Statins - chii? Statins (zvinodhaka): zita

Statins - mishonga inogona kupiwa chete chiremba uye chete pashure dzakatevedzana miedzo ropa kuti kusarudza remafuta akawandisa mumatunhu. Muzviitiko zvakadaro, chavainyanya chinangwa - kudzivirira kumwoyo nezvirwere uye vawana pathologies. Kana varwere chiremba vanosungirwa kurayira murwere anotevera zvinhu:

• statins - akadini;
• kunzwisisa divi migumisiro kubva kurapwa.

Uyewo, chiremba achiitisa kukurukura pamusoro wenyaya kuti statins zvinofanira kugara. Chete pasi ichi, ivo zvechokwadi mwoyo uye ropa midziyo uye kuva anzi kuchirapa kushanda.

Pfungwa remafuta akawandisa

Remafuta akawandisa - mumwe lipid ane rwokuzvarwa mavambo: 80 muzana ari synthesized nokuda chiropa, uye 20 ari anwa nezvokudya. remafuta akawandisa muchinangwa zvakakodzera kushanda muviri zvikuru kukosha: ndiwo mumwe zvokuvakisa panguva cellular vanochiva zvaanopa simba muviri, inodzivirira masero pamigumisiro kunaka zvinobatanidzwa kukura bile acids uye kurara mahormone ose. Remafuta akawandisa "akanaka" uye "akaipa". Uye kubva yezvokurapa nemaonero, kupatsanura uyu sezvinotevera:

• HDL - kumusoro arambe achirema lipoproteins. Vanhu rurefu zviri remafuta akawandisa muropa zviri asingakurumidzi chomwoyo. Zvakawandisa HDL remafuta akawandisa ari zvifambiswe kuna chiropa, apo chobudira kubatana kwetunhu, saka haana kuenda remafuta akawandisa plaques uye havana vangangokukuvadza utano. Muchiitiko chino, statin kurapa harudikanwi, nokuti muviri achimhanya zvakanaka uye zvichipindirana.
• LDL - yakaderera arambe achirema lipoproteins. Mukuru ngozi nhengo ivo kana zvakabatana remafuta akawandisa plaques. Chii ngozi
  Fani? Atherosclerotic deposits izvo agadzirise mukati mudziyo (pamadziro), kuzadza navo, nokudaro impairing ropa riyerere. Izvi zvinotungamirira hypoxia, sitiroko, kurwisa mwoyo.

Statins - chii?

Negore ramakumi maviri remakore atherosclerosis zvakazivikanwa somumwe vaitungamirira zvinokonzera rufu, nekuti ndiye anokonzera myocardial infarction uye sitiroko. Kwenguva yakareba zvakanga yakakanganiswa maonero vanachiremba kuti atherosclerosis - ndiye kusingarapiki uye muviri wechisikigo kukwegura rikurumidze. Kuwanikwa statins aiva yechimurenga zvokurapa munyika; vaiva simba holesterinsnizhayuschim pfuma. Zvakabuda zvidzidzo kunze mukati 5 years, vaiva zvinotevera zviratidzi:

• Zvinoderedza LDL remafuta akawandisa (remafuta akawandisa zvakaipa) ne 35%.
• Kuwedzera mwero HDL (remafuta akawandisa zvakanaka) 8%.
• Rutapudzo kuti sitiroko 30% uye mwoyo aizotambudzazve 42%.

Statin zvinodhaka - zvinodhaka kuti mhanyisa uye waidzora kwetunhu remafuta akawandisa mumuviri, kuderedza wayo wevasungwa kuburikidza zvichivhiringidza MMC-CoA reductase.

To taurira statins

Maererano zvidzidzo, pashure pokutora mishonga Zvakacherechedzwa emuchina zvakanaka varwere chisingaperi nechirwere chemwoyo. Uchapupu kuti zvakanakira statin mishonga mune dzimwe pathologies uye zvirwere zvivepo, kwete. Asi Ezvemutauro izvi hazvisi chete kuchirapa asiwo chokudzivirira. Sezvo statins - zvinodhaka kuti kuderedza remafuta akawandisa, vari basa vanhu kuva mapoka aya:

• Vanhu vane homozygous rwapedyo hypercholesterolemia, zvisina amenable kurapwa pamwe hypolipidemic zvinodhaka.
• Varwere vanenge ischemic mwoyo chirwere, zvisinei remafuta akawandisa chechetere.
• Varwere vakatambura mwoyo kurwisa uye angina pectoris.
• Varwere coronary syndrome.
• Chirwere cheshuga kudzora ropa remafuta akawandisa mumatunhu.
• Varwere vanenge zvinokosha neBP pangozi zvemwoyo chirwere.
• Varwere vanenge atherosclerotic vascular maronda. zvirwere zvakadai zvinosanganisira atherosclerosis pakati chepfungwa nhumbi rezasi maoko nemakumbo, uye renal arteries uye kuvapo atherosclerotic plaques vari carotid tsinga.
• Vanhu havasi kutambura kubva zvemwoyo, asi vaine kwevari remafuta akawandisa muropa.

Statins - mishonga kuti vari pakati yakanakisisa achishandisa muzvidzivirire mukurwisa zvirwere kumwoyo. Maererano nenhamba, munyika umo kuwedzera rokutengesa zvinodhaka izvi, mwero wokufa kwevanhu nezvirwere chokuita yakakwirira remafuta akawandisa yomuropa muropa shoma zvikuru.

"Nokuti," uye "pamusoro"

Saka statins. Chii uye sei zvikuru vari kudiwa - yatakurukura pamusoro. Asi vanachiremba pfungwa pamusoro zvinodhaka izvi ndizvo zvakawanda. Pane musoro "nokuti" uye "pamusoro" noruremekedzo zvinodhaka izvi. Pasinei chokwadi kuti pakushambadzira masirogani anovimbisa kubvisa vanhu atherosclerosis uye izvi zvose chinoreva chirwere, statins havasi nguva dzose uye kwete kune anobatsira papi. Zvikurukuru nharo ndiko mubvunzo kana vari vanhu vakura: Chokutanga, statins - zvinodhaka, nokuti icho mutengo unogamuchirika zvose; Chechipiri, nemigumisiro kungaita zvakawanda kukuvadza pane zvakanaka kana kushandisa zvinodhaka sezvo prophylaxis. Zvichienderana migumisiro nemiedzo zvekuchipatara achiitiswa zvakasiyana masangano, nyanzvi dzinoti zvinotevera:

• Kushandiswa statins kuzvidzivirira nechiyero, kuderedza ngozi mwoyo kurwisa kana ronda, zvirokwazvo yakakwirira, asi nemishonga vari kumanikidza vanachiremba kufunga usati kupa varwere vasina kare atarisana mwoyo chirwere.
• Kunyanya nokungwarira varayire statins kune vanhu vane cataract zviratidzo kana nechekare arwarewo nechirwere ichi. Maererano nenhamba, kwokubatsira zvinodhaka kunowedzera mikana tsanga kubudikidza 52%.
• Izvi zvinoshandawo vanhu vakwegura chirwere cheshuga. Statin kurapa kunomutsa pokumuka tsanga muna 5.6 nguva nokukurumidza.

Asi, zvakadaro, Newest statin mishonga inoshandiswa okurapa zvakawanda uye muuye pachavo vabatsirwe. chiremba ane unyanzvi anofanira kurayira murwere usati varayire kurapwa zvinodhaka izvi, anotevera nyaya:

• Statins - chii?
• Chii kutarisira kutora zvinodhaka: positives kurapwa uye kudzivirira.
• Marwadzo uye migumisiro zvinodhaka.
• Sezvo pane chii mishonga kutora zvinodhaka.

Statins uye remafuta akawandisa: asi pafiripi divi

Mishonga richikwidibira remafuta akawandisa yomuropa muropa kunoguma vachinje zvimwe zviratidzo mumuviri:

• Statins kuderedza kugadzirwa kwete chete remafuta akawandisa, asi akazotsiviwa kwayo - mevalonate. Ndiye muvambi zvakawanda zvinokosha zvinhu kuti aite zvoutachiona Unoshanda mumuviri. Zvakaipira izvi zvinhu zvinogona kukonzera zvimwe zvirwere.
• A pasi remafuta akawandisa yomuropa zvingava zvikuru kukuvadza pane high: inotungamirira kune mikana yakawanda kenza, kupererwa neropa, kusagadzikana tsinga uye chiropa.
• Maererano nokutsvakurudza kwakaitwa US, ikawanda remafuta akawandisa yomuropa akaparirwa kamari magnesium tigutsikane mumuviri. kushaikwa kwayo kunotungamirira angina, BP, chirwere cheshuga uye pave arrhythmias.
• "Zvakaipa" remafuta akawandisa ari kushingaira mumabasa zvinyama kugadzira panguva cellular chechetere. Statins anogona tunodzivisa basa iri, zvichitungamirira myalgia (muutera, edema, tsandanyama marwadzo) uye kunyange chinonzi dystrophy.

nemishonga

Damage statins avo vakaratidza refu kugamuchirwa divi kwakadaro mananara:

• Neutachiona: kuvaviwa, ganda mapundu, urticaria, anaphylaxis, erythema multiforme, Lyell kuti syndrome.
• Zvomudumbu hurongwa: manyoka, kuda kurutsa, kurutsa, hepatitis, pfungwa nomuviri zvemwana asati, jaundice.
• Miviri hematopoiesis: thrombocytopenia.
• Tsinga: dzungu, paresthesia, kukanganwa, peripheral neuropathy, zvakawanda zvive, utera.
• Zvetsandanyama nemapfupa hurongwa: chinyamunhari chinorwadza, musana marwadzo, arthritis, myiasis.
• Muviri: hypoglycaemia (kuderera muropa shuga), mukana nechirwere cheshuga.

Kushandisa statins refu kunogona hope, kutemwa nomusoro, kusabetsera, uremu kana neanorexia.

Vamwe Misimboti statin rwokusarudza

Kana, pashure ose "zvayakanakira" uye "pamusoro" chisarudzo chakaitwa kuti kurongera statin, zvinokosha kufunga zvimwe: kugarisana nevamwe zvinodhaka uye kuvapo chisingaperi zvirwere.

• Statin kurapa vane mishonga kuti gout, chirwere cheshuga uye BP zvinogona kukonzera ngozi myopathy kaviri.
• In zvirwere chisingaperi chiropa kutora mishonga zvimwe kuchengeteka zvinhu. Ichi pasi dose rosuvastatin uye pravastatin ( "Pravaksol"). Pamwe kwavari zvaisambobvumirwa kutora nemishonga uye doro.
• Panguva dzose kurwadziwa tsandanyama kana panguva yechiitwa, kuti kungamutsawo kukuvara tsandanyama rinenge zvinokurudzirwa kutora pravastatin.
• Nokungwarira yokunyanyisa varayire zvinodhaka varwere vane chirwere cheitsvo. Zvachose havagoni kushandisa chepfu kuna itsvo statins: zita fluvastatin mishonga - "Lescol Forte", atorvastatin - "Lipitor."

Kana chinangwa kugamuchira statin - munhu remafuta akawandisa-richikwidibira yakaderera arambe achirema, vanogona kushandiswa akabatana nicotinic acid. Ideal yomuchipatara zvinosanganisira rosuvastatin kana atorvastatin.

Vanhuwo kupatsanura pakati statins

About basa ravo kuderedza remafuta akawandisa statins vakakamurwa muzvikwata 6:

Statins (zita zvigadzirwa isu kunyora pasi apa) vanosarudzwa uye akagadzwa chiremba, kwakavakirwa padanho remafuta akawandisa muropa.

rosuvastatin

The avhareji daily chipimo chemushonga ndiyo 5-10 MG kuti rosuvastatin. Varwere kurwarisisa pakurapa rwapedyo hypercholesterolemia, rimwe zuva dose anosvika 40 MG. Ndirwowo vaifanira. Chakaita zvokugadzirwa zvinodhaka.

pravastatin

Pravastatin zvazvingava daily - iri 20-40 MG. Kufadza akashivirira dose (80 MG) haana kushandiswa nokuda kukwana kuongororwa chiito. Semi-chakaita zvokugadzirwa zvinodhaka.

atorvastatin

Atorvastatin - chakaita zvokugadzirwa zvinodhaka vorudzi rwechitatu. Pakati pechizvarwa yake statins ndiwo inonyatsobudirira Somuenzaniso, akapfuudza kushanda kuti fluvastatin hafu. Initial kurapa pamwe yakarumbidza 10-20 MG pazuva. Pasina zvinozoita iri chipimo chemushonga ichiwedzerwa kusvika 40 MG pazuva. Atorvastatin rinoshandiswa chipimo chemushonga 80 MG pazuva nokuda pakurapa varwere chakasimba coronary syndrome. Chakaita zvokugadzirwa zvinodhaka.

simvastatin

Simvastatin - a Semi-chakaita zvokugadzirwa zvinodhaka kuti runopfuura kubudirira lovastatin kaviri. The kutanga daily dose iri 10-20 MG, pasina zvinozoita anogona ngazviwedzerwe 40 MG. Kufadza zvinobvumidzwa zvazvingava nezuva - iri MG 80 pazuva.

fluvastatin

Chakaita zvokugadzirwa kugadzirira fluvastatin raitongwa ari dose pamusoro 20-40 MG rimwe zuva, asi optimum dose - 80 MG pazuva. Zvinonzi ushandiswe varwere vanogamuchira cytotoxic vamiririri mushure nhego transplantation.

lovastatin

Lovastatin - chete dzinongoitika statin. Zvikaramba kubva chakuvhe Aspergillus terreus. Kutanga dose - 20 MG pazuva. Rakashandiswa kamwe, usiku, pashure kwemanheru. Mune zvimwe zviitiko, mwero nezuva yakawedzera kusvika 40 MG pazuva. Chinenge harimboshandiswi mu kurapwa tsika nokuda chimiro yakawanda yemhando analoginen zvigadzirwa.