Prothrombin indekisi, mwero uye ukoshi

Prothrombin indekisi, mwero iri akaenzana 95-105%, - mumwe zviratidzo zvinoratidza kweropa. Kweropa - zvikuru kunzwisisa mutoo riri kuitwa ne kutora chikamu kupindana mapuroteni anokosha anonzi coagulation zvinhu. The activation uyu muitiro zvinogoneka zviviri munzira - nechinzwano zvekunze.

It prothrombin indekisi inechirevo activation kuti coagulation vachishandisa extrinsic gwara. Ndizvo sezvinotevera: zvaipesana kutendeka munyama (ronda) iri dzinounzwa anonzi zvinyama thromboplastin, imwe puroteni chaiyo inowanikwa zvose nyama dzomuviri. It zvinokonzera kupindana maitiro vanopinda zvimwewo pakugwamba (V, VII, uye X, II, I), successively simba mumwe. Pakupedzisira, mumwe ropa clot achiumbwa uye ropa rinomira.

Ko prothrombin indekisi

Pakugwamba zvinoongororwa yakaumbwa muna chiropa. Izvi, II, V, X vari vhitamini K-kuzvimiririra. Nokusava vhitamini usage yavo kwakakanganiswa. Saizvozvowo, pane kutyorwa hemostasis. Kuziva prothrombin indekisi, riri kuzivisa zvazvingava, chiremba wako gona:

1. Chiito Rate tentatively II, V, VII uye X uyewo pakugwamba zvinokonzera
2. Kwakakura chakarurama ichi kutonga mashandiro chiropa
3. On saturation vhitamini K
4. The vakawanda mamiriro ropa coagulation hurongwa
5. Maererano chakarurama ichi, unogona kuongorora kubudirira anticoagulant mishonga.

Sezvo pakutsvaga prothrombin indekisi

Prothrombin indekisi iri akatsunga rirambe richibvira kana venous ropa. Kana yechipiri kutsanya ropa inocherechedzwa bvunzo chubhu ane anticoagulant iri nhamba 9: 1. Rakashandiswa anticoagulant yavaibvisa citrate. Murabhoritari, ropa riri centrifuged. The zvichiguma yeplasma rinoshandiswa kuti Kutsunga prothrombin nguva (PT). Norm MF ari siyana kubvira 12 kusvika 20 masekonzi, zvichienderana basa thromboplastin wakashandiswa kosi nemapinduriro murabhoritari.

Kuziva murwere PT, unogona ngaaverenge PI, kureva, prothrombin indekisi, inova ndozvakajairwa mumarabhoritari dzakasiyana kunogonawo kuva zvishoma yakasiyana. Iye akaenzana reshiyo px utano munhu kuti PV murwere, kane 100:

PI = PV utano. / SA achirwara. X 100 (romuzvarirwo 95-105%)

The kunotoda kukosha PI

At yakakwirira PT coagulation kana prothrombin vane wokuyera 12 kusvika 20 masekonzi iri pfupi, uye PI inowedzerawo. Izvi zvinogona kuva panguva pamuviri, pamwe hombe kukuvara kana ropa kunouya yakawanda tishu thromboplastin.

Asiwo, MF kunowedzera uye shoma vasanyanye PI pakugwamba, dzakadai kuna vachiberekwa kushayiwa pakugwamba zvinhu, zvakaoma. chiropa chirwere, pamwe kushayikwa vhitamini K (izvo zvinogona kuitika munguva cholestasis, dysbacteriosis, kukanganisa dumbu basa). PI shoma shoma fibrinogen kana kushanda urema, pamwe chirwere DIC, pamberi zvinhu kuti tunodzivisa pakugwamba.

Chii INR

Mabatirwo zvisina kunanga anticoagulants sezvingatarisirwa kunoderedza prothrombin indekisi. wokuyera Its anogona kuva yawo ose murabhoritari. Naizvozvo, kuti kukwanisa anofananidza pakuongororwa vakawana mumarabhoritari zvakasiyana, wakatangwa munhu kwezvipimo bvunzo akadai INR. Izvi kukarukureta indekisi. It Akatsunga inobva reshiyo ari prothrombin nguva murwere, inowanzotorwa ukoshi MF uye dhigirii thromboplastin wanda indekisi (Isi).

INR = (PT b fung / MF mwero) ari mwero Isi

In hwakanaka munhu ari INR iri kuwanda 0, 8-1,2.

chakarurama ichi rinoshandiswa vachiongorora kubudirira anticoagulants chiito. Pakurapa anticoagulant kana coagulation ipfupi (somuenzaniso pashure Kuvhiya mwoyo) INR vanofanira ngazviwedzerwe 2-3. With kuwedzera INR pakugwamba ipfupi. The reshiyo pakati PI uye INR wakadaro kuti vasanyanye PI indekisi wakawedzera INR.