Urea muropa. Kurera richikwidibira zvirimo

Urea iri synthesized mu nedanho neutralization ose amoniya ari chiropa. It achiumbwa zvinoitwa amino asidhi deamination. Urea chokuita yeimwe yakaderera samolecular uremu. It anokwanisa takasununguka nomumvura sero membranes ose erythrocytes uye parenchymal nenyere. urea kubva ropa filtration rikaitika glomeruli. Asi panguva imwe chete zvayo chinokosha reabsorption (nyararisa) rinoitwa munyika tubules.

Urea ropa inonyanya maererano kwetunhu glomerular filtration exchange uye renal perfusion.

remubatanidzwa Izvi yakaderera toxicity, asi toxicity kuti guanidine nomukaka nhaka potassium ions kuunganidza nayo. Urea ndeimwe osmotically kushingaira fuma, saka kana kunoratidzwa kuunganidza edema munyama pamusoro parenchymatous nhengo, myocardium, musimboti tsinga, subcutaneous tishu.

urea ropa (rayo wevasungwa munguva yeplasma) rinowanzoshandiswa vaiona ane chokukomborerwa renal glomerular shanda mudziyo. Zvisinei, kupfuura yakarurama anoona rinoitwa pasi zviri creatinine.

Kuwedzera urea inotungamirwa kuchengetwa kushandisa yakawandisa mapuroteni catabolic inoti, uyewo Absorção de Água mapuroteni uye amino acids pashure gastric kubuda ropa. Kuwedzera wevasungwa kwayo kuchengetwa kupera mvura mumuviri nokuda vawedzere pusa reabsorption mu itsvo tubules.

Akaderedza urea ropa (plasma) pasi chakaita zvokugadzirwa hepatic basa nyonganyonga, uyewo kukwana mapuroteni yaunodya. Zviri remubatanidzwa mune serum kungawedzera nokuda negashiro wacho zvinodhaka. Mishonga iyi zvinosanganisira phenylbutazone, anabolic steroids, dopegit, zvinowedzera iron, aldomet, zvinodhaka nephrotoxic.

Kuderera kwemitambo urea muropa zvingaratidza chiropa chirwere (chiropa, mu kusanganisira nemavhairasi, cirrhosis, anomera). Izvi imhaka yokuti muviri ichi pane paumbwe chikuru akakura. Kana kukanganisa kunoitika uye chiropa nyonganyonga urea kugadzirwa. Panyaya iyi, zviratidzo chirwere havangagoni kurondedzerwa zvakajeka. Huru Zviratidzo dzinofanira kuzokurukurwa sezvo muutera, kurasikirwa kudya, kurukutika, jaundice, shungu belching, kusagadzikana zvakarurama hypochondrium.

In zvirwere zvomudumbu ezvinhu, achiperekedzwa malabsorption pakati amino acids vanoumba mapuroteni ari postoperative nguva nechokuita kupindira kuti intestinal zvirwere, chisingaperi pfungwa nomuviri zvemwana asati, parasitic zvirwere yakataurawo kuderedzwa urea muropa. Treatment izvi zvinofanira kutaurirwa kugadzirisa runotikurudzira chirwere. Kazhinji, pashure kutanga kubvisa chirwere uye normalized nemiedzo.

Zvinofanira kucherechedzwa kuti zviri mukomboni iri weti vagara vandifungira kwayo wevasungwa muropa. Uyewo anofunga kwazvo filtration mu neitsvo.

Normal ropa urea riri 2,8-8,3 mmol / l. Kazhinji, kana chakaipa muitiro mapuroteni muviri, zvirimo kashoma akacherechedza kuti anopfuura 6 mmol / l. Kana pane zvokudya risinganyanyi mapuroteni, mukomboni wevasungwa ipfupi 2 mmol / fő.

Yakawedzera urea muropa (kazhinji wevasungwa uri kanoverengeka inowanzotorwa okumusoro zviratidzo), kazhinji achiperekedzwa zvikuru kudhaka, inonzi uremia. Yakati yakafanana ezvinhu pamusoro pakanyorwa zvinotevera zvirwere:

- renal kukundikana rikwanise chimiro;

- pyelonephritis, glomerulonephritis;

- anuria (kusavapo weti chirwere, munhu asingadi defecate);

- cheshuga;

- mapundu kana concrements ari urethra kana ureter;

- Unopisa;

- peritonitis;

- kugwinha;

- phenol chepfu, mekuri munyu, chloroform;

- gastro-intestinal kubuda ropa.