Interferon inductors, kugadzirira vana: ronga, chiito. High-speed inducers ye-interferon isingagumi

Kuti zvirwere uye zvirwere zvirwere zvehutachiona, inducers ye interferon inoshandiswa. Iyo nzira yekuita kwavo inobatanidza nekugadzirwa kwemapuroteni zvinhu, izvo zvinodzivisa kuwedzera kwezvirwere zvepathogenic. Kugadzirira kunobva kune inducers kunokonzera kurwisana nehosha yekufema, heptic and hepatitis infections, fenza.

Tsanangudzo ye interferon

Iri ndiro zita rechikwata chemishonga ine protein yakabva. Iyo inobudiswa nemasero ane utachiona hwezvirwere.

Interferon zvinhu ndezvezvikonzero zvekuchengetedzwa kwemaitiro asingabatsiri mumuviri unorwisa mabhakitiriya, chlamydial, pathogenic fungal zvirwere, masero emagetsi emakumbo. Vanotambawo basa revatongi vekubatanidza kwe intercellular ye systemic immunity. Ivo vanonziwo immunomodulators vane unhu husingaperi.

Kune marudzi mazhinji emitambo ye interferon: leukocyte, kana-interferon, fibroblastic, kana b-interferon, uye immune, kana g-interferon.

Chirongwa chekugadzirisa kwebasa ravo chinotanga nekusungirwa kwemapurotini nemagadzirirwo ezvimwe zvinhu mumasero. Nekubatana uku, mapuroteni mamolekemu anogadzirwa mukati memakumi matatu. Nekubatsira kwepeptidi yepamutemo, kukurudzira kweT-lymphocyte basa uye macrophage zvivako zvinoitwa, mavharusi anodziviswa kuti apinde mukati memumakumbo esero nekuwedzera. Ivo ndivo vane basa rekudzivirira zvinhu.

Interferon inducers yemasikirini ndiwo masero eutachiona ayo akapinda mumuviri mupenyu. Izvo zvakasimba uye zvisina simba zvinokurudzira zvekudzivirira kuchengetedza mapuroteni. Zvizhinji zvezvirwere zvezvirwere zvakakomba zvakashata. Zvinosanganisira cytomegalovirus uye hutachiona hweHIV, herpes, hepatitis F uye B. Asi zvirwere zvakawanda zvinokonzera zvirwere zvepurogiramu zvinoputika zvinoonekwa sezvakasimba zvinokurudzira zvekuchengetedza mapuroteni.

Interferon inductors (zvinodhaka): chii ichocho?

Kazhinji zvinodanwa madhiragi ekirasi yezvigadzirwa zvekudzivirira muviri. Izvo zvinogadzirwa nemakambani emishonga. Interferon inductors (madhiragi) anosarudzwa seboka guru remakemikari nemakemikari akasiyana-siyana. Izvo zvinoshandiswa zvinogona kunge zvakaderera-uye zvakakwirira-masero, izvo zvekugadzira kana zvisikwa. Vanogovana nhumbi imwechete iyo inobvumira munhu kuisa mumasero emuviri muviri wake kana kuti interferon inogumira. Mishonga yakadaro inokwanisa kuratidza maitiro antiviral uye immunomodulating madhara.

Iyo inoshanda sei

Inductors ye-interferon isingaperi inodhaka inotungamirirwa muzviitiko zvakawanda kurwisana nehutachiona hwehutachiona. Iyo nzira yekuita kwavo inobva pakubatana kwezvinhu zvinoshanda zvechirwere ichi nemasero emagetsi uye zvisikwa, chigumisiro cheicho chiri kugadzirwa kweprotini inodzivirira.

Interferon inductors imishonga inowedzera kusunungurwa kwemapuroteni artificially. Basa ravo rakafanana nemasikirwo emasikirwo, ayo anosanganisira mavirari, mabhakitiriya masero nezvinhu zvakasiyana-siyana.

Kushandiswa kwevanonzi interferon inducers kunogona kukuvadza kugadzirisa. Mune hurumende iyi, kana mishonga isiri kutarisirwa zvakare, chirongwa chekudzivirira hachiiti, uye kuregererwa kwayo kunoonekwa. Panguva ino, hazvina kufanira kutungamirira mishonga. Nguva yehurumende yakadaro yakatarwa ne inductor pachake. Kuchinja kwezvinhu zvinoshanda, pamwe nekupererwa kwemishonga pamwe chete nemushandi, inobatsira pakugumiswa kwehutachiona.

Kutungamirirwa kwezvinodhaka zvinokurudzira kugadzirwa kwekuchengetedza mapuroteni hazvikonzeri migumisiro yakaipa isingadi iyo inoda kubviswa.

Kubatsira kwekupedzisira kweprotein inducers

Kune nzira mbiri dzekuwedzera hutachiona hwe interferon. Izvi zvinogona kushandiswa zvakananga kana zvakananga mumuviri. Imwe nzira inoreva kupindirana kwenguva refu nekuiswa kwezvinhu zvinokurudzira kugadzirwa kweeopferon yayo. Puroteni yakadaro haina kuratidza antigenicity, iyo isingagoni kutaurirwa ne-interferon recombinant. Kuzivisa kwenguva refu kweprotini yakagadzirirwa yakagadzirwa nenzira yekugadzirira kunotungamirira kukurudzirwa kwekusateerera kusingadiwi.

Inductors ye-interferon inogadzirisa mukudzidza kwekubudirira kwavo yakaratidza basa rezvemishonga mune zvakasiyana-siyana zvezvirwere. Bhi-functional property, inoratidzirwa nehutachiona hwehutachiona uye yakataurira kuvhara muviri, yakatanga.

Izvo zvinoitwa ne inducers zve interferon zvinotungamirira kuhuwandu hwepuroteni, iyo mumabasa avo yakafanana nemapuroteni anodzivirira akagadzirirwa. Nzira iyi inofungidzirwa kuti yakanyatsogadzirisa, inodzorwa nenzira dzinochengetedza muviri zvakasimba kubva pakuwedzerwa maitiro emishonga iyi.

Nekushandisa kumwe chete kwezvinodhaka izvo zvinokonzera interferon, kupararira kwakakwana kwenguva refu yeprotini inodzivirira inoitika paanoda kurapa maitiro. Kuti uwane dhidhi yakadaro mukugadzwa kweprotini inofanana, inofanira kudzokororwa kakawanda mumabhuku makuru. Kurapa kwakadaro kunoonekwa kunodhura.

Runyora rwezvinodhaka

Pari zvino, vanachiremba vari kuwedzera kushandisa interferon inductors - madhiragi, urongwa hwemakore ose ari kuzadza nemishonga mitsva. Nhamba yakawanda yekuzivikanwa kwemishonga inogona kumira zvirwere zvakawanda.

Sezvimwe chikamu chemuviri wezvirwere zvezvirwere zvezvirwere, pane zvinoshandiswa zvinoshanda zvakabatana izvo zvinobvisa mishonga inonzi antigenic iyo isiri yemuviri. Chinhu chimwe nechimwe chekuchengetedzwa kwepachiviriki kune majekiseni. Izvi zvinotsanangura zvakasiyana-siyana zvemishonga inobatsira pakuvandudzika kweprotini inodzivirira.

Kune mhando dzakasiyana-siyana dze interferon (zvinodhaka), urongwa huri kutungamirirwa nemishonga "Poludan". Uyu mushonga unofungidzirwa kuti ndiyo inotanga kukurudzira yeprotein inodzivirira, iyo yakatanga kushandiswa muma1970. Inosanganisira polyadenyl uye polyuridic acids. Kubudirira kwahwo pakugadzira interferon kwakaderera. Kapljami nemaziso nemajojo ezvigadziro "Poludan" inobata keratitis yake uye keratoconjunctivitis. Zvinodhaka zvinokonzerwa nemishonga inogadzirwa nokuda kwechirwere cheplpitis uye herpetic vulvovaginitis.

Interferon inducers - kugadzirira "Aktaviron", "Lavomax", "Tilaxin", "Tiloron dihydrochloride", "Amiksin", "Tiloram" - vane chikamu chinoshanda cheTylorone mukuumbwa kwavo.

Mishonga "Ridostin" uye "Sodium munyu yemadhinoucleic acid" inosunungurwa nemhando inoshanda ye sodium ribonucleate.

Chinhu cheumifenovir chikamu chemishonga Arbidol, Arbivir, Immustat uye Arpfly.

Iko kunewo inducers ye interferon, iyo yakagadzirirwa iyo inonzi nezita rekushanda zvinhu. Izvi zvinosanganisira mahwendefa "Kagotsel" uye "Tyloron."

Kubva pa meglyumin acridone acetate , mishonga "Meglumine acridonacetate" uye "Cycloferon" inobudiswa, uye sodium oxodihydroacridinyl acetate iripo mumushonga we "Neovir".

Kuumbwa kwechirwere "Yodantipirin" kunosanganisira 1-phenyl-2,3-dimethyl-4-iodopyrazolone, uye mumatafura "Alpizarin" ane munyu wemagnetrin.

Interferon inductors kuvana, tsanangudzo yavo

Kune nhamba huru yemishonga yakakura inogona kupiwa kumwana, asi pane imwe nguva. Somuenzaniso, nemishonga "Cycloferon" inotanga kubata vana vane makore mana, uye mhinduro "Ridostin" inosarudzwa kubva kune makore manomwe. Zvese zvinodhaka zvinoshandiswa zvakasiyana-siyana. Vanokodzera kurapwa zvirwere zvokufema zvehutachiona hwehutachiona, hupfumi, hepatitis chronic, herpes. Nhamo yavo ndeyokuti zvingave zvisingabvumirwi zvido zvemashure.

Inductors interferon - kugadzirira vana mune imwe nzira yakasarudzika, yakagadzirirwa zvakananga kumwana. Pakati pavo, zvinoreva Arbidol. Yakashandiswa kubva pazera remakore maviri. Chimiro chemishonga chemishonga inogadzirwa nenzira yekodhesi yehutungamiri hwemukati. Chirwere ichi chinorwisa maitiro uye chiito chekudzivirira muviri.

Inoreva kurwisa mishonga yemishonga inodzivirira masero emuviri B uye A. Nekubata kwake, kubudiswa kwekati interferon, iyo inodzivisa kubatana nekupinda mukati mechirwere, inokurudzirwa. Pasi pechiito cheprotini inodzivirira, inopupiti yevirpidal inopikisa haikwanise kushamwaridzana nesero membrane.

Inductors interferon kune vana vanoita kuti kuve nekudzivirira kwehutachiona hwemhando yehuori , pamwe nekuita kwavo muviri unowedzera kusagadzikana kune vanotapukisa, nhamba yezvinetso zvinoderedza.

Chirwere ichi "Kagotsel" chinokonzera zvakafanana mumuviri wemwana. Iyo inobudiswa nenzira yehwendefa yekushandiswa mukati. Nguva yakabvumidzwa yekushandiswa kwemishonga inobva kumakore matatu.

Therapy yezvirwere zvokufema

Interferon inductors imishonga yekurapa maitiro ekudzivirira kupora mavhariyo, izvo zvinotungamirira pakuumbwa kweprotini inodzivirira mumasero emuviri. Izvo zvinorayirwawo kuti chirwere chinokonzera zvirwere.

Mishonga inoshanda zvikuru inoshandiswa nemishonga inobva pa tyloron, iyo inosanganisira mahwendefa "Tiloron" uye "Amiksin." Nekurapa furuwenza uye chirwere chakaipa chekufema kwehutachiona hwemhuka, vanhu vakuru vanokurudzirwa kushandisa 125 mg panguva. Mukana uyu unowedzera kusvika pamazuva maviri okutanga, uye 125 mg inotorwa zuva rimwe nerimwe. Nhamba yemari yemishonga ndeye 750 mg.

Kuitisa matanho ekudzivirira, 125 mg inoshandiswa panguva imwe, uye zuva remazuva matanhatu. Iyi dzidzo inodzokororwa mavhiki matanhatu.

Kugadzirira kunoenderana nehulorone kunopesana nehupo hwekusawirirana kwevanhu, panguva yekuzvitakura uye panguva yekuyamwisa mwana.

Kutora mishonga yakadaro kunogona kukonzera kushungurudza, fivha, uye zvinokonzerwa nemagetsi.

Iyo mishonga "Umifenovir" ine basa rekutera-interferon, kukurudzira kwema-cell-type immunity, kuwedzera kukurira kwehupenyu hwose kune zvinotapukira.

Nokuda kwezviito zvekudzivirira mukutarisana nevanhu vanorwara vanogadza chirwere chezuva nezuva che 200 mg kwevhiki imwechete. Munguva yenguva yehutachiona uye zvirwere zvokufema, chirwere chemazuva ese che 100 mg chinoshandiswa panguva, saka kupera kwemazuva maviri kunoitwa. Dzidzo iyi inotora vhiki nhatu. Kurapa kwehutonho, 200 mg inorayirwa 4 kanomwe pazuva kwemazuva matatu.

Zvinodhaka nezvinonzi Umifenovir hazvisati zvashandiswa pakuvapo kwekusagadzikana kwevanhu, panguva yakaoma setictic pathologies. Kutora mishonga yakadai kunogona kukonzera zvirwere zvezvirwere.

Kurapa kwezvirwere zvinotapukira

Zvirwere izvi zvinosanganisira zvirwere zvinokonzerwa nehutachiona hunoshandiswa kana kuti majekesiti ega autoggressive emajeri eouraya anowedzera mukupindura maviri ane utano. Izvi zvinokonzera kukanganisa uye kuparadzwa kwezvipembenene zvine utano, zvichiita kuti zvive nyore kuputika.

Kazhinji, interferon inducers zvinoshandiswa pakurapa. Kugadzirira kwezvirwere zvekudzivirira muviri kunorayirwa neavo vane mafungiro ekudzivirira mafungiro.

Nekurapa kwe multiple multiple sclerosis, mushonga we "Amiksin" unoshandiswa. Pachinyanya kuratidzwa kwehutachiona hwehutachiona hwehutachiona hunoita kuti chirwere chacho chiwedzere, chirwere che 125 mg kana 250 mg chemishonga mushure mekunge kuwedzerwa kunyoreswa. Matafura akadhakwa mushure memaawa makumi maviri nemana, nguva yehutungamiri inobva pamwedzi 6 kusvikira ku12.

Kuchengetedza kuwedzera kwe multiple multiple sclerosis, 125 mg yemishonga inorayirwa, 2 nguva imwe neimwe mazuva manomwe.

Mukutambudzika kwakanyanya kwechikamu chinoshanda chechirwere pamwe nezviratidzo zvekuwedzera, mishonga inotorwa 125 mg 10 pane imwe mazuva makumi matatu kwemwedzi mitanhatu. Chirwere ichi "Amiksin" chinogoverwa pamwe chete ne peptide bioregulators, iyo inowanzoita iyo inoderedza kunzwisisika kwehupenyu kune protein myelin.

Kurapa kwakakomba nemishonga "Cycloferon" inokubvumira kurwisa arthritis neyakagadzikana uye rheumatoid, zvirwere zve systemic zvinokanganisa maitiro anobatana. Basa rake rakagadzirirwa kupedza maitiro e autoimmune, anopa anti-inflammatory and analgesic effect. Nekubatsirwa kwechigadziro, hutachiona hwemumusimba hunotungamirirwa pasi pehutano hwakasiyana-siyana hwehutachiona. Mushonga we "Cycloferon" unobudiswa mumhando yepiritsi, muchimiro chejairo sarudzo uye chigadziko.

Nekurapa kweArthritis, mushonga uyu unotarisirwa mukati-kati kana kuti kusagadzikana kamwe kamwe pazuva. Chiyero che 250 mg chinoshandiswa kubva kune chekutanga kusvika pazuva rechigumi nembiri pane mamwe mazuva. Muzvirwere zvakakomba, imwe yekutanga yakawedzera mazana 500 mg inoshandiswa.

Therapy yezvirwere zvehutachiona

Chirwere ichi "Amiksin" chinoreva interferon inducers ye fluorescent low molecular weight class. Nekubata kwake, marudzi ose ezvidziviriro zvinodzivirira zvinoumbwa, iyo yakasvika kusvika kune yakakosha zvikuru mu plasma mushure mezuva mushure mekushandiswa kwemishonga.

Mushonga uyu une huwandu hwakawanda hwehutachiona hwehutachiona. Mukuwedzera kune zvirwere zvinoputika, zvinoshandiswa kuC uye B hepatitis acute uye miviri isingaperi, herpes genital recurrent, cytomegalovirus uye chlamydia.

Mishonga yakawanda yemishonga inorwisa maitiro - inducers ye interferon, kwete imwe yega ndiyo nzira ye "neovir". Nekubatana kwake, huwandu hwakawanda hwekuchengetedza mapuroteni hunogadzirwa, kunyanya fibroblast type, inotsanangura kushandiswa kwemajeri, antitumor uye zvinopesana nemishonga yemushonga uyu. Mushonga we "Neovir" unobata encephalitis, hepatitis C uye B, urethritis, cervicitis, salpingitis inokonzerwa nechlamydia.

Imwe inducer yakafanana yepamusoro yemasikisi inorema inodzivirira mapuroteni inonzi "Cycloferon", iyo yakashandiswa iyo carboxymethylene acrydon methylglucamine salt inoshandiswa. Nekubatana kwake, alpha-interferon inoumbwa, izvo zvayo mumatomu e lymphoid zvinopfuurira kwemazuva matatu.

MuT uye B lymphocytes, macrophage inoumba puroteni inodzivirira, kushandisa tsvina yemapfupa mumapfupa emafuta, inokurudzira kugadzirwa kwezvikwata zve granulocyte. Chirwere ichi chinoshandiswa kurwaridzwa-encephalitis, herpes, hepatitis, cytomegalovirus, hutachiona hwehutachiona hwehutachiona uye mapillumasi.

Mukuwedzera kumagadzirirwo antiviral, sendimiti inoshanda mune zvakanyanya uye zvisingaperi bhakteria chlamydia, erysipelas, bronchitis, postoperative zvinetso, zvirwere zve genitourinary system, zilonda zvekuonda.

Chirwere ichi "Lavomax" chakaonekwa pamisika yemishonga, inogadzirwa naNizhpharm. Iyo ine simba rekudzivirira muviri, kukwanisa kubatanidza interferons, chiito chekuvhara maitiro chekukura kukuru.

Mune mahwendefa "Lavomax" ane 125 mg ye tylorone senhengo inoshanda. Iyo mishonga inoratidzika semuenzaniso wemishonga "Amiksin". Basa rayo rakagadziriswa pakukurudzira kubudiswa kwemhando mitatu ye-interferon muT-lymphocytes, hepatocytes, masero e epithelial mudumbu remadziro.

Izvozvo zvinokonzerwa nekudzivirirwa kwezvirwere zvinokonzerwa nekudzivirirwa kwemuviri pakati pemasocometent cells uye nekugadzirisa kwekushongedza kweanoripi. Izvo zvinoshandiswa nehutachiona hwehutachiona hunobva pakudzivirira kwehutachiona hweprotini zvakananga kune mavharusi ane utachiona hwemuviri. Izvi zvinopesana nokuwedzera kwavo kubereka.

Chirwere chacho chinonyatsorapwa nehutachiona, zvirwere zvokuputika, viral hepatitis uye herpes rashes.

Kurumidza kuita inductors

Kazhinji, Kutarisirwa mishonga dzakadaro kunoita kuti kutsanya kukura rwokudzivirira mapuroteni.
Fast-kuita inducer pamusoro endogenous interferon mukati maawa mashomanana kugara mumuviri zvinogona kukonzera kuti paumbwe mapuroteni unoratidza kugona kwavo.

tilorona fuma kunowedzera pashure kushandiswa dzakawanda mapuroteni wevasungwa kusvikira vaifanira ukoshi kare pashure 4 h. Pane zvishoma nezvishoma paumbwe interferon rokutanga ura, uchiteverwa chiropa uye usiku - muropa.

Kugadzirira "TSikloferon" induces mapuroteni pashure 4 kwemaawa, uye nhamba iri kuchengetwa pashure pemaawa 8, pashure iyo pane zvishoma nezvishoma kuderera mumisasa.