Prednisolone: mirayiridzo kushandiswa, ari pharmacological ehupfumi

Release chimiro "Prednisolone" zvinodhaka: nyoro somushonga siyana - mafuta.

Farmsvoystva

Prednisolone chinhu dehydrogenated analogue kuti hydrocortisone. Antiallergic, antiinflammatory, antiexudative uye antipruritic mugumisiro kana kushandiswa topically mafuta "prednisolone" mirayiridzo kunokonzera vasanyanye nokuumbwa, kusunungurwa uye basa kuti kuzvimba nevamiririri (kinin, mumwe histamine, lysosomal makemikari, prostaglandins). Uyewo chinovatadzisa Sero kutama kuti anogumbura kwacho zvinoderedza vasodilation ikawanda vascular permeability kuti unowanikwa kuzvimba. Achidzikisa exudation iri nokuda vasoconstrictor zviito "Prednisolone" chinodhaka. Manual kunoratidza kuti mushonga chinhu immunosuppressive chaizvoizvo kupfurikidza zvichivhiringidza Zvakaitwa antigen-antibody kunzwisisa uye kuunganidza pamasvingo midziyo ropa uye ndiwo anokonzera sema vasculitis. The mushonga kuchititadzisa kuitwa macrophages, cytokines, chipfuro masero kuti anokonzera kukura sema kuita mhando chinotapukira dermatitis. Zvanzi sensitized T-lymphocytes uye macrophages haagoni kuwana kuwana chipfuro masero.

Pharmacokinetics

Kana kushandisa mafuta "Prednisolone" woga uye zvinoshingaira fuma iri muropa. In plasma prednisolone zvokutora chikamu wakabatana sealbumin uye transcortin. Biotransformation prednisolone kunoitika kuburikidza oxidation, kunyanya chitaka, apo glucuronidation kana sulfation kunoitika oxidized siyana. Muchimiro metabolites yabudiswa muna weti uye mutsvina yadzo, chikamu - iri unmodified ezvinhu. Prednisolone inopfuura nomunyika placental chipingamupinyi zviri kuwanda duku, unogona kuwanika mukaka nevakadzi.

Prednisolone: uchapupu

The mushonga rinoshandiswa vanenge:

- sema uye irritant kuonana dermatitis,

- eczema,

- atopic dermatitis,

- seborrheic dermatitis,

- psoriasis.

Prednisolone: kurayira

Chizoro rinoshandisirwa ronda nzvimbo zvakaenzana 1-3 nguva / zuva. Duration kurapwa anokonzerwa hunhu chirwere uye kazhinji kunotora mazuva 8-14. Mafuta ari kurapwa vana nguva kurapwa kunofanira kuderedzwa mazuva 3-7, sezvo muviri wemwana ari unetseke mushonga "Prednisolone". Instruction anokurudzira kusiya nokudziya, kutara uye occlusive dressings.

Zvakakurukurwa kushanda

Ya kurapwa namafuta hakufaniri mazuva anopfuura 14 kuti kudzivisa zvingakonzerwa nemishonga kubva pakushandisa "Prednisolone" chinodhaka. Instruction prescribes kubata chete pasi zvokurapa achitarisirwa.

nemishonga

Kazhinji mushonga zvakanaka kuregerera. Kashoma, kunyanya pashure kushandiswa nguva refu, zvingakonzera kuvaviwa, akapisa manyawi, erythema. Mune dzimwe varwere parutivi migumisiro vangapikisa sezvo folliculitis, hypertrichosis, perioral dermatitis, neutachiona mishonga zvinoriumba. The pamusoro Zviratidzo regai zvinoda kurapwa uye nokukurumidza akabvisa panguva kugumiswa pokushandisa zvinodhaka. Zvinofanira kurangarirwa kuti kushandiswa okuzora kune njodzi ganda uye kushandiswa kwenguva refu (kunyanya pokukundwa nzvimbo huru ganda) kuonekwe divi migumisiro systemic hunhu.

Aiita zvimwe zvinodhaka

Prednisolone ane pfuma kusimudzira anticoagulant mugumisiro anticoagulants. It anowedzera mukana ropa vachitsigira salicylates. It anowedzera mukana wokuti electrolyte muviri zvirwere pamwe concomitant kwokubatsira diuretics. Pane kuwedzera ngozi toxicity paaishandisa cardiac glycosides. Ungaderedza hypoglycemic antidiabetic kushanda uye zvinoderedza ari antibacterial basa rifampicin. Not akakurudzira kushandiswa pachiimbwa antacids.

Contraindications

Treatment "Prednisolone" mafuta kurairirwa hakubvumidzwi mu:

- hypersensitivity;

- kwemabhakitiriya, nemavhairasi, fungal ganda maronda;

- tibhii, njovhera, ganda namamota, pamuviri, zvakajairika mburwa uye roruvara rwakatsvukuruka mburwa.

ovhadhozi

Zviitiko ovhadhozi vasingazivikanwi.

chengetedzo mamiriro

Akaramba pachikwata B, pa 5-15ºS. Pasherufu upenyu - 2 years. Panguva yapfuura kuti pasherefu upenyu kwete kushandisa.

mamiriro ezvinhu zvitengeswa

Hupenyu.