Kushanda uye mugumisiro "Cefotaxime." "Cefotaxime": ane analogue zvinodhaka

Inorwisa mabhakitiriya "cefotaxime" - munhu simba zvinodhaka nokuda pakurapa zvirwere uye kudzivirirwa postoperative yematambudziko. The chinodhaka chakaunzwa muviri kuburikidza jekiseni, chinowanzoonekwa nachiremba vakuru nevana. Zviri semisynthetic mushonga chete rinoita fuma sefotaksim yavaibvisa.

Pharmacological migumisiro

"Cefotaxime" - Rinomiririra cephalosporins, bactericidal chiito kunosimbiswa kubudikidza kudzvinyirira pamusoro paumbwe muchitokisi masvingo mabhakitiriya.

Inorwisa utachiona inhoroondo ya parenteral kushandiswa, zviri inoshanda kana chavakaona giremu negative utachiona husingakwanisi dzimwe nemishonga, anokwanisa kuita giremu positive cocci, asi sekwaserera pane giremu negative utachiona.

Pharmacokinetics

The mushonga yava kunyura, zvichienderana chipimo chemushonga iri muplasma maminitsi mashanu kana yeawa hafu pashure Kubayiwawo jekiseni uye anoramba bactericidal kuwanda muropa kwemaawa anopfuura 12. The mushonga ari kupinda zvinyama uye fluid zvakanaka akaparadzirwa pavo. Kana kushandiswa lactation mushonga anogona kupinda zamu mukaka. The kunonyanyisa chaizvoizvo "Cefotaxime" kunokwanisika kana vanobudirira kuwanda ari synovial, peritoneal uye pleural zvinwiwa. Risinganyatsozivikanwi kuti rakabva papi rinoitwa kuchinja mu weti (anenge 60%) uye dziri metabolites. For hafu-upenyu somugumisiro V / m uye / ari kunodiwa 1 hr.

Zvairatidza kuti kushandiswa medicament

Zvairatidza dzokushandisa zvinodhaka vari kutapuriranwa hunhu kuzvimba kushatiriswa Micro-zvinenge zviri sensitivities akasiyana "cefotaxime" (kunyanya giremu negative). Rakapa chete kunoreva kuti majekiseni "Cefotaxime" analogs pamahwandefa iripo, mushonga inoshandiswa panoongororwa rinoti dzakadaro:

• chirwere kukanganisa abdominal mhango;
• maronda ganda, mapfundo, nyoro zvinyama uye mapfupa;
• Zvirwere ari kufema turakiti, mhuno, huro, nzeve;
• chirwere kukanganisa Urinary hurongwa;
• Chirwere cheLyme;
• anogumbura dzinotsanagura zvinotapuriranwa hunhu ari pelvic zvomukati, mwandabvu;
• hudiki, utachiona nemaronda;
• yomumuzongoza, endocarditis, septicemia;
• Zvirwere ose immunocompromised;
• kudzivirira zvirwere pashure maoparesheni (akavhiyiwa pamusoro nemudumbu nhengo, obstetric uye gynecological uye Urological akarapwa).

Contraindications

"Cefotaxime" analogues ari majekiseni vane zvimwe contraindications kuti inofanira kukurukurwa asati kwokubatsira mushonga.

The mushonga iri contraindicated pakuparwa hypersensitivity kuti penicillins, carbapenems nezvimwe cephalosporins. Its nokungwarira nachiremba chiropa uye itsvo zvirwere, maronda colitis, lactation. Vakadzi vane pamuviri vari ushandiswe chete kana pane guru panjodzi kuti mudumbu kana amai muviri vakafunga kuti tibatsirwe yekudyidzana kupfuura zvichibvira nengozi. Parinoshandiswa pachinhu vana pasi makore 2.5, havabvumirwi kushandisa nzira intramuscular jekiseni.

Kushandisa zvinodhaka, chipimo chemushonga

Kuziva sei ruchikonzera "cefotaxime", zvakakodzera kuverenga mashoko anopiwa mirayiridzo kushandiswa kwezvinodhaka. Mishonga aiendeswa / m uye / musumo (via munhu dropper kana bolus).

The mushonga wacho nachiremba varwere vakuru nemakore 12, apo muviri kurema mukuru 50 makirogiramu:

• zvirwere zviri Urinary turakiti uye avo zviitiko apo utachiona kunoitika pasina matambudziko muviri nechinhu nzira iripo zvinopa 1 g rekugadzirira pamwe zvikamu maawa 8-12;
• nyore chenjera mwandabvu siyana dzakabatwa singly nenzira intramuscular nzira 1 g zvinodhaka;
• kushandisa mushonga kuti kurapwa kwezvirwere nezvirwere hunhu, kwokuomerwa chiri unosvikirwa, chero inobvira nzira 1-2g chinotarisirwa ane periodicity kunoreva maawa 12 (pamberi chirimwa "Cefotaxime", zvakakodzera nokungwarira kudzidza mitemo maererano iyo mhinduro vakagadzirirwa jekiseni) ;
• zvakaoma yokuvamba zvirwere, semuenzaniso, yomumuzongoza, zvinoda okusuma kupinda tsinga 2 g zvinodhaka pane zvikamu maawa 4-8, pamwe kunonyanyisa dose pazuva kungava asingapfuuri 12 d; nguva kurapa iri pakutsvaga kwokuomerwa mamiriro;
• pamberi akavhiyiwa panguva yokutindivadza kubvisa mukana wokuti utachiona chinotarisirwa 1 g zvinodhaka, mune zvimwe zviitiko maawa 6-12 unotakurwa reintroduction zvinoreva;
• cesarean chikamu rinoitwa nokusuma 1 g "Cefotaxime" Papera muitiro inodzokororwa.

The mushonga unoshandiswawo nomutsinga pachinhu vakurumidze vacheche uye vachangoberekwa:

• zera idukusa 1 vhiki - kushandiswa 50 MG pa 1 kg kurema muviri ine kakawanda maawa 12;
• makore 1 kusvika 4 vhiki - MG 50 paminiti 1 kg kurema muviri ine periodicity maawa 8.

Vana vanoyera asingasviki 50 makirogiramu aine makore 2.5, kugadza 4-6 Nhanganyaya Mumwe inobvira nzira 50-180 MG chete kilogram kurema muviri (kunzwisiswa se "cefotaxime" erudzi novocaine, unofanira kuverenga rairo nokungwarira) . Kana pane chakakomba weboka chirwere, kushandiswa 100-200 MG / makirogiramu. At zuva zvinogamuchirwa 12 g chezvinodhaka.

Kugadzirira negadziriso jekiseni

intravenous jekiseni

The chena mvura jekiseni (4 Rine mamiririta) akanga rakasanganiswa 1 g zvinodhaka. The Kugadzirisa chinotarisirwa pamusoro maminitsi 3-5, zvakakosha kupa zvishoma hurukuro kupinda mumuviri.

Intravenous aizomupa (donhwe)

At 50-100 ml solvent (dextrose 5% kana yavaibvisa chloride 0,9% ndipo) rakasanganiswa 1-2 g zvinodhaka uye aizomupa rinoitwa kwemaminitsi 50-60.

intramuscular

Muna 4 ml mhinduro (1% novocaine mhinduro -th, mvura jekiseni) tora 1 g zvinodhaka, kuita majekiseni munzvimbo magaro, tsono anofanira kupinda zvikuru kupinda tsandanyama.

Zvaidiwa mishonga mirayiridzo vachishandisa

"Cefotaxime" analogues pamahwandefa uko dziripo, kushandiswa zvaidiwa mirayiridzo. Asati kushandisa mishonga zvakakodzera kubvisa mukana wokuti Kurwara. Varwere vanogona kuva sema kwomusikirwo kuti penicillin, mushonga anofanira kushandiswa nokungwarira zvikuru. Kana paine aikanganiswa nezvinhu zviri somushonga chigadzirwa, kushandiswa kwaro akamira. In kurapwa kwemazuva anopfuura 10 kunoda nguva nenguva vakaongorora peripheral kweropa. Kubvisa zvisingadiwi siyana panguva kurapwa vanofanira kurega doro.

Overdosing nemishonga

"Cefotaxime" analogues iri kuturika vane vazhinji nemishonga:

• neutachiona (urticaria, kuvaviwa, mapundu, fivha, chills, bronchospasm, anafillaksiya, eosinophilia, angioedema, hunokachidza epidermal necrolysis uye Stevens-Johnson);
• dyspepsia (marwadzo mudumbu, dysbacteriosis, flatulence, kuda kurutsa, kurutsa, kupatirwa kana manyoka, kusagadzikana chiropa, mu zvisingawanzoitiki zviitiko - pseudomembranous colitis);
• glossitis, stomatitis;
• mhirizhonga munyika hematopoiesis ino (hypocoagulation, hemolytic kupererwa neropa, thrombocytopenia, granulocytopenia, neutropenia, leukopenia);
• abnormalities ari Urinary zvomukati (interstitial nephritis, anuria, oliguria, azotemia, mukuru wevakuru urea muropa);
• dzungu, kurwadziwa nemusoro;
• kunaka pezvakaitwa mu kumwoyo (arrhythmias akatakura vanokwanisa kukanganisa upenyu);
• chisingadiwi omunharaunda kuita (nda, inorwadza / m, phlebitis);
• kuchinja murabhoritari parameters (zvenhema zvakanaka Coombs 'bvunzo);
• superinfection (zvokuudzwa candidiasis, Candida vaginitis).

"Cefotaxime" analogue zvinodhaka kana kushandiswa pamatunhu mishonga kungaita kuti ovhadhozi, zvichiteverwa nokugwinha uye zvimwe zviratidzo, pakati pavo - kuzvidya mwoyo, chakamira pakunodengenyeka zvine, encephalopathy (chaizvo kazhinji chiratidzo ichi ari kuchengetwa varwere vanenge renal kukundikana). Kubvisa migumisiro ovhadhozi symptomatic kurapwa inoshandiswa.

Drug kudyidzana nevamwe mishonga

Kana uchida kuwana nzira vane sezvamunoita yakafanana Kuronga mari "cefotaxime" analogue Sarudza hakuzovi kwakaoma. Asi zvisinei, achibatsirwa zvinodhaka ARV kwakaita vachishandisa yepakutanga analogue kana, chero zvazvingava, unofanira kufungawo kukurukurirana pamusoro mushonga nedzimwe mishonga.

Apo "cefotaxime" rinoshanda zvose angangokuvadza nephrotoxic mishonga akadai furosemide, aminoglycoside nemishonga, zvakakosha kucherechedza basa itsvo, nokuda mukana nephrotic aaiitawo.

Nokuti kurapa zvirwere zvakawanda uye kudzivirira kukura kwavo kazhinji vanoshandisa "cefotaxime". Mirayiridzo yokushandisa zvinodhaka analogues kunge kudzidzwa, sezvo chokushandisa ichi kunogona kukonzera Kurwara, ane yakawanda nemishonga nezvimwe zvinhu. The zvingaitwa zvinodhaka rirege kushandiswa pachiimbwa dzimwe mhinduro inorwisa mabhakitiriya, haagoni kwakabatana kuti donhwe yomukati uye sirinji.

analogs

Zvinoreva kuti "cefotaxime" analoginen anofanira kusarudzwa nokuda zvinoshingaira fuma. Of STRUCTURAL analogues vangazivikanwa:

• cefotaxime yavaibvisa;
• cefotaxime chinu, Sandoz, yavaibvisa uye naAmareki;
• tsefosin;
• tsefantral;
• tsefabol;
• tsetaks;
• tirotaks;
• tartsefoksim;
• taltsef;
• mutero-to-bhidha;
• spirozin;
• rezibelakta;
• oritaksim;
• oritaks;
• liforan;
• klafotaksim;
• klaforan;
• klafobrin;
• kefoteks;
• intrataksim.

Sezvo pane maturusi akasiyana-siyana kuti gadziriro "cefotaxime" analoginen kusarudza nyore, asi t. To. The analogs angava mhiri migumisiro, uye avo kuporesa nomugumisiroi kungava simba, kutsiva yepakutanga chinodhaka anofanira kusarudzwa nokungwarira zvikuru. Kuti tidzivise varwadziwe, vanofanira kudzidza mashoko zvakawanda pamusoro zvinodhaka kuti akaronga kuti kushandiswa.