The mushonga "Metozok": mirayiridzo kushandiswa, analogs uye wongororo

mwoyo chirwere uye tsinga kuvhiringidza yakawanda vanhu. Kubvisa zvirwere izvi, akarayira "Metozok". Mirayiridzo dzokushandisa inokurudzirwa asati kushandisa mapiritsi aya bvunza chiremba uye regai kutora mushonga pachavo, nekuti akanga zvakakomba contraindications zvakasimba. Mishonga iri kubatsira zvirwere angina, zvikuru mwoyo kukundikana, tachycardia, migraine uye zvakafanana zvirwere.

mamiriro

Mushonga inzira "Metozok". Mirayiridzo zvokushandisa rinotsanangura nemashoko akadzama Zvinoumba mahwendefa.

A medicament ane chipimo chemushonga 25 MG dzine 23,83 MG kuti vanoshingaira chirungiso metoprolol tartrate, 50 MG anenge 47,66 MG kuti basa chirungiso uye 100 MG - 95,32 MG.

Adjuvants rinoumbwa mishonga ndivo: hypromellose, ludipress LTSE, povidone, colloidal nesilicon dioxide, magnesium stearate.

Hwendefa bemhapemha rine pfuma akagadzirira akagadzirwa "Opadry II», icho kupendwa orange. Zvinosanganisira zvinoriumba akadai polyvinyl doro, talc, macrogol, titanium yakasviba, yellow simbi oxide coloring, tsvuku uye dema, uye indigo.

Mahwendefa vanomiririra-refu achiita mushonga a, ivo akafukidzwa nechiedza-nyoro mumuhara. Ko tenderera, convex kumativi ose.

Dragee ari uwandu zvidimbu 30 vari kugara mupurasitiki mabhodhoro uye 10 zvidimbu zviri aruminiyamu Maronda akasiyana. The kabhodhi bhokisi rine Maronda akasiyana matatu.

Mugadziri "Metozoka" riri Russian kambani JSC "Akrikhin".

Pharmacological chiito uye farmadinamika

Anoreva cardioselective beta1-blocker piritsi "Metozok". Mirayiridzo yokushandisa tsanangura zvachose pharmacological zviito zvinodhaka. The mushonga haana Kamudzira pakudzikamisa zvivako uye sympathomimetic basa. Anozivikanwa antihypertensive, antianginal uye antiarrhythmic chiito.

rakawandisa β1-adrenergic receptors DZEMUNHU DZINODZORA mwoyo, lowers activation kuti catecholamine remubatanidzwa kumusasa ATP Small, waanodzikisira kuitika mukati karusiyamu ions, anoumba akaipa chronotropic, BATM, dromo- uye inotropic nemigumisiro. Pakutanga zvinodhaka kunowedzera zvinonyatsorehwa nemishonga midziyo. Izvi imhaka kurudziro iri α-adrenoceptor ichivharira uye β2-adrenoceptors. Pashure pemazuva mashoma (1-3), murwere anodzoka kuna yepakutanga, asi pamwe kurapa kwenguva refu kunoderedza peripheral vascular nemishonga.

Antihypertensive Impact kunoitika nokuderedza uwandu aibuda ropa miniti, uye renin yeimwe kuburikidza chinovhiringidza basa renin-angiotensin-aldosterone nerevane nechepakati tsinga, uyewo Kwemitambo susceptibility pakati baroreceptors ari kutsemuka chematenga, uye pakupedzisira akaderedza peripheral tsitsi nenhamba. Zvinoderedza kwakakwidziridzwa BP iri yokuzorora ezvinhu. Pressure rutapudzo kunoitika munguva kurovedza muviri uye mupfungwa mupfungwa. The antihypertensive kushanda rinovapo kwenguva inopfuura zuva.

Antianginal pfuma kunooneka vasanyanye myocardial okisijeni zvinodiwa, izvo pakupedzisira kunoderedza kwemwoyo uye tsandanyama susceptibility kufurirwa tsitsi innervation. It kunoderedza uwandu yokurwiswa angina pectoris uye kudzikira dzavo refu. Vakawedzera vasiri basa munhu. Nokuda Zvakawanikwa Kupedzwa diastolic nevamwe ventricle rworuboshwe uye elasticity tsandanyama zvose ventricles kunowedzera kudiwa okisijeni iri vanhu vachitambura nomwoyo kukundikana.

Antiarrhythmic zvazviri kunokwanisika kudzvinyirira arrhythmogenic kuratidzwa kuti akataurwa sezvo tachycardia, BP uye zvakafanana. D. kunoitika chaisatarisirwa rutapudzo pamusoro ectopic excitation uye sinus mutinhimira, uye chinovhiringidza kuti AV-anoitisa.

In pamberi tachycardia, supraventricular uye sinus zvakaumbwa Detective atrial fibrillation, thyrotoxicosis nezvimwe zvirwere dzichipfekeka cardiac mudziyo zvinoderedza mwoyo mwero, izvo dzimwe nguva kunoita kuti kudzorerwa sinus mutinhimira.

The mushonga ndiyo yakanaka prophylactic pamusoro migraine.

Sokushandiswa nepakati kuchirapa mishonga, hakuna raidudzwa zvainoita nhengo pamwe β2- adrenoceptors uye hapana zvazvinoita metabolic pezvakaitwa ari kabhoni muviri. Its zvazviri zvakafanana mugumisiro "Propranolol".

Kana muchigamuchira mushonga kwemakore, unogona kuderedza huwandu remafuta akawandisa muropa. Kana muchigamuchira mishonga zuva nezuva 100 MG zvinodhaka kunokanganisa panguva imwe chete kuti vose β-adrenoceptor subtypes.

"Metozok" (mirayiridzo Chinyorwa kunouya mapiritsi) ozeyewa ne 95%. Mwero soluble mune mafuta. Rinobatanidzwa yomuzana vanopfuura muviri uye bioavailability ndiyo 50% panguva kutanga kushandiswa mishonga uye 70% - zvinotevera nzira. The kunonyanyisa wevasungwa munhu fuma muropa vakachengeta pashure maawa 6-12 pashure ingestion yacho piritsi. Mukuita dzamarudzi kurapa zvishoma nezvishoma anowedzera bioavailability. Zvokudya kunowedzera bioavailability kusvika 40%.

Active fuma 10% richibatanidza neropa mapurotini. Pane kukurumidza wefodya mukati uye chinopinda muropa-uropi mhinganidzo, ari placenta. Mumwe chikamu zvinoenda zamu mukaka.

It rinoita muna chiropa, uye vaviri metabolites huru dzinoratidzwa ne Beta adrenoblokiruyuschey mabasa. The muviri zvinodhaka zvaisanganisira isozyme CYP2D6.

The hafu-upenyu Avharenji maawa 3.5-7. The mushonga haisi aburitswa muviri panguva hemodialysis.

Muuzhinji metabolites varipo vari varwere CC 5 Rine mamiririta / min., Uye iyi, ayo Beta-adrenoceptor ichivharira basa hazvirevi kuwedzera.

The bioavailability yakawedzera pamwe chiropa chirwere cirrhosis. Rinotaurawo kwakaderedza nhamba Clearance.

"Metozok": zvairatidza yokushandisa

Testimonials vanoti kugadzirira ichi anobatsira tachycardia, kuderedza cardiac marwadzo uye nechokumusoro utano. Zvairatidza kuti lozenges ndiyo BP, mwoyo nokukundikana uye chirwere chimiro, iri muripo rwakazara. Mukupera zvazvingava, mushonga inokurudzirwa kushandisa pamwe nedzimwe nzira chinangwa yakaoma.

Nachiremba cardiac ischemia mushonga "Metozok". Zvairatidza kuitika yokurwiswa angina (mudanga chimiro) achidzikisa hunofa zvinoderedza mukana wokuti apiwa infarction, vachitevera rikwanise noutachiona.

The mushonga pachii mwoyo nokukundikana muviri mutinhimira, supraventricular tachycardia kana ndiripo, kuderedza kakawanda marwadzo vose ventricles panguva atrial fibrillation uye ventricular arrhythmia.

The mushonga unoshanda kuti dzichipfekeka kusagadzikana mwoyo, ayo achiperekedzwa kwazvo tachycardia. It rinowanzoshandiswa ekudzivirira migraine. Rakanga yakarumbidza kugamuchira mushonga "Mezotok" zvairatidza. Zvinotevera hurukuro chinoongorora contraindications.

Contraindications pakushandisa

Chero zvazvingava wakarambidzwa kutora mushonga ravo voga pasina chiremba mushonga. Mahwendefa hadzina nezvaro cardiogenic kuvhunduka uye AV-blockade II-III nekuomarara. Usashandisa kushandisa sinoatrial chinogumbura uye sinus kurwara syndrome. Inoshanda kurambidza kushandiswa bradycardia (50 u. / Min) mwoyo kukundikana chakasimba uye chisingaperi decompensated. Contraindicated "Metozok" (User rinotsanangura muudzame kushandisa zvose zviri pamusoro medicament) kuti hypotension, myocardial infarction, riri kusachengeteka kukuru padanho kukura, zvikuru asima, feohromotsite, nenyonganiso ose peripheral kutenderera. Zvakasimba zano kwete nokubatanidza mapiritsi pamwe Mao FIs uye intravenous majekiseni "Verapamil".

Hazvina zvakafanira kushandisa mushonga vana, vane zera harina asvika makore gumi nemasere okuberekwa, paanenge achiyamwa, vanhu vane kusaziva uye lactose kusashivirira, uyewo malabsorption chirwere, hypersensitivity kuti Beta-blockers, kusanganisira metoprolol kuti.

Zvokungwarira ushandiswe medicament kana chirwere cheshuga, I dhigirii AV-nechigumbuso uye Prinzmetal angina. Kungwarira akonzera metabolic acidosis, chirwere pamwe Árbol asima uye pulmonary chirwere, chiropa uye renal hurongwa. Zvinenge hapana akamuraira mushonga myasthenia, feohromotsite, hyperthyroidism, kuora mwoyo, psoriasis, malfunctions ari peripheral riparadzirwe, panguva yepamuviri uye vakwegura.

miedzo Clinical vakadzi vaiva nepamuviri kubatsira kunoita mushonga kunge inoitwa. Panewo pasina mashoko pamusoro rwakadini kupinda zvinodhaka kupinda mukaka. Naizvozvo, panguva nevana uye lactation mahwendefa pamberi kushandiswa zvakakodzera kuti chiremba.

"Metozok": mirayiridzo kushandiswa

Reviews nevamwe varwere kushuma kuti mushonga inogona kukonzera marwadzo muchimiro kuneta. Saka zvinokosha kuti kutevera mitemo uye kugamuchira inokurudzirwa dose. Kana chiremba asina kumusarudza kubatwa nomumwe, unofanira kunwa pane chaiwo mhosva piritsi "Metozok". Mirayiridzo dzokushandisa anokurudzira kushandisa mushonga kamwe zuva mangwanani, pasinei kudya. Dragees hadzina rikamunya muchindwi uye ndikandoshamba pasi zvishoma mvura. Kuti tidzivise bradycardia, ari dose mishonga iri kuwedzera zvishoma nezvishoma.

In pamberi angina uye BP, kurapwa ndiye anosarudza pamwe 50 MG pazuva. Kana chaizvoizvo haina kubudirira, nezuva dose yakanga yawedzera kusvika 100-200 MG / zuva, uye BP - mune zvimwe zviitiko - kurapa mukwanisi imwe mishonga antihypertensive.

Nokuti vanhu vane chirwere chemwoyo kirasi II maererano NYHA kupatsanura, pasina rikwanise Danho kwemwedzi mitanhatu uye pasina kuchinja mabatiro pamusoro okupedzisira gumi mazuva, akapa kutanga dose 25 MG kamwe pazuva. Papera vhiki mbiri, kana zvakakodzera zuva dose yakawedzera kusvika 50 MG, uye ipapo, pashure mamwe vhiki mbiri, - kusvika 100 MG uye imwe nguva (mazuva 14) yakawedzera kuti 200 MG.

Apo III-IV chisingaperi congestive mwoyo kukundikana, kurapwa ndiye anosarudza ane mugiredhi 12,5 MG kamwe pazuva uye chete pashure pemavhiki maviri nhamba yakawedzera kusvika 25 MG uye zvichingodaro - kusvikira kufadza-zuva dose kuti 200 MG. With chirwere ichi mu varwere nokuwedzera kuchirapa dose inofanira kuva pasi pedyo zvokurapa penhungamiro, sezvo mamiriro ezvinhu anogona achiipa vamwe varwere.

Shandisa mushonga pashure akadzokorora kudzivirira myocardial infarction uye mwoyo nokukundikana mwero iri mishonga zuva dose 100 MG.

Varwere dzichipfekeka kusagadzikana mwoyo, umo kunewo tachycardia, mumwe mushonga waakaudzwa 50 MG pazuva. Kana zvakakodzera, nezuva dose yakawedzera kusvika 200 MG.

Kuti adzivise migraine zvinodhaka inokurudzirwa kunwa pa 100-200 MG pazuva.

Regai kuchinja kuchirapa dose vakwegura uye varwere renal kukundikana vari hemodialysis.

chiropa chirwere sei kubviswa metoprolol kubva mumuviri, saka muchiitiko ichi, panguva kurapwa iri kugadziridzwa kuchirapa dose, zvisinei murwere ezvinhu.

ovhadhozi

Zvakakosha vanyevere uye chete pasi yachiremba akarayira kutora mapiritsi "Metozok". Guide anorondedzera contraindications umo negashiro zvinodhaka hazvibviri. Nyanzvi vanosimbisa kuti asiri zvaidiwa nemitemo mishonga uye kugamuchirwa zvingaitika overdosing, icho pamwe ventricular extrasystole uye tachycardia, kunzwa Kutambudzika musoro, maoko nemakumbo, uyewo kuwedzera BP.

Treatment ari kuitwa intravenous majekiseni Arifa-blockers uye Beta-blockers uye.

nemishonga

Sezvambotaurwa, pane dzimwe nguva, apo achitora chinodhaka, "Mezotok" vanogona marwadzo. Maererano murwere, zvingava kuwedzera BP, wakawedzera kwemwoyo, ventricular fibrillation, cardiac arrhythmia, uye bradycardia kardialgiya.

Pamusoro chikamu Central tsinga dzungu inogona kuchengetwa, asi asingazivi kunzwa kutya, kuzvidya mwoyo, hope nenyonganiso, nomusoro, tsandanyama chinyamunhari chinorwadza, chakamira pakunodengenyeka zvine, chepfungwa ropa, paresthesia.

Nokuti vamwe zvirwere divi, kutonga nezvinooneka wongororo navanachiremba vavo varwere vari zviratidzo zvakadai ganda rakachenuruka, ischemia ganda munharaunda yacho jekiseni, nezvimwe zvinhu, necrosis, pakafunuka pamusoro pemvura zvinyama pashure kwokubatsira subcutaneous majekiseni.

Kana nemishonga, Council akasimudza zvinodhaka "Metozok" mirayiridzo Chinyorwa. Analogs zvinodhaka izvi kuchakubatsira kusarudza kurapa chiremba.

Zvokungwarira

Ko chaizvo zvinokosha kugadzwa zvinodhaka "Metozok" zvairatidza. Analogs anoshandiswa kurapa zvirwere izvi hazvisi kudaro isingawanzowanikwi. mapiki dzavo nyanzvi, vachinyatsoongorora dzinoongorora ezvinhu omurwere, iri chiitiko kuti "Mezotok" nokuti vamwe chikonzero havana kufanira.

Mumazana kurapwa inofanira kunyatsoongororwa zvazvaiita kuti zviratidzo pamusoro ECG, BP, kufamba kweropa mumaoko nemakumbo, uyewo cardiac goho.

In varwere chirwere cheBP uye congestive mwoyo kukundikana, zvinokosha kuti tirambe systolic BP pa 30-40 mm HG. Art.

Kana kuwedzera BP, achiteverwa zviratidzo tachycardia kana bradycardia, dzimwe nguva pane disruptions ose cardiac mutinhimira. Pakadaro, kurapwa pamwe "Metozok" (Chinyorwa anonyevera pamusoro zvingakonzerwa nemishonga) inofanira kumiswa. Kuti tidzivise kuderera yechipiri BP pashure caffeine zvinodhaka, asi dose iri zvishoma nezvishoma shoma, kunyanya kana paiva kwenguva refu aizomupa, inodonha uye tichiisa murwere kana kumanikidzirwa ipfupi kuti kukosha 70-80 mm HG. Art.

In vanhu vakwegura nhamba adrenergic receptors, anonyanya kubatwa phenylephrine kunodzikira. Uyewo, monoamine oxidase FIs, kuwedzere compressing mugumisiro sympathomimetic, kutsamwisa marwadzo ari musoro, arrhythmia, kurutsa dzepanguva, vane chirwere cheBP dambudziko. Somugumisiro, varwere vachishandisa monoamine oxidase FIs, nokuti mazuva 2-3 kuderedza uwandu sympathomimetics.

Panguva iyoyo, vanachiremba havana kutokurudzira kosi mishonga iri ngozi basa, iyo inobva maitiro nokukurumidza - zvose nepfungwa uye vasiri.

Nokungwarira yokunyanyisa vanofanira kunwa mapiritsi munhu chirwere cheitsvo, uye vakwegura. The mushonga haafaniri kutorwa vana pasi gumi nemakore nokuda kushayikwa ruzivo zvachinokonzera.

The mushonga asunungurwa Pharmacies kunoparirwa mushonga.

Analogs medicament

Zvakadini kana "Metozok" risisina kukodzera vamwe chikonzero? Analogs anogona kugara pana chemishonga. Vane zvakangofanana vanoshingaira fuma uye nenzira iyi sei muviri. mishonga Idzi dzinosanganisira:

• "Betalok".
• "Serdol".
• "Egilok C".
• "Vazokardin kutadzisa."
• "Metoprolol".
• "Korvitol 50".
• "Metokard".
• "Emzok".
• "Atenolol".
• "Lidalok".

Izvi uye zvimwe chinotsiva "Metozok" analogues zvave vakabudirira kushandiswa pakurapa zvirwere zvemwoyo. mari All zvinoda zvakakomba nzira, uye haigoni kubatwa pachavo, pasina chiremba mushonga.

Testimonials

Kugadzirira "Metozok 'ratings ndiyo vacho zvakanaka. Vanhu vanoti zviri vakasununguka kunwa (zvavakabvumirana dose ndiyo - rimwe piritsi pazuva). Ivo nezvazvo hune kushanda. Varwere vakawanda vanoti kuti mushure kunwa zvinoreva vanokanganwa pamusoro marwadzo mumwoyo mangu.

Nyanzvi mune zvokurapa zviri vakarumbidza zvakasimba mapiritsi "Metozok". Reviews kuvarapi zvinoratidza kuti mushonga unoshanda uye yakachengeteka, saka chinowanzoonekwa chairayirwa cardiologists varwere vavo. Nyanzvi dzinoti panguva kurapwa chinhu chikuru - kusarudza zvakarurama chipimo chemushonga, zvimwe unogona kuona divi migumisiro akadai kuneta, kuda kurutsa, kurutsa uye manyoka.