The mushonga "Chlorpromazine": wongororo vanachiremba, mirayiridzo kushandiswa, akafanana uye tsananguro

Antipsychotic zvinodhaka - a psychotropic zvinodhaka, yakaitirwa kuti mishonga pfungwa zvirwere. Zvinofanira kucherechedzwa kuti chinyakare zita mishonga yakadaro - neuroleptics. zvinodhaka izvi zvinogona zvinobudirira kufurira zviratidzo zvakadai zvinovadadira, neunyengedzi, aone zvinhu zvisipo, vakafunga wenyonganyonga, pfungwa yokushatirwa, mufambiro nyonganyonga , uye zvichingodaro. D. Muzvitsaurire chete zvinodhaka izvi zvinogona kuitikawo chiremba.

The kupfuura mukurumbira antipsychotic zvinodhaka anoita "Chlorpromazine". Mirayiridzo yokushandisa, mutengo, ongororo, analogs, contra-zviratidzo uye mushonga dzinoturwa pazasi.

Zvinoumba, tsananguro, chimiro

Wakadiniko tinoberekwa mushonga "Chlorpromazine"? Instructions, nhoroondo dzinoshuma kuti zvinodhaka izvi yaitengeswa muchimiro brownish-Pink mapiritsi, uyewo mhinduro intravenous uye intramuscular yaitonga. The kushingaira fuma zvinoreva mashoko ari chlorpromazine hydrochloride. Uyewo, zvichienderana kusunungurwa fomu ane zvakasiyana-siyana Extras.

pharmacological zvinhu

Chii chinoshamisa zvinodhaka "Chlorpromazine"? Mirayiridzo yokushandisa, mhinduro dzinoratidza kuti ichi chinhu antipsychotic mumiririri, akabata pharmacological boka rayo rinoreva neuroleptics. It ane hypotensive, antiemetic uye antihistamine nemigumisiro.

The vanoshingaira wemafuta kwezvinodhaka ichi rinobva phenothiazine. Kuwedzera ehupfumi izvi vanoshingaira medicament ane kunyaradza, hypothermic simba, antipsychotic, zvomunharaunda kunovhiringidza, vasodilating uye zvine mwero M-anticholinergic anokonzerwa.

Antipsychotic mugumisiro wacho chishandiso zvinoitwa ichivharira dopamine D ₂ receptors uye mesolimbic nehurongwa Mesocortical. Ndapera nokuda ehupfumi zvinodhaka kwakadaro anokwanisa kubvisa fungidziro, zvinovadadira uye zvimwe zviratidzo zvibereko pakati psychosis.

Zvinofanira kucherechedzwa kuti "Chlorpromazine", wongororo iyo dziri pasi apa, anobatsira-siyana psychomotor nokusagadzikana, utsinye uye kunoderedza kwokuomerwa pfungwa kutya.

Kunyaradza mugumisiro zvinodhaka zvinoitwa rakavhara adrenergic reticular chemishonga kuti dziri munzvimbo brainstem.

ehupfumi zvinodhaka

Ndezvipi ehupfumi kuri muna medicament "Chlorpromazine"? Reviews akashuma kuti zvinodhaka izvi mwoyo zvainoita vakaumbwa dzepanguva basa, relaxes ari skeletal tsandanyama, kunoderedza vaingoerekana gwenya basa, kunoderedza aikanganiswa endogenous uye exogenous kuitika pamwe vachiwana pfungwa. Kushandiswa guru mishonga zvinodhaka kunokonzera kwazvo hope.

Blockade of vagus etsinga iri nemudumbu uye dopamine _D2 receptors riri emetic rukungiso mapazi uye muzinda zvinopa antiemetic mugumisiro zvinodhaka. Zvinofanira kucherechedzwa kuti chivako ichi hahuna kuchinja M-cholinergic receptors. Uyezve, ayo iziviswe chaizvoizvo aona kuti Alpha-adrenergic receptors.

Zvakaitwa zvinodhaka

zvinodhaka "Chlorpromazine" sei kushanda? Reviews vanoti chokushandisa ichi anokwanisa kubvisa zvachose zvinokonzerwa vakanga anokonzerwa epinephrine. Its hypothermic migumisiro nokuda blockade pamusoro dopamine receptors kuti dziri munzvimbo hypothalamus.

Viewed mushonga lowers BP, kwemwoyo kunowandawo, ane simba antihistaminic kushanda uye akaratidza kataleptogennoe chiito, uye kunoderedza permeability yacho rirambe richibvira masvingo.

Nokuti intramuscular Kutarisirwa ari medicament kunokonzera nyaradzo mumaawa ¼, uye pashure kunanzvana Kutarisirwa - maminitsi pashure 120. Patient achishivirira kuti kunyaradza uye hypotensive kushanda ikabuda munenge imwe vhiki.

Kana ukapiwa mishonga iyi muruoko rwake antipsychotic ehupfumi zvine zvazvinoita pane 4th kana 7th zuva. The kuchirapa mugumisiro zvinodhaka runogara inenge 2-6 mwedzi.

The pharmacokinetics zvinodhaka

Ko "Chlorpromazine" vakanwa? Reviews anoshuma kuti nomuromo chlorpromazine kutsanya asi haana kunyura chose kubva zvomudumbu hurongwa. kuwanda Parainge ropa kubudirira pashure 4 h.

mushonga uyu kaviri tanga ichipfuura chiropa. Naizvozvo wevasungwa kwayo muropa mushure waiita Kutarisirwa iri shoma zvikuru pane wevasungwa pashure intramuscular yaitonga.

The mushonga rinoita ari chiropa kune vakaneta uye tichishingaira nomukaka.

Chlorpromazine ane mukuru chisungo kuti mapuroteni eplasma. Zvinonzi rinoparadzirwa mumuviri murwere, rakapinza kuburikidza BBB.

Hafu-upenyu vanoshingaira zvinhu zvinodhaka riri maminitsi anenge 30. Nokudaro kubviswa nomukaka aro ave yakareba.

Akaratidza medicament vaiona pamwechete weti uye bile.

Drug "Chlorpromazine": zvairatidza yokushandisa

Reviews akashuma kuti mushonga wacho zvinowanzoshandiswa vepfungwa tsika. Zvinonzi ushandiswe pakurapa kugadzikana mune munhu schizophrenia. Uyewo, mushonga uyu rinoshandiswa chisingaperi psychosis, chenjera delusional inoti, hypomanic mafaro, kushaya hope, psychopathy, mupfungwa chirwere, kufunganya, kutya uye kuzvidya mwoyo.

Kuwedzera zvinhu dzakanyorwa zvairatidza kuti kushandisa zvinodhaka ichi ndiwo: Kuramba hiccups, zvinwiwa psychosis, chin'a kurutsa uye zvikuru svoto. Kana paine marwadzo zvinodhaka runogonesa migumisiro analgesics.

Zvinofanira kucherechedzwa kuti nzira basa munyaya nezvirwere izvo pamwe yakawedzera tsandanyama matauriro, tetenasi (sezvo mubatanidzwa kurapa pachiimbwa barbiturates) uye pashure zvakasiyana kuvhiringidzika chepfungwa wechiGeorgian.

Kwete kare, mushonga uyu rinoshandiswa kuti chakagadzirwa hypothermia anoumbwa lytic wemisanganiswa. In anesthesiology mishonga iyi kakawanda nachiremba nyaradzo uye zvayo yokutindivadza potentiation.

In dermatological tsika "Chlorpromazine" (mhinduro wevarwere pamusoro mushonga vari kunyanya zvakanaka hunhu) rakashandiswa yokufunuka dermatoses. Uyezve, unogona kushandiswa pakurapa rikwanise porphyria hunhu.

Contraindications

Mune zvimwe zviitiko, kwete ushandiswe antipsychotic "Chlorpromazine"? Reviews vanachiremba kushuma kuti chokushandisa ichi haina kushandiswa comatose anoti chero kupi, uyewo varwere zvikuru kudzvinyirirwa tsinga, zvikuru mwoyo chirwere uye vascular kusashivirirana kuti kushingaira fuma, kunoramba chirwere uropi uye musana systemic hunhu uropi, maronda maronda ari nemudumbu uye panguva zamu dzichifura.

Tichifunga mukuru pangozi hepatotoxic siyana, zvinoreva ndishandise nokungwarira akanyanyisa mu chidhakwa. The Ndozvakaitawo kenza yemazamu, ropa dyscrasias, hyperplasia isiri yekenza kweprostate gland, yemaziso, akadzivira-chimiro, Parkinson, chirwere chepfari, myxedema, kurutsa, cachexia, Reye chirwere uye vakwegura.

Drug "Chlorpromazine": mirayiridzo kushandiswa

Mahwendefa ratings ayo akapa hereinafter, anoshandiswa vepfungwa tsika kutanga zuva chipimo chemushonga akaenzana 25-100 MG. mari iri muzvikamu 1-4 mishonga. Nokufamba kwenguva, kuwedzera dose ose mazuva mana 25 kana 50 MG kuti vabudirire zvinozoita.

Mwoyo preoperatively kushingaira zvokunwa zvinodhaka kwemaawa 2-3.

Kufadza kuroorwa dose kuti mumiririri uyu 300 MG, uye nezuva - 1,5 d

Maererano mhinduro, izvozvo chinotarisirwa nomutsinga kana intramuscularly. Initial chipimo chemushonga zvinodhaka izvi 25-50 MG.

zvakanga Asati kwokubatsira mushonga rakasanganiswa 2,5 ml yavaibvisa chloride mhinduro kana procaine. Majekiseni kuita yakadzika intramuscular jekiseni.

Kufadza kuroorwa dose kuti mumiririri uyu 150 MG uye chamazuva - 1 g Kana intravenous kutarisira tsika idzi anoenderana 100 uye 250 MG.

sadikanwa migumisiro

Achiita chero divi migumisiro "Chlorpromazine" (Mahwendefa)? Reviews akashuma kuti nzendo kurapwa mangwanani mishonga iyi inogona kukonzera muromo chakaoma, paresis akkommodasie, frigidity, wakawedzera hope, kupatira, hope zvirwere, dzungu, havachanyatsogoni kudya, tachycardia, akaratidza chimiro orthostatic hypotension, Urinary chengetedzo, akaderedza potency, chisimbwa uye kuwa BP.

Refu kurapa pamwe zvinodhaka izvi zvinokonzera tsandanyama chinyamunhari chinorwadza mutsipa uye rurimi, neuroleptic mwoyo Akinetes-vanachandagwinyira chakajairika, extrapyramidal zvirwere, amenorrhea, akathisia, kunonoka paakasangana mikana yakawanda yokukurudzira siyana, hypercoagulability, kurutsa, mupfungwa kuchinja, cardiac arrhythmia, pigmentation ganda, chinovhiringidza kuti mwongo hematopoiesis , gynecomastia, cholestatic jaundice, galactorrhea, giperplolaktinemiyu, oliguria, manyoka, uye neuroleptic akaipa syndrome. With intravenous aizomupa phlebitis vakaumba uye intramuscular - infiltrates.

chaizvo kurumbidza

Zvipatara zviri chokushandisa ichi zvinoda kungwarira kudzora BP, kupomba, mudzimu itsvo chiropa.

mushonga uyu zvinogona kukonzera photosensitivity, uye saka panguva kubvuma kwake inokurudzirwa kudzivisa nezvemidzimu.

Analogs uye mutengo

Mutengo mishonga iyi zvinoenderana nokubudiswa fomu. Kavha 10 ndiro zvinogona kutengwa nemari 60 rubles, apo yakafanana nhamba mahwendefa anenge 150 rubles.

By analogues zvinodhaka ichi zvinosanganisira "Chlorpromazine hydrochloride" uye "Tisercinum".

Reviews

Maererano nenyanzvi vaiona medicament ane simba antipsychotic zvazviri kubvisa zvose zviratidzo psychomotor nokusagadzikana. Zvisinei, zvinofanira kucherechedzwa kuti ichi chinoreva ongororo dzakasiyana hunhu.

Vamwe varwere vanoti mushonga uyu uri kubatsira cheAlzheimer, schizophrenia, psychosis, pfari, uye tsime-anobatsira kufunganya uye kuzvidya mwoyo. Vamwe vane vatengi vanodavira kuti vaiona mushonga chinokurwadzai pave zvipusha nezvipusha, ruoko-kuzungura, siyana unhu zvirwere uye kunyanya Kurara mamiriro.

Chero zvazvingava, chingamubatsira ichi vanofanira chete kushandiswa sezvo nechinangwa uye pasi kutarisira kupinda chiremba.