"Rosuvastatin": mirayiridzo kushandiswa, wongororo. Cheap analogue "rosuvastatin"

The mushonga "Rosuvastatin" rave richizivikanwa kubvira 2003 uye sechibayiro statin Generation IV. Chinhu ano uye yepamusoro inhibitor kuti wegamma-methylglutaryl-CoA reductase. enzayemu Izvi anokonzera kwetunhu remafuta akawandisa mumuviri womunhu. chinovhiringidza Its zvinotisvitsa rutapudzo pamusoro endogenous remafuta akawandisa uye yekuzvidzivirira chemwoyo.

Kuwedzera "rosuvastatin" pane dzakawanda kirasi dzomuzana, nhengo statin boka. Izvi "Simvastatin" "Pravastatin", "cerivastatin," "Lovastatin," "Fluvastatin," "Atorvastatin", "pitavastatin." Clinical efficacy uye nokukurumidza achidzikisa zvachose remafuta akawandisa uye yakaderera arambe achirema "Rosuvastatin" wechipiri chete "pitavastatin," izvo haisati kushandiswa zvikuru nokuda shoma vaunganidza Database miedzo zvekuchipatara.

To musi, "atorvastatin" rinoshandiswa kakawanda kupfuura dzimwe statins nokuti ndicho yakakwana tsvakurudzo chawo uchapupu zvayo kunotoda kushanda. Uyewo, iye generics vari isingadhuri zvikuru, "rosuvastatin". Asi sezvo okupedzisira mugumisiro (normalization pamusoro lipid Profile of plasma) riri kufamba, uye ipapo iye otanga kushandisa yainyanya. Iyi chaizvoizvo yepamusoro chigadzirwa, nokuti izvo zvinofanira mari.

Isa "rosuvastatin" iri pharmacotherapy

Mukugadzirira "Rosuvastatin" chikumbiro, pasinei kuvapo mukirasi dzomuzana, zvakanaka rwakafara. It kunorondedzerwa zvairatidza uye contraindications zvakawanda. The zvinoratidza aripo zvinenge zvose mhando hypercholesterolemia uye kusagadzikana lipid muviri. The kuderera atherogenic lipid zvikamu zviduku vane kunobatsira nhengo. Nokuda kwaizvozvi, mukana wokuti pave atherosclerotic maronda ipfupi, uye upenyu anotarisirwa (uye unhu) kuwedzera zvishoma.

Kugadzirira "Rosuvastatin" anogona kushandiswa kudzivisa zvemwoyo, uye kuvabata. Last niche pharmacotherapy iripo nokuda kokumanikidza dzinotsanagura atherosclerosis uye endothelial Kudzikamiswa kuti chikwangwani chakanyorwa. Sezvo chepfungwa infarction uye mwoyo kuva kubva kusachengeteka kukuru thrombosis kutungamirira arteries, ipapo chiremba mugumisiro hunobatsira kudzivirira chakasimba coronary zviitiko.

Mirayiridzo yokushandisa

Vasiyana mushonga "Rosuvastatin" mirayiridzo Chinyorwa (analogues mapepa yakadaro iripo) rine rakamanikana zvakawanda zvinoratidza kuti kushandiswa. Zvisinei, hazvina ane ruzivo chero murwere kuti kunodiwa asati kushandisa kuona chikamu remafuta akawandisa. Mune ramangwana, shanduko yavo kuongorora kunotoda efficacy kurapwa mune imwe chipimo chemushonga. Uyewo mashoko rine ruzivo pamusoro njodzi uye zvinoitwa kurapwa, contraindications, uye zvikuru kugara uye chinokosha nemishonga.

zvairatidza

Pakati zvose zvirwere chokuita zvakawedzera yeplasma lipid zvikamu zviduku, anosimbisa vamwe zvekuchipatara zvairatidza:

• heterozygous enhaka (rwapedyo) hypercholesterolemia;
• Classified ne Fredrickson polygenic hypercholesterolemia mhando IIa;
• zvabatanidzwa dyslipidemia, Classified ne Fredrickson sei IIb;
• Homozygous rwapedyo (rwapedyo) hypercholesterolemia;
• coronary, chepfungwa kana renal arteriosclerosis, occluding ari lumen of tsinga;
• Atherosclerosis pakati arteries repasi wamativi, kusanganisira Leriche urwere ;
• hypertriglyceridemia (IV mhando maererano Fredrickson);
• Mabatirwo myocardial infarction uye pfungwa, sezvo rikwanise kumwedzi;
• kudzivirira myocardial infarction uye sitiroko.

Contraindications

Chero isingadhuri analoginen "rosuvastatin" ane chete nemishonga sezvo yepakutanga "Crestor". Pahwaro zvavo chakarondedzera contraindications kuumbwa, izvo zviri sezvinotevera:

• hepatic cytolysis chirwere chirwere pamwe hepatocytes uye anopfuura matatu-nedanga kuwedzera transaminase kuwanda;
• chiropa kukundikana, cirrhosis pamwe yakawanda 9 Child-Pugh;
• chisingaperi renal kukundikana chakarurama mashandiro pamwe creatinine Clearance asingasviki 30 Rine mamiririta \ min.;
• Myopathy chipi mavambo;
• neutachiona kuti idzidziso hurongwa kana "Rosuvastatin".

Pane boka rimwe contraindications 40 MG chipimo chemushonga:

• chisingaperi renal kukundikana nechiidzo creatinine Clearance kwete asingasviki 60 Rine mamiririta \ min.;
• chero nhaka myopathies;
• concomitant Kushandiswa fibrates;
• kudhakwa;
• Mongoloid dzinza;
• kushandisa imwe statin kokutanga.

Features zvinodhaka

All "rosuvastatin" - zvinodhaka, analogues zvacho zvikuru pa pamusika. Uye nokusarudza muchiso zita imwe, murwere vanofanira kutora mushonga uye. Kureva, kuchinja mumwe mishonga musoro. Sam mushonga anoendeswa pasina panyaya zvokudya chero nguva yezuva. Pane dzimwe dzave shoma nyanzvi aimbovenga vakashanda pamwe yokutanga chizvarwa statins. Ivo ane ruzivo kuti statins zvinofanira kutorwa panguva yokurara. Kunyange hazvisi zvinokosha, sokuvapo mishonga rakatorwa panenge chete uye akaramba.

Kudzora zvavo ezvinhu anofanira kuva kugara kusvikira abvuma "Rosuvastatin" (analogues). Reviews kubvumira Nyanzvi kushanda zvakanaka zvidobi ose pakuongorora. Kunyanya, pashure pokugadzwa kuvapo hypercholesterolemia kutanga kutora mushonga ane yakamisirwa dose. Pashure 2 mwedzi kuongororwa - lipidogram kakawanda anoitwa uye vakaongorora basa aminotransferases.

Kana paine normalization pamusoro lipid Profile ropa plasma, izvozvo kunodiwa kuramba kugamuchira imwe chete dose. Kana zvachose remafuta akawandisa anoramba yakakwirira, uye uwandu yakaderera arambe achirema remafuta akawandisa yekudyidzana ipfupi, kuwedzera dose kunodiwa. Kana transaminase yakawedzera katatu, zvinoda kubviswa statins. Zvinofanira kunyanya kuzivikanwa kuti zviduku katsika kukonzera cytolysis pamusoro statins zvose zviri "Rosuvastatin." Analogs (Ukraine uyewo zvishoma nezvishoma ochinja "atorvastatin" kuti "rosuvastatin") kirasi zvisinganyanyi vakachengeteka. A "pitavastatin" kunoramba muduku akadzidza.

Analogs "rosuvastatin"

Semunhu Fananidzo, "rosuvastatin" ( "Crestor") kare inopa zvinopfuura 10 zvigadzirwa. Pakati pavo, "AKORT", "Merten", "Rozart", "Rozistark" "Rosuvastatin Canon", "Rosuvastatin SOTEX" "Rosuvastatin NW", "Rozulip", "Rozukard", "Roxer", "Rustor" " Tevastor ". Mari vachivabata yakasiyana, uyewo kunyatsoshanda. Nokuti mutengo zvinodhaka izvi zvinogona kupatsanurwa muzvikamu zvitatu:

• nemitengo yakaderera (kubvira 250 kusvika 650 rubles), "Rosuvastatin NW", "Rosuvastatin Canon", "AKORT" "Rosuvastatin SOTEX";
• Avhareji mitengo (kubvira 400 900. rubles), "Merten", "Rozart", "Roxer", "Rozukard", "Tevastor", "Rozulip";
• yakakwirira mitengo (kubvira 1100 kusvika 2200 rubles): "Crestor".

mutengo kuongorora kwakaitwa nokuenzanisa mari mishonga, kurema vanoshingaira remubatanidzwa chakanga 10 MG. Mutengo siyana inoratidza mari mwedzi mumwe yokurapa remafuta akawandisa-richikwidibira. The yakachipa pashiri analoginen "rosuvastatin" kugadzirwa ne "Northern Star". "Rosuvastatin Canon" uye "AKORT" ndiyewo siyanei mutengo. mutengo wavo kashoma kuchinja zvichienderana Gengi nokufamba.

Zvakaita yakachipa pashiri "CRESTOR" Generic

The mushonga "Rosuvastatin" aburitswa AstraZeneca, anonzi "Crestor". Ndiwo mushonga yepakutanga, iyo inofanira kuenzaniswa vamwe vose. Izvi zvinoshandawo comments: kuti hunhu imwe Generic chigadzirwa rinofanira kubva kuenzanisa ayo ne "Krestorom". Asi nekuda kwayo nekaupenyu kudhura, varwere vakawanda pakarepo kutanga Mabatirwo hypercholesterolemia pamwe isingadhuri generics.

Objective mashoko chete unyanzvi anogona kupa munhu review, vari kazhinji nomubvunzo nokushandiswa generics uye "rosuvastatin" uye yepakutanga "CRESTOR". A kureva mushonga "Rosuvastatin 'mirayiridzo kushandiswa, murefu uchapupu uye kurapwa ruzivo kuchaita dzimwe varwere kusarudza kutengeserana zita yakati.

Reviews kuti vanachiremba "Crestor" uye generics

Enzanisa "CRESTOR" kunze chete nokuda vanachiremba yeRussian Society of Cardiology. ruzivo iri kazhinji yakabudiswa mumagazini inonzi "pfungwa pharmacotherapy mu cardiology." Zvikurukuru, unozvitaura nyaya bioequivalence ose Generic zvinodhaka "Crestor". Maererano migumisiro pharmacoeconomic netsvakurudzo kuti zvinodhaka "Merten", "Rozart", "Roxer", "Rozukard" uye "Rozulip" bioequivalent "Crestor".

Izvi zvinoreva kuti chero "rosuvastatin" Fananidzo iyi ane mishonga nomugumisiro yakafanana chepakuvamba zvinodhaka ine nhamba nekuomarara nemishonga. Nepo mishonga "Rosuvastatin NW", "Rosuvastatin Canon", "Rosuvastatin SOTEX" uye "AKORT" iri miedzo yakadaro havana kushandiswa. Nokuti zvidzidzo izvi Statistical havasi mari zvakasimba nemakambani anogadzira mishonga, kunoguma ruzivo Chinangwa uye inoita zvekuchipatara zviri nokurapa hypercholesterolemia. Zvisinei, migumisiro chete nokuda dzimwe generics.

Reviews pamusoro Nyanzvi zvakachipa generics "rosuvastatin"

Modern analogue ane "rosuvastatin" zvakachipa vanofanira kuratidza kwavo bioequivalence "Crestor" uye zvadaro rwoga anopiwa kuremekedzwa nyanzvi. Pasina bioequivalence zvidzidzo nyanzvi vanogona kutaura chete zvekuchipatara zviri kushanda. Mumwe wavo ichi: kana akashandiswa kuramba isingadhuri dzomuzana "rosuvastatin" (zvinodhaka pamusoro apa), kakawanda kumuvengi zviitiko akafanana kuchengetwa paaishandisa Generic bioequivalent "Crestor".

Nokufamba munzira plasma wevasungwa "rosuvastatin" kunobva pakushandisa yakasimba chipimo chemushonga fomu ane zvakasiyana siyana, vanoonekwa mumeso iyi. Nekuti chipa Russian analogue kuti "rosuvastatin" anogona here kutsiva yepakutanga zvinodhaka "Crestor" uye ayo zvinodhaka Generic nokuda nokurapa hypercholesterolemia.

Zvinoitwa wevarwere wongororo

Maererano mhinduro wevarwere vanotenda pamaonero avo pamusoro kushandisa zvinodhaka nachiremba wako, pane musoro mhedziso dzakawanda. Chekutanga, varwere kutonga pamusoro kunaka zvinodhaka nekambani. Chechipiri, nokuti imperceptible murwere kunotoda kushanda kuomerera kurapa yakaderera, kunyange kurapa zvakafanira kudzivirira ngozi chakasimba coronary zviitiko. Chechitatu, varwere vanowanzotevedzera vanowedzeredza kukosha nemishonga uye kurerutsa simba pamusoro yeplasma lipid profile.