Karusiyamu mhandu - yakafara-chakarondedzera zvinodhaka

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Muupenyu nhengo chengetedza karusiyamu ions kutamba asi rinokosha. Chokwadi zvakanga calcium, rakapinza muzvitokisi vanokwanisa simba zvose zhiznenovazhnye intracellular pezvakaitwa iri muviri, semuenzaniso, kutendeuka ATP mumusasa kana mapuroteni phosphorylation pezvakaitwa.

Regulation calcium ions mumuviri

Karusiyamu chinopinda masero kuburikidza anokosha migero, izvo guru mapuroteni mamorekuru izvo kutekeshera kuburikidza multilayer Kamudzira nemasero. Izvi "channel", Inter Alia, vane zvakananga receptors, izvo zvakataurwa kuziviswa calcium ions, pasina kurovha nevamwe inoramba.

The kuyerera calcium ions iri muviri iri nokudzorwa dzakananga endogenous zvinhu chingava neurogenic mavambo uye kuva kwemakemikari anobudiswa nevamiririri zvakadai acetylcholine kana kweserotonin.

Zvinodhaka kuti adzikatidza kupinda calcium ions muzvitokisi

Studies zvinodhaka kuti anogona tunodzivisa karusiyamu dzokuwana ndima kwakatanga 60s uye chichiri kuitika. Pakutanga zvidzidzo izvi rakavhurika fuma fenilakilamina nomukaka, iyo panguva dzave dzichitaurwa kushandiswa sezvo gadziriro koronorasshiryayuschih vaiva. Today akazarura chaizvo vazhinji vakadaro zvinhu, izvo ikashandiswa kupinda rimwe boka, iro vakagamuchira zita - karusiyamu mhandu.

Use calcium mhandu

Karusiyamu mhandu ava kushandiswa chaizvo muminda zvokurapa-siyana, izvi imhaka yokuti vane zvikuru zvakawanda chiito. Saka, Somuenzaniso, karusiyamu mhandu zvingaita myocardial contractility, atrioventricular conduction uye sinus raiva pedyo nebundu basa.

A ndozvinoitawo ndiko aldosterone mhandu kuti adzikatidza chiito nokuda kwayo conductivity aldosterone Kanotokonya, nokudaro kuwedzera uwandu calcium ari mumasero.

Mune dzimwe nzira pathological ezvinhu akadai hypoxia kana ischemia, kunyanya karusiyamu ions vangawedzera intracellular urongwa, nokudaro vachiwedzera zvinyama okisijeni kudiwa, izvo zvingaita kuti siyana pathological migumisiro. Panyaya iyi, iyo karusiyamu mhandu vane mishonga chaizvoizvo, Kuderedza chiito calcium ions kupinda muchitokisi chepamusoro.

Karusiyamu mhandu nokuti kurapwa kwezvirwere chokuita CAS

Kushandiswa kwaro chikuru calcium mugero blockers vakawana nhasi pakurapa zvirwere zvemwoyo. Zvinodhaka zvine zvazvinoita conductivity uye excitability kwomwoyo, ane antianginal zvinokonzerwa, kuvandudza ropa kuyerera coronary uye kuderedza BP.

Zvinodhaka kuti chokuita cardiac conduction uye excitability wanhasi sezvo antiarrhythmic zvinodhaka, izvo zvakazoita pakusarudza siyanei pharmacological boka (angianginalnye nzira).

Mhandu yekudyidzana kukanganisa platelet aggregation, nokuderedza coalescence yavo uye kufambisa mashoko disaggregation pamusoro maplatelet. mishonga iyi inoshandiswa kuderedza ropa viscosity uye kuwedzera elasticity pamusoro maplatelet. Kuwedzera mano ropa anticoagulant anogona kushandisa uye vhitamini K mhandu kuti kukanganisa activation pakati prothrombin, ichivharira paumbwe fibrin clots.

The chakarondedzera chiito zvinodhaka

The chakarondedzera chiito calcium mhandu zvechokwadi siyana, nekuti vava kushandiswa kwete chete nokuda ichitarisira mhando chikuru zvemwoyo chirwere, asiwo kurapa migraine, asima, kusagadzikana chepfungwa kutenderera. Karusiyamu mhandu basa rinokosha pakurapa vairwara nepfungwa, anoshandiswa kurapa tsviyo uye dyskinesia pavarwere vane schizophrenia.