Cytokine therapy - chii ichocho? Kuongorora nezvechitokine therapy

Kwemazuva akawanda vanhu vave vachiedza kuwana mushonga wekenza. Vakawanda vanoedza kukunda chirwere ichi chave chichiita kuti vasvike, asi tsvakurudzo inopfuurira. Saka, masayendisiti akawana kuti inoshanda zvikuru kutungamirira masimba ose ezvirwere zvezvirwere zvezvirwere zvinorwisa chirwere chinotyisa. Vanachiremba ve immunology-oncologists vari kushanda nguva dzose pamusoro peizvi. Saka pane imwe yenzira dzekenza kurapa - cytokinotherapy. Chii ichi, tichakurukura zvakare. Zvinonakidza kuziva mhinduro dzeizvi pamusoro pemhando iyi yekurapa.

Tariro yoruponeso

MuMoscow, kune chizvarwa chitsva chekushaya chiremera - kliniki ye oncoimmunology uye cytokine therapy. Pano, vanachiremba vanoshandisa nzira dzekupedzisira mukurapa kenza. Nzira dzechirongwa dzakadai sedhemotherapy, radiotherapy uye chirwere mumakirini inoshandiswa pamwe chete ne cytokinotherapy. Oncologists-immunologists vakagadzira nzira yakasiyana-siyana yekurapa, iyo isina sero rakanaka rinotambura, nepo kenza inoparadzwa pamwe nehuwandu hwemigumisiro. Iyi nzira yekurapa yainzi "cytokine therapy." Icho chiri kuburikidza nekudzidza kwe oncoimmunology iyo nzira iyi yakasiyana yekurwisana nechirwere ichi yakaonekwa.

Chii chinokonzerwa ne oncoimmunology?

Mumuviri wedu masimba ose anoiswa kuitira kuti iye pachake aigona kurwisana nehutachiona uye matumbo. Nheyo huru ye oncoimmunology ndeyekukurudzira kwemuviri wezvidziviriro kurwisana nechomuviri. Masayendisiti akacherechedza kuti maitiro ose anonyangadza anowirirana nehutachiona hwemuviri hwemuviri. Zvirwere zvedu zvezvirwere zvinosanganisira:

• Masero akasiyana-siyana eropa, matukisi (macrophages, T masero, B-cells, masero dendritic , nezvimwewo);
• Zvigadziriswa zvinhu zvinowanikwa munzvimbo ye-intercellular, iyo inotumira zviratidzo kubva pane imwe sero kuenda muchitokisi uye inoita basa rinogadzirisa.

Mushure mekunyatsoongorora kwechiitiko che mononuclear phagocytes, zvakawanikwa kuti vanoita basa rekudzivirira, vane kodzero yekuwana uye kugadzira zvinhu zvekunze. Uyewo, masero aya anoshanda zvakasimba mumatambudziko akawanda emuviri mumuviri.

Mukuvhiringidzika kwemaitiro, phagocytes anobatsira kurwisana nekuputika, kuita chidziviriro basa. Ndiyo masero aya anogadzira puroteni iyo, sezvazvakaitika, kukwanisa kudhinda zviratidzo pamusero wepakati uye kukanganisa masero kuburikidza nemagamuchirwa.

Vane simba rokurwisana nemakumbo akasiyana. Kiriniki ye oncoimmunology uye chirwere che cytokine muMoscow inoshanda uchishandisa nzira iyi yakasiyana yekurwisa kenza. Vanachiremba vakakwanisa kushandisa simba remukati remuviri kurwisa tumarara. Iyi nzira yainzi cytokine therapy. Ndezvipi izvi, funga nezvenyaya.

Chii chinonzi "cytokine therapy" chinorevei?

Chokutanga pane zvose, zvakakosha kutaura kuti zita reyo nzira inobva kune mazita emapurotini e-cytokines, nemhaka iyo yakave yakakwanisa kurwisana nemamota. Therapy, inoshandiswa nekushandiswa kwe cytokines, inonzi "cytokine therapy." Chii ichocho, mapurotini akaita sei asina kujairika?

Cytokine mapurotini anobudiswa muropa, maune immune nemamwe masimba emitambo, anotumira zviratidzo zvekugadzirisa uye anokwanisa kukonzera masero kuburikidza nemakwenzi. Icho chirongwa che cytokine chinonyanya kukosha kuchengetedza nguva dzose uye kuzvidzora kwezvisikwa muhutano hwemazuva ose kana mukukanganisa kwepfungwa. MaCytokine anoparadza chete tumor cells, asi asingagunisi utano hwakanaka. Kubata kwavo mafungiro ehupenyu kwakatarwa zvakare. Nezviito zve cytokines zvinogona kugoverwa mumapoka akawanda:

1. Vanoita kuti kukura uye kuumbwa kwemasero masero eropa.
2. Chengetedza muviri kubva kuhutachiona hwehutachiona uye hwehutachiona nekukanganisa masero macrophage uye granulocytes.
3. Vanokurudzira kukura, kushandiswa uye kusiyanisa kwemarimine lymphocytes.
4. Inobatsira cytotoxic macrophages uye vanhu vemuurayi.

Zvinyorwa zvinoshandiswa zvose pakuonekwa kwezvirwere uye kurapwa, pamwe chete nekudzivirira zvirwere.

Maererano nebasa remasero, zvinokwanisika kuziva rutivi rwakanaka rwechitokine therapy.

Izvozvo zvinoitika zvektokine therapy

Chii chinonzi cytokinotherapy mu oncology? Inogona kupedzerwa nekudzidza kuti chii chinogadzirisa chirwere che cytokine pane mhuka yemurwere.

Funga nezvenyaya dzakanaka dzakakosha paunoshandisa cytokine therapy:

• Kusarudza zvinoitika pamatomu masero uye mastasisita.
• Kuwedzera kwakakosha mukubudirira kwechemotherapy.
• Prophylaxis yekupararira kwemasastases uye chirwere chekare.
• Kupera kunokosha kune zviitiko zvinotyisa zve chemotherapy, kuderera mune zvinokonzera.
• Kurapa uye kudzivirira zvinetso zvinotapukira panguva yekurapa.
• Icho hachisi cheshushi uye chinogona kushandiswa kune varwere vane mazita ekurumbira.
• Inogona kushandiswa pamwechete chemotherapy uye zvakasiyana.

Sezvo tava kunyatsoziva zvinhu izvi zvakanaka, tinogona kufungidzira kuti nezve nzira, yakadai seytokine therapy, kuongororwa kunosara chete mukana mukurapa kenza.

A bit of history

Cytokinotherapy yekurapa kenza inoshandiswa munyika kwenguva refu. Zvisinei, mishonga yepakutanga yakanyanya kutyisa uye yakakonzera migumisiro yakawanda, iyo yaiwanzopfuura kubudirira kwehutano hwakadaro. Saka, muU.S. neEurope, pakutanga kwema1980, TNF-alpha (tumor necrosis factor ) yakatanga kushandiswa. Inogona kushandiswa muchiitiko icho chinokwanisika kuparadzanisa muviri kubva muropa rose nekuyerera nekuda kwehuwandu hwehutachiona. Chirwere ichi chinopararira nemubatsiro wechigadzirwa chekugadzirwa kwepanyama chete munhengo iyo pane chirwere chekutura kuitira kuti kuderedzwa kuratidzirwa kwekusagadzikana kwakaipa.

Kune zvinodhaka izvo zvakashandiswa kwenguva yakareba uye zvakanyatsobudirira, izvi zviri kugadzirira mapoka maviri:

1. Interferon-alpha ("Intron", "Reaferon", nezvimwewo).
2. Interleukins (IL-2).

Iyi mishonga inobudirira chete mukurapa kemaperembudzi uye chirwere chepfungwa. Asi vanachiremba vanoramba vachitsvaka mushonga unogona kukunda chirwere ichi chinotyisa.

MuRussia, mishonga mitsva inoshandisa kliniki ye oncoimmunology uye chirwere che cytokine muMoscow.

Kugadzirira cytokine therapy

Muna 1990, chirwere ichi "Refnot" chakasikwa muRussia, iyo ikozvino inoshandiswa. Yakagadzirwa naVa VA Shmelev, Doctor of Medical Sciences, Yakakosheswa Nhengo ye International Academy of Social Sciences. Iyo mishonga yakabudirira kupedza zviyero zvemakiriniki uye kubva muna 2009 yakabvumirwa kushandiswa mukurapa marudzi akasiyana-siyana emakumbo. Iine zvakakosha zvakasiyana pamusoro pemishonga yakambobudiswa kare:

• Mushonga hauna hutachiona, inenge ka100.
• Iyo inoshanda zvakananga pamasero ekenza kuburikidza nemakagadziro pamusoro pepanyika.
• Endothelial cells uye lymphocytes zvinoshandiswa, izvo zvinotungamirira ku tumor necrosis.
• Ropa rinopa hutachiona huderera, mujeri anogona kupinda mukati mawo ndokuriparadza.
• Mushonga unowedzera basa rekuchengetedzwa kwemishonga ye referbinant interferon 1000 nguva.
• Inowedzera kubudirira kwechemotherapy.
• Inokurudzira basa rekuuraya masero masero, pamwe chete nemasero anonzi antitumor.
• Zvinonyanya kuderedza purogiramu yekudzoka zvakare kune varwere vanorapwa.
• Kukanganisika kwakanaka.
• Hapana madhara.
• Inovandudza mamiriro ose ehurwere.

Sezvambotaurwa, chirwere che TNF-alpha chinonyanyisa uye chinokanganisa chete chinonyanya kukosha chemuviri.

Imwe mishonga inoshanda zvikuru uye inoshandiswa murotokine therapy is Ingaron. Inobva pamushonga weCriferon-gamma. Chirwere ichi "Ingaron" chinokwanisa kudzivisa kubudiswa kwehutachiona hweprotini uye hutachiona hweRNA neDNA.

Yakanyorerwa muna 2005 uye inoshandiswa kurapa nekudzivirira zvirwere zvakadaro:

• Hepatitis B uye C.
• AIDS neHIV.
• Tuberculosis yemapapu.
• Zvirwere zvinokonzerwa nepapillomavirus yevanhu.
• Chlamydiosis is urogenital.
• Zvirwere zvekenza.

Uyewo kuitira kudzivirira zvinetso mukurapa kwechirwere granulomatosis.

Kurapa nekudzivirira kwehutachiona hwehutachiona hwehutachiona hwehutachiona, fenza inoshandisa sarudzo yeInharone yekurapa mucous membrane.

Kana uchitora tumorum, "Inharon" inobatsira zvinogamuchirwa zvekenza masero, izvo zvinoshandiswa ne "Refnot". Nokudaro, mukurapa kwe cytokine, kushandiswa kunobudirira kwemishonga iyi miviri inoshanda.

Chiito cheIngaron ndotevera:

• Inomisa kupararira kwehutachiwana RNA uye DNA mumasero.
• Hazvibvumi kuparadzira intracellular pathogenic viruses, mabhakitiriya, fungi.
• Inowedzera basa re macrophage.
• Inowedzera basa rekuuraya masero masero.
• Kudzorera zvinhu zvinowanzoitika zvemasero emajeri.
• Inoderedza kukura kwekenza masero.
• Icho chinoparadza mamwe marudzi emasero ekenza pamasero emagetsi.

• Inoita kupararira kwemarara midziyo.
• Zvinonyanya kumira kukura kwemarara.
• Kunounza kudzokera kuhutano hweropa.
• Inoderedza huwandu hwepopoproteins.

Mishonga iyi "Refnot" uye "Inharon" yakabatanidzwa zvakabudirira murotokine therapy. Kurapa nenzira iyi kunoitwa nekliniki ye oncoimmunology uye cytokine therapy muMoscow.

Ndiani anogona kubatsira cytokine therapy?

Dzidzo dzakaratidza kuti cytokinotherapy yakaitwa vhiki isati yasvika chemotherapy inobatsira zvikuru kuderedza zvinokonzera kusvibiswa. Kuenderera mberi kwe cytokine therapy mushure mekuita chemotherapy kunodzivirira muviri kubva pakuvandudzwa kwezvirwere, kuwedzera kupesana kwehutachiwana hwehutachiona. Panguva imwecheteyo, kubudirira kwemishonga kuchawedzera zvikuru.

Nzira ye cytokinotherapy inoshandiswa mukurapa kwemakumbo sezvakaita:

• Kanzira yemukirini uye muviri wechibereko.
• Tumors of the mammary glands.
• Mesothelioma.
• Kanza yemaperembudzi.
• Oncology yemudumbu, musikana muduku uye mukuru.
• Tumha yepancreas.
• Chirwere chepoyo.
• Ovary.
• Chidimbu.
• Kanzira yeuropi.
• Chirwere chinosuruvarisa chesophagus.
• Sarcoma yemapfupa uye zvinyoro zviduku.

• Glioma.
• Tumhe dzenheyo yenheyo.
• Kanzera reganda, melanoma.

Cytokine therapy ye granulosa cell tumor is also possible for both prevention and treatment.

Ndiani usingashandisi cytokine therapy nzira?

Tichifunga nezvekuti kugadzirira kweytokine therapy haina migumisiro yechirwere, anenge munhu wose anogona kuishandisa. Zvisinei, kune boka revanhu vanobatwa nehutano iyi inopesana:

• Vakadzi vane pamuviri.
• Nguva yekuzora.
• Mukuvapo kwekusagamuchirwa kwezvinodhaka zvinodhaka, izvo zvisingawanzoitiki.
• Zvirwere zvinodzivirira.

Mhando dzakawanda dzekenza dzinogona kurapwa ne-cytokine therapy, takataura pamusoro pavo kare, asi matumbo ehutachi haagoni kupinda muhuwandu hwavo, sezvo zvirongwa zve-interferon zvakagadzirisa maitiro uye mabasa. Inogona kukonzera kuparadzwa kwemasero uye kuvhiringidza kushanda kwayo. Cytokine inobatsira zvikuru pakuvandudza zvirwere zvinotapukira, zvinosanganisira chirwere chetrojeni. Kuvimba uku hakukwanisi kunyatsonzwisiswa. Ko chirwere chekenza chinogona kuve neAIT chingabatsira cytokine therapy here? Yakave ichangopfuura kuti taura pamusoro peizvi. Sezvo nzira ye cytokine therapy inosanganisira mishonga ine interferon "Ingaron".

Mishonga inogona kurongerwa chete nechiremba-chiremba-oncologist.

Zvikanganiso

Sezvambotaurwa kare, hapana kupindira kwakashata kwakaonekwa. Zvisinei, pachinotora chirwere ichi "Refnot" mune zvisingawanzoitika, pakanga pane kuwedzera kwekushisa kwe 1-2 degrees. Muchiitiko ichi zvinokurudzirwa kutora "Ibuprofen" kana "Indomethacin". Migumisiro yemishonga haigoni kuitika.

Kuongorora nezvechitokine therapy

Zvechokwadi, ndinoda kuziva mhinduro dzevarwere vakaona nzira ye cytokine therapy.

Tichifunga kuti nzira iyi yekurapa inoshandiswa muRussia munguva ichangopfuura uye chete kliniki ye oncoimmunology uye chirwere che cytokine muMoscow chiri kushushikana, pane dzakawanda dzakaongororwa. Vanhu vane mibvunzo yakawanda pamusoro pemishonga mitsva, sezvo kune hunyengeri huzhinji munzvimbo ino, uye mishonga yakadaro haisati yakadhura zvachose. Zvisinei, kune zvingasarudzwa zvemhinduro zvinotarisirwa kutarisirwa.

Saka, somuenzaniso, murume akaonekwa kuti ane kenza yeprostate ye 4th degree. Mushonga wacho wakarambwa nokuvhiyiwa. Vakatendeukira kuchipatara, vakakumbirwa kuti vawane chirwere cheytokine therapy pamwe nehomoni inorapwa. Somugumisiro - kuderera kwechirwere, kusasha kwemasimisita. Sezvatinoona, chirwere che cytokine nechirongwa chechina chekenza chinopa migumisiro yakanaka uye tariro yekudzoka. Uye iyi haisi nyaya yakasarura.

Mumwe mukomana akaonekwa kuti aiva nekenza yekramha. Takadzidza kuti kune kliniki ye oncoimmunology uye cytokine therapy. Kuvhiyiwa kwakasarudzwa, chemotherapy neytokine therapy yakarongerwa. Paiva nemamiriro akanaka. Chirwere ichi chakanyanya kuderera muhukuru, kurapwa kwakaenderera mberi.

Mukadzi wacho akaonekwa kuti ane kenza yemazamu. Munharaunda ye oncology panzvimbo yekugara vakaramba vachiita basa. Mushure mokushanda kune kliniki ye oncoimmunology uye cytokinotherapy, kurapwa kwakarongerwa. Chemotherapy pamwe chete ne cytokines vakakunda chirwere chacho, chifuva chakakwanisa kuchengetedzwa.

Incoimmunology uye chirwere che cytokine nguva dzose chiri kuidzidzwa uye kukura, uye migumisiro yakanaka yekurapa inongova uchapupu hwokuti kurwisana nekenza kune nzira yakarurama. Cytokinotherapy inoita kuti zvikwanise kumira chirwere chacho, kwete kuti chiite kuti chifambire mberi, uye iyi nguva yakawedzerwa uye inoda kushandiswa kuwana mishonga inogona kukurira chirwere ichi chinotyisa. Incoimmunology uye cytokine therapy mazano muzhinji anogamuchirwa chete, izvi zvinoratidza kubudirira kweiyo nzira yekurapa maitiro.

Kuongorora nezvekliniki muMoscow

Kiriniki ye oncoimmunology uye chirwere che cytokine muMoscow inogamuchira mhinduro dzakanaka chete . Vanhu vanocherechedza kutendeseka nekuverenga nekunyora kwevashandi. Simba rekutsigira tsika, kugadzirisa kune mafungiro akanaka uye kutenda mune zvakanakisisa. Mhinduro dzakawanda, iyo inotaura kuti vanachiremba vanokwanisa kurapa kurapa kwevarwere vane simba vane chirwere chekenza 4, apo zviitiko zvezvechikoro zvekare zvinoramba varwere vakadaro.

Uyewo yakanyora nhamba yakawanda yenyaya iyo vanachiremba vakabatsira kuchengetedza nhengo yakagadzirirwa, regai kuvhiyiwa. Zvose izvi zvinotaura nekuda kwepamusoro-soro uye kugadzirira kuuya kununura. Zvakakosha kuziva panguva ino kuti kune nzira yakadaro yekurapa seytokine therapy, chii ichocho uye zvipi zvinogona kuwanikwa kana zvichishandiswa. Izvi zvichapa tariro kuvanhu vakawanda. Chinhu chikuru ndechekurwa uye kutenda mune zvakanakisisa.