Levonorgestrel: chii kemikari ichi, uye nokuda yaakanga ane basa pamuviri?

Vanhu vazhinji vanoshamisika: levonorgestrel - chii kemikari ichi? Ichi chinhu chakaita zvokugadzirwa progestagen kuti vatendeuki endometrium waanodzikisira ovulation zvichivhiringidza muchangosangana oocyte agadzirwa. Uyezve, unogona mucosal receptors ungaderedza utetsa inotengwa. Munyaya ino tichakurukura gadziriro ine hormone inonzi.

pharmacology

The mushonga "Levonorgestrel" - ndiko estrogen, iyo kunotadzisa kuti activation kuti dzisingaoneki yakafanira kuwedzera madzihwa viscosity ehupfumi. The mushonga anoita munharaunda mukati dumbu iri fallopian chubhu, ari endometrium, kuti kusachinja-chinja kubva madzihwa, zvichiguma follicle-anotokonya kemikari kunoderedza kwayakaita.

Ingestion inonzi mushonga vachishingaira kunakidzwa nemudumbu, Bioindication kusvika 100%. Muropa, hurongwa yaro pfungwa panguva kunonyanyisa kugamuchira razovo 75 Rine mamiririta pashure 60 - 130 maminitsi. Viewed kemikari interacts pamwe yeplasma uye globulin, anosunga iri vanenge 50%.

Muviri rinonyatsotarira chiropa, pusa chimiro pharmacologically metaboliks. The chikuru isoenzyme kuti kemikari uyu CYP3A4. The hafu-upenyu nguva agare maawa 30.

ehupfumi

Achipindura mubvunzo "Levonorgestrel - chii kemikari ichi?" zvinofanira kutungamirirwa kuraira chete zita zvinodhaka uye kunenge ari kupinda chiremba. Zviratidzi kazhinji musiyano kukosha sezvakarayirwa 1.0 Rine mamiririta / min. / Makirogiramu (plasma). Kemikari panobviswa ainyanya kuburikidza ureter, chikamu chiduku rinobviswa pachituru.

In pakurapa systemic hunhu akawira nokukurumidza zviratidzi ari dumbu haasi anopfuura 20 MG nezuva, uye pashure pemakore mashanu mumusungo 11. The paavhareji goho mwero kemikari zvinosiyana kumativi 14 ug / 24 hr. Over 50-60 mwedzi.

Intrauterine kurapa akabvumira vakadzi vane yokutsiva kemikari kurapwa pachiimbwa estrogen, progestin haisi kusanganisira nziyo. Levonorgestrel - hormone anodyara mu yeplasma maminitsi 60 pashure kutarisira. Kunonyanyisa wevasungwa mairi yakanyorwa mushure memazuva 14 chikumbiro.

umboo

Kushandiswa kwezvinodhaka izvi zvinogoneka intrauterine kurapa, uyewo inotevera nyaya:

• Idiopathic menorrhagia dzidziso.
• Long-rokuti pamuviri kudzivirirwa.
• Matanho kuti kuzvitsinhanisa rutapudzo pamwe inonzi estrogen.
• Emergency kudzivirira nhumbu.

The kemikari levonorgestrel, migumisiro ine upamhi zvezvinotaurwa, zvinotevera zvinofanira kushandisa chete pashure kurumbidza kwacho kunoita chiremba.

Use uye chipimo chemushonga

Vaitirei mushonga kusashanda ne intrauterine jekiseni - jekiseni kupinda uterine mhango. Kushandiswa 4 Mazuva pashure kurara mu uwandu 0.75 kusvika 1.5 MG. Emergency nhumbu nyanzvi zano zvakasimba kuti murege kuita zvinopfuura kamwe mwedzi mitanhatu ose.

Kubvisa kuenda kumwedzi, zvakakodzera zvinoenderana zvavakabvumirana chipimo chemushonga pasina kuzodzosera kushandisa. Usashandisa kushuma zvinodhaka nomuromo sezvo nzira nhumbu zvachose, sezvo izvi chinokurwadzai chitarisiko nemishonga uye anoderedza kubudirira chezvinodhaka. Kana uterine ropa inotungamirwa pashure nhumbu nechimbichimbi zvikuru varumbidzwa nzira kuongororwa pedyo gayinakorojisiti, uye zvaipesana kubereka vhiki kupfuura mumwe zvakafanira kunonotsa pamuviri.

Chete pashure kubvunzana uye akaudza sarudzo gayinakorojisiti mu vanhuwo kacho rinobvumira nezvokupindira zvinodhaka pamuviri vari vaduku panguva yokukurumidzira.

Rakashandiswa kemikari levonorgestrel?

muviri anoshandisa sei kemikari zvinorondedzerwa, uye chii kuita kudzivisa kurutivi migumisiro? Saka mubvunzo wakamutswa nevakawanda. Kunyatsotevedza nyanzvi zano, vanoremekedza chipimo chemushonga uye kutevedzera mirayiridzo - nayo anosimbisira kushandiswa njodzi pamusoro zvinodhaka.

Usati kushandiswa, unofanira kupfuura Kuedzwa of Navy gayinakorojisiti, kusanganisira cheki mammary omumuviri, pelvic zvomukati, zvichiita remuromo zodzera.

Re-Kuongorora rinoitwa mushure memazuva 30-40 mushure kugadzwa kuva zononoka, ipapo pagore, uye pose pane presuppositions - kazhinji. Ichi kurapa intrauterine unoshanda kuti 4 kusvika 5 years. kugadzwa Its vanofanira kubata bedzi pamwe chiremba kushandisa munda uyu kana vane ruzivo pamwe vaiona worudzii chezvinodhaka.

nengozi

Women kushandisa zvinodhaka pamwe progestogen, zvinokwanisika zvibereko venous thrombosis munguva yakaoma. Kana zviratidzo zvakadaro yaida kutora zvokukurumidzira matanho kuti chirwere uye kurapwa.

Mushure kushaya of Navy rokubereka vana resuscitated pashure pemwedzi mitanhatu hafu yevakadzi wokushandisa pashure pemwedzi 12 - zvinopfuura 96 muzana. Nhumbu wezwi iri shoma zvakabatsirawo varwere kufutisa.

Contraindications

Achishamisika "Levonorgestrel - chii kemikari ichi?" vanofanira kufunga contraindications zvose. Pakati pavo:

• Beyond (hyper) nehanya, tromboflebitnye inotungamirwa.
• Thromboembolism, kuchinja arteries.
• Cerebrovascular chirwere dzidziso, pamuviri.
• Achitaura ingestion: jaundice (kusanganisira nhoroondo), pathological yematambudziko bile goho kana chiropa, lactation.
• Sexual pakunamata.
• Uyezve, nokuti loop - raiva pedyo nebundu urogenital chirwere recurrences kana kushingaira kuzvimba ari chiuno, kunyanyisa postpartum endometritis, rikwanise chiropa chirwere.
• Septic abortifacient Kupindira mu chokupedzisira trimester, dysplastic tinoshandurwa uterine cervix zvokurwara rakafanana ropa pamusoro vasingazivikanwi mavambo, malignancies.
• Uyai kana vachiberekwa anomalies vachikanganisa fibroids.
• Progestagenoz (bundu, kusanganisira kenza yemazamu maronda).

kurambidzwa

The vakaomerwa ndechokuti kazhinji akakodzera kuti kuchirapa apindire mukati dumbu, nzvimbo kuti kana uine zvinotevera zviratidzo kana chisingaperi zvirwere:

• chakakomba nomusoro, nevakawanda uye zvomunharaunda migraine pamwe madzerere, zvimwe zviratidzo, nezvezvaiitwawo mukana coronary tsinga chirwere;
• yakajeka chirwere cheBP mirayiridzo, jaundice, kunzwisisa inoparadza pezvakaitwa munyika kweropa ezvinhu, kusanganisira mwoyo kurwiswa uye Kurohwa;
• chirwere cheshuga mellitus.

Unofanira pakarepo kubvunza pamusoro kubviswa pakati Navy panguva paumbwe kana kuvapo chero inoti izvi.

Pamuviri uye lactation nguva

Pasinei yokuti levonorgestrel - hadzi kemikari, kushandiswa kwayo nezvisingabvumwi panguva yepamuviri. Kana akauya, nayo yakarumbidza kubviswa ezvinhu nokuti kuti intrauterine nhumbu chero kunowedzera mukana vakurumidze kuzvarwa uye kupfupfudzika. Kuitisa mai vachifunga hurongwa kana rai kurega dzimwe nguva kuguma nokupfupfudzika kuitika randomly. Zvinoda zano nyanzvi pamusoro feasibility kubata kugumiswa pamuviri pakuparwa chisingabviri akarurama pamuviri dzokubudisa.

Kana hazvibviri kubvisa intrauterine maitiro uye kukurumidza kuda kuzoponesa pamuviri murwere vanofanira kungwarira pezvingazoitika uye njodzi nokuda mwana nokuda rokusamhanyira pakuberekwa. Muzviitiko zvakadaro, unofanira kuva nechokwadi kuti kunyatsotevera kuongorora pamuviri. Pamberi murwere vanofanira kuuya ruzivo kuti zvinofanira pakarepo kuudza pamusoro zvose zviratidzo, izvo zvichakubatsira kuti vafunge muitiro kuomesa.

lactation

Kana kuyamwisa uye kushandisa "Levonorgestrel" anenge munhu chegumi mushonga anopinda muviri mwana. Pamukaka mukati kupiwa nhumbu inofanira vakarega panguva mazuva 1.5.

panguva rakarumbidza chipimo chemushonga kuti kuchirapa ezvinhu kuiswa mune utero, kufanana pamuviri nzira ipi progestogen-chete, maitire kuti kushandiswa kwemwedzi nehafu pashure pokuberekwa hakuna nemigumisiro pamusoro kukura mwana, saka, kuti mushonga hakusi kazhinji kukuisa panjodzi kuti mudumbu .

ipa zviratidzo

Uye vodzokera mubvunzo "Levonorgestrel" - chii, "ngatitarisei zvingakonzerwa nemishonga uye contraindications zvinodhaka Vanogona kuitika nenzira dzakasiyana mugadziriro mumuviri uye anotevera zviratidzo :.

1. Kubva tsinga: kurukutika, kuora mwoyo, nomusoro, chinja kwemanzwiro.
2. Git. Kurutsa, fufune, chinyamunhari chinorwadza, bloating.
3. Genito-Urinary nhengo. Ropa, kuparadzana, marwadzo, candidiasis, kuti ndingangokuvara inotungamirwa nyanyisa uye benign anomera.
4. Skin rashes, kuratidzwa eczema, kuvaviwa, mapundu, mburwa.
5. Other: kuzvimba, kurwadza kwemajoini, kumanikidzwa RINOFAMBIRA, sepsis.

Mune zvisingawanzoitiki Muzviitiko pfari kubva nepfari, chinyamunhari chinorwadza uye kufenda.

Pamwe nemamwe zvinodhaka

Kudzidza "Levonorgestrel" (worudzii kemikari), zvinokosha kutaura mukana akabatana nevamwe zvinodhaka uye zvinodhaka Organic. Kana iri pfuma iri mubvunzo pamwe inducers pamusoro cytochrome P450 isoenzymes vanogona kuderera kunyatsoshanda nekuda kuwedzera metabolic zvayo pezvakaitwa.

Zvinotevera zvinodhaka anogona kuderedza migumisiro "Levonorgestrel":

• Group barbiturates, "Tretinoin", "carbamazepine" nziyo ane sana St. John yacho komponatsiyu.
• Kunoderedza kubudirira anticoagulants, hypoglycemic, anticonvulsant zvinodhaka.
• "Levonorgestrel" anowedzera inogona glucocorticoids muropa, uye zvakare anokwanisa kuvhiringidza muviri.
• Nokuda kuti kudzvinyirira dzepabonde steroids recirculation, nokuda nokubatanidzwazve ari intestinal kasvisto, vakawedzera kumwedzi ropa kunogona kuitika kana kunzwisisa kushanda zvimwe zvinodhaka.

Mumwe haagoni asi kuwedzera, kutaura sei kushandisa "Levonorgestrel" kuti chingamubatsira ichi chinoita nokuwedzera kudivi Migumisiro nemimwe mishonga, mushonga haisi. Kana ovhadhozi inoda symptomatic kurapwa.