"Boudin" inhalation: mirayiridzo kushandiswa, description, akafanana uye wongororo

Mune nokurapa Árbol asima pamwe agonist Beta-blockers zvinonzi nevakawanda kushandiswa inhaled corticosteroids kuti kuderedza kakawanda nekuomarara Zvikamu ose bronchospasm. Pakati boka iri zvinodhaka kupa "Boudin" nokuda inhalation. pamusoro pokushandisa "Budenita" Chinyorwa chine mashoko akazara pamusoro kushandiswa kwezvinodhaka, saka isu kuteerera kufunga zvayo kiyi zvinhu zvekushandisa nuances chikumbiro panguva nebuliser mishonga.

Zvinoumba rinoreva "Boudin Steri-Nebhukadrezari" (kuturika)

Instruction kunoratidza kuti mushonga uri kuturika kuti inhalation, isina ruvara uye kwakanaka, kugara mu polyethylene ndiro 2 Rine mamiririta, rine 1 MG (0.5 MG / Rine mamiririta) kana 0.5 MG (0.25 MG / Rine mamiririta) zvinoshingaira chirungiso budesonide. Izvi zvinhu inobatana pharmacological boka glucocorticoid mahormone kuti kukamura uchishandisa kushanda.

pharmacodynamics

Sezvo umboo zvinodhaka "Boudin" mirayiridzo inhalation, budesonide (huru vanoshingaira chirungiso) ane Anti-sema, Anti-anogumbura uye Anti-edema maturo. By masero mapuroteni lipocortin kugadzirwa budesonide ane inhibitory zvazvinoita phospholipase usage, izvo zvinozoita kunotungamirira kune vasanyanye arachidonic iine acid usage, zvinoderedza kugadzirwa prostaglandins uye leukotrienes. azvaiitwa panguva cellular pamwero kunotungamirira zvinoderedza cytokine kugadzirwa, kuderedza yokutama macrophages uye kutungamirira vasanyanye cellular infiltration. Pakupedzisira izvi zvinotungamirira kuderedza kwevari anogumbura nevamiririri uchiratidza chokwadi pamusoro chokubvisa Árbol asima kurwisana uye Kudzikamiswa yaro kunotoda kosi.

Sezvo umboo zvinodhaka "Boudin Steri-Nebhukadrezari 'mirayiridzo kushandiswa, ayo kushandiswa dzose kunoita kuti kudzorerwa nehanya of Árbol muti nezvinodhaka, dilates ari principales. Izvi zvinozoita akazoita multiplicity pakati ichangobva kushandiswa, zvinoderedza uwandu wakadenha sputum Árbol secretion, kunoderedza aikanganiswa allergens, izvo kunobatsirawo pamusoro kunotoda weboka chirwere.

The mushonga hakuna mineralocorticoid basa, uye hakuna systemic migumisiro nokuda omunzvimbo chiito, izvo zvinoderedza kakawanda nekuomarara nemishonga zvakanaka akashivirira kushandiswa kwenguva refu.

Sezvo medicament kuti "Boudin Steri-Nebhukadrezari" mirayiridzo manual, analogs zvinodhaka uye zvichishivirirwa zvakanaka uye regai kuti panowanikwa nemishonga chokuita nokushandisa systemic corticosteroids.

Pashure chete pokushandisa kuchirapa kushanda ikabuda mumaawa mashomanana, richisvika kunonyanyisa mashoko pashure pemavhiki 1-2 pashure kutanga kushandiswa. The mushonga inogona zvinobudirira kushandiswa kudzivisa Árbol asima mumuviri kushushikana, asi nokuda refu Isimba rakadini rinogona kubudiswa nguva, kutanga kuchirapa chiito chepakarepo kwete akakodzera zvakazorodza chakasimba ezvinhu chokuita bronchospasm.

Pharmacokinetics

The mushonga chinotarisirwa vachishandisa nebulizer. Kamwe inhaled budesonide wakanaka mhute rinopedza pamusoro pemvura yacho Árbol muti. About 15% of mushonga nokuda Absorção de Água ari Árbol lumen anopinda systemic kuparadzirwa uye mberi rinoita nokushandisa cytochrome mamiriro ezvinhu anenge vakaneta metabolites (basa ravo kusvikira nguva 100 isingasviki basa yokutanga zvinhu). About 70% of zvinodhaka riri yabudiswa ne itsvo kuburikidza, uye vanenge 10% iri yabudiswa kuburikidza muura.

zvairatidza

Sepokuwana zvinodhaka budesonide uye ayo analogues vanoonekwa kuti kurapwa uye kudzivirira asima kurwiswa, ari ineffectiveness yokushandisa zvokusarudza Beta-adrenergic agonist kuti kudzivirira chirwere uye Kudzikamiswa kunotoda kurapwa mufananidzo, uyewo kuderedza kuchirapa mishonga nomumukanwa glucocorticoid nevamiririri. The mushonga yave kushandiswa zvinobudirira nokuti pakurapa stenotic laryngotracheitis uye chisingaperi obstructive pulmonary chirwere.

Contraindications

"Boudin Steri-Nebhukadrezari" (kuturika nokuti inhalation) iri contraindicated pamberi neutachiona imwe kana kupfuura zvinoumba murwiyo zvinodhaka, uyewo vana pasi pemakore 6 makore. With hanya zvikuru mushonga wacho nachiremba pulmonary tibhii, pokukundwa respiratoria nemavhairasi, kwemabhakitiriya, fungal microflora, chiropa. Kutorambidza kushandisa zvinodhaka pamberi zvirwere zvinokonzerwa nevanhu immunosuppressive zvainoita mucous kuti kuguma rutapudzo pakati masoja mhinduro uye chirwere kunoita.

nemishonga

Nokuti kuti mushonga chinotarisirwa nokuda inhalation uchishandisa nebulizer, kuti ndingangokuvara panowanikwa mucosal kuoma muromo uye yokumusoro Airways, kwazvo huro kunzwa uye akashatirwa, ipa uye kujairika kuravira, hoarseness kana hoarseness, chikosoro. Izvi imhaka subsidence mikrochastichek mushonga pamusoro mucosal pamusoro.

Quite kashoma vaichengeta kusagadzikana tsinga, iyo anozviratidza muchimiro kutya uye yakawedzera excitability pamusoro neuro-mupfungwa, maitiro asina kutsarukana, nomusoro. Uyezve, varwere kushandisa "Boudin" dzimwe nguva kukonzera neutachiona akati sezvo urticaria, kuvaviwa kana akatsvuka ganda, spasm pakati Árbol wakatsetseka tsandanyama, uye kukura candidiasis pamusoro nomumukanwa mhango uye yegurokuro.

The panowanikwa gangaidzo bronchoconstriction uye mberi dyspnea atanga wokutanga dose inhaled nokuda muchishungurudza zviito mushonga iri yemweya mucosa. With kukura mhiri maturo inhalation Zvinokurudzirwa kurega uye kugadza imwe nzira kurapa.

Pasinei yakaderera bioavailability zvinodhaka uye ayo vakawanda veko zvinokonzerwa, mazhinji kushandiswa anogona kuva systemic migumisiro yose glucocorticoids. Izvi vakaratidzawo chinovhiringidza basa adrenal cortex, tava kuderera kuwedzera muvana, kuderera mune mapfupa chicherwa arambe achirema, kukura kutyorwa kuri maonero.

Mune zvimwe zviitiko (Kashoma) zvingakonzera ganda kutsamwa kana kushandisa nebulizer chifukidzo. Kuitira kudzivirira kuomesa ichi rinofanira kushandiswa disinfecting negadziriso asingazivikanwi, uye pashure inhalation ganda pasi pemvura inodziya. Unogonawo kusunungura hunyambiri rabha zvisungo vachibatirira masiki kumeso. A akanaka nzira inogona kushanda kushandisa kutaura kana mutauri inhalation.

Shandisa nepamuviri uye lactation

Mirayiridzo "Boudin" rinorumbidza mushonga kushandiswa nokungwaririra vakadzi vane pamuviri uye panguva pamukaka (kunyange mashoko pamusoro chigadzirwa inopinda ndisipo mukaka waamai). The mushonga inokurudzirwa kushandiswa chete kana makomborero ayo kuna amai kupfuura zvinoita nemigumisiro uye zvakaoma kunzwisisa kuti azvarwa. Saka zvinokosha kushandisa shoma anobudirira budesonide ari dose kuti achibvumira kudzora chirwere.

Drug kwavatori

At padanho nekuita pakati mishonga Pfungwa inowirirana ane isotonic mhinduro pamusoro yavaibvisa chloride, uyewo mamwe inhaled Beta-agonists, mucolytics uye expectorants. Kuti kuwedzera efficacy uye muviri kushanda Árbol spasm chokubvisa zvinodhaka mapoka aya anogona kuiswa pamwe nebulizer mukamuri. Kugoverana bronchodilators kwete chete anovandudza chekubuda "Budesonide" iri bronchoalveolar muti, asi kunoitawo kuti zvakadzama kupinda mariri lumen.

Nokuda kunobatanidza cytochrome P450 makemikari boka iri muviri kuti budesonide dose dzinofanira kudzokororwa kana kushandisa zvinodhaka izvo inoodza mwoyo kana anotokonya basa enzayemu. Not varumbidzwa kwemajoini zvinodhaka pamwe antifungal mishonga yakadai se "ketoconazole" uye "Itraconazole", sezvo izvi zvingaita kuti nokuwedzera wevasungwa kuti "budesonide" plasma.

Medicaments izvo kuwedzera basa microsomal makemikari ( "Phenobarbital", "Phenytoin", "Rifampicin") kuderedza basa "budesonide".

Dosing

Pretty nyore kushandisa, "Boudin" nokuda inhalation. Mirayiridzo kushandiswa anoratidza kudiwa kushandisa nebulizer kuti kurapwa. The mushonga anoiswa mukati nebuliser mudziyo, uye inhales. Ya inhalation uye dose zvinofanira kusarudzwa kana nechimwe kufungisisa kunotoda ezvinhu omurwere uye kwokuomerwa hosha kana uchishandisa mushonga "Boudin" nokuda inhalation. Instruction vana kubva 6 mwedzi 12 apfuura kunoratidza kugadzwa budesonide kaviri muduku chipimo chemushonga. Varwere vakuru makore 12, kwerunyararo dose inofanira kuchinjwa nomumwe.

Kana zvakakodzera, "Budenita" akabatana nomumukanwa glucocorticoid zvinodhaka yakarumbidza kuwedzera dose kuti "Budenita" nokuti kudzivirira panowanikwa uye kuderedza kwokuomerwa nemishonga.

Reviews

Tikaitira vanachiremba uye varwere akagutsa efficacy zvinodhaka. Izvi runoratidzwa kudzokorora (kuturika nokuda inhalation din email «Boudin" - rakanaka nevakawanda mushonga) Pfungwa. Mafungiro akanaka vakaumba nechezasi kuitika nemishonga uye nyanzvi kurapwa. Maonero pamusoro "Boudin" Pfungwa yokuti inhalation vana (kurairirwa, ari chipimo chemushonga rakapiwa munyaya) vane vanaamai zvakanaka, riri nokuda yakaderera kuitika nemishonga. Nyarara inhalation kushandisa nebulizers (izvo zvinogona kuitwa nenzira dzakasiyana-siyana matoyi) muvana vaduku akataurawo vachida kushandisa zvinodhaka, kana ayo analogues.

ovhadhozi

In chenjera ovhadhozi zvikuru zvekuchipatara zviratidzo zvinochengetwa. Treatment riri symptomatic, pamwe abolition zvinodhaka uye kugadzwa pfupi-nokuita bronchodilator chiito mhando.

Zvinofanira kurangarirwa kuti kushandiswa kwenguva refu "Budenita" panguva mishonga kwazvo sredneterapevticheskih zvingamuka marwadzo pane systemic pamwero (hypercortisolism, kuora mwoyo pamusoro adrenal shanda). Izvi runoratidzwa "Boudin" mirayiridzo inhalant. mutengo wayo kushandiswa kwenguva refu zvinodhaka sechinhu chikuru kurapa nokuda Árbol asima.

Separate nhungamiro uye zano

Mirayiridzo kushandiswa zvinodhaka "Boudin" inoti haisi rakagadzirirwa asunungure rikwanise kurwisa bronchospasm. The paavhareji Nguva kuchirapa mugumisiro anenge 10 mazuva, asi izvozvo zvinogona yakawedzera kuvapo muna lumen pamusoro Árbol muti kana yakawanda viscous madzihwa secretion. Muchiitiko ichi zvinokwanisika kuitisa kurapwa akabatana nemumuromo glucocorticoid pamwe unozotevera Kuchinja chete "Boudin Steri-Nebhukadrezari" inhalation.

Mirayiridzo kuti mushonga anoti, kunyange zvazvo ndingangokuvara nemishonga panguva hurongwa pamwero dererei zvikuru, zvinokosha kuti titrate shoma inobudirira kuchirapa dose nokuda kunonyanyisa kushanda. In nokushandisa mushonga vana vaine maonero kuti nenguva kuziva nemigumisiro zvinofanira kugara kuongorora mwana kukura pamusoro yakareba nguva. With kukura nemishonga anofanira kuderedzwa kuvaduku inobudirira dose, izvo zvinoita kudzora yokurwiswa asima.

Nokuti kudzivirira fungal zvirwere zviri nemumuromo mhango murwere inofanira kuziviswa kudiwa pavaisukira muromo uye bvisa residues pashure mumwe inhalation. Izvi anokurudzira kudzorerwa omunzvimbo kutapata uye kunanzvana mucous.

Technical zvinhu Shandisai

Inhalation "Budenita" vachishandisa ultrasonic nebulizers contraindicated. Chinobudirira dose zvinodhaka anofanira dzaona kufungisisa Kunyanya hwokugadzira zviri nebulizer (kufungisisa mhepo aibuda zvazvingava, Vhoriyamu nebuliser uye t. D.) Uye murwere ezvinhu.

Asati kushandisa zvinodhaka "Boudin" inhalation nebulizer ari nebulizer murayiridzo mutemo unoti vanofanira kudzidzwa. Izvi tichadzivisa kubatana emunhu mudziyo uye va neudhadha kushandiswa kwezvinodhaka. Kana nebulizer rinoshandiswa kokutanga, Zvinokurudzirwa kuti aedze kushandisa vasiri yavaibvisa chloride mhinduro kuitira operability ayo uye akabva ashandisa zvinodhaka.

ari inhalation bhokisi asati abvisa mapurasitiki chinu iri rakazaruka kudhonza chivharo, mushonga anoiswa mukati nebuliser mudziyo, kupfeka kumeso (kana chinosimudzira mutauri) uye anoshanda wokufema. Panguva inhalations uchishandisa mutauri vanofanira kufema chete kuburikidza muromo wako (yaipfekwa pamusoro mhino chaiyo clips). Paaishandisa kufema chifukidzo chikumbiro optionally mhino Vanthan.

Nokuti inhalation Zvinokurudzirwa kushandisa nebuliser kuti vharafu mano iyo inopa jekiseni yakaisvonaka aerosol zvinodhaka zvakananga panguva nguva inhalation uye anovhara nzira yokubudisa zvinodhaka panguva kuregedza kushanda. Izvi anowedzera zvinodhaka hurukuro iri bronchoalveolar matanda anoderedza kurasikirwa mishonga panguva nedzinovengwa.

"Boudin Steri-Nebhukadrezari": analogues, mutengo

Drug analogues "Boudin Steri-Nebhukadrezari" vari zvinodhaka akadai "Pulmicort" uye "Pulmicort Turbuhaler", "Kortimen", "Tafen", "Budoster", "Budenofalk" uye vamwe vakawanda. Pana zvinodhaka izvi, sezvo mukugadzirwa "Boudin" inhalation, mirayiridzo iri akafanana nokuda pamberi chete vanoshingaira chirungiso. Data mutengo zvinodhaka kunobva chemishonga zvakarukwa nekudunhu, uyewo chipimo chemushonga. Paavhareji, mutengo anoda kubva 650 kusvika 2550 rubles.

mhedziso

Zvikuru zvinobudirira medicament kuti mishonga uye kudzivirira asima kurwiswa ndiyo "Boudin" inhalation. Mirayiridzo kuti mushonga anopa kwemashoko akazara pamusoro chipimo chemushonga uye mamiriro ezvinhu nokushandisa zvinodhaka ichi. Kunopiwa budesonide kushanda maererano nemirayiridzo uye yakarumbidza dosages pamusoro medicament zvinopa anobudirira kurapwa. Kana kuti zvimwe chikonzero haugoni kutenga chokutanga, pane analogues. "Boudin Steri-Nebhukadrezari" (mirayiridzo mutengo yauri kuzivikanwa) achaponesa iwe nezvirwere zvizhinji kufema hurongwa.