Bile asidhi sequestrants, zvinodhaka: nyora

nemafuta iine acid sequestrant zvinodhaka vanonzi, vanokwanisa kuderedza ropa remafuta akawandisa. Izvi upiyona mushonga inoshandiswa pakurapa. Pane chaicho kupatsanura zvinodhaka lipid-richikwidibira, izvo kudzivirira remafuta akawandisa synthesized muropa. Sequestering nevasori zvinosanganisirei kupatsanura ichi. Hazvina zvimiso, ine zvinhu zvakasiyana-siyana, izvo zvakafanana mashandiro nezvaaiita. Most anozivikanwa bile asidhi sequestrants - zvinodhaka "Colestipol", "Cholestyramine", "colesevelam."

Risk chemwoyo ipfupi nokuda sequestering ehupfumi, kusanganisira ischemia. Clinical ruzivo inosimbisa kubudirira SCF pfungwa dzinotevera muna:

• matambudziko anoitika coronary nemaitiro tava kuderera;
• kwakaderedza nzufu myocardial infarction.

Makemikari anoumba zvinodhaka izvi dzinovabvumira anosanganisira Mapato ose Ion chinjanai Inogadzirwa nemasiridzi anobuda mumiti. Izvi yakakwirira samolecular uremu chakaita zvokugadzirwa yeimwe izvo vanotova insoluble Polymers vari chakasimba nidzwa pamwe aqueous svikiro iri Ion Exchange rikurumidze. Ndizvo sequestering bile acids.

The mashandiro chiito zvinodhaka

Shoko "sequestrant" rinoreva "insulator", kuti zviri kuitika mumuviri womunhu voga kuti bile acids. Remafuta akawandisa anotsinga pamwe bile acids, izvo takura remafuta akawandisa kubva chiropa kuyerera kuti pave kubatana kwetunhu. Bile asidhi achiparadzira ari zvomudumbu ino vasati isvike ura apo haina kunyura. Somugumisiro, muviri chaizvo zvinokosha zvinhu muupenyu.

Inoshanda migumisiro lipoproteins kuti vane pasi arambe achirema. Izvi anonzi remafuta akawandisa zvakaipa.

Sezvo basa bile asidhi sequestrants (kugadzirira tsanangura zvizere pazasi).

Sequestrants hadzina wefodya unopinda muropa, saka marwadzo kana, iri shoma vanochiva uye vanoonekwa kwazvo kashoma.

Pregnant uye lactating vakadzi vanogona kushandiswa zvikonzero izvi. Uyewo, vana uye vechidiki rwapedyo hypercholesterolemia vari kushandisa zvinodhaka izvi kunetesa muitiro. It is nhaka ezvinhu muviri, umo raidudzwa yakakwirira remafuta akawandisa uye zvichiguma nemigumisiro.

Kana portability FFA kuipa, unogona kushandisa navo kwenguva yakareba. Noobyazatelno vanofanira kudzora remafuta akawandisa, chiropa makemikari uye tsandanyama tishu.

Statins akabatana FFA vari hubudirire pamwe mazhinji nzira yokurapa. A remafuta akawandisa zvakaipa ipfupi nehafu. Kana paine hyperlipidemia vasanganiswa (kana zvakawanda mafuta neropa), ipapo migumisiro zvichava nani nokuda 70-75%. Sezvo muviri chiito pamusoro bile asidhi sequestrants? The Formulations kazhinji zvakanaka zvaitombova.

Ndezvipi kurutivi migumisiro?

Marwadzo kuitika chaizvo kashoma. Kana vari, ipapo hapana zvakakomba nokuti muviri asingadi votendeuka. Kunyange zvakadaro, vamwe vanhu angava nokuratidzwa zvinotevera zviratidzo zvakaitika nokukurumidza:

• kupatira;
• fufune (dyspepsia);
• svoto;
• kunyanya gasi inotungamirwa ari ura (flatulence);
• bloating;
• chirungurira, uye ndicho divi mugumisiro bile asidhi sequestrants.

Kuti tidzivise akaipa chinja pamusoro chikamu chomuviri, unofanira tikanwa zvinwiwa zvakawanda uye kudya pakutanga mishonga iri mishonga diki.

Kana akashandisa FFA vana vanoda kuti taurira simbi uye folic acid. Mawa kurapwa nedzimwe zvinodhaka zvinogona kukonzera murombo Absorção de Água kuti basa zvinoriumba. Pano zvakafanira kuchengeta zvinotevera mutemo: sequestering kunwa awa pashure kushandiswa nedzimwe nzira, uye kwemaawa mana.

Very kashoma zvinogoneka tsandanyama marwadzo (myalgia), kuzvimba pharynx (huro). Zvikuru kashoma panowanikwa chikosoro, marwadzo kumashure, kutonhora.

Contraindications

Ko contraindications sequestering bile acids? Drugs hadzina nezvaro zvinotevera nyaya.

Kana hyperlipidemia mhando 3 uye 4 (izvo kukanganisa pathologies pakati kumwoyo) havasi inokurudzirwa sequestrants. Anogona kusimudza triglycerides muropa. Kana akarova ne bile mutsinga dzinofamba nemukaka (biliary cirrhosis uye kwakakwana biliary mhingaidzo) havagoni kupa mashoko medicaments. Kana munhu anotambura kakawanda kupatira, mushonga unogona chete sembura zvinhu. Cheitsvo, dumbu maronda, Mamota ropa wenyonganyonga - zvose contraindications kuna SLC.

With hanya varayire vave vanhu vane gastrointestinal zvinetso, malabsorption syndrome (vasingadzoreki intestinal Absorção de Água, uye zvokudya zvinokosha zvakaoma kugara muviri).

Possible chete idiosyncrasy.

Zvinotevera Kutarira kupfuura mukurumbira bile asidhi sequestrants. Zvinodhaka (zvawanyora kunogonawo bvunza chiremba wako) vachaparadzwa kurongwa kuitira neevakawanda yakakurumbira kusvikira kuvaduku akakurumbira.

The mushonga "Cholestyramine"

It Anonziwo "Cholestyramine". Remubatanidzwa iri insoluble Ion chinjanai Inogadzirwa nemasiridzi anobuda mumiti. It zvinotisvitsa zvinoderedza ropa remafuta akawandisa yomuropa pedyo muzvina. Ko chinoshingaira kunyorerana bile acids, pakwakanga vari kure dzemuviri. Kana mushonga zvinokosha kunwa kwenguva refu, zvino unofanira kushandisa mamwe mvura. Statins chiwedzere zvinokonzerwa, asi pfungwa dzavo ipfupi muropa. Pazera makore 60 ushandiswe nokungwarira.

Medicament "Colestipol"

Zviri kumusoro insoluble copolymer. Properties vasunge bile acids iri zvishoma kuipa pairi kupfuura "Kolestiramin".

Zvairatidza, nemishonga uye contraindications zvakafanana rose boka zvinodhaka. Tikafunga "Kolestepola" uye statins kupa zvakanakisisa kushanda.

Drug "colesevelam"

No risingafadzi manakiro ehupfumi yacho chigadzirwa kunoita kuti chokwadi kuti kuramba kuitwa tichienzanisa nedzimwe mishonga.

Ita Data sequestering bile acids vane divi migumisiro?

Migumisiro yakaipa pamusoro nemudumbu vaizivikanwa. Zvinoitika nevamwe mishonga vasingadaro. "Colesevelam" anogona kushandiswa pakurapa vakadzi vane pamuviri uye lactating.