The mushonga "Carboplatin": mirayiridzo kushandiswa, analogs uye wongororo

Chii chinogona kutsiva zvinodhaka ichi se "Carboplatin"? Analogs zvinodhaka ichi chichange pasi apa. Uye zvinhu ino zvichakurukurwa mashoko pamusoro kushandiswa zvakarurama akati mari, ayo zviratidzo, nemishonga uye contraindications.

Kuronga description, pezvakaita medicament

In chii chimiro aripo zvinodhaka "Carboplatin"? The mugadziri anoti kuti mudziyo inogona kutengwa somunhu chena lyophilized upfu akaronga kuti gadziriro ane intravenous mhinduro. Its vanoshingaira chirungiso ndiye carboplatin, uye mamwe - mannitol.

In kutengeswa jekiseni Kuisa pfungwa pachinhu chimwe "Carboplatin", murwiyo zvatakapfidza kukurukurwa pamusoro, anouya nehombodo kuti inoiswa makadhibhokisi kavha.

pharmacological ehupfumi

Chii chinodhaka "Carboplatin"? Mirayiridzo yokushandisa, inofambiswa mashoko yakaoma inorganic remubatanidzwa ine weheavy metal akadai Platinum.

Nyanzvi dzinoti mashandiro chiito kuti chokushandisa ichi imhaka kukwanisa kwayo kusunga kuti DNA. Somugumisiro, yakaumbwa vnutrispiralnye crosslinking kuchinja DNA marongerwo uye tunodzivisa kwetunhu kwayo. A ndozvinoitawo kunoitika pasinei sero kutenderera danho. Zvinofanira kucherechedzwa kuti hydration carboplatin, panguva iyo yakaumbwa kushingaira chimiro zvinodhaka riri nomumugwagwa kwaitora nguva zvikuru kupfuura hydration pakati cisplatin.

Kinetic parameters of medicament

sei Muviri womunhu "Carboplatin" kuparadzira zvinodhaka? Mirayiridzo dzokushandisa inoti kuti pashure chete kwokubatsira mumiriri ichi muchimiro aizomupa (iv) maminitsi 60, muropa wevasungwa chokuzvisarudzira (i.e. amenable ultrafiltration) uye zvachose Platinum kunodzikira maererano maviri-danho muenzaniso wokutanga kurongeka pharmacokinetics.

Kutanga nguva rusununguko Platinum-upenyu anenge 2 kwemaawa, uye chirwere T1 / 2 - 3-6 maawa. Zvinofanira kucherechedzwa kuti yose Platinum kunoratidzwa yakafanana kutanga hafu-upenyu, asi pakupedzisira-kwayo yakareba (nezvezvinoswera).

Akadzokorora kwokubatsira mushonga nokuda 4 mazuva mumutsetse muropa kuunganidza Platinum yaiitwa. Pashure rimwe zuva pashure pokushandisa zvinodhaka vanenge 85% yezviri pazvokudya plasma chichaparadza mapurotini ezvinhu.

Sei kubviswa pakati zvinodhaka "Carboplatin"? Guide anoti kugadzirira rinobva kunyanya itsvo (anenge 30% of dose yakabudiswa muna unmodified chimiro).

Muvanhu CS 60 Rine mamiririta / Maminitsi uye pamusoro vanenge 65% uye 70% of vakashandisa metering goho kuti 11 uye 23 maawa, ukuwo.

Sezvo kubviswa "Carboplatin" kunoitika anenge zvachose nokuda glomerular filtration, chete chiduku wevasungwa akaona renal tubules, iro rinotsanangura zviri pasi nephrotoxic zvinogona zvinodhaka sezvo zvichienzaniswa cisplatin.

Anticancer zvinodhaka "Carboplatin": uchapupu

Mune zvimwe zviitiko, chinoratidza kushandiswa kwezvinodhaka pasi kukurukurwa? Maererano mirayiridzo, vourawa mishonga anotevera anomera:

• ovarian kenza;
• gomarara;
• utachiona Sero mapundu zviri varume nevakadzi;
• osteogenic sarcoma;
• kenza yemapapu;
• medulloblastoma;
• kuzvimba pamutsipa uye musoro.

Kurambidzwa kushandiswa aizomupa mhinduro

Ndezvipi contraindications zvinodhaka ane "carboplatin"? Kushandiswa kwezvinodhaka ichi hakubvumidzwi kana:

• uchiyamwisa;
• chakakomba itsvo pathologies (semuenzaniso, CC asingasviki 15. / Nha);
• pamuviri;
• hypersensitivity kune carboplatin nezvimwe mishonga, kusanganisira Platinum;
• zvakakomba myelosuppression;
• chinokosha kurasikirwa neropa, kusanganisira avo kuchengetwa ichangobva kare;
• muuduku.

Uyewo nokungwarira mishonga iri nachiremba:

• zvichangobva kubaya;
• kunzwa vanotaura;
• renal zvirwere;
• mwoyo mwongo hematopoiesis, kusanganisira mamiriro ezvinhu pashure radiotherapy uye mishonga;
• zvinofambirana Kushandisa nephrotoxic zvinodhaka (semuenzaniso, "Cisplatin");
• chenjera Zvirwere pamusoro nemavhairasi, fungal uye kwemabhakitiriya mavambo.

Medicament "Carboplatin": mirayiridzo kushandiswa

Kurapa munhu anticancer zvinodhaka rinofanira kushandiswa? Maererano nenyanzvi, medicament iyi ingashandiswa somunhu monotherapy, kana akabatana nevamwe kunoreva ndozvinoitawo (semuenzaniso, akabatana "Paclitaxel" gadziriro).

Zvichienderana chii ukuru uye apo murwere vemunyika bundu, vanachiremba kushandisa dzakasiyana dosing "Carboplatin". Chinofanira kupiwa nomutsinga somunhu aizomupa pamusoro maminitsi 17-55.

Ndingatarira kushandisa mishonga "Carboplatin"? Tungamirira pfungwa kune zvinotevera dosages pamusoro chokushandisa ichi:

• 100 MG / mativi mita murwere muviri zuva nezuva kuti 5 mazuva;
• 300-400 MG / mativi mita murwere, kamwe ose 4 mavhiki.

Zvinofanira kucherechedzwa kuti chinguva pakati yaitonga kuti chinodhaka, pane imwe nhamba 100 zviuru maplatelet / mm uye 1.5 zviuru neutrophils / neMM, zvinofanira kuva dzinenge 4 mavhiki.

Usati uye pashure pokushandisa "carboplatin" mamwe anoitisa mvura uyewo kuita rokumanikidzirwa diuresis kunodiwa.

Kana murwere ane kwazvo hematological toxicity kana nepakati vangafanira kuderedza uwandu husingakuvadzi zvinodhaka kuti 26%.

Kana renal pathologies zvikuru kunowedzera ngozi yacho chepfu mugumisiro zvinodhaka, uye saka kuderedza dose inobva CC chechetere.

Vakwegura, uyewo kare achiitiswa myelosuppressive kurapa, kuti chipimo chemushonga anofanira kuderedzwa 22-25%.

Vasati kushandisa, kuti aizomupa mhinduro inofanira kuitisa zvayo kutarisana rokuongorora kuti kuona kana paine chakaipa ruvara kwayo kana tsvina.

Chii chinogona vanosanganisa upfu zvinodhaka "Carboplatin"? Mirayiridzo Kushandisa zvinotaurwa vanoshingaira zvinodhaka anofanira rakasanganiswa mu shuga 5% mhinduro kana yavaibvisa chloride 9%. Panyaya iyi vakachengeta wevasungwa inofanira kuva 0.5-1 MG / Rine mamiririta.

The mushonga Kugadzirisa inofanira kugadzirirwa asati kuishandisa, sezvo kunonyanyisa pasherefu upenyu zvakavhenganiswa kugadzirira akaenzana zuva rimwe.

Zviito ne-hunhu

akaita sei akaipa chinokonzera zvinodhaka "Carboplatin"? Reviews pamusoro chokushandisa ichi vanoti kuti kungakonzera kukura inotevera nemigumisiro:

• Gastrointestinal nhengo: mumaawa 11-12 mushure kushandiswa kwezvinodhaka, murwere anogona kuona svoto uye kurutsa. Kwakaderedza mukana emetic siyana uchishandisa rapfuura kugamuchirwa antiemetics, uyewo inoratidza kwokubatsira mumwe medicament nokuda 5 mazuva, kana kuramba intravenous aizomupa kwemazuva. Uyewo, vamwe varwere vaiva nenjodzi dzakadai manyoka, abdominal marwadzo, kuzvimba mumuromo uye kupatira.
• hematopoietic maitiro: kushandisa dzakakwirira mishonga kuti "carboplatin" anogona kudzvinyirira mashandiro mwongo hematopoiesis. Uyewo, vakawanda varwere pachena zviratidzo kupererwa, kusimba iyo kunoenderana chipimo chemushonga zvinodhaka kushandiswa. Kazhinji vasangana uye kurapwa yematambudziko zvakadai zvirwere, nefivhiri, kubuda ropa uye kuvhunduka septic.
• NA peripheral uye nechepakati tsinga: pane mukuru mukana wokuita kusimukira peripheral neuropathies, uyewo rutapudzo womumvuri mudzira hunenge, kunyanya vanhu makore 65. Uyezve, zvinoita zviratidzo CNS zvirwere kushanda. Refu kurapwa pamwe mishonga inogona kukonzera tinofanira kugara neurotoxicity.
• Nhengo wokuratidzwa; pakushandisa mari zvingangodaro kuti kwekanguva kudzikira kana kurasikirwa chiono rakakwana, uye kurasikirwa kukwanisa kuona chiedza uye kusiyanisa mavara. Kuona kudzorerwa uye kuvandudzika kazhinji kunoitika mukati mavhiki pashure discontinuation zvinodhaka. In vanhu vane havachanyatsogoni itsvo basa, vakanga zvakaipa pamwe dzakakwirira mishonga yacho chinodhaka, akacherechedza cortical upofu.
• kunzwa nhengo: pakatanga "Carboplatin" mune dzimwe varwere pane ototoxicity, izvo kunooneka pacharo ari muchimiro kunzwa kurasikirwa uye tinnitus.
• Allergies: fivha, mapundu erythematous, pruritus, anaphylactic maitiro, urticaria, hypotension uye bronchospasm. Migumisiro izvi zvingaitika mune kwemaminitsi mashomanana pashure zvinodhaka kutarisira. Uyewo, pane zvisingawanzoitiki zviitiko, varwere vanogona exfoliative dermatitis.
• Renal maitiro: pakatanga "Carboplatin" vamwe varwere kwenguva pfupi uye munyoro kuwedzera ropa zvinodhaka uye urea kuwanda. Muchiitiko chino, rikwanise vaikuvadza itsvo hariwanikwi chaizvo. Ngozi nephrotoxicity pamusoro pakanyorwa kushandiswa mumiririri uyu kunowedzera dose, uyewo vanhu kare kubatwa cisplatin.
• Electrolyte pachiyero; hypocalcemia, hypokalemia, hypomagnesemia, uye hyponatremia.
• Chiropa: kwekanguva kuwedzera bilirubin kuwanda, ITA uye alkaline phosphatase muropa inogona kuchengetwa. Vanhu vakabatwa vaine mishonga yacho zvinodhaka autologous mwongo transplantation, vaichengeta hadzina kufambiswa zvakanaka mune chiropa.
• Kumwe kuita: hemolytic-uremic urwere, kurukutika, alopecia, congestive mwoyo kukundikana, dzihwa-kufanana zviratidzo, myalgia / arthralgia, neutachiona, cerebrovascular zvirwere.

chaicho mashoko

Chii varwere vanofanira kuziva asati kushandisa zvinodhaka "Carboplatin"? Instructions, mhinduro vanoti aizomupa zvinodhaka ichi chete pasi kuramba pokudzora navanachiremba zvinogona kuitwa, izvo unyanzvi pakurapa cytotoxic nevamiririri. In ichi Opsioneel tarisisa zvichibvira chepfu zvinokonzerwa, kunyanya kana matunhu mishonga yacho zvinodhaka.

Nokufamba kurapwa pamwe mumiririri uyu uye pamusoro inotevera mitatu, varwere vanofanira kushandisa yakavimbika pamuviri.

Achigadzirira kwaizotevera kwokubatsira zvinodhaka mhinduro zvakakodzera kushandisa mishonga kuti dzisina aruminiyamu. Izvi imhaka yokuti kana interacts pamwe zvinodhaka precipitate achiumbwa uye mavara zvinoderedza zvinodhaka efficacy.

Panguva kurapwa, "Carboplatin" zvaida nguva nenguva chetsinga bvunzo, kusanganisira vanhu vakwegura uye kare kubatwa cisplatin.

Kushandisa mishonga iyi kungaita kuti pave ototoxic zvinokonzerwa, uye saka pre-kurapwa yaifanira audiometric nemiedzo.

Pasi pokudzora munhu akaora zvinokosha kutyorwa kunzwa angada dose kuchinja "Carboplatin" kana rakwo abolition.

Kana chigadzirwa anopinda ganda kana maziso, sukurudza pakarepo zvakawanda mvura. Kana ikavamedza, zvinodiwa kugadzirisa rubatsiro vanokwanisa.

zvinodhaka Similar

Chii mushonga analogues zvinogona kutsiviwa "Carboplatin"? Mirayiridzo dzokushandisa harina panyaya iyi hapana ruzivo. Shure kwayo uchava kuenda chiremba ane ruzivo. Kazhinji, nyanzvi dzinokurudzira kushandiswa analogues izvi "Carboplatin" "Tsitoplatin", "Teksalok", "Displanor", "Oksiplat", "Oxaliplatin", "Platinol", "Cisplatin", "Eloxatin", "Platikad", "Plaksat "" Oksitan "," Oksatera "," Ekzorum ".

Reviews kuti anticancer zvinodhaka

Zvino munoziva sei uchida mushonga akadai "Carboplatin" ( "Carboplatin din email"). Mirayiridzo yokushandisa zvinodhaka ichi yavewo inorondedzerwa pamusoro.

Kunyatsoongorora varwere toxicity uye efficacy zvinodhaka "carboplatin" riri nharo. Vamwe vanhu vanotaura pamusoro kwazvo migumisiro pakurapa-siyana kenza uye zvimwe kazhinji kutaura chepfu Migumisiro zvinodhaka ari siyana dzevanhu nhengo uye hurongwa, uyewo dzinoodza mananara. Nyanzvi dzinoti inobatanidzwa mumwe murwere achishivirira yezviri zvinodhaka fuma yaro zvayo ezvinhu. Chero zvazvingava zvinoda kuti kenza mishonga. Kana mushonga "Carboplatin" murwere haasi akakodzera vamwe chikonzero kana mumwe, zvino ari kutsiviwa analogs. Izvi yokutsiva antitumor zvinodhaka inobatsira muna 90% nyaya.