Antidepressant 'Azafen', mirayiridzo kushandiswa, marwadzo

Drug "Azafen" anoreva boka racho tricyclic antidepressants. It ane mukuru kunyaradza, anxiolytic uye antiaggressive nemigumisiro. mushonga uyu unoshandiswa nevakawanda nekuda kurapa yemapapu uye yechipiri dzegirini, yakadai se:

- endogenous;

- astenodepressiya;

- exogenous;

- chidhakwa;

- aramu;

- mamiriro munguva somatic ezvinhu ane chirwere hunhu.

The kushingaira wemafuta mushonga "Azafen" tsanangudzo rinoreva pipofezine. The mashandiro chiito ane pfuma inobva chinovhiringidza pamusoro neuronal uptake ose norepinephrine uye kweserotonin. Izvi zvinotungamirira nokuwedzera wevasungwa kuti pipofezine muna CNS uye zvokuora mwoyo zviratidzo yakasvikawo.

Pane imwe paanopfuura zvakafanana zvinodhaka zviri antidepressant zvinodhaka chiito "Azafen" mirayiridzo kushandiswa anoreva kusavapo ayo cardiotoxic migumisiro. It rinozivikanwa sezvo tambira rinoreva "Azafen" riri kuvhiringidzika nepfungwa, vachinetesa somatic, vanoziva remangwana kana zvinofunga uye autonomic zvirwere chokuita nokuora mwoyo. High efficacy "Azafen" mirayiridzo Chinyorwa rinorondedzera kurwisa asthenia, matambudziko anomuka nokuda somatic dzevanhu psyche. Munguva kwokubatsira mushonga pavarwere anonyangarika kufunganya, kushushikana. Positive emuchina vari varwere neanorexia nervosa, zvakajairika hope uye nehope haazombotaurwi masikati.

Medicine "Azafen", pana avo pharmacokinetic ehupfumi ane digestibility zvakanaka, izvozvo wefodya zvakanaka kuburikidza zvomudumbu turakiti rine yakakwirira bioavailability (80%), kunonyanyisa ropa wevasungwa rinosvika kare mukati 2 maawa. In chiropa kunoitika kuburikidza biotransformation pipofezine kuti vakaneta metabolites kuti anonyorwa zviri neitsvo. Full kusunungurwa zvinodhaka mumuviri kunoitika mumaawa 16.

Treatment mwoyo pamusoro siyana mavambo chinhu chinokosha chinoratidza kuti kushandisa zvinodhaka "Azafen" mirayiridzo Chinyorwa rinoti hurumende, uchinyora zvose mhando depressioy, pachena kuti zvinodhaka.

Pane contraindications akawanda pakugamuchira antidepressant "Azafen" mirayiridzo kushandiswa kuratidza zvinotevera inoti Hakupindirani kurapika:

- cheshuga;

- kuudzawo Mao FIs ;

- myocardial infarction, mwoyo kukundikana, coronary tsinga chirwere;

- hepatic kana renal kukundikana;

- zvirwere yakanyanya;

- mamiriro pashure chakakomba cerebrovascular tsaona (sitiroko);

- Pregnancy, lactation.

Zvinofanira kungwarira zvaibvira panowanikwa nemishonga panguva kurapwa, ivo varehwa dzungu uye nemusoro, neutachiona, kurutsa uye svoto. Sezvineiwo, hapana ruzivo pamusoro kurapwa kana zvinodhaka ovhadhozi, mune zviitiko zvakadaro, zvinoda symptomatic. Panyaya contraindications anofanira kuwedzerwa chete dambudziko "Azafen" uye doro. Ava vaviri zvachose kungoreva chete pfungwa panguva kurapwa inofanira vakarega kunwa doro uye mawa negashiro kugadzirira ane panyaya iyi.

The "azafen" kwete kuwanikwa anticholinergic ehupfumi, saka hatiregi zvinodhaka pakurapa varwere pamwe yemaziso. Uyezve haawirirani doro, pane njodzi mawa pokushandisa zvinodhaka pamwe anticoagulants, antihistamines uye zvose zvinodhaka, CNS kuora mwoyo. Tapota ziva kuti mawa negashiro "azafen" pamwe antiepileptic zvinodhaka kuderedza kubudirira yokupedzisira.

Kusunungurwa "Azafen" zvakasimba maererano aiitwa, kufadza pasherefu upenyu 5 makore, zvinofanira kuchengetwa pana tmax 25.