Beta-blockers

Beta-blockers anoshandiswa sezvo antihypertensive zvinodhaka kubvira mangwanani sixties. Sezvo kuonekwa pakati migumisiro mishonga uye musi kubudirira kwavo chokutanga zvakanaka muMagwaro kudzorwa zveBhaibheri zvakawanda, uyewo kana tichienzanisa matambudziko zvakawanda nzira ano.

Beta-blockers anoshandiswa vakabudirira tikarega BP uye kudzivirira kukura zvemwoyo chirwere uye kufa. The mashandiro avo antihypertensive richifanira inobva zvinoderedza cardiac goho nokuda zvinoderedza simba uye kakawanda sunga. Uyezve, Beta-blockers kubatsira kudzvinyirira pamusoro secretion pakati renin ari juxtaglomerular (okoloklubochkovom) itsvo midziyo uye panyaya iyi, kuti zvinobudirira kudzvinyirira basa renin-angiotenzinaldosteronovoy uye nechepakati vasomotor enyika.

Kushandiswa dzavo refu kungakonzera vasanyanye pamusoro vascular nemishonga (zvachose peripheral), nokuda vawedzere baroreceptor nehanya uye kugadzirwa munyika vascular rusvingo prostacyclin (prostaglandin vasodilating).

Various Beta-blockers yaishandiswa rinoenderana mishonga, vane hypotensive nomugumisiro wakadaro. Full antihypertensive Migumisiro anova mukati maviri mana vhiki. "Kukanzura" chirwere kunogona kuitika tikafunga kurapwa kwenguva refu. Nokuti dziviriro rayo zvinodhaka haina kumborega pakarepo, uye zvishoma nezvishoma kuderedza dose kuti gumi kusvika gumi mazuva.

Systemic kugarotamba zvinodhaka, kunyanya dzisiri zvokusarudza, kungakonzera kukura akaora kukosha cardiac uye noncardiac nemishonga.

Boka rokutanga zvinosanganisira zvinetso zviri psycho-mupfungwa kumashure (mwoyo, hope zvirwere, etc.), kufema zviratidzo (bronchospasm), peripheral vasoconstriction (inoratidza claudication, kutonhora migumo, etc.), tsandanyama simba, kusabetsera. Extracardiac nemishonga vanomiririra vanotaura pamusoro renal nerevane kunokonzerwa ropa riyerere kuderedzwa ari itsvo, nematambudziko lipid uye carbohydrate muviri.

In cardiac kuratidzwa boka rinosanganisira:

• cardiac kupomba basa pakakoromoka pamwe zviratidzo kushaikwa;
• blockade (atrioventricular sinoatrialnaya) mwoyo uye bradycardia;
• hypotension pamusoro kunyanya kuderera BP;
• antiarrhythmic kushanda.

Zvinofanira kucherechedzwa kuti dzakasiyana-siyana pharmacological zvivako blocker unokubvumira kusarudza Zvakanyanya Kunaka Panguva Yepamuviri chinodhaka anenge ose nyaya. Izvi inorangarira uye tolerability ari kurapwa, yakadereresa mukana yaivhuvhuta zviitiko, nguva dzokuteerera uye mhando kunotoda kurapwa ezvinhu.

Kudomwa Beta-blockers somunhu bedzi kurapa kunoita kuti normalization kuti BP munenge 40-50% varwere neBP. Tichienzanisa kuti kubatsira varwere munyika muduku, pakati uye vakura zera, mugumisiro wacho kudzika mune vakwegura. Kushandiswa thiazide diuretics akabatana ine Beta-blocker anobvisa kusiyana. Saka, kubudirira kurapwa mune mubatanidzwa akadaro chinowedzera 78-80%.

Beta-blockers kuti kurapa angina kugara nzvimbo inokosha. In chirwere ichi, mishonga yakadaro dzinoshandiswa sezvo Anaprillin (obzidan), Sotalol, Atenolol, Konkor, Monotard.

The mugumisiro zvose zvinodhaka izvi nechinangwa mukuderedza BP uye "deceleration" kwemwoyo. The chipimo chemushonga chero mushonga anofanira kusarudzwa chiremba evasingatombonamati nomumwe.

Zvinodhaka zviri contraindicated mu asima, chisingaperi obstructive pulmonary zvirwere, atrioventricular chinogumbura wechipiri kana dhigirii yechitatu. Not ashandise Beta-blockers mu havachanyatsogoni shuga kushivirira, peripheral arterial chirwere, vatambi uye mumuviri kushingaira vanhu.