Parkinson chirwere

Parkinson nehosha (aka "Parkinson", izvozvo "idiopathic parkinsonism", izvozvo "chikuru parkinsonism," aka "PD", izvozvo "hypokinetic Parkinsonism" uye izvozvo - "kuzunungusa mitezo") - mumwe atadze kushanda zvakanaka of nechepakati huta chinopedza hunhu wegadziriro. Motor zviratidzo izvo pematanho chirwere Parkinson chokuita substantia nigra masero kufa kubvisa (pakati munharaunda uropi) kuti pave dopamine. Haiwa, sayenzi yemazuva haagoni asi anopa mhinduro yomubvunzo wokuti nei masero aya pakarepo kutanga kufa. Pakutanga kupfuura pachena nzira chirwere pachena zviratidzo vaya nzira imwe kana mumwe, ukama racho.

Zviratidzo Parkinson nehosha kunoratidzwa pachangu vachibvunda, Rigidity uye kunonoka rwokufamba, Somugumisiro, pamwe sangano danho racho. Gare gare, pamwe kukura chirwere, pangava dambudziko zvishande uye maitiro. In akazotevera nzendo chirwere pavarwere rinowanzoshandiswa kuchiratidzwa dementia. Other zviratidzo Parkinson nehosha zvinosanganisira matambudziko nehope, manzwiro uye sensorics. chirwere chinonzi Parkinson chinonyanya mune vakwegura, uye hosha iri kakawanda vakachengeta pashure pamakore 50.

Kazhinji vanachiremba kana achiita chirwere "chirwere chinonzi Parkinson", iri pazviri asi uye shoko "idiopathic", kureva, uyo chaiwo, pakarepo chikonzero hakusi kuti asimbise zvinobvira. Zvisinei, kuti mushonga anozivikanwa akawanda zviitiko atypical parkinsonism umo kukudziridza chirwere aiva rakananga kukanganisa ndiyo yezvakaita masero okutodza.

To musi, masayendisiti akaratidza zvinhu zvinoverengeka sezvo mukuvhiringidza kukura Parkinson, chirwere uye dzinobatsira ayo budiriro. Saka, Somuenzaniso, hapana mubvunzo kuwanikwa kuti njodzi kuva chirwere vanosvuta ... pazasi. Asi vanhu kazhinji kuuya neZvapupu zvimwe mishonga yezvipembenene, nekusiyana, dzine mikana nezvirwere chirwere chinonzi Parkinson.

Pathologically maperembudzi kunoratidzwa kuunganidza puroteni munyama muviri, rinozivikanwa Alpha-synuclein. kuwanda kwakadaro aizivikanwa se "miviri Lewy", aonekwa mukati Tutsinga tunofambisa mashoko utwu yacho substantia nigra. Uyezve, kana paine kukwana kusimudzira Parkinson nehosha uye dopamine kwebasa zvinoberekwa uropi.

Lewy miviri vari mhando vanozivikanwa idiopathic parkinsonism. Number masero zviri muuropi kutambura nechirwere chinonzi Parkinson, ndiyo munhu indekisi, asi unogona kuva chokuita kwokuomerwa uye nzira hosha iri munhu. Chirwere kuti Parkinson nehosha kakawanda kwakavakirwa zviratidzo chirwere. siyana neuroimaging miedzo inoshandiswa kusimbisa chirwere.

Current nzira, iyo rinoitwa Mabatirwo Parkinson, chirwere zvakakwana kurarama zvinobudirira chete mangwanani kuratidzwa nezvirwere chokuita sangano. Zvisinei, pamwe kukura chirwere pamwe nekutambira sero rufu inobereka dopamine, kurapa kwakadaro vari kuva zvishoma uye zvishoma inobudirira. Uyezve, pakava ichibudira mumoyo murwere chirwere, rinozivikanwa "dyskinesia", iro kunooneka pacharo mu involuntary jerky masangano. Zvisinei, maererano zvechiuto zvokurapa tsvakurudzo zvabuda, ichi inogona kuderedzwa kuburikidza kudya uye mamwe vapore kurovedza. Mukuwedzera, chivezwa zvingaratidza kushandisa oparesheni uye rakadzika pfungwa dzishande. Nzira iyi dzabatsira apo kushandiswa zvimwe zvinodhaka uye kurapwa regai kubatsira. Zvisinei, tsvakurudzo zvainanga kutsvaka nzira itsva uye hwakavimbika kurapa chirwere chinonzi Parkinson, kuramba kuitwa.