakaoma. Danho iri zvinoitika pasina kunobatanidza makemikari, uye ndiye reversible. Steroid mahormone kupinda muchitokisi, kusungira kuti Kanotokonya. Pashure kushandurwa akaumba zvakaoma anopinda muchitokisi neerekitironi inosimudzira paumbwe nezvezuva RNA iri cytoplasm iyo enzymatic kwetunhu nezvimedu kukonzera mugumisiro mahormone pamusoro sero.

Gonadotropic hormone: mashandiro uye migumisiro pamusoro dzokubereka nadzo pezvakaitwa

FSH basa rinosvika-soro mune mukadzi. Kunomutsa kukura follicular masero kuti vari pasi pokudzora GSIK dzikava matema uye ripen pamberi ovulation rwakazara.

Pasi pokudzora nokuwedzera vazhinji SFS ovaries uye testes. Zvisinei, kunyange pakatanga chakagadzirwa chakaita zvokugadzirwa kemikari hazvibviri kuti kukura interstitial zvinyama, izvo kunokanganisa secretion pakati androgens ose testicular hunhu.

GSIK anokonzera ovulation uye inotungamirwa ovarian corpus luteum mbeu. Uyewo pachiimbwa follicle nekurukurirano kemikari zvinokanganisawo secretion ose inonzi estrogen. Pasi pokudzora kemikari kuti zvinoita interstitial masero, pane kukura zvomukati anokonzera yechipiri bonde unhu.

The zvipenyu mugumisiro LTG

LTG zvakafanana zvikuru kukura kemikari. Pashure sokuongorora kwomurabhoritari kwakaratidza kuti vari chete Morekuru, saka munhu anogona hazvigoni kusarudzwa nomumwe, mumwe nomumwe mahormone izvi. The LTG Mabasa zvinosanganisira mukaka secretion uye progesterone. Zvakakosha kuziva kuti azvaiitwa zvinokonzerwa nesungano pakati vakawanda mahormone, sezvo nokufumura muviri chete LTG izvi zvinhu haamo.

Saka, nokuti mugove mukaka zvinoda zvinotevera mahormone:

• FSH uye GSIK - muchiswededza secretion ose inonzi estrogen muna ovaries;
• pasi pokudzora kukura kemikari uye inonzi estrogen ari kukura mukaka ducts;
• LTG chinokonzera secretion kuti progesterone muna corpus luteum mbeu;
• Progesterone kunomutsa wakazara kukura mammary shwanu iri pamwero alveolar-lobed.

Gonadotropic mahormone Zvinoda kugara kusakarongeka kuitira kuti zvizere basa muviri uye zvose zvayo nehurongwa. Ndokusaka yoga simba neimwe (mu nyaya yaitonga chakaita zvokugadzirwa mahormone) haakonzeri inotarisirwa zvavaifunga.

hypothalamic kemikari

The hypothalamus zvabudiswa gonadotropin kusunungura kupinda ropa-kemikari. It ane polypeptide marongerwo uye zvazvinoita secretion kuti pituitary mahormone. Kazhinji zvinokanganisawo luteinizing kemikari, uye follicle ipapo. GnRH anogadzirwa imwe zvakajeka nguva zvikamu, vakadzi, ivo siyana 15 kusvika ku45 (zvichienderana kutenderera), uye varume kemikari secreted chose maminitsi 90.

In chakagadzirwa chakaita zvokugadzirwa kemikari kutarisirwa munhu dropper akambokanganiswa basa secretion pamusoro mahormone, izvo sezvo pfupi dzekugonesa secretion, uye ipapo - panzvimbo kumira kugadzirwa gonadotropins rakakwana nokuda Anterior pituitary.

GnRH vachiona rikurumidze pamusoro nhengo

GnRH dzishande rinopa Anterior pituitary akafukidza, izvo masero (gonadotropins) vane GnRH Kanotokonya chaiyo nokuda secretion pakati FSH uye LH mahormone, izvo zvaizoitawo chokuita nokushanda gonads.

PG zvinoita kuibvisa kuti dzisingaoneki uye zai masero, LH kunokanganisa secretion dzepabonde mahormone (estrogen, progesterone, testosterone). Vakadhakwa dzepabonde Makemikari masero dzokubereka nadzo ripen uye vakagadzirira nokuda muchangosangana.

At zvakanyanyisa nokukurumidza aibuda dzinotsanagura spermatogenesis uye oogenesis dzinounzwa inhibin achifurira gonadotropic mahormone ari Anterior pituitary shwanu inosimudzira kunetesa kuibvisa dzinotsanagura gametes kuburikidza chiito pamusoro follicle mutange kemikari.

Sei kushandisa gadziriro gonadotropic

Kuwedzera mune okurapa kurapwa nokusuma chakagadzirwa mahormone. Mune dzimwe zvirwere kwemakemikari anobudiswa kana zvinetso dzokubereka nadzo munhu aishandisa zvinodhaka gonadotropins. Kutarisirwa yavo pamwero kufurira kugadzirwa bonde hormone kune pezvakaitwa kuitika mumuviri.

Kana kwetunhu gonadotrophins zvingamuka zvimwe kwemakemikari anobudiswa zvirwere (pamuviri rokutanga trimester, pabonde umbishi, pabonde infantilism, panhypopituitarism uye Sheehan kuti urwere).

Kuti tikurire pathologies izvi, ropa riri tsvakurudzo uye kuongorora yaro hormone sezvamunoita. Zvino prescribers kuti zvinodiwa kuti saka chidzosai zvakakodzera pakuenzanisa hormone,, murau pamusoro pezvakaitwa zvinokosha pamuviri.