"Cymbalta": mirayiridzo kushandiswa. Reviews, mitengo, zviratidzo

Nhasi isu vachakuudza kuti uri mushonga "Cymbalta." Mirayiridzo kushandiswa kwezvinodhaka, ayo akafanana, marwadzo, uye kuverengwa zvichabviswa kurondedzerwa pazasi. Uyewo kubva pasi nyaya, uchadzidza pamusoro fomu umo zvinodhaka kuwanikwa, sei yaiita, kana ane contraindication uye sei kurishandisa nemazvo.

kusunungurwa Form

In chii fomu unogona kutenga zvinodhaka "Cymbalta" mirayiridzo iri akanyudzwa mukati pasuru? Pari mushonga chete kusunungurwa muchimiro enteric capsules. Chimwe nechimwe rine pellets, vane chena kana grayish chena ruvara.

mushonga

Zvii zvinoumba zvinosanganisira zvinodhaka "Cymbalta?" Mirayiridzo Kushandisa capsules rinoti dzavo huru kushingaira maatomu akafanana zviri pfuma duloxetine. Zvinofanira kucherechedzwa kuti nemamiriro vaiona medicament uye anowedzera zvinhu sezvo sucrose, hypromellose, talc, succinate, chena colorant, hypromellose acetate, titanium dioxide, triethyl citrate, gelatin, yavaibvisa lauryl sulfate yellow simbi oxide ruvara.

Capsules ingasanganisira 60 uye 30 MG zvinodhaka. Ivo vari kugara mu Maronda akasiyana 14 kana 7 capsules. Mune imwe atorwa rongedza anogona kuva 1, 2 kana 6 Maronda akasiyana.

Pharmacological zvechadenga zvinodhaka

Ndechipi rinoita fuma zvakadai duloxetine? Mirayiridzo kushandiswa somushonga capsules rinoti kuti yakadaro zvinodhaka ane akati chaikosha zvikuru antidepressant rakanaka. Inguva inhibitor pamusoro reuptake ose norepinephrine uye kweserotonin. Iye zvakaneta kuchititadzisa dopamine uptake uye hapana sungano kuti dopamine, histamine, uye adrenergic receptors holino-.

Sei Duloxetine? Guide rine zvinotevera mashoko panyaya iyi: nheyo zviito pfuma ndiyo kutitadzise reuptake pamusoro norepinephrine uye kweserotonin. Somugumisiro, yekudyidzana kunowedzera noradrenergic uye serotonergic neurotransmission munyika tsinga. Zvinofanira kucherechedzwa kuti duloxetine nokukurumidza dzvanyirira marwadzo.

Pharmacokinetics zvinodhaka

Formulations ari kuora mwoyo iri "Cymbalta" woga kubva nemudumbu, Absorção de Água rinotanga maawa mashomanana pashure kutarisira. The kunonyanyisa pfungwa kunoitwa pashure pemaawa 6. Mawa kugamuchira zvokudya asingadi kukanganisa wevasungwa uye anowedzera nguva kubudirira maawa 6 kusvika 10. Nyanzvi dzinotaura kuti zvisina kunanga akazoita rwakadini Absorção de Água (11%).

Nokusungwa zvinodhaka mapuroteni eplasma zvakakwirira zvakakwana uye rinosvika vanopfuura 90%.

The hafu upenyu zvinodhaka ndiko maawa 12. Panguva iyoyowo achibuda ari weti sezvo metabolites.

Maererano zvidzidzo, pane misiyano pakati pharmacokinetic pezvakaitwa kuti kuitika vakadzi nevarume. Saka, avhareji Clearance yezviri wemafuta pazasi naka pabonde. Zvisinei, dose kugadziridzwa hakusi zvakakodzera.

Zvinofanira kucherechedzwa kuti kusiyana pharmacokinetic pezvakaitwa kuti kuitika varwere vakwegura repakati dzakatangwa panguva kuferefeta. Yakaratidza kuti hafu-upenyu zvinodhaka riri kumusoro vakwegura pane vechidiki. No chipimo chemushonga kuchinja haina kuzvireva kana.

In varwere chisingaperi renal insufficiency mu chinouraya danho, vari pamusoro dialysis, wevasungwa maitiro uye AUC pamusoro duloxetine inowedzera panguva chaiyo 2 nguva. Ndokusaka inokurudzirwa kufunga rinenge ratangwa rinofanira kupera kuderedza uwandu husingakuvadzi zvinodhaka pavarwere vane zvakakomba vanotaura kuti renal ushande.

Varwere zviratidzo chiropa kukundikana kunogona kuderedza muviri uye kubviswa hafu-upenyu duloxetine.

Zvairatidza kuti kushandisa mari

Apo prescribers "Cymbalta?" Mirayiridzo yokushandisa zvinosanganisira zvinotevera mazita kuverengwa:

• chirwere cheshuga neuropathy kurwadziwa chimiro;
• kuora mwoyo uye zvokuora mwoyo inoti;
• generalized kufunganya nyonganyonga;
• marwadzo zvetsandanyama nemapfupa urwere, kusanganisira avo kunokonzerwa fibromyalgia uye osteoarthritis.

Contraindications pakushandisa mari

Kana iwe usingagoni kutora mishonga "Cymbalta?" Mirayiridzo yokushandisa zvinosanganisira zvinotevera mazita contraindications:

• mawa pokushandisa simba FIs ose isoenzyme CYP1A2 (semuenzaniso, enoxacin, ciprofloxacin kana fluvoxamine);
• Inosimudzira aikanganiswa murwere zvinoreva zvinoriumba izvozvo;
• vana pasi makore 18;
• kwenguva pfupi womuchato Mao FIs;
• Chirwere cheBP iri kudzorwa;
• uncompensated kuvhara yemaziso;
• zvakakomba chisingaperi renal kukundikana (pamwe CC asingasviki 30 Rine mamiririta / Nha);
• isomaltase kukanganisika kana saccharase, shuga-galactose malabsorption uye fructose kusashivirirana;
• chiropa nezvirwere izvo pamwe hepatic insufficiency.

Apo inofanira kushandiswa nokungwaririra zvinodhaka

Zvinofanira kushandiswa nokungwarira akati mushonga mu bipolar uye zvokudarikidza, nokugwinha ngozi kurwiswa angled-kuvhara yemaziso. Uyewo, Kutarisirwa anofanira kutorwa kana ocular neBP, kuzviuraya, hyponatremia, chiropa uye itsvo.

Drug "Cymbalta": mirayiridzo kushandiswa

Mutengo chigadzirwa ichi zvakakwirira kwazvo. Zvisinei, kubudirira kwayo haisi pasi chero mubvunzo.

mishonga nechipiriso iri ushandiswe chete nomumukanwa yaitonga. The capsules achamedzwa rose pasina kupwanya kana kutsenga pavo. Zvinofanira kucherechedzwa kuti chero zvazvingava hazvigoni kuwedzera mushonga kana chikafu vanosanganisa nayo chero zvinwiwa, sezvo izvozvo zviri nyore kukuvadza enteric unhani.

Formulations ari kuora mwoyo zvinofanira kutorwa ari kutanga chipimo chemushonga 60 MG kamwe pazuva. Kuti vabudirire nemigumisiro yakanaka mune vamwe varwere kuwedzera akati chitsama kuti kunonyanyisa dose 120 MG kaviri pazuva.

Varwere chirwere renal kukundikana, kunoitika muna chinouraya danho, kutanga chipimo chemushonga pamusoro medicament ndiyo 30 MG kamwe pazuva. Kana varwere chiropa atadze kushanda zvakanaka, kuti akaratidza chitsama zvinodhaka inokurudzirwa kuderedza kana kuderedza multiplicity kugamuchirwa.

Zvinofanira kucherechedzwa kuti kudzivisa chimbichimbi kurega kugamuchira medicament. Huwandu zvinodhaka zvakakodzera kuderedza kwemavhiki zvishoma nezvishoma pamusoro 1-2. Kana ichi kumashure, pane raidudzwa zviratidzo urwere, Zvinokurudzirwa kunorapwa ari akasarudzwa chipimo chemushonga. Zvadaro, chiremba anogona kuramba kuchiderera dose, asi zvishoma nezvishoma.

zviitiko ovhadhozi

Chii vanamazvikokota vanoti pamusoro zvinodhaka ovhadhozi mhosva, "Cymbalta?" Reviews vanachiremba ane mashoko Data akadaro iripo kwavari. To musi, pane zviitiko ovhadhozi kubudikidza ingestion zvinodhaka muhuwandu kusvika 3000 MG, uye kana kubatanidzwa nemamwe nevamiririri. Sezvineiwo, wakaiswa uye mumwe rufu.

Zviratidzo ovhadhozi kana yoga kubatanidzwa zvinosanganisira zvinotevera ezvinhu: clonic kugwinha, somnolence, kurutsa, pakoma, kweserotonin chirwere uye tachycardia. Kana preclinical tsvakurudzo (kwakaita mhuka), chikuru zviratidzo toxicity chokuita kusingadzorwi kugamuchirwa medicament, muri zvirwere zviri nechepakati huta uye zvomudumbu nehurongwa. Uyewo, varwere kuonekwe tremor, ataxia, clonic kugwinha, kurutsa uye kurasikirwa kudya.

Zvokuita nyaya ovhadhozi? With kukura kweserotonin chirwere rinofanira pakarepo kupedzwa kwokururamisa kurapa cyproheptadine, uyewo nzira dzinoshandiswa normalize murwere muviri tembiricha.

The murwere anofanirwa kupa mhepo yakachena. Unofanirawo kuongorora basa mwoyo uye kuongorora zviratidzo zvinokosha. ichi zvose zvinofanira kuitwa pavanoparidza kunhaka rutsigiro uye symptomatic kurapwa.

Kana mushure kwokubatsira mushonga haana refu, zvakakodzera kugeza kunze mudumbu. Uyewo, kuti tizvidzore yaunodya kurapwa murwere akakumbirwa kunwa neactivated charcoal.

divi kushanda

Anogona inokanganisa utano hwevanhu kuti paakapiwa vakati mishonga? Funga divi Migumisiro antidepressant zvinodhaka muudzame:

• Kakawanda (muna 10% nyaya) ari kurapwa zveBhaibheri, varwere vane zvinotevera rinoti: dzungu, kutemwa nomusoro, muromo yakaoma, kushaya hope, kushaya hope, kuda kurutsa, hope uye kupatira.
• Kuderera yose (1 kusvika 10% nyaya) varwere vakanga vakachengeta Flushing, manyoka, madzerere, kurutsa, vangadikitira, tremor, wakawedzera anorgasmia, ungaderedza kudya, kurasikirwa libido, uremu, kurukutika, erectile dysfunction, uye kunonoka kusaririra ejaculation.

Hatigoni kutaura kuti zvakadai divi migumisiro sezvo dzungu (dzimwe nguva nomusoro uye kuda kurutsa), kazhinji kuonekwa chimbichimbi Kudzimwa ane medicament. By panzira, varwere kunorwadza chirwere cheshuga neuropathy siyana vanogona kuwedzera ropa shuga usina chawadya.

Reviews kuti medicament

Maererano nezvokurara, uye varwere vaiona mishonga zvakazara kukurira basa. Pamusoro kukudzwa anobvisa ane mwoyo nyonganyonga, uyewo inosimudzira kunyangarika mwoyo inoti. Uyezve, vanoshingaira medicament tsime Unotsigira marwadzo syndromes munyika zvetsandanyama nemapfupa ino.

Kudyidzana nedzimwe nzira

Zvinoita kuti mushandirapamwe kwokubatsira zvimwe zvinodhaka mishonga "Cymbalta?" Nyanzvi Guest vanoti akati rinoreva chinhu rakananga kukanganisa kubudirira vamwe mishonga.

Saka, pane mukana kweserotonin chirwere, duloxetine kana ikashandiswa pamwe MAOIs.

Nekuti CYP1A2 isoenzyme iri kuitika mu muviri kuti "gadziriro Cymbalta ', kushandisa kwavo mawa kungaita kuti vawedzere kuwanda yokupedzisira.

Not pachii akati medicament pamwe nemamwe zvinodhaka kuti chokuita musimboti tsinga. Uyewo panguva kubvuma kwake haafaniri kunwa doro.

Dzimwe nguva, apo pakushandisa SSRIs uye serotonergic vamiririri Varwere vakacherechedza kweserotonin syndrome. Naizvozvo, unofanira kungwarira zvikuru apo uchishandisa mushonga uyu serotonergic antidepressants.

Nokuda kuti pane vanokwanisa zvakawedzera ngozi ropa havafaniri kushandisa zvose duloxetine uye anticoagulants (antithrombotics).

Achiyamwa uye pamuviri

Ndinogona kushandisa zvinodhaka "Cymbalta", mitengo yakanga zvichakurukurwa mberi, panguva pamuviri? Nokuda kwokushayikwa mashoko yakakwana, kushandiswa nefuma duloxetine panguva gestation mishonga anogona kupiwa chete kana zvinobatsira kuti amai vanepamuviri kwakakwirira zvikuru kupfuura ngozi mwana.

Zvinofanira kucherechedzwa kuti varwere kutora mumiririri uyu anofanira kuva nechokwadi kuti ndizivise chiremba wako pamusoro chiitiko kana kuronga pamuviri.

Ongororo dzakaratidza kuti vakadzi kutora antidepressants ari mamiriro, kunyanya paya matanho, anowedzera zvikuru mukana kuramba pulmonary neBP of vana vachangoberekwa. Panyaya iyi, iyo chirwere vo kakawanda kuonekwa nevana kana akangoerekana vanorega kushandisa mai duloxetine ramangwana pane kunonoka padanho pamuviri. Vazhinji zviratidzo ichi yaiitwa pakukurukura kana pamazuva okutanga pashure.

Nekuti duloxetine anokwanisa kupinda mu mukaka, hazvina chinodiwa kuti breastfeed mwana wako panguva mushonga. Zvikasadaro, wevasungwa zviri pafuma ari mudumbu achava chinhu mari 0,14% of wevasungwa munguva mai.

nhungamiro chaiwo pamusoro kushandiswa kwezvinodhaka

By rakavapa mushonga kuti murwere wake "Cymbalta", chiremba vanosungirwa kuzivisa kuti categorically unorambidza rimwe nguva kubvuma pomutumwa pamwe Mao FIs. Zvikasadaro, anogona kutyisidzira zvinouraya uye dzakakomba matambudziko ose hyperthermia, myoclonus uye akaratidza excitation yokuchinjira pakoma.

Zvinofanira kucherechedzwa kuti wakarambidzwa dzi- akati mushonga kwevhiki mbiri pashure kurapwa Mao FIs.

Maererano zvidzidzo, mune varwere nemanic mamiriro paaishandisa zvimwe zvinodhaka kuti chokuita tsinga, pavanoparidza rinoreva "Cymbalta" anogona achiipa aivapo chirwere.

Nokuti mune mwoyo inoti pane mukana wokuti kuedza kuzviuraya, vanofanira kunyanya kuongorora varwere weboka racho ngozi.

Kugamuchira zvinodhaka zvinogona hazvivanetsi kukonzera hope. Naizvozvo, varwere tora mushonga uyu, unofanira kutora mamwe hanya kana uchityaira uye kana achishanda ngozi kubvongodzwa muchini.

Price uye analogues zvinodhaka

How zvikuru ndivo "Cymbalta" enteric capsules? mutengo wavo dzingasiyana. It kunobva mugadziri uye chemishonga ngetani varikumahombekombe. Zvisinei, zvinofanira kucherechedzwa kuti paavhareji, mushonga inenge 1,050 rubles Russian (30 MG, zvidimbu 14). Kana uchida kutenga mushonga mu zvakaenzana, asi pane imwe chipimo chemushonga 60 MG, uchabva kubhadhara anenge 1150 rubles.

Zvino kuti munoziva zvakawanda duloxetine. mutengo wayo kungawedzera kana kuderera zvichienderana zvimwe zvinhu. Pari kuritenga anonzi mushonga hachisi chinhu matambudziko. Zvisinei, unogona kutenga nayo chete mushonga.

Asi chii kana iwe vamwe chikonzero havana kukwanisa kutenga "Cymbalta" somushonga capsules? Analogs zvinodhaka izvi zvinowanikwa munenge munyika dzose chemishonga. Kunyange zvazvo kuunganidza kuchaitawo zvinoda kuvapo mushonga kubva chiremba.

The mushonga inogona kutsiviwa "Cymbalta?" Vezera ake vangada kunyanya kutaura zvinotevera mishonga:

• "Intro";
• "Azafen" (Mahwendefa);
• "Duloxetine Canon" (Enteric capsules);
• "Venlafaxine Sandoz";
• "Alvent";
• "Mirtazapine Canon";
• "Eprobemide" (mhinduro iri / uye / m);
• "Wellbutrin";
• "Eprobemide" mahwendefa;
• "Agomelatine";
• "Neyroplant";
• "Velafaks";
• "Calixtus";
• "Venlaksor";
• "Vensuert";
• "Dapfiks";
• "Venlift: od";
• "Despres ';
• "Efevelon kutadzisa";
• "Doppelgerts Nervotonik" somunhu mushonga;
• "Inkazana";
• "Efevelon";
• "Coaxil";
• "Esprital";
• "Lerivon";
• "Trittiko";
• "Normazidol";
• "Mirzaten";
• "Tetrindol";
• "Mirtazonal";
• "Remeron";
• "Mirtalan";
• "Pirazidol";
• "Negrustin";
• "Nyuvelong";
• "Noksibel".

The nzira okuchengetera uye sherefu-upenyu

Chii pasherefu upenyu zvinodhaka "Cymbalta?" Maererano mirayiridzo, uye musi kavha, chokushandisa ichi hazvifaniri kutorwa kwenguva yemakore matatu. Muchiitiko ichi kunofanira kuchengetwa panzvimbo yerima apo tembiricha asingadi kupfuudza madhigirii 20.