"Hydrea": mirayiridzo yekushandiswa, maitiro, mapikicha, zvinyorwa

Mushonga we "Hydrea" ndeyekudzivirira zvinodhaka. Iyo mishonga inokonzerwa ne-cytostatic, iyo inogadzirisa iyo inowanikwa mukudzivirira kweDNA synthesis, asi iyo inogadziriswa kujekesa kweRNA uye mapuroteni haisipo.

Mukugadzirira kwakagadzirwa sei, inobatanidza chii?

Mishonga inowanikwa nenzira yekaseti, inogadzirwa pamusana pehydroxycarbamide, iyo iyo imwe neimwe capsule iri 500 mg imwe neimwe. Kugadzirira kunogona kutengwa muhogi yegirazi (100 capsules) kana blister (10 capsules). Pakati pezvinhu zvakabatsira, magnesium stearate uye citric acid inoshandiswa. Uyezve, kuumbwa kunowedzerwa ne sodium hydrogen phosphate uye lactose monohydrate.

Zvishandiso zvinoumba shell cap "Hydrea", murayiridzo unoreva titanium dioxide, madhayi uye gelatin. Nyora yacho inoumbwa neini, iyo inowanikwa nekuda kwekubatana kwepropylene glycol, shellac, doro (isopropyl, methylated industrial uye N-butyl), pamwe chete nemvura yakachena uye iron yakasviba yemuvara.

Pharmacodynamics

Mishonga iyi is antimetabolite, iyo inoshanda inoratidzwa muchikamu S chesero. "Hydrea" inobvumira kumisa kufambiswa kwemasero muG1-S inopindira, iyo inonyanya kukosha apo radiotherapy inowanikwa panguva imwe chete nekutora mishonga iyi, kubva muchikamu cheG1 masero emuviri anosvika pakuva nehanya nemirairo. Iyo mishonga inosimudzira mhizha ye ribonucleoside diphosphate reductase (inhibitor yeRNA reductase). Nemhaka yekushandiswa kwayo, nzira yeDNA yakagadziriswa yakadzivirirwa, asi mapuroteni uye RNA maumbirwo haagadziriswi.

Pharmacokinetics

Kubvisa mukati momuviri wezvirwere zve "Hydrea" zvinoshandiswa zvinoshandiswa zvinotsanangura kuti zvinokurumidza sei, zvisingabatsiri nokudya zvokudya uye zvinotungamirira kumwero wakakura wezvinhu zvinoshanda mumuviri anenge maawa maviri mushure mekushandisa kwemukati kwechirwere. Chirwere ichi chinopfuurira kuburikidza neropa reuropi, rinoratidzwa nekuparidzirwa nokukurumidza, riripo ku ascites uye cerebrospinal fluid. Mushonga unowedzera mu erythrocytes uye leukocytes, zvishoma nezvishoma zvakanyanyiswa kubva mumuviri mukati maawa matatu kusvika mana. Chikamu chinoshandiswa chemasabetism chinoitwa muchiropa. Zvizhinji zvechirwere zvinodedzeswa neitsvo nenzira yehydroxyurea, kureba kwenguva yakareba yeiyo maawa gumi nemaviri. Chimwe chikamu chayo hachichinje chitarisiko chazvo, chiduku chiduku chechirwere chinobviswa mumuviri nemuyo. Kuburikidza nehutano hwemapfupa, mishonga inobudiswa se carbon dioxide. Mushure mokugamuchira kweHydrea, murayiridzo unozivisa kupedzisira kwapera mukati memaminitsi makumi maviri nemaviri. Sezvo huwandu hwechirwere ichi huchipfuura kuburikidza neitsvo, varwere vane zvirwere zvezvikamu izvi vanoderedza chirwere chechirwere.

Zviratidzo

"Hydrea" mirayiridzo yekushandisa inokubvumira kuisa pasi pemamiriro ezvinhu akadaro emuviri:

• Melanoma;
• Myeloid leukemia;
• Kanzira, neyokugadzirisa iyo inobata chibereko chechirwere, mapapu, prostate gland, colon kana mavhai (chirwere chinofanira kubatanidzwa);
• Osteomyelophybrosis;
• Erythremia;
• Kuvapo kwezvirwere zvinouraya mumutsipa nemusoro, kunze kwechirwere chete chinokanganisa miromo (pane chido chekunyatsorapwa);
• Thrombocythemia inokosha;
• Chorionepithelioma yemukaka;
• Acute lymphoblastic leukemia;
• Thrombocytosis sechinhu chinokonzera myeloproliferative syndrome;
• Lymphogranulomatosis;
• Chimiro chemasastase mukenza inokanganisa mazamu emakumbo uye mudumbu.

Contraindications

Pane zviitiko umo kurapwa neHydrea hakugamuchiri. Murairo wezvinodhaka unorambidza kusarudzwa mumamiriro ezvinhu akadaro:

• Kunyanya kunzwisisika kune zvikamu zve capsules;
• Thrombocytopenia neukoukopenia pamitengo isiri pasi pe 100,000 uye 2500 / μL, zvichienderana;
• Kuberekwa, kudya mwana nemukaka wemvere.

Kunyangwe mune zviitiko zvinotevera mushonga hauna kupindirana, kushandiswa kwaro uye kushandiswa kunoda kutarisirwa kwakakwana:

• Malabsorption glucose-galactose;
• Lactose kusawirirana;
• Lactase kukwana;
• Kunyanya kunokonzera anemia;
• Renal uye hepatic insufficiency.

Kana murwere akambotanga chemotherapy kana radiotherapy, pane ngozi yekuwedzera kwemazuva ano erythrema uye kukura kwekuita myelosuppression, saka munyaya iyi, iwewo unofanira kunyatsoshandisa mushonga.

Penguva yekurapa, kubata pamuviri kunovimbika kunodiwa, kana kubata kwave kwatoitika, murwere anofanira kunge achiziva njodzi iripo ye fetus. Pamusana pekupindira kwemishonga mukugadzirwa kwemukaka wehadzi kuvakadzi vanoyamwisa, zvakakosha kusimisa rudzi rwekudya. Kana mushonga wacho wakarongerwa kukwaniswa, nyanzvi inofanira kufungisisa zvose zvehutano asati abvumira murwere kusiya mishonga kubva pakutora capsules yeHydrea.

Kurapa

Munguva yekurapa neHydrea mishonga, mirayiridzo yekushandiswa inokurudzira kushandisa maitiro akasiyana emishonga mumamiriro akasiyana, achifunga nezvemamiriro emuviri wemurwere.

Kana zvakaoma kumurwere kumedza capsule, inogona kuvhurwa kuti iparadze mishonga mumvura. Mumamiriro ezvinhu akadaro, inwa chigadzirwa pakarepo. Iko kunofanirwa kurangarirwa mupfungwa kuti haisi yese yezvinhu zve capsules inopera mumvura, inoramba iri pamusoro payo. Varwere vanobatwa neHydrea vanofanira kunwa mvura zhinji.

Myeloid leukemia (chronic form)

Kurapa kunoitwa pasina kukanganisa. Nokuti imwe kilogiramu yekuyera inotora 20-30 mg yemudhi. Iyi ndiyo miitiro yezuva nezuva, zuva rimwe nerimwe mishonga inodhakwa kamwe. Iko kunogona kuongororwa kubudirira kwechirapa kwave ikopo pashure pemwedzi miviri yeiyo. Kana mitsara yakanaka ichicherechedza, kurapwa kunogona kuva kwenguva yakareba (kana zvichidiwa), kana platelet kuverengwa uye machena masero eropa achiwira pasi pasi pemaitiro, inomiswa. Kana kuumbwa kweropa kunowirirwa mumazuva matatu (kwete kare), unogona kudzoka zvakare nehana neHydrea. Mirairo yekushandiswa inoratidza kuti izvi zvinogona kuonekwa nokukurumidza.

Erythremia

Chirwere ichi chinodiwa kuti zuva nezuva rive nehuwandu iine 15-20 mg. Sezvakaitika munyaya yapfuura, chiyero ichi chechirwere chinotarirwa imwe kirogiramu yekuyera. Mune rimwe zuva, murwere anowanzopiwa 1 kana 2 capsules. Chirwere chekupedzisira kune murwere mumwe nomumwe chinotsanangurwa nechiremera chacho, zvichienderana nehuwandu hweplatelet uye hematocrit inotorwa pamagariro akaenzana.

Thrombocythemia inokosha

Nhamba yekutanga kirogiramu yehuremu inofananidzwa ne 15 mg. Nhamba yezuva nezuva yakasarudzwa pane imwechete kuitira kuti zviratidzo zvinokosha zvive panzvimbo yakada. Kana iyo mirayiridzo inorambidzwa negadziriro yeHydrea, mazwi okufananidza anotaridzirwa nachiremba uye mishonga yakakodzera yakasarudzwa.

Melanoma

Pamakumbo emakona makuru, kurapwa kunogona kunge kuri mukati kana kuenderera mberi, zvichienderana, chiyero chinodiwa chechirwere nechikero chekurema chiri 80 kana 20-30 mg. Nekurapwa kunoramba kuripo kwemavhiki matatu, chirwere chinodhakwa zuva rega rega. Kana chirwere chacho chikaitwa nekudengenyeka kwemazuva matatu, inodhakwa kamwe chete, asi mune imwe nhamba yakawanda.

Carcinoma (chironda chechirwere, musoro kana mutsipa)

Kune kilogram imwe yemutoro, 80 mg yemishonga inotorwa. Chirwere chakakosha chemishonga inodha mazuva ose matatu (kamwe).

Zviitiko zvakashata

Apo kurapwa ne "Hydrea", murayiridzo, zvinyorwa zvinorondedzera zvimwe zvinokonzerwa nemutemo we hematopoiesis, kutya, urinary, kuporesa nekugadzirisa zvirongwa. Uyewo, ganda uye zvipfeko zvaro zvinogona kuchinjwa, zvichida kukura kwehutachiona hwehutachiona hwakadai sekuputika. Panogona kunge kune mamwe maitiro asina kunaka emuviri.

Mutengo wekugadzirira, zvakafanana

Iwe unogona kutenga purogiramu Hydrea ye 243-250 rubles. (20 capsules). Pakati pezvinotsiviwa ndezvokugadzirira zvinoshandiswa zvakafanana zvinoshandiswa se Hydrea, uye zvinodhaka zvinenge zvakafanana.

Kubva pane zvinyorwa zvaunogona kutenga "Hydroxyurea" kana "Hydroxycarbamide medak". Apo murayiridzo unorambidzwa neHyrea, mifananidzo inogona kusarudzwa kubva kune nhamba yakawanda yemishonga, somuenzaniso, kubva kuTromboreductum, Amilan FS, Colotecan, Milanfor, Prospidina, Iritena, Halavena, Estracit , "Irinotela", "Camptothecan" kana "Estracite". Unogona kutora nzvimbo dzakadai se "Agrilin", "Kampeter" kana "Erivage". Pakati pezviito zvechiito chakafanana ndi "Aranoza", "Irinaks", "Arglabin". Nhamba yemishonga yakadaro ndeye "Zaltrap", "Irnokam", "Hexalen". Iwe unogona kurapwa ne "Proxifein", "Gikamtin", "Campto", "Verotecan", "Chloditan", "Prospidin", "Oncophagus", "Irinotecan" kana "Velcade."

Ongororo

Varwere vazhinji vanotenda kuti kusati kwatanga kurapwa, tsanangudzo yeHydrea chirairo, murayiridzo, inofanira kuverengwa. Mifananidzo pamberi uye shure kwechiremba inogonawo kuonekwa. Kutarisa nekuongororwa, vanhu vanofarira kurapwa chete pasi pekuongororwa kwehutano uye havazviisi pangozi kuzvirapa, sezvo kune ngozi, vanonwa mvura zhinji. Kana mishonga isingabatanidzwi ne radiotherapy, migumisiro inogona kuonekwa (mumamiriro ezvinhu apo yaimbove isipo), kana kuti ichinyanya kutaurwa. Asi izvi hazviiti nguva dzose.