The mushonga "Remicade": mirayiridzo kushandiswa, zvechokwadi

Zvinobudirira zvinoreva "Remicade"? Mirayiridzo yokushandisa, murefu wongororo kuti mushonga uyu zvichakurukurwa pazasi. Uyewo munyaya ino, uchadzidza pamusoro chero nyaya, taurira mushonga, kana ane contraindications uye nemigumisiro, izvo zvinoumba vari chikamu uye zvichingodaro.

Form, akafanana

Kugadzirira "Remicade" iri wakabudiswa muchimiro lyophilized upfu akaronga kuti kugadzirira aizomupa mhinduro. The kushingaira wemafuta zvinodhaka ndiko infliximab. Rinewo mimwe zvinoriumba sezvo polysorbate 80, yavaibvisa rehydrogen phosphate dihydrate, sucrose uye monohydrate yavaibvisa dihydrogen phosphate.

Key ehupfumi

Chii mushonga "Remicade"? Mirayiridzo Use anoti chinhu immunosuppressive mumiririri.

Achipfuura mukati mumuviri, mushonga anotanga kutaura pamwe soluble uye transmembrane siyana bundu necrosis Alpha (TNFα), nokuderedza basa radzo paumbwe mudanga kunzwisisa.

Research nyanzvi dzinoti yezviri zvinodhaka fuma kunoderedza cellular infiltration (anogumbura), uye uwandu anogumbura zvezvinangwa mu njodzi nzvimbo ura. Saka pane kumbonyanya nokukurumidza nokuporesa mucous membrane.

Pharmacokinetics

Ndezvipi pharmacokinetic parameters rave mushonga "Remicade"? Note, inofambiswa hurumende kuti rimwe intravenous jekiseni infliximab mune mari anosvika 20 MG / makirogiramu chinoteverwa Proportional kuwedzera zvayo kunonyanyisa yevasungwa.

Akadzokorora pokushandisa zvinodhaka kunokonzera zvishomanana kuunganidza basa fuma iri serum.

Nzira kubviswa pakati zvinodhaka haina kuzivikanwa.

zvairatidza

Nokuti chii zvinangwa anogona yakatarwa zvinodhaka "Remicade"? Kushandiswa mishonga iyi unoratidzwa zvinotevera nyaya:

• Dzinonzi rheumatoid arthritis ari basa chimiro (kana kubatwa varwere dzinokosha antiinflammatory zvinodhaka rakanga sashanda). Zvipatara akanga akatakurwa achiburitswa kunze akabatana "methotrexate". Kubatana uku rinobvumira kuderedza zviratidzo chirwere, uyewo kuvandudzika ari muhudyu rose.
• Crohn nehosha pavarwere akura. Muchiitiko ichi zvinobatsira "Remicade"? Guide rinoti kuti kurapa pamwe kugadzirira ichi zvinofanira kuitwa kana asingashiviriri kana ineffectiveness, asiwo contraindications kuti mureza zvinodhaka. In chirwere kwakadaro "Remicade anosimudzira kubviswa zvose chirwere zviratidzo, kuramba kuregererwa uye kukurumidza maronda, fistula mukuvhara uye kuvandudza murwere ezvinhu.
• Crohn nehosha mune kuyaruka. Treatment pamwe mushonga uyu kuitwa nyaya asingashiviriri kana ineffectiveness, asiwo contraindications kune mwero Zano mushonga. Medicament "Remicade" kunoderedza zviratidzo uye anotsigira kuregererwa uye anovandudza upenyu wevarwere vaduku.
• Maronda colitis nedzevakuru. Drug "Remicade", iro akaongororazve kukurukurwa pazasi, chinotarisirwa mune chiitiko kuti kwakajairika kurapa kwakanga isashande. Mabatirwo mutumwa uyu akazoita zviratidzo hosha, kuti intestinal mucosa kuporesa, zvinoderedza kana abolition kuti GCS dosages. Zvinofanira kucherechedzwa kuti, pashure basa iri mudziyo anobvisa kudiwa muchipatara pokugara.
• Maronda colitis muvana. Treatment pamwe mushonga uyu ushandiswe vana vane makore makore 6-18, kana akaratidza sashanda kwakajairika kurapa.
• Ankylosing spondylitis (pamwe mureza kurapa inefficiency). Sezvakanga nechirwere kunobatsira mushonga "Remicade"? Mirayiridzo dzokushandisa inoshuma kuti chokushandisa ichi akazoita zviratidzo chirwere uye anovandudza kushanda mapfundo.
• Psoriasis (pamwe mureza kurapa inefficiency). Sezvo mu psoriasis kubatsira "Remicade"? Nyanzvi Guest vanoti mushonga uyu kunoderedza kuzvimba paganda uye normalizes chirongwa keratinocyte Kusiyanisa.
• Psoriatic arthritis (nokuti mureza kurapa inefficiency). The medicament "Remicade" raitongwa akabatana "MTX" kana sezvo monotherapy pamwe contraindications kana kusashivirirana kune ekupedzisira. Somugumisiro, marapirwo kwakaderedza zviratidzo arthritis, varwere akavandudzika dzichipfekeka basa, uyewo zvinoderedza mwero radiographic kufambira mberi mune psoriatic chearthritis.

Contraindications

Treatment "Remicade" hazvitenderwi nomufambiro kana:

• zvakakomba kutapuriranwa muitiro (semuenzaniso, sepsis, pute, tibhii, mikana zvirwere) ;
• zvakawedzera aikanganiswa murwere kuti infliximab uye murine mapuroteni uye zvimwe zvinoumba zvinodhaka;
• pasi pemakore 6 makore (maronda colitis uye Crohn chirwere);
• pamuviri;
• mwoyo kutadza;
• pasi makore 18;
• achiyamwa.

Drug "Remicade": mirayiridzo kushandiswa. Uye apo kupinda (kana chete ari muchipatara)?

mishonga Viewed anofanira kuzviita chete pasi pokudzora nyanzvi (kureva chipatara) ane zvakakwana chiitiko nechirwere uye vabudirire vabatwe pamusoro zvirwere.

The Kugadzirisa kutaurwa dropwise nomutsinga pamusoro maminitsi 120. The zvazvingava hakufaniri kupfuura 2 Rine mamiririta paminiti. Dzika nzira zvakafanira pamwe kushandisa aizomupa hurongwa.

The chipimo chemushonga zvinodhaka kunobva uchapupu.

dzinonzi rheumatoid arthritis

In basa chirwere chakadaro kutanga dose anofanira anenge 3 MG pa makirogiramu. The medicament chinotarisirwa kakawanda vhiki 3-6. Zvadaro shandisa ose mwedzi miviri.

Kuri kuti mishonga mugumisiro haina kubudirira, tichifunga kugumiswa mishonga.

Kazhinji mushonga ndiye "Remicade" pamwe dzinonzi rheumatoid arthritis raitongwa pamwe "methotrexate".

maronda colitis

Initial chipimo chemushonga kana chirwere kwakadaro 5 MG pa makirogiramu muviri uremu. Chete dose zvinodhaka chinotarisirwa vhiki 3-6 papera. Ipapo kurapa kunze ose mwedzi miviri.

Kana zvakakodzera, kuti dose anogona ngazviwedzerwe 10 MG muzana makirogiramu. The mugumisiro kurapa Kazhinji mukati memasvondo 14. Pakadaro, kana hazvisi, unofanira kuramba kurapwa.

psoriatic chearthritis

Psoriatic chearthritis zvinodhaka "Remicade" raitongwa mu kwokutanga dose 5 MG pa makirogiramu. The medicament chinotarisirwa kakawanda vhiki 3-6. Zvadaro shandisa ose 7-8 mavhiki.

Mishonga inogona pamwe "methotrexate".

Crohn chirwere

In chirwere zvakadaro vakuru vanoonekwa mishonga kuroorwa 5 MG por makirogiramu. Kana mishonga mugumisiro haina kubudirira kwemakore 2 weeks, nokuishandisa akapidigura.

Kana uine zvinodhaka chiito, zvinotevera mazano:

• Kugadzirisa raitongwa zvakafanana dose sezvo ari wokutanga aizomupa, uye pashure 3-6 mavhiki kushandiswazve. Pashure paizvozvo, kuti majekiseni ose mwedzi miviri. Kana waida kuti dose anogona ngazviwedzerwe 10 MG muzana makirogiramu.
• The mushonga chinotarisirwa chete panguva zvazvo mavhiki kana asina kupfuura 16 pashure kushandiswa kutanga.

Crohn nehosha mune vana vaduku

Crohn mwero kana yakanyanya vana pasi pemakore 18 kunosanganisira kushandisa kwokutanga dose 5 MG pa makirogiramu. Tevera majekiseni zvinofanira kuitwa mavhiki 3-6. Ipapo mishonga inoshandiswa ose mwedzi miviri kana waida, kugadziridzwa kuti chipimo chemushonga 10 MG por makirogiramu.

Kazhinji, mushonga unobatanidzwa pamwe immunomodulators 6-mercaptopurine, "azathioprine" kana "methotrexate". Kana mishonga mugumisiro haina kubudirira (kwevhiki 10-11), kushandisa zvinodhaka ndiko kunaka.

chirwere Crohn kunoperekedzwa ne fistula

A chete dose zvinodhaka panguva zvokuongorora kwakadaro 5 MG paminiti makirogiramu (nedzevakuru). Mishonga kushandiswazve pashure pemavhiki 3-6. Kana mishonga mugumisiro pashure 3 majekiseni haina kuchengetwa, ipapo mamwe marapirwo hakuna kunaka.

Tiine Mugumisiro wacho chinodhaka, zvinotevera mazano:

• reintroduction pashure pemavhiki 3-6 uye ose miviri;
• ari medicament chinotarisirwa panguva kuitazve kana zvakatora mavhiki asingasviki 16.

ankylosing spondylitis

Sezvakanga nechirwere zvinodhaka "Remicade"? Mirayiridzo zvokushandisa rinoti kuti chirwere ichi chokutanga chipimo chemushonga zvinodhaka kunofanira 5 MG pa makirogiramu. Shure kwaizvozvo, kuti mushonga chinotarisirwa pashure pemavhiki 3-6.

Treatment hakufaniri mberi kana, mukati memasvondo matanhatu kushanda hakusi kuchioneka.

psoriasis

Pakurapa psoriasis pokutangira dose 5 MG mushonga pa makirogiramu. Akadzokorora pokushandisa medicament raitongwa pashure pemavhiki 3-6, uye ipapo - kamwe ose kwemavhiki masere.

Process gadziriro aizomupa mhinduro

The Kugadzirisa anofanira kugadzirira sezvinotevera:

• It anoti ari dose uye uwandu ndiro.
• The mushonga upfu yakanga zvazvichanyungudutswa 10 ml mvura uchishandisa sirinji. Kuti aite izvi, kubvisa solvent chinu chivharo (mapurasitiki), uye uchapusika kuti chimiso nedoro. The tsono akaiswa kuburikidza payo, uye Urume runotungamirirwa rusvingo.
• The mhinduro yakanga nokungwarira yabvongodzwa (rotational kufamba) kusvikira madota yakanyauka. Drug mvura inofanira kunge Hauoneki kana tsvuku tint. Kana munguva nokusanganisa chinu furo wakaumba, zvakakodzera richadzipa chigadzikiso kwemaminitsi 5. Kwokupedzisira chipimo chemushonga siyana anogona kuvapo translucent yakanaka inoramba.
• The zvachose Vhoriyamu mishonga iri kugadziridzwa kuti 0,9% chloride (250 Rine mamiririta) kuti yavaibvisa mhinduro. Nokuda kwaizvozvi yakagadzirirwa chinowanika inowedzerwa bhodhoro, izvo kare rine yavaibvisa chloride. Both zvinoriumba yakasananiswa kwazvo.
• Nhanganyaya rekugadzirira rinoitwa kwete paya pane 3 maawa pashure gadziriro zvinodhaka mhinduro.

Zvinonzi rambidzwa kupinda mushonga nevamwe vamiririri kuburikidza chete hurongwa. Kana paine zvinhu vavatorwa kana opaque inoramba iri mhinduro, haina inokurudzirwa.

Tsva uwandu zvinodhaka kuti kushandiswa.

nemishonga

Kana tichishandisa medicament, zvinotevera divi siyana:

• kuora mwoyo, nokusakendenga, wakawedzera kufunganya, dzungu, somnolence, kutya, kukanganwa, psychosis, kutemwa;
• pulmonary edema, sinusitis, bronchoconstriction, dyspnea, neutachiona, mabayo, epistaxis, bronchitis, pleuritis;
• conjunctivitis, keratoconjunctivitis, endophthalmitis;
• kuzvimba uye Urinary turakiti zvirwere;
• Maze, kuvhiringidza peripheral kuparadzirwa, bradycardia, ecchymosis, hematoma, vascular kurwadza kwacho, syncope, palpitations, cyanosis, petechiae, arrhythmia;
• thrombocytopenia, kupererwa neropa, neytrotsitopeniya, leykotsitopeniya, lymphopenia, lymphadenopathy, lymphocytosis;
• cheilitis, kupatira, cholecystitis, reflux, diverticulitis, manyoka, kuda kurutsa, fufune, havachanyatsogoni chiropa chaitika;
• ganda mapundu, ganda yakaoma, alopecia, seborrhea, kuvaviwa, abrasions, mapundu, vangadikitira ikawanda, dermatitis, fungal, warts, hyperkeratosis, erysipelas, kutyorwa ruvara rweganda, bullous kuputika.

Reviews kugadzirira

Zvino munoziva kuti kushandisa zvinodhaka "Remicade". Mirayiridzo kushandiswa kwezvinodhaka akarondedzerwa apa.

Kazhinji, vaiona nzira kukurira basa. Saka, inofambiswa kubva varwere rinonyanya kuwanikwa zvakanaka. Vanhu vanoshandisa ichi mhinduro, vanotaura kuti mushure jekiseni kurwadziwa aenda anenge chose. Zvisinei, vamwe varwere vanotya nedoro, zvinogona kukonzera.