"Imipenem + Cilastatin": tsananguro, User ratings uye wongororo

Vamwe zvirwere kukundwa hakusi nyore. Havagoni chete zvakakomba kanganisa utano, asi kunyange kusika kukanganisa chaiyo upenyu murwere. Muzviitiko zvakadaro, vanofanira kushandiswa chaizvo yepamusoro uye mishonga inoshanda kuti zvinobudirira kunogona kukunda munhu chirwere ngozi uye kudzorera utano. Kuti tikurire zvakasiyana zvirwere rinowanzoshandiswa rinoreva "Imipenem + Cilastatin". Maererano mhinduro wevarwere uye vanachiremba, zviri kusimba ichibudirira. Usati wasarudza kutanga kurapwa kuti mari, zvakakosha kuziva mashoko akawanda pamusoro zvinodhaka "Imipenem + Cilastatin": nemugwagwa zita zvinodhaka, kunyanya chiito uye nzira chikumbiro chacho. Ndiani anofanira kushandisa mushonga mu mubvunzo? Ndezvipi contraindications? Chii nemishonga Ndinogona kutarisira? ruzivo urwu zvose unogona kudzidza nokuverenga nyaya ino.

mamiriro

Kugadzirira "+ Imipenem Cilastatin" ndiyo kururama cilastatin mubatanidzwa (ndiro inhibitor pamusoro enzayemu renal digidropeptidazy) uye yavaibvisa munyu pamusoro imipenem (asingaurayiwi). Kazhinji rimwe gadziriro chinu chine milligrams mazana mashanu zvose zvinhu.

kusunungurwa Form

Vaiona zvinodhaka "+ Imipenem Cilastatin" inowanika upfu muchimiro nokuda majekiseni (nokuti intravenous Kutarisirwa) mune ndiro pamusoro hukuru siyana, zvinoti makumi matanhatu uye zvine zana namakumi maviri milliliters. upfu ichi zvinofanira zvazvichanyungudutswa mhinduro (buffered) pamwe yavaibvisa rehydrogen carbonate.

In Kana apo zvinodhaka riri nachiremba intramuscular Kutarisirwa vanofanira kuwana ndiro, mumwe rine 0.5 kana 0.75 giremu kuti imipenem uye cilastatin (zvichienderana dose, rakanga dzakabatwa murwere nokuda kupinda chiremba).

zvairatidza

The medicament "Imipenem + Cilastatin" nachiremba kushandiswa nevarwere pamberi zvinotapukira uye anogumbura nezvirwere kuti vave kunokonzerwa chero inonyatsoziva zviito dzinokosha vanoshingaira zvinhu kubudikidza tusingaoneki zvinodhaka, anosanganisira vose polymicrobial saka vakavhengana Kurovedza-anaerobic chirwere (izvi zvinosanganisira rwarisa zvirwere Urinary turakiti uchingodzikira kufema turakiti, sepsis, zvirwere zviri mapfundo mapfupa; peritonitis, intra-abdominal zvirwere, anogumbura, etc. pezvakaitwa kuti kuitika mune pelvic zvomukati ,. siyana zvinotapukira ganda uye akapfava munyama, uyewo endocarditis Uyewo, mushonga wacho zvinobudirira kushandiswa senzira kudzivirira yematambudziko pashure kuvhiyiwa.

Pharmacological migumisiro

Efficacy zvinodhaka "+ Imipenem Cilastatin" riine vakabudirira mubatanidzwa vanoshingaira zvinoriumba. Chokutanga, imipenem, chinomirira imwe Beta-lactam mushonga chinouraya achishingaira bacteria (iyoyo bactericidal mugumisiro). Izvi zvinhu ane zvakakwana chakarondedzera basa. Izvi zvinoreva kuti utachiona zhinji vane hanya zvachinokonzera. Wechipiri zvinoriumba, cilastatin yavaibvisa ari kushingaira kushanda enzayemu iyo uchiora imipenem ari itsvo murwere, kuchititadzisa chiito kwayo, izvo zvinoita kuti kuwedzera yakakwana iri wevasungwa dzinopfuura mushonga ari mu unmodified muchimiro murwere. Somugumisiro, zvinonyatsorehwa kubudirira zvinodhaka "Imipenem + Cilastatin" vachiwanda.

kunyoresa

Kuti vabudirire mukuru zvazviri, uye kuitira kudzivisa chero nemigumisiro yokurapa kunokosha nokungwarira kutevera kunenge pamusoro kushandisa zvinodhaka. The medicament "Imipenem uye Cilastatin Dzhodas" chinotarisirwa kuti murwere nomutsinga (donhwe).

Pasinei nokuti muperekedzi anopa avhareji dose zvinodhaka, asati atanga kurapwa, zvakakosha kuchinja Zano yokurapa zvakananga kubva chiremba anogona zvakakodzera kuisa rakakodzera chipimo chemushonga tichifunga murwere nhoroondo yaro chaiyo zvinhu.

Mishonga iyo rine medicament "+ Imipenem Cilastatin" mirayiridzo iri vaiona fuma aiendeswa avo varwere vane uremu runopfuura makumi manomwe kilogram. Varwere avo vane muviri uremu iri shoma, zvinofanira kuderedzwa kuenderana nokushanda dose zvinodhaka (zvakakosha kuti izvi rinotungamirirwa munhu akwanise munhu).

Varwere vakura zuva nezuva paavhareji dose of zvinodhaka "Imipenem uye Cilastatin Dzhodas" ndeimwe - magiramu maviri, akapa nokupesana yawo matatu - adhimini mana. Panguva iyoyowo, kufadza dose riri anogamuchirwa Kutarisira zuva mumwe mana namakumi mashanu magiramu kana milligrams por kilogram kurema muviri (sarudzo inofanira kuwira pamusoro diki mbiri zvinobvumidzwa mishonga).

Uyewo, iyo dose zvinosiyana zvichienderana kwokuomerwa chirwere. Saka, kune mumwe murwere munyoro kwokuomerwa utachiona, nekubata dose kwaari vachava mazana maviri namakumi mashanu milligrams (akadzokorora majekiseni vanofanira kuva nguva vana pazuva). Kana avhareji mwero zvakaoma kwazvo, uwandu Pfungwa nokuda kuroora Kutarisirwa anofanira kuva milligrams mazana mashanu. Chiyamuro rinoreva vanofanira kuva katatu pazuva. Kana utachiona akakomba, ipapo dose mishonga inofanira kushandiswa nguva vana pazuva. Kana murwere ezvinhu zvokuti pane ngozi hwake, chinofanira kupiwa pamusoro mumwe giremu matatu - runa pazuva. The mushonga anofanira kuzviita zvishoma nezvishoma (magiramu paawa, maviri namakumi mashanu - milligrams mashanu namakumi - nokuti maviri - maminitsi makumi matatu).

Kana mushonga unoshandiswa kuti kudzivirira postoperative zvirwere Zvakakosha kusuma mumwe giremu panguva yokutindivadza imwecheteyo dose, maawa matatu pashure paizvozvo.

Kana panguva oparesheni paiva nengozi ipi chirwere (kunyanya panyaya akavhiyiwa ari mugaranhoko uye muura), "Imipenem + Cilastatin" mirayiridzo kushandiswa anokurudzira kupinda milligrams mazana mashanu, masere uye maawa gumi pashure yokutindivadza.

Kuti agadzirire nekubata mhinduro iri chinu zvakakodzera kuwedzera upfu zvinhu zana milliliters pamusoro unyanzvi solvent, izvo zvinosanganisira mashanu muzana kana gumi kubva muzana aqueous dextrose, 0,9% yavaibvisa chloride mhinduro. Izvi mhinduro imipenem mushonga wevasungwa haafaniri kupfuudza milligrams shanu chete milliliter.

Hazvifaniri seva kushandisa mushonga pachiimbwa zvimwe zvinodhaka antibacterial, uyewo munyu lactic acid.

The fuma haienderani nevamwe Beta-lactam mishonga (izvo zvinosanganisira cephalosporin, kuti penicillin uye monobactam). Kushandiswa kwavo mawa kungaita kuti muchinjikwa neutachiona.

Kudyidzana pamwe ganciclovir dzimwe nguva chinokurwadzai generalized nokugwinha.

Various zvinhu kuti vanovhara tubular secretion, kuwedzera wevasungwa kuti imipenem muropa plasma, uye ayo hafu-upenyu nguva. Saka, kana kuti zvinobudirira mishonga zvinoda vachiita mutumwa pamatunhu mishonga haisi zvakakodzera kushandisa mapoka aya zvinhu panguva imwe chete.

Zvinonzi rambidzwa kushandisa mushonga mu mubvunzo munguva gestation mwana, uyewo panguva kuyamwisa.

The mushonga harifaniri kushandiswa dambudziko yomumuzongoza.

Weti panguva mushonga anogona mavara zvishoma iri yakatsvukuruka tint.

Chipimo chemushonga chimiro zvinodhaka (nokuti intravenous uye nokuda intramuscular Kutarisirwa) kushandiswa zvachose nokuda chinangwa. Havasi kuchinjaniswa. Asati atanga mushonga pakurapa kuti inokoshesa kuitisa anonyatsotsvaka tsvakurudzo pamusoro penyaya neutachiona kana munhu hypersensitivity kuti Beta-lactam inorwisa mabhakitiriya.

Kana murwere akanga achitova navamwe zvirwere nemudumbu, zvakadai colitis, kuti kana uchishandisa mushonga pasi review, pane mukana pseudomembranous enterocolitis.

Kuti abudirire kudzivisa chero rakashonyoroka chinja nechepakati tsinga pavarwere avo vaiva chero zvinokuvadza uropi kana vakatambura nokugwinha iripo varumbidzwa mishonga kurapa Qualitative antiepileptic nevamiririri.

Zvinofanira kurangarirwa kuti varwere vakwegura zvichida kuti zera-ukama renal dysfunction, izvo zvingada dose rutapudzo.

Zvakakosha kuyeuka kuti varwere vakwegura vanofanira kushandisa mushonga nokungwarira. Kazhinji, vanoratidza zviratidzo zvakasiyana-siyana zera-nezvimwe zvinetso zviri kushanda neitsvo. Muchiitiko chino, kana zvakakodzera, kushandiswa kwezvinodhaka "Imipenem + Cilastatin" murayiridzo Chinyorwa anokurudzira kuti iwe bvunza chiremba wako kuti mukuderedza zvinodhaka chipimo chemushonga kushandiswa.

Kune dzimwe zvinhu chaizvo nokushandisa mishonga iyi vana. Kana muviri uremu hwavo kwazvo mana kilogram, zvakafanana mirayiridzo inogona kushandawo kwavari kuti vakura. Kana mwana mukuru mitatu, uye ayo kurema idukusa mana kilos, kufadza zuva dose murwere yakadaro yaizova magiramu maviri. Vanofanira kupiwa gumi milligrams por kilogram kanokwana rimwe zuva.

Hapana nyaya havagoni kushandisa mushonga "Imipenem + Cilastatin" nokuti vana vasati asvika mwedzi mitatu, uye vana vaya kwakakanganiswa kunowanzoitika kushanda itsvo, izvo zvinogona kutaurwa padanho serum creatinine wevasungwa kupfuura milligrams muzana deciliter maviri.

Contraindications

Pane zvimwe nuances kuti kuda kuonekwa kana uchishandisa "+ Cilastatin Imepenem". Instruction anokurudzira Nyatsodzidza contraindications kuti chinodhaka ichi. Uye pakati pavo pane zvinotevera:

• Nguva gestation mwana;
• achiyamwa;
• Vana vari pasi pemakore mitatu;
• Vana vanotambura vasingadzoreki renal inoshanda chokuita dzakakwirira kuwanda serum creatinine;
• nomumwe aikanganiswa munhu zvinoriumba zvinodhaka pasi kukurukurwa, uyewo kune dzimwe Beta-lactam mishonga uye carbapenems.

Zvakakosha kuyeuka kuti varwere vakwegura uye vaya vanotambura kana kuti nokusingaperi akatambura zvirwere musimboti tsinga kana zvirwere nemudumbu vanofanira kutora mushonga nokungwarira pasi kuramba pokudzora chiremba. Kuti iye anogona nounyanzvi basa yakarurama chipimo chemushonga zvinodhaka "Imipenem + Cilastatin". Contraindications zvinokosha kudzidza usati watanga kurapwa.

nemishonga

Zvakakosha kuziva chimwe chinhu pamusoro mudziyo "Imipenem + Cilastatin". gadziriro fomura ndechokuti vamwe varwere vanogona vamwe nechokoko siyana munzvimbo dzakasiyana-siyana dzomuviri enyika. Pakati pavo vane: thrombophlebitis, kuravira chinovanetsa, candidiasis, oliguria, myoclonus, aone zvinhu zvisipo, paresthesia, kuvhiringidzika, chenjera renal kukundikana, zvinetso zvepfungwa, nezvipusha, polyuria, anuria, manyoka, hepatitis, kuda kurutsa uye kurutsa, leukopenia, pseudomembranous enterocolitis, lymphocytosis, hyperbilirubinemia, eosinophilia, pruritus, leukopenia, ganda mapundu, thrombocytosis, hypercreatininemia, monocytosis, urticaria, basophils, maonero zvakananga Coombs bvunzo.

Hakuna mashoko chaiwo kuti mabatirwo ane ovhadhozi zvinodhaka pasi kukurukurwa. Zvisinei zvinozivikanwa kuti unorapa izvi kuti abudirire achiona hemodialysis. Kunyange zvakadaro, zvichiri haizivikanwi sei zvinobudirira nzira iyi iri nyaya ovhadhozi. Saka zvinokosha kuti vachengete zvose kunenge, izvo unotora nzira kushandisa "+ Imipenem Cilastatin" tsanangudzo gadziriro.

chengetedzo mamiriro

Kuitira kuti pokushandisa zvinodhaka kuti vabudirire, zvakakosha kufunga imwe pfungwa inokosha. Kureva kuti achengetere mishonga "Imipenem + Cilastatin". Description of fuma ine mazano anotevera.

The upfu zvinofanira huri kamuri umo mumba tembiricha hwaponeswa. inofanira kushandiswa kugadzirira kushanda mhinduro hapana paya pane awa rimwe pashure azoshandiswa. yavaibvisa chloride mhinduro pa nzvimbo tembiricha inogona kuchengetwa kwemaawa anopfuura gumi uye mufiriji - kwete anopfuura makumi mana namasere. shuga mhinduro inogona inochengeterwa hapana anopfuura makumi maviri nezvina maawa, ukuwo.

analogs

Pane zvinhu zvinoverengeka zvinodhaka kuti vari muboka rinoreva analogues "Imipenem + Cilastatin". Substitutes vaiona mishonga - "Inemplyus", "Miksatsil", "Lastin", "Sinerpen", "Tiaktam", "Piminov", "Supranem" uye "Tienam". Kazhinji, zvose zvinodhaka izvi zvakafanana vanoshingaira wemafuta sezvo mushonga vaiona. The chikuru unorapa mishonga iyi - imipenem, cilastatin (zvokutengeserana zita uye iyo hunoratidza mishonga izvi). Saka, mishonga aya zvikurukuru zvakafanana, uye contraindications uye nemishonga uye pharmacological nemigumisiro. Zvisinei, tinofanira kuyeuka kuti chipimo chemushonga unofanira kugadza chiremba achakwanisa funga ose nuances. The mushonga "Imipenem + Cilastatin" analogues mishonga haafaniri kushandiswa varwere pasina mvumo, pasina kubata chiremba uye kugara kwake kudzora. Kusanganisira zano rake chinodiwa uye kusarudzwa zvakakodzera Ringanidzo.

kungotaurawo

Practice inosimbisa kubudirira zvinodhaka "+ Imipenem Cilastatin". Reviews akashuma kubudirira kurapwa zvaitika. Zvisinei, zvose vanachiremba uye varwere vave pfungwa chii zvakakosha zvakarurama vanoomerera kunenge zviri mirayiridzo vakabayira kupinda chiremba. nzira iyi yokurapa chete anogona kuunza zvikomborero nemuviri murwere.

Havafaniri kungosiyiwa contraindications, kuvapo iyo haabvumiri kutanga kurapwa vaitirei mushonga. Zvikasadaro, kushandisirwa haigoni chete kupa yakanaka mugumisiro, asi kukuvadza mamiriro murwere. Uyewo, kushandiswa zvisiri of vaiona zvinodhaka kungaita marwadzo, zvimwe zvinogona yekudyidzana achiipa murwere ezvinhu. Zvakakosha kuti kurapa kwakaitika pasi pokudzora munhu akwanise chiremba, uyo asingadi chete kunyatsoziva pamwe peculiarities pamusoro pokushandisa zvinodhaka, asi kugona unyanzvi hunodiwa uye ruzivo kukurira emergent ezvinhu akaoma. utano hwako kuva mumaoko vechokwadi nenyanzvi.

Usati wasarudza kutanga kurapwa vaitirei mushonga, zvakakosha nyatsoverenga mashoko ose pamusoro payo, izvo zvinoratidza hunhu migumisiro dzayo muviri. All unofanira kuziva pamusoro zvinogona nenjodzi, panowanikwa zvinogona kununura yakawanda kuzvuzvungudza murwere uye matambudziko chiremba wake.

Pakazosvika kusarudza kurapwa kunokosha kurapa zvakanaka. Sarudzai chemhando yepamusoro zvigadzirwa!