The mushonga "Mikosist": wongororo, analogues, mutengo. Drug "Mikosist": mirayiridzo kushandiswa

Drug "Mikosist" mirayiridzo Chinyorwa rinorondedzera sechinhu antifungal mumiririri. The kushingaira wemafuta mushonga fluconazole mabasa - a inhibitor zvokusarudza kuti sterol usage ari fungal masero. It anovanza iri cytochrome kwevanhu hurongwa P450 haadi kuratidza androgenic basa, zviri inoshanda panyaya utachiona kubva Mycosis.

Pharmacokinetics

Pashure nemukanwa kana intravenous medicament "Mikosist" (User rinoratidza ichi) zvakanaka mumuviri zvinwiwa uye munyama. In sputum, peritoneal mvura uye articular, nemate, mukaka zvinodhaka wevasungwa akafanana kubudirira mune plasma. Zviri fluconazole ari cerebrospinal mvura iri varwere fungal yomumuzongoza ndiko makumi masere muzana wevasungwa munguva yeplasma iyo, akavapindurawo, ndiyo Proportional kuti dose zvakananga. Kana kamwe-zuva chikumbiro kuna chechina rechishanu zuva 90 muzana kunoitwa zvakanyatsoenzana yevasungwa. Kana zuva rokutanga kutora dose zvinopfuura zvatinosiita kaviri, unogona kuva zuva rechipiri kusvika 90 muzana zvakanyatsoenzana kuwanda. Gumi nerimwe gumi muzana fluconazole sunga kuti mapuroteni eplasma. In peripheral ropa metabolites vasiri dzakaonekwa. Pharmacokinetics kunotsamira chaizvoizvo pamusoro netsvo, nokuti mushonga wacho yabudiswa kunyanya anoratidza navo, uye vanenge makumi masere muzana - kuchinja. Mumaawa matatu dialysis wevasungwa kuti basa fuma iri plasma ipfupi nehafu.

zvairatidza kuti

Zvinokurudzirwa kushandisa zvinodhaka "Mikosist" thrush, kusanganisira generalized, neakangwara, pasikarudzi, kana nezvimwe invasive Candida chirwere, candidemia, uye pamberi zvikonzero zvinoita kuti kwaita thrush. Also kuratidzwa ndiko kushandiswa kwezvinodhaka nokuda vanhu mucosal candidiasis: pharynx; zvokuudzwa candidiasis kusanganisira atrophic, kunobva kupfeka dentures; yegurokuro. Medicine "Mikosist" mirayiridzo Chinyorwa rinokurudzira raitongwa varwere kutambura kubva cryptococcal yomumuzongoza, kana sepsis, cryptococcosis, cryptococcal noutachiona ganda kana nemapapu. Akashandisawo kuti kudzivirira dzokororo ine abnormalities idzi varwere AIDS uye mune dzimwe nyaya immunodeficiency. Mishonga inoshandiswa kudzivisa zvirwere fungal mune vanhu vane nyanyisa namamota, kubatwa nemhaka nemwaranzi kana mishonga kukunda mashoko. Uyewo, kuti zvinodhaka "Mikosist" rinoshandiswa pakurapa fungal noutachiona groin uye mutumbi, zvakadzika endemic mycoses, kusanganisira paracoccidioidomycosis, coccidioidomycosis, histoplasmosis pavarwere kwomuzvarirwo zvirwere.

The chipimo chemushonga chimiro, kavha, akafanana

Two chipimo chemushonga siyana medicament ane "Mikosist": capsules uye mhinduro kuti aizomupa. Capsules dzinoitwa ine 50, 100 uye 150 milligrams ose fluconazole. Vose zvakaoma gelatin, ane chena muviri opaque, uye akasiyana chete ruvara lids: y capsules ane 50 milligrams ose vanoshingaira chirungiso, chiedza yebhuruu chivharo 100 milligrams - tekoizi, 150 milligrams - mutema. Content iri guru weupfu yakasimba kana chena (anenge chena) upfu. Chishongedzo zvinhu vanoita magnesium stearate, lactose anhydrous, colloidal nesilicon dioxide, talc, titanium dioxide, chibage starch, gelatin, indigo Carmine. Capsules ane 50 uye 100 MG pamusoro fluconazole, vari kutengeswa mune Mabhokisi pamwe chete, vaviri, Maronda akasiyana zvina, zvidimbu nomwe nerimwe. Uye avo kuti ane milligrams 150 vanoshingaira chinoita - mune imwe kana mbiri zvidimbu.

Aizomupa mhinduro ane chimiro segirazi, Hauoneki kana tumafuta mavara mvura. Mumwe aive milligrams por milliliter yezviri fuma maviri. The yechipiri zvinoriumba vari mvura jekiseni uye yavaibvisa chloride. Hwatinopiwa mhinduro iri girazi ndiro milliliters zana akaisa mumabhokisi makadhibhokisi. Mumwe rongedza ine chimwe chinu.

Sei kutora "Mikosist"? chipimo chemushonga

Zvatinosiita dose kuti fluconazole mu cryptococcal chirwere izuva kurapwa, 400 MG, zvinotevera mazuva okutanga - 200-400 milligrams. Ya yokurapa kunobva yasimbiswa mycological kudzidza ari kurapwa efficacy, kazhinji hapana anopfuura matanhatu - kwemavhiki masere. In cryptococcal yomumuzongoza kushandisa mushonga "Mikosist" mirayiridzo kushandiswa pachii gumi - gumi mavhiki pashure zvaiita kunaka kudzidza mimwe cerebrospinal mvura. Varwere AIDS pashure pokupedza kwokutanga kurapwa inoratidzwa kuti kudzivirira dzokororo ine cryptococcal yomumuzongoza kwenguva yakareba kugamuchirwa rinoreva "Mikosist" pane imwe dose kwete asingasviki mazana maviri milligrams pazuva.

In varwere neakangwara candidiasis, candidemia nezvimwe invasive Candida zvirwere, kazhinji pazuva achitora milligrams mana zvinodhaka wokutanga, uye mune inotevera shoma mazuva - milligrams mazana maviri zuva. Kana chakakomba systemic mbiriso dose anogona ngazviwedzerwe mazana masere milligrams pazuva. Treatment inofanira akaramba kwevhiki dzinenge mbiri pashure kuchaitwa zviratidzo uye kuwana kunaka ropa tsika. Kana oropharyngeal candidiasis, kusanganisira varwere havachanyatsogoni kutapata, zvinodhaka chipimo chemushonga pazuva iri mashanu - zana milligrams, kuushandisa kuti nguva nomwe - gumi mazuva. In atrophic candidosis kwaizokonzerwa kupfeka dentures kazhinji ushandiswe daily yaunodya makumi mashanu milligrams zvinodhaka akabatana akambozvishandisa kuuraya utachiona. Treatment mberi kwevhiki mbiri. Nokuti dzimwe Candida zvirwere (candiduria, esophagitis, ganda uye mucosal candidiasis) dose zuva nezuva mushonga mashanu - zana milligrams, kurapa iri gumi - matatu mazuva.

Kuti kubvisa kusangana nekutsi kwemukadzi candidiasis medicament "Mikosist" mirayiridzo Chinyorwa kuratidzirana vakazotanga singly mune imwe mari 150 milligrams. Zvinogona nokuda mana - gumi mwedzi kamwe pamwedzi kunwa mumwe Kamudzira (150 MG) yokuderedza kakawanda zvazvo. Kazhinji nachiremba candidiasis kuwedzera mushonga "Mikosist" makenduru Somuenzaniso, "Terzhinan", "Clione-D", "Ginezol". Zvichienderana mwero pangozi fungal hweHIV, nokuti kudzivirira candidiasis zuva Recommended dose zvinodhaka anogona dzinosiyana mashanu milligrams mazana mana.

Kana yakadzika endemic mycoses vangafanira kutora mushonga ari chipimo chemushonga vaviri mazana - mazana mana milligrams pazuva kwemakore maviri. Ya kurapwa kunobva munhu uye kurapwa mufananidzo: pamwe coccidioidomycosis, nayo ingabva gumi nerimwe makumi-mina, paracoccidioidomycosis - kubva maviri namanomwe mwedzi, histoplasmosis - kubva matatu namanomwe mwedzi.

chikumbiro mitemo

Intravenous kugadzirira donhwe anofanira kuzviita pamwero kwete kupfuura makumi maviri milliliters paminiti. Hapana chikonzero chokuchinja nezuva dose apo tama varwere kubva intravenous mishonga nemumuromo. A mhinduro aizomupa inowirirana dvadtsatiprotsentnym shuga mhinduro; zvingaitwa Hartman uye Ringer; mhinduro kubva yavaibvisa rehydrogen carbonate, potassium chloride ari shuga, yavaibvisa chloride (0,9%). Aizomupa anogona kuitwa kushandisa munhuwo fluconazole Kits vozoriwedzerwa, uchishandisa imwe anotevera mhinduro.

nemishonga

Vazhinji varwere akatora zvinodhaka "Mikosist 'wongororo nezvazvo inosiya zvakanaka. Drug chaizvoizvo zvinobudirira anobvisa fungal zvirwere asi anogona kukonzera nemigumisiro. Saka, kubva zvomudumbu kwava ngozi kuda kurutsa, flatulence, zvemamiriro chiropa basa, matambudziko pfungwa kuravira, manyoka. Uyewo, vamwe vanhu vanotaura kuti panowanikwa musoro, nezvipusha, dzungu. Vanoti kuti vakadaro mananara vavapo achangobva kutora zvinodhaka, "Mikosist". Reviews nevamwe varwere ane ruzivo pamusoro kukura husaberekana chisimbwa muchimiro erythema, mapundu, angioedema, urticaria. Zvimwewo zvingakonzerwa nemishonga zvinofanira kucherechedzwa alopecia, ventricular fibrillation, havachanyatsogoni itsvo basa, hypertriglyceridemia, hypercholesterolemia, uye hypokalemia.

Contraindications

Muchimiro capsules havafaniri kupiwa mishonga kuvana pasi mwedzi pazera mitanhatu (nokuti vachangoberekwa akabvumira kushandisa mushonga muchimiro mhinduro kuti aizomupa). Usashandisa zvinodhaka ichi "Mikosist" lactating vakadzi (vakadzi vane pamuviri vanofanira kupa izvozvo nokungwarira), uyewo vanhu vane mukuru aikanganiswa zvokubikisa vanobatanidzwa murwiyo. With chichiwedzera vanofanira kushandisa yambiro varwere renal / hepatic insufficiency, kusada acetylsalicylic acid.

ovhadhozi

"Mikosist" rakanyorwawo zviitiko zvinodhaka ovhadhozi. Reviews vanhu akatora mushonga zvakawanda mishonga, anoratidza kukura manyoka, kuda kurutsa, kurutsa. In Muzviitiko zvakaipisisa, pane chimiro nezvipusha, paranoid maitiro, aone zvinhu zvisipo. Munhu zviratidzo ovhadhozi zvinofanira kuendeswa kuchipatara, uko gastric lavage vachaitwa kwaari dialysis, kumanikidzwa diuresis, symptomatic kurapa.

"Mikosist" kana "Fluconazole": riri nani?

Saka mubvunzo uchibvunzwa nevarwere. Kutaura zvazviri, zvose zvinodhaka ndiwo chete, tinogona kutaura kuti vane zvakafanana. Musiyano chete ndechokuti chinodhaka "Mikosist" inoita muHungary mishonga kambani "Gidheoni Richter", apo "Fluconazole" - kugadzirira mumhuri kugadzirwa. Chokwadi, ichi ane zvakananga kukanganisa mari mishonga. Kusarudza chii kutenga - "Mikosist" kana "Fluconazole" - vakawanda vanosarudza kuti mushonga, inova isingadhuri. Zvechokwadi, mutsauko rinokosha mutengo. Saka, nokuti kavha kuti "Mikosista" (imwe Kamudzira ine milligrams 150 fluconazole) unofanira kubhadhara avhareji 295 rubles, ukuwo chete pasuru "Fluconazole" mutengo rubles 8-20 chete. Avhareji mutengo 100 ml dende mhinduro kuti aizomupa "Mikosist" ndiyo 311 rubles.

Pamusoro pharmacological ehupfumi zvinodhaka maviri, ivo dzinenge kufanana, musiyano anogona kuonekwa kunze kuti mwero Absorção de Água: maererano dziripo data, kufadza wevasungwa mumuviri "Fluconazole" runowanikwa pashure maawa 1-2 mushure kushanda, uye "Mikosista" - 0.5 maawa -1,5. Zvisinei, kwete varwere vose vanoteerera mishonga maviri zvakafanana. Vamwe havaoni mutsauko pakati pavo, apo yokupedzisira vanodavira kuti unhu kunobva mutengo, izvo zvinoreva kuti mushonga uri anodhura, nani. Kazhinji ungawana wongororo umo vakadzi vanoti pashure kutora "Fluconazole" thrush vakadzoka, asi "Mikosist" akabvumira kuchiparadza zvachose. Chero zvazvingava, sarudzo ndeyako.

analogs

Kuwedzera "Fluconazole", pane dzimwe mishonga inogona kutsiva zvinodhaka "Mikosist". Analogs medicament rine kutoshanda chirungiso imwe fuma, vari zvakanaka kumiririrwa. Muchimiro capsules kuti kurapa mbiriso uye nezvimwe zvirwere fungal, unogona kushandisa "Diflucan" zvinodhaka "Flucostat", "mikomaks" uye vamwe. Zvinobudirira nzira iri "Mikoflyukan" (Mahwendefa). "Mikosist" kubva zvose analogs izvi zvakasiyana maererano zviratidzo zvakadai bioavailability, hafu-upenyu, mwero Absorção de Água.

zvinodhaka kwavatori

Zvakakodzera nokungwarira kuongorora prothrombin nguva pavarwere kugamuchira fluconazole pamwe isina kunanga anticoagulants coumarin boka, nekuti pane mukana kuwedzera VWP. Kana concomitantly ne sulfonylureas zvinodhaka "Mikosist" awedzerwe hafu upenyu wavo, saka unofanira kufunga mukana yomuropa. Kana fluconazole uye phenytoin nokugoverana zvingaita akaora chinokosha mwero Zvakawanikwa wokupedzisira wevasungwa, saka, kana zvakakodzera kukabatanidzwa kugamuchira dose anofanira kuderedzwa. Pamwechete kubvuma kunoreva "Mikosist" uye rifampicin zvichabviswa akacherekedza kuderera wevasungwa pamusoro fluconazole saka dose "Mikosista" kunodiwa kuwedzera. Kushandiswa kwose ane azole rinobva ane medicament akabatana terenadinom contraindicated, sezvo anogona kuva zvakakomba, arrhythmia zvinouraya. Kana iwe tora mushonga "Mikosist" pamwe cisapride, anogona kuratidza zvisingadiwi chinja pamusoro chikamu mwoyo, kusanganisira ventricular tachycardia. Tiine mawa kushandiswa fluconazole uye theophylline akaderedza avhareji Clearance mwero kubva muplasma wokupedzisira ropa, uye saka kunowedzera mukana wokuti kukura kwayo chepfu migumisiro uye ovhadhozi.

Zvokungwarira

Kuramba kurapwa ne "Mikosist" kusvikira kurapwa uye hematological kanganwiro. Vakurumidze discontinuation yokurapa hwakazara zvazvo. Sezvambotaurwa, varwere renal insufficiency vanofanira kushandisa mushonga pamwe kunonyanyisa ngwarira, nokuti yabudiswa kunyanya nokuda itsvo. Chipimo chemushonga munguva kurapwa kwenguva refu kunofanira kuitwa, kufungisisa CC. Apo neapo fluconazole kunosanganisira chepfu migumisiro pamusoro pechiropa, saka zvinokosha kuti kuongorora kushanda muviri ichi. Pamusoro kuonekwa kuti maronda Zviratidzo ngaanyarare kurapwa.

Varwere pamusoro pakanyorwa "Mikosist" kunoreva anga zvisingawanzoitiki sightings exfoliative cutaneous siyana, akadai chepfu epidermal necrolysis uye Stevens-Johnson syndrome. Varwere nyanyisa neoplasms uye AIDS vari tichikurumidza kuti chidzoke chakakomba ganda siyana paaishandisa gadziriro ane fluconazole. Kana panguva pakurapa zvachero fungal chirwere ari mapundu rinowanika, mushonga unoda kudzima. Kana mukawana mapundu mune vanhu vane invasive kana systemic fungal chirwere chiremba vanofanira kusimbisa cherechedzo uye bvisa mushonga ari chiitiko kuti pachava erythema multiforme, kana bullous maronda. Panguva kurapwa, mishonga "Mikosist" (wongororo ngaadarowo) zvingakonzera dzungu, saka varwere vanofanira kungwarira kunyanya kana tichishanda magadzirirwo uye kutarisirwa motokari.