The mushonga "El-Thyroxine": mirayiridzo kushandiswa, analogs, wongororo

Drug "Al-thyroxine" - chakaita zvokugadzirwa thyroid kemikari, thyroxine analogue zvakasikwa. Pamusoro pokugamuchira medicament chinhu haasaruri kutendeutsa thyroxine kuti triiodothyronine, iodo kemikari kuti zvinobatanidzwa zvose metabolic pezvakaitwa uye ane wandei simba pamusoro mabasa mazhinji nhengo. The mushonga inoshandiswa zviitiko apo yekudyidzana kuderedzwa thyroid chaitika.

Pokushandisa medicament kunoratidzwa pashure nokubviswa thyroid shwanu uye ayo zvinyama Kutumbuka kana shwanu basa haina kuremara. Dzimwe nguva kunwa mushonga kune vanhu vanenge kwakakwidziridzwa thyroid basa, asi kutanga kuita kurapa kudzvinyirira secretion kuti ayodhini tubhokisi mahormone. Varwere zvakadaro, pashure pokushandisa "El-Thyroxine" woutsinye TTG chizvarwa muitiro iyo rinobatanidzwa kwetunhu thyroxine.

Form kusunungurwa zvinodhaka pakugadzira

"El-Thyroxine" inowanika pamahwendefa. The rinoita fuma iri levothyroxine yavaibvisa. The Kuronga zvinodhaka anogona kuuya yakasiyana nenhamba zvinokosha zvinoriumba, akakodzera mushonga waakaudzwa nachiremba. Ebetsero zvinhu akauya yavaibvisa starch glycolate, karusiyamu rehydrogen phosphate dihydrate,-refu neketani zvishomanana glycerides, dextrin uye microcrystalline cellulose. Siyana vagadziri maumbirwo ebetsero zvinhu hungasiyana zvishoma.

Pharmacodynamics, pharmacokinetics, "El-Thyroxine"

The kushingaira wemafuta zvinodhaka uye thyroxine, izvo goho kunoitika mumuviri, achiita basa rakafanana. "El-Thyroxine" rinoita kuti normalization pamusoro metabolic urongwa, kwemasayendisiti okukura uye kukura. Zvakaitwa zvinodhaka riri pakutsvaga kugutsikana yezviri fuma. Kushandiswa duku mishonga "El Thyroxine" inotungamirira kukura ane anabolic maturo, yakakwirira - anofanira kuwedzera sero uye zvinyama okisijeni kudiwa, ari kweiyi oxidative pezvakaitwa, kuwedzera muviri uye kuparara makabhohaidhiretsi, mapurotini, mafuta. Mukuwedzera, panguva yakakwirira mishonga mushonga zvaanopa simba musimboti tsinga, kumwoyo.

The medicament anotanga kuita mushure anenge mashanu mazuva shure kwerekutanga kushanda. Nokuti vatatu mitanhatu dzamarudzi kurapwa zvinogoneka ndeyokubvisa ari diffuse goiter kana kuderedza saizi yayo.

Absorção de Água anotora nzvimbo kunyanya duku ura somugumisiro nokugamuchira vakatsanya hwendefa haasi kupfuura 80%, nokushandiswa chikafu ipfupi. Well chokuita kuti mapuroteni eplasma, "El-Thyroxine", mashoko anoratidza kuti kubatana zviri anenge 100%, saka mushonga asingadi kukanganisa kana hemodialysis kana hemoperfusion.

The kunonyanyisa wevasungwa huru zvinoriumba ndee mumuviri pashure maawa mashanu pashure ingestion zvinodhaka. Rushoma nokubviswa mushonga pavarwere kunoitika nenzira dzakasiyana, zvichienderana padanho thyroid mahormone pamuviri.

In hypothyroidism Kubviswa racho kuitwa mipfumbamwe kana gumi mazuva, pamwe euthyroid - matanhatu kana manomwe, thyrotoxicosis hafu-upenyu runoyerera nokukurumidza - mumazuva matatu kana mana.

Ingangoita-muzvitatu dose mishonga chikuru chinoita iiswe chiropa, apo tikacherechedza nokukurumidza kusakarongeka pamwe thyroxine chiri chipo muropa. It anowanikwa paumbwe metabolites pashure ingestion mahwendefa "El Thyroxine". Mirayiridzo yokushandisa nezvembiri kuti zvikuru muviri zvinodhaka mugove rinoitwa muuropi, tsandanyama, itsvo uye chiropa. Excretion pamusoro metabolites zvinoberekwa neitsvo ura.

Zvairatidza yokushandisa rekugadzirira "El Thyroxine"

Kuzvitsinhanisa kurapwa kunobva pakushandisa zvinodhaka ichi ushandiswe varwere vane hypothyroid in etiologies siyana, t. H. Hypothyroid (chikuru, yechipiri) yokuvamba pashure kuvhiyiwa uye ezvinhu kushatiriswa kugamuchira nzira iyo akaumbwa radioiodine . "El-Thyroxine" mirayiridzo iri kushanda kunoita kuti basa iri zvinotevera nyaya:

• cerebro-hypophyseal zvirwere;
• Hypothyroidism vachiberekwa uye vawana;
• euthyroid goitre;
• chirwere Hashimoto vake, Graves 'chirwere (kurapwa vari kunzwisisa);
• vane zviratidzo kufutisa kana hypothyroidism cretinism, achiperekedzwa chete zvinhu;
• euthyroid hyperplasia isiri yekenza (Kubatana kurapa);
• idzokororo nodular goiter pashure resection pasina shwanu zvirwere (mahwendefa aishandiswa senzira prophylactic medicament);
• bundu malignancy (kuzvitsinhanisa uye suppressive kurapa);
• neoplasms, izvo dzinoratidzwa sezvo kusiyaniswa zvikuru, kemikari, vane akaipa hunhu.

Mishonga inoshandiswa kuita chirwere miedzo. Dzimwe nguva vanhu tora "El Thyroxine" slimming kusavapo nezvinetso thyroid shwanu, asi vanachiremba hazvitenderi kushandisa medicament chakadaro chinangwa.

Contraindications kugamuchira mushonga, "El-Thyroxine"

The medicament haisi raitongwa varwere vane aikanganiswa yenhengo dzayo. Contraindications dzinosanganisira:

• myocardial infarction (rikwanise Danho);
• achimhanya gipokortitsizm yakapfuura untreated kana thyrotoxicosis;
• kuzvimba pomwoyo rikwanise hunhu;
• nhaka galactosemia;
• urwere, izvo kuzvirega zvichikanganisa Absorção de Água ari ura;
• lactase kukanganisika.

The mushonga rinoshandiswa kungwarira varwere cheshuga mellitus, kana zvakaoma inoyerera hypothyroidism, inova nguva refu asina kubatwa, uye zvirwere chokuita zvemwoyo maronda:

• sredtsa nechirwere chemwoyo;
• neBP;
• arrhythmia;
• myocardial infarction (nhoroondo);
• atherosclerosis.

Kana murwere ane zvimwe zvirwere izvi, kuti dose ipfupi kana yasarudzwa analogue.

kurapa

Panguva kurapwa, senzira "El-Thyroxine" mishonga vanosarudzwa mumwe nomumwe murwere mumwe pauchapupu. Mahwendefa regai kutsenga, zvokunwa usina chawadya, kwemaminitsi 30. vasati vachidya. Varwere zvirwere kumwoyo uye zvasvika kwemakore makumi mashanu nemashanu ari 1 kg kurema riri basa vaifanira kubva 0,9 MG zvinodhaka. The zororo kuratidzwa kubva 1,6 .mu.g kusvika 1,8. Panguva kutanga kwekupwanyiwa kurapwa, zvavakabvumirana dose zvinodhaka kuti varwere hypothyroidism ndeinotevera:

• Varwere vane matambudziko kumwoyo, kuti ushandiswe zvinodhaka kubva 75 mcg kusvika 150, izvo unoenderana dose nezuva.
• In zvemwoyo maronda, uyewo varwere vakwegura raitongwa chinodhaka mune mari 25 g. Pashure pemwedzi miviri dose yakawedzera kusvika 50 mcg. Gare gare, parameter kuchinja pamwe chete chinguva, vachiwedzera kuti 25 g, kusvikira akatsunga optimum chitsama Pfungwa uye kwete zvakajairika TSH.

How kuti "El-Thyroxine" dzakasiyana nguva zvinokosha kuziva chiremba. Kana ezvinhu midziyo uye mwoyo kunowedzera, zvinokosha kuti adzokorore nzira nokuda pakurapa zvirwere kumwoyo.

Kana hypothyroidism vachiberekwa yezvakaita dose zvinodhaka anosarudzwa maererano nezera. The duku varwere (kusvika 6 months) raitongwa 25 micrograms zvinodhaka, asi hapana anopfuura 50, runodiwa nezuva chipimo chemushonga kubva 10 kusvika 15 micrograms muzana kilogram. Vana vari pasi pemakore hapana anopfuura 1 gore, kugadza 50 MG por makirogiramu. Kana makore murwere iri kuwanda mumwe makore mashanu, shoma dose pa75 mcg, asi hapana anopfuura 100 micrograms. Pashure pemakore matanhatu zera (vana pasi 12) anobvumirwa kushandisa 100 mcg mari isingadariki ari dose kuti 150 mcg. Other vana vaida dose anosarudzwa mu kuwanda 100 kusvika 200 micrograms.

Panguva mushonga, mishonga, "El-Thyroxine", sezvinotaurwa murayiro kushandiswa vana pasi makore matatu dose nezuva zvinoreva kupa kamwe. Pashure zvinodhaka Kutarisirwa dzichifura anogona kuitwa hafu yeawa. In pakurapa vana vaduku akashandisa mhinduro kugadzirirwa kubva pamahwendefa.

Kazhinji, vanhu vanotambura hypothyroidism, mushonga upenyu. Avo kwakaratidza thyrotoxicosis, pashure pokumuka euthyroid mamiriro "Thyroxine" zano kushandiswa pachiimbwa antitireoidinymi kunoreva kwenguva pakutsvaga chiremba.

Kushandiswa zvinodhaka uremu

Kubvisa yokufutisa kushandisa micrograms 50 pazuva zvinoreva. The daily Kushandisa dose matanho maviri kuti kunofanira kuitwa mangwanani. Pamwe chete rinoreva "El Thyroxine" kutora β-blocker ari chipimo chemushonga yasarudzwa inobva kurova kwemwoyo maitikiro. Zvimwe dose panova akabvumira "Thyroxine" 150 micrograms. Kuwedzera dose zvishoma nezvishoma, mushure zvibereko nokugamuchirwa zvinoreva rakakamurwa katatu. Panyaya iyi, ekupedzisira nzira yaifanira hapana paya pane 18:00. Uyewo, kuwedzera dose β-blocker, inodiwa chitsama zvinodhaka anosarudzwa nomumwe, ndakazorora kwemwoyo vanofanira kuva kuwanda anorova kubva 60 kusvika 70 paminiti.

Dzimwe nguva unofanira kutapudza dose rinoreva "Al-thyroxine". Side migumisiro anoratidza kudikanwa kukanzura kana kuderedza zvinodhaka dose. The kosi inofanira kugara pamusoro mwedzi, usazvisarudzira mishonga kupfuura vhiki nomwe.

Regai payakakurudzirwa kusiya kushandiswa kwezvinodhaka, ayo abolition yakabereka zvishoma nezvishoma, zvishoma nezvishoma achidzikisa dose kuti-vhiki mbiri zvikamu. Kana manyoka humwe zvinobata mumiririri "Loperamide" mune capsules imwe kana maviri pazuva. Kudzokorora kosi zvainanga nokuderedza uremu, unogona kuva nhatu kana ina Kwapera vhiki.

Possible nemishonga

Zvimwe nenjodzi kunogona kuitika panguva kurapwa ne "Al-thyroxine". Marwadzo kana tichishandisa zvinodhaka panguva Recommended mishonga hadziwanzowaniki chaizvo. Nokuda yakawedzera havi kungawedzera uremu, bvudzi anogona kuwira panze, zvinokwanisika kuti chidzoke matambudziko pamwechete netsvo. Vana vane nepfari uye mikana yakawanda nezvipusha, chirwere inogona zvikuru kana iwe kusapfuudza yakatarwa dose "Thyroxine". In marapirwo vaine mishonga zvingangodaro kuti pokumuka zviratidzo hyperthyroidism.

Pakati mhiri kukanganiswa - kufunganya, kufunganya zvirwere, chimiro muzvidimbu tremor, hope matambudziko, zviratidzo arrhythmia uye tachycardia. Uyewo, pangava uremu uye kukura manyoka, kuvapo kurutsa. Zvichida vangadikitira, kuvapo zviratidzo pematanho kurwisa kuti angina pectoris. Vamwe varwere vane sema dermatitis. With kukura nenjodzi muviri ezasi dose "Thyroxine" kana vanomboenda kubvisa zvinodhaka uye gare gare kushandisa dose duku.

Tikafunga zvinodhaka nedoro

Kazhinji, munhu chete dose pakati shoma doro kamari nhare haana simba pamusoro nokuitika pomutumwa "Al-thyroxine". Reviews anoratidza kuti kunwa doro munguva kurapwa dai vanhu chete vasina matambudziko nemidziyo ropa uye mwoyo. Mune zvimwe zviitiko, wemishonga zvinodhaka doro kunoita kuti varwadziwe. Zvichida kwete chete kuderera kubudirira yokurapa, asi kutyora chiropa, musimboti tsinga.

Drug analogues "El-Thyroxine"

Of STRUCTURAL analogs pane "Al-thyroxine" anogona kushandiswa "Eutiroks", "Bagotiroks". The kazhinji vakasarudzwa zvinodhaka "Eutiroks" iro rine zvakafanana zvairatidza, contraindications uye uwandu husingakuvadzi. From "El-Thyroxine" zvakasiyana chete nokuda wevasungwa yezviri fuma. Kana murwere haasi rakakodzera, "El-Thyroxine" analogues vakagadzwa nyanzvi kufungisisa peculiarities yacho muviri.

Reviews kugadzirira "El-Thyroxine"

In review, izvozvo akashuma kuti mushonga kana kushandiswa pasi mishonga kunoita mafuta echipiriso nokuda kumhanyisa kuti muviri, kudzvinyirira kuti kudya uye awedzere caloric zvekushandisa. Kuderedza nechitarisiko nemishonga kana kudzivirira zvavo budiriro rubatsiro β-blockers. Reviews inoratidza kuti vakawanda nokubatanidza mishonga pamwe nzira dzakadaro. Pasinei chokwadi chokuti "Thyroxine" kazhinji kunobatsira kuderedza uremu, kurishandisa uremu haisi inokurudzirwa. Nokuti vanhu utano, mishonga inogona kuva nengozi.

In kurapwa kwezvirwere chokuita havachanyatsogoni thyroid basa, mushonga kazhinji unoshanda, sezvinoratidzwa ongororo. Rinorondedzera zvishandiso kunotungamirira dzose pakuenzanisa mahormone, saka varwere anzwe zviri nani. Pane kunaka wongororo nekuti dzimwe nguva kuva marwadzo. Kunyange zvazvo mushonga uye anokwanisa kukonzera vakawanda nenjodzi, izvozvo inotsigira thyroid, mauri muviri uri kushanda zvakanaka.

Uchishandisa "El-Thyroxine" pamusoro nguva inogona kubviswa chirwere thyroid chirwere kana kuderedza kukuvadza zviratidzo kumarudzi hwavo.