"Nimesulide": wongororo, kushandiswa analogues

Nonsteroidal antiinflammatory yomuchipatara iboka chaiye zvinodhaka ane zvinokosha Migumisiro matatu: antiinflammatory, antipyretic uye marwadzo. Nokuda izvi pharmacodynamic unhu boka iri zvinodhaka riri zvinowanzoshandiswa okurapa. Ngatitarisei zvaidiwa chikumbiro "Nimesulide" chinodhaka, murefu uchapupu pamusoro ichi somushonga chigadzirwa, uyewo zvichibvira nemigumisiro uye zvinoitwa dosing.

pharmacodynamic unhu

"Nimesulide" ndiko mumiririri boka asiri steroidal Anti-anogumbura zvinodhaka. In boka rayo zvinodhaka zvinoreva kusarudza FIs ari enzayemu cyclooxygenase-2, kuti unoshanda kuti vabudirire chinovhiringidza kuti kugadzirwa prostaglandins ari kuzvimba.

Chimwe pachena chepfungwa mashandiro chiito "nimesulide" Pfungwa yokuti zviri kukwanisa kwayo kutitadzise kusunungura imwe enzayemu inonzi myeloperoxidase, izvo yekudyidzana kuchititadzisa kugadzirwa vakasununguka radicals pasina kukanganisa pezvakaitwa chemo- uye tigmotaksisa uye phagocytosis. Uyezve, "nimesulide" hunoita kuti kudzvinyirira pamusoro paumbwe bundu necrosis chinhu uye dzimwe nevamiririri munyaya anogumbura zvinoitwa nhengo.

The pharmacokinetic zvechadenga

The chikuru nzira chourongwa of medicament riri nemumuromo, nokuda kudunhu bioavailability zvinodhaka, mwero kunonyanyisa wevasungwa munguva yeplasma wevarwere. Saka, kufadza pfungwa kunoitwa pashure 120-180 maminitsi pashure kutarisira uye ukuru nokusungwa zvinodhaka pamwe mapuroteni eplasma ari pedyo 98% of pakutanga akasuma mari "nimesulide" gadziriro (ratings kuvarwere uye vanachiremba ngaadarowo).

Huru muviri umo zvinodhaka muviri ndiwo chiropa. In nedanho biotransformation kupinda vanoshingaira metabolite inonzi hydroxynimesulide. The chikuru Pamigwagwa excretion zvinodhaka raro excretion iri weti (saka dzinoratidza vanenge 65% zvinodhaka), vanenge 35% of zvinodhaka riri yabudiswa muna faeces.

Zvinenge varwere asati kushandisa chero mamwe mashoko pamusoro zvinodhaka "Nimesulide" zvose. Mirayiridzo yokushandisa, analogs, zviratidzo uye contraindications, nemishonga - inowanzobvunzwa mibvunzo.

zvairatidza

Zvairatidza kuti zvinodhaka "Nimesulide" kwete zvokuti. Pakati pavo zvinokosha kuziva kurwadziwa zvisamuka, pamwe chikuru chinonzi osteoarthritis marwadzo uye chepuraimari dysmenorrhea kunoitika. In chiremba tsika sezvo kushandisa zvinobudirira zvinodhaka. Izvi runoratidzwa kuburikidza kubvuma akasiya "Nimesulide" zvinoreva wongororo. haina varumbidzwa kutenga vana pasi makore 12 - anofanira kuziva izvi.

Contraindications kuti mushonga

Kufanana zvose nonsteroidal Anti-anogumbura zvinodhaka "nimesulide" iri contraindicated pamberi gastric urikanwi kana duodenum urema (12 duodenal urikanwi) iri rikwanise danho, achideredza detoxifying chiropa basa, apo agadza mushonga chete hepatotoxic zvinodhaka. The mushonga iri contraindicated pavarwere vane chinokosha vasanyanye excretory renal basa (creatinine Clearance asingasviki 30 ML / Nha), hematological zvirwere uye matambudziko pakugwamba, varwere havachanyatsogoni zvemwoyo ushande.

"Nimesulide" iri contraindicated pamberi varwere kuvhiya zvokurwara, vanaamai pamuviri uye ukoti, uye vana pasi pemakore 12 okuberekwa nemhaka mukuru ndingangokuvara nenjodzi. Hazvina zvakafanira kuti ndipe "Nimesulide" nokuti dambudziko yokuSpain uye yokuSpain-kufanana mamiriro ezvinhu hyperthermia.

nemishonga

Izvi zvinoreva kwete chete inozivikanwa mukuru Anti-anogumbura basa asiwo refu kuitika nenjodzi. Kazhinji zvaitika mukati vhiki yokutanga yokurapa ne "Nimesulide". Reviews of panowanikwa nemishonga siya zvikuru anodikamwa.

Skin uye divi ganda migumisiro chokuita kuratidzwa neutachiona kuti zvinodhaka uye izvo zvinoratidzwa sezvo panowanikwa ganda kuvaviwa uye rashes, dermatitis, akatsvuka, urticaria. Ndoda nemishonga kuitika akadai chepfu epidermal necrolysis, Stevens-Johnson syndrome.

Pamusoro chikamu nemudumbu Kashoma zvingakonzera ropa, perforation nemaronda. Kazhinji simuka kurwadziwa epigastric nharaunda, kuda kurutsa, kurutsa, manyoka kana kupatira.

Pamusoro chikamu nechepakati tsinga zvingakonzera lethargy, kunyanya nehope, kuramba nomusoro uye vanyanye dzungu, vestibular zvirwere.

Kubva kurutivi hematopoiesis maitiro uye kumwoyo zvingamuka eosinophilia, thrombocytopenia, uye pancytopenia, kupererwa neropa chirwere, tachycardia, yakakwirira BP, kukura hyperkalemia.

Kushandiswa "Nimesulide" uye wongororo

Uchishandisa "Nimesulide" zvakasimba atora yaro panzvimbo kunotoda rheumatologic zvirwere zvetsandanyama nemapfupa ino. Pasinei zvinokosha kuita zvimwe zviri uchapupu mushonga "nimesulide" nyaya dzinovaka nezvazvo nokuda kwayo yakakwirira kunyatsoshanda pakurapa rheumatic zvirwere. Izvi nokuda specificity kuti kukuvara cyclooxygenase-2 uye yakakwirira mwero selectivity nokuda enzayemu ichi.

Zvokungwarira

Chii kungwarira kana kutora zvinodhaka uku se "Nimesulide"? Mirayiridzo yokushandisa, murefu wongororo kunoudza pamusoro vamwe nyevero. Chinhu chinokosha ari kuenda "nimesulide" gadziriro ndiko kushandiswa shoma kuchirapa dose zvinodhaka. Pasina efficacy shoma dosing kugamuchira mushonga anofanira vakarega.

Kana hepatotoxicity zvinodhaka (ndiko kuongororwa neropa nemakemikari omuviri) kugamuchira mushonga vanofanira kumiswa nokukurumidza. boka iri varwere (vanokudziridza chiropa sero kukuvara) mberi basa wairambidza "Nimesulide." Zvinofanira kucherechedzwa kuti kunyange pasina divi anokonzerwa chiropa zvinodhaka hakufaniri nezvaaiitawo hepatotoxic zvinodhaka, vamwe NSAIDs, analgesics. Uyewo, zvinofanira kusanwa doro.

"Nimesulide" vanofanira kuva anokudzwa renyevero wakapiwa varwere vane hepatic kana renal insufficiency kudzivisa ngozi kuchiita yokupedzisira.

Cherechedzai inofanira kubhadharwa kuti kugadzwa mushonga varwere vane yokuSpain-zvakadai zviratidzo. Izvi imhaka yokuti "nimesulide" ane antipyretic kushanda uye anokwanisa masiki zviratidzo zvechirwere noutachiona.

Drug kwavatori

Nokuda mukuru mano zvinodhaka kuti intestinal ropa "Nimesulide" harifaniri pamwe anticoagulants akadai "Warfarin" sezvo kuine yakakwirira mukana nemishonga.

Mano zvinodhaka kuvhiringidza mashandiro cytochrome P450. Tichifunga dzichipfekeka basa chinovhiringidza pamusoro enzayemu chipimo chemushonga mishonga rinoita pachishandiswa cytochrome inofanira anodzokororwa pasi.

"Nimesulide": analogues, wongororo

Huru analogs (kutoshanda mumiririri) vari "Nimid", "Nimesil", "Remesulid", "nzombe-sanovel". The mushonga inowanika piritsi muchimiro 100 MG sachets kana muchimiro gel 10 MG (pa 1 g gel). Kuchirapa basa analogues zvinodhaka yakanaka, saka varwere pamusoro wongororo vavo vasara sezvo zvakanaka. Varwere ndabva "Nimesulide" rinoreva wongororo, mahwendefa kuva duku kupfuura mushonga ari muchimiro sachet.

mhedziso

"Nimesulide" riri simba Anti-anogumbura mumiririri kubata anogumbura zvirwere, kunyanya zvetsandanyama nemapfupa hurongwa. kuva nechokwadi kuti bvunza chiremba wako pamusoro nokutora "Nimesulide" chinodhaka nokuti mukuru ngozi nemishonga inodiwa. Anodzokorora vanachiremba varwere zvinodhaka, uye varwere vachitora zvakwakanakira, sezvo unokurudzira nokukurumidza rutapudzo chirwere zviratidzo.