Jekiseni-kufanana kukura chinhu: ndozvakajairwa uye kutsauka

Jekiseni-kufanana kukura chinhu inonzi kemikari zvakafanana kwemakemikari chivako kuti jekiseni. It inodzora Sero Kusiyanisa pezvakaitwa, avo kukura uye kukura. Chinonziwo mumabasa shuga muviri.

History yakawanikwa

Back mukupera 50s remakore rechimakumi maviri, masayendisiti pfungwa kuti pakati kukura kemikari (STH), rinonziwo kukura kemikari uye masero omuviri, pane nhume. mhedziso iyi inomuka kubva chokwadi kuti kukura kemikari aiva kushanda chete mupenyu muviri, asi kana chinotarisirwa kupinda tsandanyama mumasero, kunyange kana vakanga vari inotonhorera svikiro, hapana zvazvinoita yaiitwa.

In 1970, yakanga vakawana somatomedins, zvakanga zvakataurwa nevamiririri. Vakadaidzwa jekiseni-kufanana kukura zvinhu. Pakutanga MAPOKA vatatu zvinhu: A somatomedin (IGF-3) uye B (IGF-2), C (IGF-1). Asi akanga akatsunga ari 1980s kuti jekiseni-kufanana kukura chinhu-2, uyewo 3 - iyi ndiyo chete experimental kwebhokisi, asi chaizvoizvo haako. Chete akasimbisa kuvapo IGF-1.

mamiriro

Jekiseni-kufanana kukura chinhu 1 (IGF-1) inoumbwa 70 amino acids kuti vanoumba intramolecular linkages pamwe cheni-mabhiriji. Zviri peptide runokusunganidzai kuti mapuroteni eplasma, vanonzi chizvarwa kukura chinhu. Vanobvumira somatomedins kuramba tichishingaira yakareba. Zvinotora maawa akawanda, nepo isina chimiro akati nguva haisi maminitsi anopfuura 30.

Kemikari akafanana proinsulin, nokuti yaakanga apiwa zita rake. Zvino kwetunhu somatomedin hombe basa reDare jekiseni zvakananga. Pamusoro pazvo, kunobatsira kuti pakuwana zvose zvinodiwa amino acids kutanga mashandiro rezvisikwa zviri FMI pedyo chiropa.

kwetunhu kemikari

Akati kukura chinhu vaiona kwemakemikari anobudiswa mediates ichipa matanho kukura kemikari. Zvinonzi synthesized kubudikidza hepatocytes chiropa semhinduro Kanotokonya dzishande. Munenge munyama zvose zvinoitwa kukura kemikari inopiwa IGF-1. Anoomesa kubva chiropa kupinda muropa, uye kubva ipapo, kuburikidza Mediation uyo akaendesa mapuroteni vari munyama uye nhengo. Akati kemikari kunomutsa kukura mapfupa, connective zvinyama uye tsandanyama. Uyewo, jekiseni-kufanana kukura chinhu synthesized nekugona nyama zhinji. Kana zvakakodzera, sero rimwe anogona vakazvimiririra kupa pachavo nenhumbi ichi.

Secretion kuti IGF-1 ne chiropa kunowedzera pasi zvinoitwa estrogens, androgens, jekiseni. Asi glucocorticoids ipfupi. Zvinonzi kuonekwa chimwe nei izvi zvinhu zvinokanganisa kukura pamusoro Muviri wayo mwero pabonde kuibvisa.

ehupfumi

IGF mu tsandanyama mumasero rine kukura nekurukurirano basa uye jekiseni. It catalyzes ari kwetunhu mapuroteni , uye DZEMUNHU DZINODZORA muitiro nokuparadzwa. Rinotaurawo vachambokanganwa kuti muviri, vatsigiri nokukurumidza mafuta pomoto.

Jekiseni-kufanana kukura chinhu-1 kunobatanidzwa pamwechete pituitary shwanu uye hypothalamus. Akariwana muropa kunoenderana kusarudzwa mamwe mahormone. Somuenzaniso, pane imwe pasi pfungwa kunowedzera secretion kukura kemikari. Kunowedzerawo kugadzirwa kukura kemikari-kusunungura kemikari. Asi panguva mukuru wevakuru IGF-1 secretion pamusoro vakati kemikari ipfupi.

Pakati somatostatin uye jekiseni-kufanana kukura chinhu ndechokuti ukama wakananga chinosimbiswa. With kuwedzera mumwe wavo kunowedzera uye wevasungwa wechipiri.

Tinofanira kuonawo kuti kurishandisa sechinhu anabolic Vamhanyi kufanira. Rave kakawanda rakabudiswa migumisiro zvidzidzo izvo anoreva akaipa migumisiro pokutongwa kushandisa zvinodhaka kuti ane jekiseni-kufanana kukura chinhu (IGF). nzira dzavo kunogona kukonzera chirwere cheshuga, kutadza kuona zvakanaka, kusagadzikana mwoyo tsandanyama, neuropathy, hormone disruptions. Uyezve, fuma iyi ndeimwe mikuru catalysts kukura anomera kenza.

Features IGF

Zvave zvichinzi kuti jekiseni-kufanana kukura chinhu 1 iri akatura pakukwegura uye vaduku, uye ndicho chikuru pakati kuyaruka. Asi sezvo vanotsvakurudza vakaona kuti vakura vanhu vane pamwero kemikari iri pedyo rokumusoro panogumira nevamwe vezera ravo boka kurarama kwenguva yakareba. Uyewo, ivo zvishoma havatani chomwoyo uye tsinga. Oga, zvinokosha kuziva kuti kuwedzera mari panguva yepamuviri.

Blood wevasungwa munguva zuva riri pamusoro chete. Saka, rinoshandiswa rokuongorora vachivavhiringidza kukura kukura kemikari. Pashure pezvose, wevasungwa kuwedzera kemikari muropa kunosiyana-siyana zuva rose, kufadza pamwero raanotaura usiku. Naizvozvo, kuti zvakarurama kuisa mari iri matambudziko.

Kuderedza wevasungwa kuti kemikari

IGF-1 rakaonekwa chete muna 1978. Kubvira ipapo kare takapedza chaizvo yakawanda tsvakurudzo, semubairo wakange amire wandei mitemo. Nokudaro, dhefisiti uduku hwake ndicho chikonzero kunonoka kuti kukura kwemwana chaiko. Asi ngozi kana jekiseni-kufanana kukura chinhu kuderedzwa nedzevakuru. Handiti zvinonzi Wakacherechedza underdevelopment tsandanyama, ndokuramba mapfupa arambe achirema, kuchinja maumbirwo kwemafuta.

Kunokonzerwa kushaya IGF angava nhamba zvirwere. Pakati pavo, itsvo matambudziko, chiropa. Kazhinji mhosva kwakaderedza huwandu IGF chirwere akadai hypopituitarism. Ichi chimiro umo mhango anogona kumisa kana kuderedzwa chaizvo kugadzirwa pituitary mahormone. Asi kunoderedza kugadzirwa somatomedin ane dhefisiti simba, kana, kupfuura kungoti, nzara.

Kuwedzera IGF

Pasinei migumisiro, izvo chinoita kutadza IGF-1, hazvina zvakafanira kufunga kuti kuwedzera kwenhamba yacho hakuna kuipa.

Saka, kana jekiseni-kufanana kukura chinhu 1 upgraded, izvozvo zvichaita kuti acromegaly nedzevakuru uye gigantism muvana. Nendumure chirwere kunoratidzwa sezvinotevera. Vanotanga zvikuru mapfupa kukura. Izvi somugumisiro zvinokonzera kwete chete kukura rakakura, asi magumo rakawedzera kuti zvisinganzwisisiki huru yese.

Acromegaly, kunoitika nedzevakuru kunotungamirira rokuwedzera gumbo mapfupa, maoko uye chiso. Uyewo kutambura uye nhengo dzomukati. Izvi zvingaita kuti rufu nokuda cardiomyopathy - chirwere umo sei cardiac tsandanyama, chibharo kwayo ushande.

Kakawanda chikonzero kuti anowedzera jekiseni-kufanana kukura chinhu, munhu pituitary bundu. Pairi unogona kuwana kuparadza tichibatsirwa mishonga, mishonga, uye rinogona kubviswa surgically. The Kuongororwa kunobatsira kuziva sei kubudirira kurapa, kana kutarisa kana oparesheni rakanga raitwa zvakanaka. Somuenzaniso, kana bundu haasi chose yabviswa, wevasungwa pamusoro IGF inowedzerwa.

kuitisa tsvakurudzo

Rokuongorora kuchinja wevasungwa insulin yakakodzera-kufanana kukura chinhu ano murabhoritari nzvimbo vanoshandisa IHLA nzira. Saka akadana immunohemilyuminestsentny kuongorora. Zvinonzi inobva zvirwere zvinoita maantigen. In danho voga inodiwa fuma zvakabatanidzwa nayo zvikwangwani - phosphors, izvo zvinoonekwa pasi ultraviolet chiedza. pamwero wavo luminescence kunoyerwa kushandisa chinokosha midziyo - munhu luminometer. Sezvazvakanyorwamo, wevasungwa kuti kusarudzwa zvinhu zviri pasi serum.

Survey Preparation

Kuti usarudze IGF-1, jekiseni-kufanana kukura chinhu, zvakakodzera kuti vape ropa mangwanani kwairayirwa achitsanya. Kubvumirwa kunwa mvura pachena chete. The penguva pakati rokupedzisira kudya uye fence zvinhu yokutsvakurudza kuva maawa anopfuura masere. Zvakakosha kuti maminitsi 30 pamberi chokuendesa ari kuongorora murwere yaiva zororo. Yokutsvakurudza tora venous ropa.

Uyezve, nyanzvi dzinokurudzira kuti kusiya kuongorora munguva chakasimba zvirwere zvokufema (nemavhairasi kana kwemabhakitiriya kwakabva) kuti kubvisa migumisiro venhema.

Avharenji

Kana kuzadza kunze siyana murabhoritari zvakakosha kutaridzwa zera. Pamusoro pazvo, zvinoenderana naye zvino chii chinofanira kuva chinhu insulin yakakodzera-kufanana kukura. Ndozvakajairwa chakasimbiswa mumwe nomumwe chikamu nomumwe. Zvinokoshawo kuti pfungwa kwete Avharenji asi mashoko ose murabhoritari umo wawatora nemiedzo. Somuenzaniso, mune kuyaruka vane makore makore 14-16 mahomoni zvingava 220 kusvika 996 Ng / Rine mamiririta. Uye vakuru, vari makore anopfuura 35, hazvifaniri kusapfuudza kukosha 284 Ng / Rine mamiririta. Mukuru murwere, rezasi kufadza pachiyero IGF inofanira kuva. Pashure pemakore 66, mwero yakaitika kuwanda 75-212 kumar / Rine mamiririta pashure 80 - 66-166 Ng / Rine mamiririta.

Children IGF zvese vachange kuvimba zera. In vana vachangoberekwa, zvisina kunyange 7 days, zvinofanira kubva 10 kusvika 26 Ng / Rine mamiririta. Asi pashure pemazuva 16 uye kusvika 1 year, mwero wakaiswa pa 54-327 Ng / Rine mamiririta.

kuongorora chirwere zvirwere

Tatsunga kuti jekiseni sezvinoita kukura chinhu, zvinokwanisika rokuongorora zvinoverengeka zvirwere. Kuwedzera kwaro pamwero uchapupu kwete gigantism muvana uye acromegaly nedzevakuru. Izvi zvinogona kuva chiratidzo anomera yemapapu uye dumbu, chirwere renal kukundikana. Asi Tinofanira kuonawo kuti zvinokwanisika kuwedzera, akatora dexamethasone, adrenostimulyatorov Alpha, Beta-blockers.

Akaderedza IGF mumatunhu ari vana zvingaratidza dwarfism. In vakuru, mwero iri kazhinji wakaderedzwa apo hypothyroidism, cirrhosis, neanorexia nervosa kana kungoti kutsanya. Chimwe mumwe inobvira zvinokonzera echirwere Kusarara runhare uye kugamuchirwa nhamba zvinodhaka vaine mishonga pakati estrogens.