ICSI - insemination. ICSI - muitiro. Chii chakasiyana IVF IVF + ICSI?

Vakawanda mbereko vakaroorana vaigona kuva vabereki refu-akamirirwa mwana anoonga pakatanga dzokubatsira kubata pamuviri ruzivo. Chakagadzirwa ezvokunambira kunze kwomuviri waamai muchangosangana (IVF) - kupfuura mberi nzira. The zvairatidza kuti kushandiswa kwayo vari-siyana mwana zvose navarandakadzi. Zvichienderana zvokurwara nzira kunyatsoshanda anogona kusvika 50% uye pamusoro. ICSI-nourume - mukuru-unongotaura musiyano pakati IVF.

A Nhoroondo shoma

Kokutanga ezvokunambira kunze kwomuviri waamai muchangosangana nzira yakashandiswa kuEngland muna 1976. Asi zvinosuwisa, nhumbu uyu ectopic (Tubhari). Asi kare muna 1978 imwe kiriniki akaberekwa Bourn Hall - wokutanga mwana "kunambirwa". mai vake - Luizy Braun - akabviswa fallopian sepombi. Uye muna 1993, yokutanga mumwe akanga kuitwa Belgium ICSI-muchangosangana. Reviews ose nzira, kazhinji kacho, muprista kushanda kuti nzira iyi. Asi mumwe mhosva kunoshamisa, uye makasimba muna zvose zvakanaka uye kunaka mugumisiro Chokwadi, haagoni kuva.

Kuita ezvokunambira kunze kwomuviri waamai muchangosangana zvichiitwa?

Chokutanga, unofanira kumbotambudzika kuchipatara Kunyatsoongororwa. Sezvo nzira rinoitwa "ezvokunambira kunze kwomuviri waamai", muviri mumwe mukadzi uye munhu hwokurara utachiona masero. Kuti aite izvi, kushandisa zvinodhaka amai yemberi inotokonya achikura mazai uye kugadzirira endometrium kuti pamuviri. Mushure asvika zvaida kuita, kubudikidza ponji pamusoro ovarian oocyte wacho. Zviitike fertilization, ivo inoiswa bvunzo chubhu pamwe urume, apo mamiriro ezvinhu akafanana dzinongoitika. Mushure matatu shanu Mazuva zvimwe mazai aya vari zvifambiswe kupinda uterine mhango. Kazhinji takura anenge matatu kana mana, sezvo vamwe vangava orambwa hadzi muviri uye pachava chete mumwe wavo. Asi somugumisiro IVF anogona kuuya uye vakawanda pamuviri.

Chii chakasiyana IVF IVF + ICSI?

In chinyakare IVF zai ne dzisingaoneki raizoiswa chaiyo ezvinhu apo mamwe muchangosangana wechisikigo nzira (pane yoga pakatanga dzisingaoneki kupinda cytoplasm ari zai). ICSI-nzira Kunosanganisira Kubayiwawo jekiseni dzisingaoneki kupinda zai kubudikidza microneedle jekiseni. Of dzisingaoneki yepamusoro uye pamuviri kakawanda parinowanika, sezvinoita mutemo, regai kuvimba. Nokuti nzira, unofanira kuva pane imwe nokunaka urume.

Sei nzira kuna ICSI?

Ndapedza regadziriro muzvikamu zvose (sapamazuva kwakajairika IVF): ovarian dzishande, ponji kurapwa urume muunganidzwa uye anotanga kugadzirira kuti isa fotereza zai. Kuti izvi zviitike, embryologist uchishandisa inokosha reagent Kunobvisa ayo inodzivirira. Pasi maikorosikopu, akatorwa zvikuru basa dzisingaoneki. Masero Vose inoiswa chaiyo chena ezvinhu chete tembiricha kunodiwa. Zvadaro, kushandisa micropipette chinokosha yakamisirwa ovum kubudikidza dzisingaoneki muswe chakaparadzaniswa uye akaisa ari microneedle. Embryologist vachishandisa manipulators nokungwarira akaipisisa, takatarisa mamiriro ezvinhu achishandisa maikorosikopu uye nokudzora sangano ravo rimwe otaura dzisingaoneki kupinda zai. ICSI-nzira wazadziswa. Zvino unofanira kumirira kusvikira pashure muchangosangana uye wokutanga muchitokisi kupesana. Chii chakasiyana IVF IVF + ICSI kuwedzera nzira yokunambwa? Kutaura zvazviri, izvi mutsauko uye magumo. Pashure inobudirira fertilization, mukadzi achava pasi kuramba pokudzora vanachiremba uyewo pashure IVF.

Ndezvipi zvinhu zvinoratidza nzira ICSI?

Aberekeswe ICSI kunze pasi zvikuru kwazvo siyana varume kushaya mbereko, untreatable. Somuenzaniso:

• Azoospermia - vamborega rakazara urume ari ejaculate.

• Teratozoospermia - kuvapo spermatozoa ane kwagara configuration, mune mari isingasviki 14%.

• Oligozoospermia - kukwana Nhamba dzisingaoneki.

• Vachiberekwa pasina vas deferens.

• Condition pashure vasectomy.

Uyewo, ICSI nzira kushandiswa varombo mabasa ari Qualitative uye quantitative Zvinoumba urume, kbps "unfrozen" dzisingaoneki dzokutambura kundikana kuedza IVF, kushaya mbereko isingakwanisi mavambo.

How kugadzirira nzira?

Pamberi nzira, ICSI mukadzi uye murume anofanira kupfuura nhevedzano miedzo:

• ropa mhando, kusawirirana kweropa raamai chinhu;

• njovhera;

• AIDS;

• hepatitis C uye B.

Kunobva Analyses zvinokosha inotevera mitatu.

Mukadzi anofanira aite ongororo dzakadai:

• ropa kuongorora pamusoro mahormone (FSH, LH, prolactin, estradiol, testosterone, progesterone, TTG, DHA-S);

• swab kubva dzokubereka turakiti kuti zvirwere yakavanzwa uye zvirwere zvinotapuriranwa pabonde;

• ropa kuongorora uye zvekuchipatara nemakemikari omuviri;

• urinalysis mukuru;

• Zodzera pamusoro nemiti;

• coagulation kuongorora.

Sezvo kugadzirira ICSI kunosanganisira fanira kubvunza ane gayinakorojisiti nokuda zvichibvira contraindications.

Nokuti varume, kutsvakurudza zvikuru kugadzirira pakusangana nzira iri urume. Zviri kuburikidza ongororo iyi pakutsvaga mano womunhu pamuviri. Urume ongororo inoratidza quantitative uye Qualitative maitiro dzisingaoneki, uyewo nhengo zvinotevera zvidzidzo:

• spermotest - kuongorora dzisingaoneki kukwanisa kuramba kufamba mune bvunzo chubhu;

• kuziva nhamba kuti leucocytes mune urume ;

• kuziva zvirwere;

• Pawaitengesa-bvunzo;

• Stained zodzera kuongorora.

Pazuva oocyte ponji mukadzi chinorambidzwa kudya, kunwa chete pashure chiremba wacho mvumo. Murume mazuva matatu kana mana pamberi nzira iri kurega kurara nokuti haana kunwa doro dzakawanda mazuva.

kubudirira nzira

ICSI-muchangosangana kunotungamirira pamuviri muna 30-60% nyaya. It zvinoenderana mamiriro nemasero embeu, vose vakadzi nevarume (zvichida nomumwe wavo anotakura nemagene anomaly), uyewo kodzero embryologist vaichengeta nzira (panguva nzira kuti zai zvinogona wakaremara). Kana pakusangana harina mukana kuti rekuUnited masero kuchaita kuva Muviri hwakanaka 90-95%. Zvinofanira kucherechedzwa kuti zvakanaka kunoguma vakawanda pamuviri dererei pane kwakajairika. Kana Pamusana anoverengeka embryo nzira vakawana anogona kuitwa kuchengetedza vachishandisa mvura senitrogen. itwotwo twakachengetwa haazorambi kurasikirwa ehupfumi ayo kunyange pashure akawanda.

Izvo zvinogona kukanganisa mugumisiro nzira?

vanobudirira ICSI-muchangosangana Zvinoenderana siyana zvinokonzera on:

• Partner zera;

• zvinokonzera kushaya mbereko;

• kumakiriniki;

• Chiremba tsika;

• zai mamiriro.

Nokuti zvakanaka mugumisiro nzira kunoda kushingaira spermatozoa kubva mbeu vechirume yepamusoro oocytes. Kana munhu asina basa dzisingaoneki, mukana yokunambwa kunoderedza.

Pakusarudza dzisingaoneki physiologically vakasimba

Male chinhu rine kukanganisa kukura embryo. Kazhinji mhosva mukono kushaya mbereko anoshanda vazhinji saibva dzisingaoneki ari ejaculate. The akura dzisingaoneki kusunga kune hyaluronic acid. Zvinonzi kwakavakirwa nzira iyi uye wasarudza unodikanwa masero. Physician embriologist Anosarudza biochemically ruzivo dzisingaoneki chokuita gialorunanom. Zviri masero aya physiologically akura kudirwa ICSI.

ICSI-muchangosangana: mari nzira

Zuva nezuva, vakawanda vakadzi vanofarira kunyatsoshanda, Mari muitiro, uchitsvaka zvakanaka kiriniki kuti nzira. MuRussia, unoedza paiva mutengo chete-ICSI muchangosangana ndiyo 150-200 zviuru rubles. Kunze, mari muitiro kwakadaro pamusoro. vanenge 2-nedanga - In Israeri. MuUnited States, Germany, Switzerland - muna 3-4 nguva.

zvinogoneka njodzi

Pasinei dzakawanda zvakwakanakira, ICSI, muchangosangana It ane zvakakura drawback - dzinongoitika kusarudzwa chinhu haashandi pano. Izvi zvinonyanya kukosha kune vanhurume vane kuvapo masero zvirwere (semuenzaniso, Klinefelter kuti urwere, uye vamwe) kuti havagoni pamuviri pasina kushandisa ancillary nzira. zvirwere yakadaro inogona nhaka uye kuitika kwemakore akawanda. Genetic glitches vana yemberi regai kuva nokuda IVF zvichiitwa pachayo. Zvisinei, kushaya mbereko vabereki vanogona kukanganisa utano yevana. Kuti kuona zvinoita chromosomal uye nemagene abnormalities ari mudumbu nomumwe, Zvinokurudzirwa kuti aite pre-muchibereko kuongorora chirwere. Zvinogona kuitwa pachikuva pamusoro blastomeres matanhatu.

Ndezvipi zvimwe nzira ezvokunambira kunze kwomuviri waamai muchangosangana?

CHIPO - oocytes uye dzisingaoneki (gametes) vari hwakatamisirwa fallopian chubhu, kana pane mumwe zvazvinombobatsira yavo.

Zefta - nourume oocytes (zygotes) vari zvifambiswe kupinda fallopian chubhu.

Od - ECO oocyte anyatsoronga , uchiteverwa kutakura embryo kupinda dumbu retsipientki. Nzira iyi rinoshandiswa pasina ovaries vakadzi uye kutyora mashandiro avo, masero zvirwere ari mai, yepanyama kubereka.

The "kuberekerwa mwana nomumwe amai" - tuvana vabereki majini kuti mwana kubereka zvaive vakapinda dumbu womumwe mukadzi. Chikonzero ichi chingava kusavapo kana havazozvikwanisi pamusoro dumbu murwere, asi pamwe richengetedzwe ovarian ushande.

IVF nzira Zvechokwadi, munhu inodhura uye nguva-pakuzadza, kuti midziyo zvakakodzera kuti tiite insemination, hamuna vose makiriniki kuwana chiremba anokwanisa kuri zvakaoma. Zvisinei, chirongwa ichi rinobvumira vakawanda mwana vakaroorana pakuziva mufaro mukuru amai uye baba.