"Neofilin" (Mahwendefa): mirayiridzo kushandiswa. "Neofilin 100 MG": rondedzero gadziriro

Nokuti pakurapa pulmonary chirwere yakakonzerwa spasm ari kufema turakiti, rinoshandiswa bronchodilators pamusoro Methylxanthine boka. mumiririri wavo chikuru pamusoro pfuma theophylline.

Kwakavakirwa zvinodhaka kuderedza asima kurwiswa mu Árbol asima, obstructive bronchitis uye hope kufema.

Description mishonga

The medicament "Neofilin" (Mahwendefa) mirayiridzo kushandiswa sechinhu medicament ichazivikanwa pauri wokuUkraine mishonga zvakasimba "Darnitsya" iri mishonga zviviri: 100 uye 300 MG. The mushonga ane kwenguva refu zvikuru.

Zvazvakaita pamusoro muviri

The kushingaira wemafuta mushonga (theophylline) ane bronchodilatory zvainoita muviri umo chakavhara adenosine receptors hwakaipa phosphodiesterase kunowedzera zviri intracellular Camp, zvinoderedza wevasungwa calcium ions. It relaxes tsandanyama kumeso ari principales, nemudumbu, biliary turakiti, dumbu, coronary, pulmonary, chepfungwa nemidziyo, dilation pamusoro coronary arteries, kuderera peripheral vascular nemishonga.

Pasi pokudzora kwomudzimu zvinodhaka vakachengeta kuwedzera mataurire kufema tsandanyama, izvo zvinosanganisira intercostal tsandanyama uye diaphragm. Uyezve, akaderedza pulmonary vascular nemishonga, kunonatsiridza oxygenation kweropa yorwizi, iro activation ari kufema muzinda iri medulla oblongata, anowedzera susceptibility wayo carbon dioxide, nani alveolar kufefetedza.

Izvi kunoderedza kwokuomerwa uye kakawanda kwamira kunoderedza kufema masangano. Theophylline idzidziso "Neofilin" (Mahwendefa) kudzidziswa Chinyorwa anotsanangurwa zvinoreva kuti kubvisa vasoconstriction, kuwedzera rubatso ropa kuyerera uye okisijeni saturation ropa, kuderera pamusoro perifocal uye vakawanda pfungwa edema, zvinoderedza doro uye intracranial kuvafurira.

The medicament rinotarisirwa kuvandudza rheological unhu ropa kutadzisa paumbwe ropa clots, kuderedza platelet clumping masero normalize microcirculation. Theophylline kuratidza antiallergic chiito, sezvamakaropafadzwa degranulate rechikepe masero uye zvinoderedza wevasungwa pamusoro sema nevamiririri, akadai histamine, kweserotonin, leukotriene.

Nokuwedzera renal ropa riyerere aona diuretic mugumisiro kuti anoratidza mvura, chloride ions uye yavaibvisa.

Kuti anobata mushonga

Drug "Neofilin 100" (Mahwendefa) kudzidziswa Chinyorwa anokurudzira kubata Árbol asima, asthmatic chinzvimbo, bronchitis, obstructive chisingaperi chimiro, Árbol zvemapapu, pulmonary neBP, usiku kufema kusungwa.

mazano aya anoshandawo hombe chipimo chemushonga zvinodhaka - 300 MG.

How kutora

The medicament "Neofilin" (Mahwendefa) kudzidziswa Chinyorwa rinokurudzira achitora dose yakaiswa yoga kuti chirwere chimwe nechimwe uye novimba nokumhanya ari metabolic urongwa, zera uye uremu muchikwata yepasi murefu.

The mushonga anwe 1 nguva pazuva panguva zvemangwanani kana chisvusvuro. Medicament "Neofilin" (Mahwendefa) mirayiridzo rinoratidza kutora kuomesa nzira. Hazvibviri zuva rimwe kunwa mushonga panguva zvokudya, uye rakatevera - mushure kudya.

Kukarukureta of chipimo chemushonga kuti chakaipa renal Clearance

Nokuti kutanga uye mberi nokugadzirisa uwandu zvinodhaka zvakakodzera kuona kusimba anokoshesa yokunatsa kuti plasma kubva chepfu zvakasiyana siyana pedyo neitsvo.

Kugadzirira "Neofilin" (Mahwendefa) mirayiridzo kushandiswa vana kubvira 12 kusvika 15 makore ane muviri uremu makirogiramu asingasviki 45 varumbidzwa kushandisa mazuva yokurapa okutanga matatu zuva dose 12 kusvika 14 g pa 1 kg muviri uremu. Asi imi hamuna kutora anopfuura 300 MG zvinodhaka.

Mushure mamazuva matatu kurapa kwakadaro pasi kwomuzvarirwo akashivirira daily dose yakawedzera kusvika 16 MG pa 1 kg uremu. Asi havafaniri kupfuudza 400 MG pazuva.

Pashure zvimwe mazuva matatu pasi kwomuzvarirwo akashivirira dose inowedzera kuti 20 MG pa 1 kg uremu. Asi zvino hakufaniri kuva MG anopfuura 600.

Kugadzirira "Neofilin" (Mahwendefa) mirayiridzo kushandiswa vana makore 16 uye vakuru makore 60 okuberekwa ane muviri uremu anopfuura 45 makirogiramu mumazuva matatu kurapwa rokutanga anokurudzira kushandiswa mune mari 300 kusvika 400 MG pazuva nomuromo.

Mushure mamazuva matatu pasi kwomuzvarirwo akashivirira dose inowedzera kuti 400-600 MG.

Pashure pemazuva matatu, pasi chete ezvinhu ezuva nezuva dose anogona kupfuudza 600 MG, asi zvinotarisirwa kuti asimbise kudzora theophylline wevasungwa muropa murwere.

Kukarukureta of chipimo chemushonga pamwe havachanyatsogoni renal Clearance uye vakwegura

Sei kugamuchira mamwe Mapato wevarwere mushonga "Neofilin" (Mahwendefa)? Mirayiridzo vana varumbidzwa kugamuchira ari dose, izvo zvinofanira kuva kupfuura 16 MG pa 1 kg kurema muviri pazuva, asi hapana anopfuura 400 MG mu yose. mazano aya kuyaruka kubva 12 kusvika 15 makore ne havachanyatsogoni renal Clearance rates, kana pasina anokwanisa chamber plasma wevasungwa pakati theophylline.

Nokuti gadziriro "Neofilin 300" (Mahwendefa) mirayiridzo kushandiswa rinosanganisira zvinotevera mashoko. Ivo hanya ndiko kushandiswa kwezvinodhaka nokuda kuyaruka pashure pemakore 16, uye varwere vakwegura pamwe havachanyatsogoni renal Clearance rates, uyewo vanhu vakanga vasingagoni kuyerwa yeplasma wevasungwa kuti theophylline. Yemanyorero nokuti Mapato wevarwere dzakadaro uwandu basa wemafuta mushonga haafaniri kupfuudza 400 MG.

Chipimo chemushonga kukarukureta pamusoro yeplasma Kuwanda theophylline

Zvichienderana zviri basa pazvokudya plasma rinoitwa dose kururamiswa "Neofilin 100" (Mahwendefa). Instructions izvozvo zvinoda kuti pave uye kana achitora yakakwirira mishonga kurapwa. Kuderedza huwandu basa chirungiso uye kudzora uwandu serum kunodikanwa zvinoitirwawo nenjodzi, vasiri wenyonganyonga, izvo kunoita kuti kurwadziwa kuve excretion zvinodhaka.

Kana yepamusoro Kuwanda theophylline muropa idukusa 9,9 g pa 1 Rine mamiririta, kushaya maturo pamusoro medicament chaiye shiviriro kunoda 25 muzana kuwedzera uwandu husingakuvadzi. Pashure pemazuva matatu, nokuti akatevera shanduko chitsama zvinodhaka kutakurwa plasma wevasungwa pakati theophylline.

Kana marapirwo kushanda uye tolerability kuuya zvakanaka okuberekwa dose kumwe kurapa zvinogoneka chete pashure kutsunga yeplasma kuwanda yezviri chirungiso. Mumufananidzo uyu unofanira kuva kuwanda kubva 10 kusvika 14.9 micrograms muzana 1 Rine mamiririta. Kana pasina maturo, asi portability chakanaka, akawedzera kune vamwe mishonga.

Kana dose anofanira kuderedzwa

Kana plasma wevasungwa kuti theophylline iri kuwanda 15 kusvika 19.9 micrograms muzana Rine mamiririta, zvinoda chipimo chemushonga rutapudzo 10%.

Kana chinoratidza fuma 20 kusvika 24.9 micrograms muzana Rine mamiririta Zvakakodzera kuderedza uwandu zvinodhaka ndiko 25%, kunyange kana pasina pachena nenjodzi. Mushure memazuva matatu pashure dose rutapudzo rinoitwa richiona nezvezvabuda yeplasma theophylline chakarurama kuti zvinobvira humwe kushandisa zvinodhaka.

Kana pachiyero basa fuma iri kubva 25 kusvika 30 micrograms muzana 1 Rine mamiririta, zvichiteverwa mabiko dosing kuyerera, uye mune ramangwana vanofanira kuderedza uwandu mishonga kubudikidza 25%.

Mushure memazuva matatu pashure dose rutapudzo rinoitwa richiona nezvezvabuda yeplasma theophylline paakati kusarudza kushandisa ramangwana zvinodhaka. Kana zvichiita zviratidzo nemigumisiro, tora matanho akakodzera.

Kana wevasungwa kuti theophylline muropa micrograms kupfuura 30 paminiti 1 Rine mamiririta zvingaitika overdosing. For pamwezve dose kuderedzwa nehafu. Mazuva matatu gare gare, akaita apiwa nokuyerwa uwandu zvinodhaka munyika yeplasma uye zvakarurama chipimo chemushonga.

Zvakakurukurwa kushanda

Kana muchigamuchira "100 Neofilin" vanosvuta Mahwendefa User chikumbiro chinonyevera pamusoro zvichibvira rutapudzo anoitwa ari kurapwa.

Nokuti vanhu vane kwazvo zvirwere zvomwoyo, tsinga, chiropa, chaikonzerwa noutachiona, akwegura pakati chipimo chemushonga iri kugadziridzwa nomumwe uye kutora mishonga iyi nyaya nokungwarira zvikuru.

zvakawandisa mushonga

In varwere mukuru, mishonga ovhadhozi "Neofilin 300" (Mahwendefa) Chinyorwa rinotsanangura chinyamunhari chinorwadza, fivha, mwoyo hadzina kufambiswa zvakanaka, kusanganisira tachycardia, ventricular arrhythmia, hypotension.

Zviratidzo runozivisa pauduku, zvinosanganisira yakawedzera kushatirwa, unhu zvirwere, fivha, kuda kurutsa, convulsive mamiriro, tachycardia, hypotension, cardiac kufema siyana.

Kurapa anofanira kutanga kunwa mapiritsi, uye ipapo kugeza kunze mudumbu, ura diridza munyu akabatana polyethylene glycol, kutora nemarasha. Rinokurudzira munhu Clearance pamusoro theophylline kweiyi ropa achishandisa kumanikidzwa diuresis, hemosorption, yeplasma sorption, hemodialysis, peritoneal dialysis.

Kana svoto uye kurutsa murwere raitongwa symptomatic vamiririri Somuenzaniso, kugamuchirwa "Ondansetron" kana "MCP". Kubvisa pfari vanogona kugamuchira "Diazepam".

Ndiani anofanira kutora

Mukugadzirira "Neofilin 100" (Mahwendefa) kudzidziswa zvinosanganisira mazita contraindications, riri zvisingaiti apo mishonga. Izvi zvinosanganisira zvakawanda aikanganiswa zvinoriumba zvose zvinoreva mishonga xanthine series, izvo zvinosanganisira caffeine, theobromine, pentoxifylline.

Hazvigoni kugamuchirwa mune chakasimba myocardial tsandanyama myocardial hunoshamisa, tachyarrhythmias, hypertrophic obstructive cardiomyopathy, BP yakakwirira, pfari, hyperthyroidism, peptic urikanwi mudumbu kana duodenum, zvakakomba kusagadzikana chiropa, porphyrin chirwere.

Rinoreva contraindicated vana pasi makore 12.

nenjodzi

Vanoverengeka nemishonga zvingamuka kubva kugamuchira "Neofilin" gadziriro (Mahwendefa). Mirayiridzo dzokushandisa anoudza varwere ruzivo pamusoro mukana zvinetso zviri nemudumbu. Ivo dzinoratidzwa uchirwadziwa mudumbu, kuda kurutsa, gag dzepanguva, gastroesophageal reflux, chirungurira, kusemburwa nemaronda, manyoka, ungaderedza kudya.

Nenjodzi kuonekwa kumwoyo muchimiro palpitations, tachycardia, cardiac arrhythmias, BP, venhema angina, angina pectoris.

Theophylline anogona ine zvainoita epfungwa. Inogona varehwa dzungu, nomusoro, kudzikama kana kufara mamiriro, hope, tremor, delirium, nokugwinha uye pfari.

Pamberi mushonga neutachiona pamwe panowanikwa ganda mapundu, erythema, exfoliative dermatitis, urticaria, fivhiri.

Other zvisingadiwi migumisiro yokurapa zvinosanganisira bvudzi kurasikirwa mumusoro, chipfuva marwadzo, kudzika kukurumidza kufema, Flushing, sealbumin excretion mapuroteni iri weti, kuvapo ropa weti, yakawedzera weti goho, vakawedzera vangadikitira uye ganda tembiricha.

Theophylline kunokanganisa pamusoro mumarabhoritari parameters. Mukurapa zvinodhaka "Neofilin" kungachinja zviri potassium ions mu serum downwards kusvika kukura hypokalemia. Panguva iyoyowo padanho creatinine, ions, karusiyamu oxalate, vari munyu pamusoro uric asidhi uye shuga rwuchiwanzwa, iyo inotungamirira hypercalcemia, hyperglycemia uye hyperuricemia.

Pashure dosing kuti medicament kuderedza mwero migumisiro inokonzerwa ipfupi.

Pregnancy uye lactation

Mahwendefa Active zvinoriumba anogona napakati placental mechidziro iyerere ichipinda zamu mukaka.

Maternity kugamuchira zvinogoneka chete kana zvakakonzerwa pakurapa mai mukuru njodzi kuti mwana asati aberekwa. Kana mishonga yakadaro inofanira kuva chikamu chimwe yeplasma kuwanda theophylline, uye runoenzanirana kugadziridzwa zvinoreva kuti dosing. Chisingadiwi kutora mushonga mumwedzi mishoma pamuviri nokuda kudzvinyirira kuti uterine tsandanyama.

Vakadzi vari zamu yakakodzwa uye kubatwa theophylline inofanira kuongororwa kuti chitarisiko mwana hypersensitivity. Possible kukura excitation kana kurara matambudziko, izvo zvinoda discontinuation zvinodhaka.