"Flosteron": mirayiridzo yekushandiswa (injini), kuongororwa, zvinopesana

Ndeipi chinangwa chemishonga "Flosteron"? Mirayiridzo yekushandiswa (injections), kuongororwa kuchaiswa gare gare. Uyewo tichakuudza nezvekugadzirwa kwechirwere ichi, izvo varwere vari kutaura pamusoro payo, zvingava nemigumisiro uye izvo zvinopesana nezvinofanira kuzivikanwa vasati vashandisa mushonga wechinangwa chinangwa.

Kuumbwa kwechirongwa chechiremba, kugovera uye fomu yekubudiswa

Ndeipi rudzi rwekusununguko iyo mishonga "Flosteron" ine? Mirayiridzo yekushandiswa (injections), kuongorora kwevanyori vanoti chimbo ichi chinogona kutengwa chete nenzira yekusimudzirwa kunoitirwa kujowa.

Zvinhu zvinoshanda zvechirwere ichi zvinotevera: betamethasone dipropionate uye betamethasone disodium phosphate. Kuvhiringidzika kunotengeswa mumaboules, ayo anoiswa mumapuranga epurasitiki.

Zviratidzo zvepamusoro zvechirwere

Chii chinonzi "Flosteron"? Mirayiridzo yekushandiswa (shots), vanachiremba vanoti kushanda kwemishonga iyi kunokonzerwa nekugadzirwa kwayo.

Betamethasone ishandiswa GCS. Icho chinoshaya simba, anti-inflammatory, anti-shock, anti-allergenic, immunosuppressive uye antitoxic action. Uyewo, mishonga inowedzera kusununguka kwehutachiona hwehurwere, inoderedza nhamba ye eosinophils uye lymphocytes, inowedzera nhamba ye erythrocytes (nemhaka yekusimudzirwa kwekugadzirwa kwe erythropoietins).

Uyu mushandi anongobatanidza nyore nyore ne cytoplasmic receptors, anokurudzira kushandiswa kweRNA, uye anoumba dambudziko rinopinda mukati memagetsi emasero.

Mechanism of action

Mushonga weWallsteron unoshanda sei kune injections? Anotora chikamu chinoshingaira munenge maitiro ese emagetsi emuviri.

Lipid exchange. Iyo mishonga inowedzera hutachiona hwehroroid-stimulating hormone, pamwe chete namafuta acids (akakwirira). Inoparadzanisa mafuta uye inotungamirira pakuumbwa kwe hypercholesterolemia.

Protein metabolism . Mushonga we "Flosteron", iyo yakagadzirirwa iyo inogona kuiswa pamusoro, inoderedza chiyero chemapuroteni mu plasma. Muchiitiko ichi, inowedzera kukosha kwe albumin uye globulin, inowedzera kubatanidza kweAlbumines muitsvo uye chiropa, uyewo inowedzera mapuroteni catabolism mumasumbu matukisi.

Carbohydrate metabolism . Ndeapi nyanzvi dzinotaura nezvechirwere ichi? Zvakadini nezvayo kubva maongororo? "Flosteron" mishonga inoshamisa inowedzera kubvongeka kwemakhahydrates kubva pamigwagwa yekudya, inowedzera basa rekushandiswa kweaminotransferase uye phosphoenolpyruvate carboxylase, iyo inotungamirira pakuita gluconeogenesis, uye inowedzera kudya kweglucose kubva pachiropa kusvika muropa.

Water-electrolyte exchange . Mishonga ne "Flosteron" inokurudzira kuchengetedzwa kwaNa + nemvura mumuviri, inokurudzira kubuda kweK, Inoderedza kushandiswa kweCa ^{2 +} kubva ^pamugwagwa wekudya, kuchiputika kubva pamapfupa, uyewo kunowedzera kuwedzera kwetsvo.

Zvigadzirwa zvemishonga

Ndezvipi izvo zvinoshandiswa nemishonga Flosteron? Mirayiridzo yekushandiswa (injections), kugadziriswa kukurudzira kuti kana ikashandiswa, mushonga une zvinotevera:

• Anti-inflammatory. Izvi zvinosanganiswa nekuderera kwehuwandu hwemasero emasero anounza hyaluronic acid, pamwe nekudzivirira kwevhiringidzi vanopisa, izvo zvinobudiswa ne eosinophils.
• Anti-allergenic. Kuita kwakadaro kunowedzera mukupedza kubviswa kwekuvharidzirwa uye kupindirana kwevanopindirana zvekurwisa, pamwe nekudziviswa kwekusunungurwa kwebasophils histamine uye mast cells.
• Antitoxic uye anti-shock. Mhedzisiro yakadaro inomuka pamusoro pemamiriro ekuwedzera kwehutano hweropa, kuderera kwekunonoka kwemasvingo emasvingo, uye kushandiswa kwemavirisitiri emuropa.
• Immunodepressive. Izvozvo zvinokonzerwa nekudzivisa kusunungurwa kwemaktokine kubva macrophage uye lymphocytes.

Pharmacokinetics ye-agent

Inguva yakareba sei mishonga iri mubvunzo inotora? Ndezvipi zvinyorwa zvinotaura pamusoro peizvi? "Flosteron" mishonga yejozi ye intra-articular. Mushure mokushandisa mushonga uyu, huwandu hwekuchengetedzwa kweplasma hunosvika munenge hafu yenguva.

Mushonga wacho unosunga nyore nyore kune mapuroteni, uyewo unopfuura nepakati pezvinyorwa zvake zvemhetambo, kusanganisira iyo inopisa.

Metabolism yemushonga unoitika muchiropa. Muchiitiko ichi, kunyanya kusagadzikana metabolites kunoumbwa. Iyo yakanyanyisa kuburikidza neitsvo, pamwe chete nemari shoma, pamwe ne bile uye mukaka wemvere.

Chiratidzo chechirwere

Ndinokwanisa kushandisa mushonga we "Flosteron" we psoriasis, arthritis nezvimwe zvirwere here? Nhamba yezviratidzo zvechirongwa ichi icharatidzwa pasi apa.

Sezvokurapa kwemukati:

• Nokuda kwehutachiona hwehutano muhupo hwe synovitis, pamwe chete nedzimwe zvirwere zverheumatic degenerative (pasina mamiriro ezvinhu zvinogona kushandiswa kweArthrosis yezviputi zvechiuno) ;
• Ne periarticular and intraarticular administration in rheumatic inflammatory disorders (seronegative spondyloarthritis, rheumatoid arthritis, arthritis mu systemic inogadzirisa zvirwere zvechirwere), psoriatic arthritis ne tendosynovitis nekubatana kwekubatana, posttraumatic arthritis uye crystalline arthritis;
• Kurapa kwezvipembenene zvinoputika zve periarticular tissues (epicondylitis, bursitis, tenosynovitis, plaque fasciitis uye tendonitis);
• Kuti uwane mukana wehutachiona mukurapa kwezvirwere zveganda (kana pasina kupindira kune dzimwe nzira dzomutachiona wepakati): psoriasis, sclerosing folliculitis, alopecia areata, keloids, mari-se eczema, annular granuloma, flat red lichen, sarcoidosis, neurodermatitis, chirwere cheshuga Lipodystrophy uye lupus erythematosus discoid.

Sekurongwa kwemuitiro:

• Nzira inoshandiswa yemishonga "Flosteron" inoshandiswa chete kune dzimwe zvirwere zvinokonzera zvirwere (Quincke's edema, allergic rhinitis, zvipembenene zvinokonzerwa nezvipembenene, chimiro chechirwere chemahara, kugadzirisa kwehutano kumishonga).

Mishonga yemiti "Flosteron": zvinopesana kuti zvishandise

Usati washandisa mushonga uyu mubvunzo, iwe unofanira kugara uchiverenga mirayiridzo iyi. Izvi zvinokonzerwa nekuti iyi mishonga ine nhamba yakawanda yemigumisiro. Ngatimboongororai mazita avo ikozvino:

• Osteoporosis;
• Peptic ulcer we duodenum kana mudumbu, diverticulitis, intestinal anastamosis;
• Glaucoma;
• Thrombophlebitis;
• Iyo Itenko-Cushing syndrome;
• Tuberculosis;
• Mamiriro mushure mekuvhiyiwa uye kukuvara kwakakomba;
• Diabetes mellitus;
• Thrombocytopenic purpura idiopathic (chete yeropa inopinza);
• Izvo zvakanyanya fungal, bhakitiriya uye zvirwere zvehutachiona (kana zvisati zvarapwa zvakanaka);
• Postvaccinal period (mwedzi miviri isati yasvika uye kwevhiki mbiri);
• Kusabatwa kwezviratidzo zvekuvhiringidza mubatanidzwa;
• Periartrikulyarnye utachiona, hutachiona (kana zvinonzi septic) chirwere chokuputira muzvibatanidza;
• Kuputika kwemafupa mapfupa;
• Kubatana kusagadzikana semagumisiro eArthritis;
• Previous arthroplasty;
• Necrosis (aseptic) ye epiphyses yemapfupa achiita sangano;
• Inoshandurwa sangano rinopindirana uye kuparadzwa kwemapfupa;
• Nhanganyaya kune tendlles Achilles;
• Lactation period;
• Kubvumira pathological character;
• Kuwedzera kwekunzwa kwevanhu kune betamethasone, pamwe chete nedzimwewo chikamu chemuiti.

Mukuona kwekuti chirwere "Flosteron" chine benzyl alcohol, hachibvumirwi kuishandisa pamusoro pevana vanozvarwa, pamwe nevana vari pasi pemakore matatu.

Nzira dzekushandiswa uye kuwedzerwa

Kugadzirwa kwemishonga "Flosteron" ine psoriasis (kuongororwa pamusoro pemishonga kuchaiswa pasi apa), pamwe nezvimwe zvirwere zvinoshandiswa parenterally. Mune mamwe mazwi, mishonga iri mubvunzo inogona kushandiswa ye intraarticular, periarticular and intradermal administration. Inofanirawo kutariswa kuti mumashure akasiyana-siyana uyu mujeri anotungamirirwa muurwere.

Chirwere chechirwere chevanhu vakuru nevana vaduku chinogadzirirwa mumwe nomumwe. Inzwi raro rinoenderana nekuoma kwechirwere chechirwere, mhinduro yemurwere, ukuru uye nzvimbo yejojo, zvichingodaro.

Periarticular and intraarticular administration:

• Majoka makuru (kazhinji hip) - 1-2 ml;
• Majoka marefu (humeral, bondo, chiuno) - 1 ml;
• Pakati pehuta (bhokoni, wrist) - 0.5-1 ml;
• Zvinyorwa zviduku (interphalangeal, metacarpophalangeal, sternoclavicular) - 0,25-0,5 ml. Acute gouty arthritis inoda kushandisa 0.5 kusvika 1 ml yemishonga.

Injections muzvikamu zvakakura hazvifaniri kuitwa kudarika nguva 3-4 pagore. Chirwere chimwe chete chechirwere chacho hachifaniri kuva pamusoro pe 0,2 ml pa cm ² .

Kupinda kwemukati:

• Tendonitis uye tenosynovitis - 0.5 ml;
• Bursitis - inenge 0.25-1 ml (mumukati wakaoma kusvika 2 ml);
• Fibrositis inenge 0.5-1 ml.

Mushonga unoshandiswa masvondo maviri ose. Kana zvichidiwa, chirwere ichi chinosanganiswa neanesheti yekunzvimbo mune imwe sir'i.

Kurongeka kwehutano hwemagetsi:

• Nhamba imwe chete - kubva pa1 kusvika 2 ml (inongova intramuscularly) chete.

Mishonga inoshandiswa yakadzika mukati memusero we gluteus.

Vana vanobva pamakore matatu kusvika kune mashanu, chiyero chekutanga chinonzi 2 mg, uye makore 6-12 - 4 mg.

Overdose

Mukuwedzeresa, zviratidzo zvinotevera zvinogona kuitika kune varwere: kushungurudzika, kushungurudza, kushungurudzika kwehope, kurutsa, kuora mwoyo uye kuwedzerwa. Nekushandisa kwenguva refu kwechirwere ichi muwedzerwa madheji, mishonga inokonzera myopathy, osteoporosis, kushandiswa kwemvura mukati memuviri, Itenko-Cushing's syndrome, kuwedzerwa kweropa nekudzvinyirira kweAdrenal cortex. Mukurapa, zvakakosha kuderedza chiyero chechirwere, uye wozonyatsopedza.

Zvimwe zvikanganiso zvejenisi

Chirwere "Flosteron" panguva yekuzvitakura chinorambidzwa. Izvi zvinokonzerwa nekuti iyi mishonga ine nhamba yakawanda yemigumisiro. Vanogona kuzviratidza pachavo kubva kumagadziro ose nemitumbi.

• Endocrine system: hirsutism, kuderera kwekushushikana kweglucose, kunonoka mukurudzirwa kwepabonde muvechiri kuyaruka nevana, steroid diabetes nezvimwe zvakadaro.
• Chirwere chekudya: erosive esophagitis, oropharyngeal candidiasis, pancreatitis, nausea, kuora mwoyo, nezvimwewo.
• Zvipfeko nemwoyo: arrhythmia, hypercoagulation, bradycardia, vein thrombosis, nezvimwewo.
• Nervous system: kukanganisa, kuora musoro, manic-depressive psychosis, kuora mwoyo, chizuru, kushungurudzika, pseudotumor ye cerebellum, euphoria, kutya, paranoia, nezvimwewo.
• Nhengo dzeSensory: trophic kuchinja mu cornea, kurasikirwa kamwe kamwe kamwe kwemaono, cataract, maziso, maziso, epophthalmos nezvimwe zvakadaro.
• Metabolism: hypernatremia, hypocalcemia, kuchengetedza kwemvura uye sodium mumuviri, kuwedzera kuwanda.
• Musculoskeletal system: muscle tendon kuputsika, kukura kwevana muvana, osteoporosis, steroid myopathy, kushaya simba kwezvinyama zvishoma, zvakaderera musimba.
• Ganda uye mucous membrane: ganda atrophy, petechiae, kuponda kweganda, ecchymosis, steroid acne, kunonoka kuporesa maronda.

Kubatana Kwemishonga

Usati washandisa mishonga iri pasi pekufungisisa zvakakosha kuziva kana zvichibvira kushandisa mushonga we "Flosteron" panguva imwechete nemimwe mishonga.

• Kuvharwa kwemisumbu kunowedzera pamwe nekushandiswa kumwechete kweimwe GCS.
• Kubudirira kwe betamethasone kunonyanya kuderedzwa kana inoshandiswa pamwe ne phenobarbital, rifampicin, phenytoin, uye carbamazepine.
• Kubatanidzwa kwechirwere "Flosteron" uye ritodrine kunopesana, sezvo kusangana uku kunogona kukonzera pulmonary edema.
• Nechinhu chimwe chete chekushandisa nemishonga inorwisa maitiro (kurarama), njodzi yehutachiona uye kushandiswa kwehutachiona hunowedzera.
• Iyo mishonga inowedzera hutsinye hweasparaginase, inoderedza zvinoitika zve somatotropin, uye inoderedzawo metabolism ye cyclosporine.

"Flosteron" kana "Diprospan": chii chiri nani?

Izvo zvinoshandiswa zvezvinhu zvose zviri zviviri zvakafanana, uye zvakagadzirwa zvakafanana. Asi pasinei neizvi, mari yekutanga ndiyo yakawanda kupfuura yechipiri. Izvi zvinokonzerwa nekugadzirwa kwemishonga. Zvisinei, dzimwe nyanzvi dzinotaura kuti chirwere "Flosteron" chinoshanda. Panguva imwecheteyo, ndinoda kuona kuti kune nhamba yakawanda yemhinduro dzakanaka pamusoro pemishonga ye "Diprospan". Varwere vanoti chirwere ichi hachina madhara. Izvo hazvo hazvikonzeri kugadzirisa kwehutano uye zvakanyatsorambidzwa. Zvisinei, havatauri zvakanaka nezvemishonga "Flosteron", achitaura nezvekusakwanisa kwayo. Zvisinei, inofanira kurehwa kuti zvinhu zvose pano zviri zvakakwana pachavo.

Nenzira, mubvunzo wekugadzirisa imwe mishonga kune mumwe unofanira kuiswa mushure mekunge uchitaurirana nechiremba anouya.

Analogs zvinoreva

Mukuwedzera kumushonga we "Diprospan", mushonga we "Flosteron" une zvimwe zvakafanana. Izvi zvinosanganisira mishonga inotevera: Acriderm, Betamethasone sodium phosphate, Acriderm Genta, Betamethasone valerate, Betnoveit, Celederm, Beloderm, Betamethasone dipropionate, Beloderm Express, Celeston, Diprospan, Betazon, Celestoderm-V, Betamethasone, Betliben, uye Kuterid.