Embryo embryo mu IVF: zvinoitika sei?

Upenyu hwemazuva ano hunotsanangura kukura kwakasimba, uye kubudirira kwebhizimusi nguva dzose kunosanganisira kurasikirwa muhutano hwemhuka hwevanhu uye zvisikwa. Kuwedzera, mamiriro ezvinhu anomuka apo vaviri vakaroora havagone kubata mwana kuburikidza nekuedza pamwe chete. Dzimwe nguva mutongo unoratidzirwa mumwe wevakaroorana, asi kunyange utano hwakakwana hwevakaroorana hahuvimbisi kuti hurumende ichapiwa mubayiro nemwana akamirira kwenguva refu.

Muzviitiko zvipi IVF inoratidzwa

In vitro fertilization (IVF) inosarudzwa kwete mberi kune iyo inobvunzurudzwa inosimbisa kusakwanisa kwekuberekwa. Kuedza kubata kurapwa kunowanzononoka kwemakore mazhinji, asi nguva isingabatsiri yegadziriro inogona kungoita kuti kuderedzwa mukana wehupenyu hunogutsa. Kuona kusakundikana kwematanho akatorwa, murume nomudzimai vane kodzero yekuomerera pane nzira yeVFF makore maviri kubvira pakutanga kwekurapa.

Iyo iyo embryo inotanga sei

Mushure mokusimudza, dhi rinowanikwa mumhepo yakasununguka iripo, inofananidzwa nehutano hwemwana chaiye. Iko kushandiswa kweija rinowanzova zygote, kureva, unicellular embryo, haisati yaita kuti chirongwa chacho chizadzike. Pamberi peiyo embryo yakabatanidzwa neIVF, panofanira kuva nekuparadzaniswa kwechiremba pasi pekutaridzika kwemazwi embryologist, kuisa chikamu chega chega chitsva mukugadzirwa kwemhuka.

Kutanga kubva pazuva rechipiri kubva pakusangana kwechiremba, chiremba anogona kutotanga kupa nhoroondo yekuberekwa kwema embryo nemiganhu yezvigadzirwa. Dzimwe nguva, kana iine simba, asi inobatsira, inobvumirwa kukura mune imwe nzvimbo yekuvaka pamberi pe blastocyst maitiro (izvi zvinoitika musi wechitanhatu), uye chete ipapo inoshandiswa muuterine cavity. Kudzorerwa kwakadaro kunoruramiswa kuburikidza nekuderedza ngozi kune amai, sezvo zvisingabatanidzi maitiro emakumbo akawanda mumimba, uye zvinoderedza mutoro pamuviri.

Nemazuva ose masero ekuparadzanisa, iyo inotenderwa embryo kutsungirira nguva mazuva matatu. Pashure pacho, chikamu chazvo, asi chisina kupfuura maviri, chinoshandiswa mumuviri wemurwere, uye mienzaniso yakasimba kubva kune yakasara yakanyoroveswa mumvura ine nitrogen. Asi iyo inonzi embbryo inowanikwa sei neVF?

Kugadzirira mukadzi kuitira embryo kudzorera nzira

Ikozvino chisarudzo chekuva mai nenzira yakaoma yekuita mwana mucheche ne IVF ndeye chikonzero chakanaka chekuti mudzimai agadzirise kudya uye hurumende yezuva racho. Inobva kune utachiona hutano hwakanaka uye hutano hwakasimba hwemamai huchauya kuti kubudirira kwehutano hunoenderana.

Mavhiki mashomanana isati yasvika zuva rokubudiswa kweii, puroteni inoratidzwa kumukadzi ane mafuta mashoma uye kubviswa zvakakwana kubva pamenyu yeupfu hwakatsetseka, uyewo zvine soy protein uye inogadzirisa zvirongwa zvezvokudya. Inokurudzirwa kunwa mvura yakachena yakawanda, yakachena yakachena pasina zviiti zvekugadzira. Nezvibereko, zviri nani kupa zvakanakisisa pineapple itsva (kana pasina kutengesa).

Pakarepo pazuva rekuberekwa kwechibereko muhutachiva panguva yeVIV, zvinodiwa kuti zvikurudzire kupararira kweropa munhengo dzemazamu, izvo vanachiremba vanokurudzira vakaroorana kuti vaite zvepabonde uye ipapo, mushure mokunge mukadzi wacho aita zvirongwa zvehutsanana, agadzirira kugadziriswa.

Maawa maviri nguva isati yatemwa yekujova mukadzi inoda kumwa piritsi Piroxicam. Kuenda kuECO, zviri nani kudzikama, yeuka kuti embryo embryo embryo teknolojia yakasuruvara uye haina kuora mwoyo.

Embryo Embryo Kudlulisa Nzira

Mukadzi haaoni kuti embryo iri kugadzirira sei kutengesa, naizvozvo hazvizive kuziva kuti mwana asati azvarwa embryo envelopu inokuvadza nemaune kuti iite kubuda kweii. Iyo nzira inonzi "hatching" uye inosungirwa.

Saka, iyo inonzi embbryo inowanikwa sei neVF? Mushure mokunge taurirana nachiremba, mukadzi anotora nzvimbo yakanaka pane chigaro chechikadzi. Panguva imwecheteyo, zviri nani kwaari kuti asunungure uye avhare maziso ake, uye kuti arege kunetseka, kutarisa kuti embryo inogadziriswa sei. NeAVF, kugadzirira kwomurwere kuchengeta kudzikama kunokosha zvikuru. Iyo catheter, iyo chiremba inopinda mumuviri wemukati, iyo inotungamirirwa nekucherechedza kwema ultrasound, haisi kukonzera kusuruvara kwakanyanya kana miviri yakasviba yakasununguka uye isina kusimba.

Kutarisana nevakadzi vakawanda vanoongorora, kuendeswa kwemazamu panguva yeVII inopfuura, sezvakaratidzwa munhaurirano yekutanga: isina njodzi uye mumamiriro ekunyatsocherechedza kwevashandi. Mushure mekuregererwa kwecatheter, murwere anokumbirwa kurara pasi pamubhedha mushure make uye munzvimbo iyi kuti atore zvishomanana neawa. Munguva ino, embryologist ichaongorora mazai akachengetwa anogara mu catheter tube uye, kana murwere achibvumirana, achavatumira ku- cryogenic freezing.

Chii chinonzi cryopreservation

Sezvo vagamuchira kubvumirana kwekutanga kwevanhu vaviri, kubva kuhuwandu hwemasero akabatanidzwa, asi chete yakasimba uye yakasimba mienzaniso yakasarudzwa, iyo inogona kurarama pasi pematambudziko ekudengenyeka kwakatevera. Kana huwandu hwembrus huchikanganiswa, huwandu hunoita kuti mukadzi awane zvakare IVF munguva inotevera inogona kuitika makore akawanda gare gare.

Mishonga inokonzera mazai inowanikwa panzvimbo yakadzika ye mercury column column, zvakanyanya -196 ^° C. Sezvo nzira yekugadziriswa neine nitrogen yemvura uye inotevera kubudiswa kwekuberekwa kwemuviri ndeyekuoma kwekuoma zvakaoma mumamiriro ekugadzirisa kusinganzwisisiki kwehupenyu, hazvishamisi kudyara mazamu nema IVF uchishandisa masero akawedzerwa zvakanyanya Kune mukadzi.

Kugadziriswa mushure mokudzorerazve

Kubvira panguva iyo mukadzi achibva muimba yezvokurapa, kwaari iye anokosha zvikuru mumazuva matatu anotevera ndeyekuzorora. Ihurumende mushure mekuvhara IVF mubereki kuiswa kwemaawa 72 inopa kugadziriswa kwakakwana kwomurwere. Kunyangwe nekumhanya kusingaoneki muimba yeimba yepachivako, kutsigirwa kwemuviri kwemurume kunofadza kuitira kuti kuderedza kuwedzerwa kweropa pamapapiro. Maitiro emvura pazuva rekutanga anopesana!

Pamberi pacho, kudya kunoratidzwa nechiremba, asi kana mukadzi ane hutano uye asina zvaanoda, ipapo mushure mokunge mwana aberekwa kutengesa neAVF mumwe anogona kudya zvose zvaivepo, asi nekusimbisa nezvezvinhu zvakasikwa, uye, zvisinei, zvisingaverengi mukudya kwekofi, mafuta kana akawanda Zvokudya zvekudya.

Mushure memazuva matatu ehurumende yakagadziriswa, chikwata chemuitiro unotangira unotanga. Pasina kufamba kamwe kamwe, mukadzi anogona kunyatsoita mabasa epamba, kufamba mumugwagwa, kudzivisa chero manzwiro. Panguva ino zvakakosha kunwa mvura yakawanda isina ye-carbonated.

Kudzora

Mumazuva okutanga mushure mokunge uchangobva kuberekwa, mukadzi anowanzotarisana nechinetso chefivha, asi kana uchiyeuka chinangwa chekupindira kwakaitwa mumuviri, maitiro ezvirwere zvezvirwere zvezvirwere achave akajeka. Pasi pe thermometer haifaniri kuva, kana iyo column ye mercury isingasviki 37.6 ⁰ . Zvakakosha kupa mutumbi waro "kumira" ruzivo rutsva uye kuuya maererano nemashoko. Mukushanyira kwepedyo kune chiremba, chiitiko ichi chakanyorwa uye chinongororwa.

Zvakakosha kubhadhara kune majekesti akaiswa. Nhamba yose yemishonga inenge iri mitatu (ine mutemo wakanyorwa): majekiseni maviri e "Utrozhestan" usiku humwe mushure mekuita, chirongwa chimwe cheProgesterone chemangwanani uye majirisi mashanu chete (maererano nemirairo yakarongwa) ye "Fragmina" inokonzerwa nekupararira kweropa muzvikamu zvepachiviri. "Fragmin" inogona kubviswa kubva pane urongwa urwu kana, maererano nemigumisiro ye coagulogram, coagulability yeropa romurwere haisi kubva pane zvisizvo.

Maitiro emuviri semigumisiro yeHIV

Kuvhunduka kwevakadzi, apo pavanosangana nezvakaitika mushure mekuvharwa, izvo zvinoratidzika sezviri zvisinganzwisisiki, zvinokonzerwa nehuwandu hwekudzidzira hunokosha. Pasi pane urongwa hwezvinhu zvakadai, pamwe chete nezvisarudzo zvekuita zvakanaka kwavari:

• Dhiyabhorosi, kurwadziwa kwakanyanya mumudumbu wezasi mushure mekuita, sekuenda kumwedzi, ndiyo yakakwana. Usatora chinhu chakawedzerwa.
• Vaginal tsvina mumamiriro emvura inopenya pazuva rechitanhatu kusvika pazuva rechigumi nemashure memubhedha kutengesa chinhu chinotarisirwa uye chinoda, chinoreva kuti kuiswa kunogadziriswa pamadziro eUterine. Kazhinji, kana kubuda ropa kworudzi urwu hakuperi maawa mana. Chiremba anofanira kuziviswa nezvemamiriro acho ezvinhu uye kuitisa uongorori kuti aongorore zvakanaka mamiriro emurwere.
• Kubuda ropa kwakanyanya kana kubudiswa kwemavara ane dense zvinoratidza kusakundikana kudzorerazve uye kudiwa kwekukurumidzirwa kwechipatara. Muzviitiko zvisingawanzoiti, zvinokurumidza kutorwa matanho kusaita pamuviri.

Kunyatsopera mavhiki maviri mushure mokuputika, muedzo unoitwa nokuda kwevanhu chorionic gonadotropin (HCG). Migumisiro inopiwa pazuva rimwe chete, uye mukadzi anokwanisa kuzvirumbidza kana mazamu ehomoni ino inowedzera. Dzimwe nguva muedzo weHCG unoda kudzoka shure kwemaawa 72; Kudzora kwakadaro kunokonzerwa nekuvapo kwekunyatsorondedzerwa kunongororwa.

Mazuva manomwe mushure mekupa ropa kune hormone (ine mhinduro yakanaka), an ultrasound inoitwa kuti aone kutanga kwekuzvimba. Mune mamwe mazuva 14, wechipiri inopiwa kuti iongorore kukura kwe fetus.

Mune mhaka yeHC inoshata, kutungamirirwa kwemishonga yekuchengetedza zvinodhaka kuchengetedza mugumisiro weVF inomiswa.

Mazuva anokosha, anofanirwa kuenderera mberi pazuva re5-7, anoshumira sechiratidzo chakanaka chekuedza kwakakundikana kwekudzorerazve.

Chii chinogona kuchinja mugumisiro wekudzorerazve

Chinhu chinowanzopindirana chinongedzera kusungirirwa kwemukati kumusvingo wechibereko chinonzi myoma. Embryo 1 embryo IVF mumamiriro ezvinhu aya inoitwa nenzira yakadai kuti zygote haisi pedo nechirwere, iyo ine nzvimbo yekuwedzera. Mamwe mamiriro ezvinhu anokosha ekuchengetedzwa kwakanaka kwemukati mumuviri wemwana ndiyo nguva yakakodzera (kazhinji pazuva rechi20 remhepo) uye kukura kwakakwana kwesero rinogadzirwa. Kana vanachiremba vachiisa dzimwe nguva, iwe unofanira kuitora zvakadzikama, nokuti mutumbi hausi kushanda nguva dzose nekururama kweawa, uye mitambo inofunga nezvehutano hwemukadzi inokwanisa kugona zvakanaka.

Asi kunyange munyaya yechirwere chakaipa, iwe haufaniri kufunga kuti mufaro wekuva amai hausi iwe - iyo chaiyo yezana yenhanho mushure mokunge muedzo wokutanga hauwanzopfuura 45%. Zvingave zvakakosha kushandura zvishoma kudya kana kusiya tsika dzakaipa, dai zvisiri kuitwa kare, uye zvechokwadi kuedza zvakare, uchishandisa embryonic cells mushure mekunyorwa kwegyopreservation.