"Moxifloxacin": mirayiridzo kushandiswa, tsananguro, akafanana

The medicament "Moxifloxacin" pharmacological mugumisiro iyo dzichakurukurwa hereinafter, rinoreva boka quinolones. The turusi ane bactericidal, antibacterial mugumisiro. Next, tinokurukura chii chinoumba mushonga "Moxifloxacin". Mirayiridzo yokushandisa, analogues zvicharehwawo kuratidzwa munyaya.

kushanda

sei kushingaira mumiririri "Moxifloxacin"? Description of zvinodhaka vanofanira kutanga rondedzero mashandiro ayo zvainoita kwemabhakitiriya. Bactericidal zvazviri rinoreva chokuita chinovhiringidza (kudzvinyirira) kwemabhakitiriya topoisomerase IV uye II. Izviwo, zvinotungamirira kuvhiringidzika kuberekana dzinotsanagura transcription, DNA kugadzirisa biosynthesis masero microbial. Somugumisiro, kunouya kuparadzwa kwavo. Medicament "Moxifloxacin" mirayiridzo Chinyorwa rinotsanangura se munhu chakarondedzera mushonga.

musimbwa

Pazuva antibacterial basa zvinodhaka "Moxifloxacin" regai kukanganisa nzira kuti vakatsamwisa kuramba tetracyclines, macrolides, aminoglycosides, cephalosporins uye penicillins. Hazvina anozivikanwa zvakanaka uye migumisiro muchinjikwa nemishonga. Kusvikira ikozvino, zviitiko yeplasma nokugadzikana hadzina kuzivikanwa. Kurapika "Moxifloxacin" dzichiri zvisanduke nenzira vakawanda kunotouraya.

kuwanda kwebasa

Rinoreva "Moxifloxacin (mirayiridzo Chinyorwa - uchapupu) chinobata utachiona vazhinji giremu-akanaka uye giremu negative utachiona, asidhi-kutsanya utachiona, anaerobes, atypical tupukanana tusingaoneki (mycoplasma, chlamydia, etc), uye utachiona husingakwanisi macrolide uye Beta-lactam asingaurayiwi zvinodhaka .

kubvisa

Kana kugamuchira waiita Absorção de Água zvinodhaka "Moxifloxacin" nokukurumidza uye anenge wakakwana. Mhedziso bioavailability kana achiita nomutsinga uye kushandisa poura - of Unorudzi 91%. Kana achiita nomuromo (50-1200 MG dose, 600 MG / zuva kwemazuva 10) Linear pharmacokinetics zvinodhaka. The kunonyanyisa wevasungwa pamwe 400 MG kuchengetwa pashure pemaawa 0.5-4. Kana rikashandiswa panguva imwe chete nezvokudya kuzadzisa nokuwedzera nguva nguva Cmax (maawa maviri) uye wayo rutapudzo munenge 16%. Saka Duration Absorção de Água anoramba kuzochinja. Asi, mashoko aya havana kunotoda ukoshi unobvumira kushandiswa zvinodhaka "Moxifloxacin", pasinei chikafu. Zvichitevera rimwe intravenous aizomupa 400 MG kweawa kunonyanyisa wevasungwa kunoitika pakuguma aizomupa.

kugova

Mukati mamazuva matatu chikumbiro zvasvika zvakanyatsoenzana. Unosungira kuti mapuroteni eplasma - vanenge 45%. Rinotaura kumbonyanya nokukurumidza kuparadzira zvinodhaka "Moxifloxacin" nhengo uye munyama. Soro kuwanda vari zvemapapu rinenge uye principales mucous, ganda uye subcutaneous zvivako, sinuses, anogumbura foci. The mate uye interstitial mvura medicament rinowanikwa vasina kusungwa mapuroteni, vakasununguka chimiro. wevasungwa Its wakakwirira kupfuura plasma. Pamwe chete mushonga uyu unowanikwa yakawanda vari nhengo peritoneum munyama hadzi sikarudzi uye peritoneal mvura.

muviri

Medicine "Moxifloxacin" (rondedzero zvinodhaka ari Musumo Data unotora ruzivo) inopfuura yechipiri biotransformation danho. Renal excretion chinozoiswa maitiro uye ura unaltered muchimiro sulpho yeimwe uye basa glucuronide. The metabolites vanowanika plasma. wevasungwa ravo repasi kupfuura pakutanga akakura. Ongororo dzakaratidza kuti izvi kudzikisirana zvigadzirwa havana pakufurira pamusoro muviri.

Rinoreva "Moxifloxacin", izvo zvinonzi ushandiswe?

The mushonga pachii noutachiona anogumbura pathologies nedzevakuru kushatiriswa tusingaoneki vane nehanya nazvo. Kunyanya, kuverengwa dzinorondedzera ane exacerbation echirwere bronchitis aibuda, rikwanise sinusitis, munharaunda vawana nemabayo (kukonzerwa okuva utachiona nedzokunze vakawanda mumweya t. H. The mushonga). Rinoreva "Moxifloxacin" mirayiridzo kushandiswa pachii zvirwere zviri nyoro zvinyama uye ganda, subcutaneous hurongwa kuoma maronda (utachiona tsoka shuga uyewo), uye intra-abdominal zvirwere (polymorphic urongwa, intraperitoneal abscesses nezvimwewo). Ko basa kana medicament kubva Streptococcus pneumoniae husingakwanisi vakawanda antibacterials, kusanganisira kuvapo nemishonga utachiona kuti kuti penicillin, mapoka maviri kana kupfuura zvinodhaka rechipiri chizvarwa cephalosporins, macrolides, tetracyclines. By zvairatidza zvinosanganisirawo anogumbura maronda ari pelvic zvomukati nyore hunhu. Kana endometritis uye salpingitis vanokurudzirwawo kuti kufunga nzira (sezvinoratidzwa vasiyana mushonga "Moxifloxacin" mirayiridzo kushandiswa). Ziso Madonhwe nachiremba kwemabhakitiriya conjunctivitis, kushatiriswa tusingaoneki inonyatsoziva medicament. Zvinokoshawo kuti kufunga huripo kurapwa kwezvirwere zvakawanda zvinotapukira pathologies utungamiri.

Medicament "Moxifloxacin": iri chipimo chemushonga uye nzira chourongwa

Mari akasarudzwa ura (nomuromo) uye nomutsinga. . Duration kurapwa yacho medicament "Moxifloxacin", iro chipimo chemushonga iyo - 400 MG / zuva, zvichienderana Chirwere chacho zvakaoma kwazvo, uyewo kuchengetwa kuchirapa chaizvoizvo:

• Exacerbation echirwere bronchitis kosi - 5-10 mazuva.
• Community-vawana nemabayo - mazuva 7-14 sequential kurapa (intravenous akateverwa nemumuromo yaunodya).
• Soft zvinyama, ganda (nyore), uye rikwanise sinusitis - 7 days.
• Apo intra-abdominal zvirwere (kuoma) - Mazuva 5-14 sequential kurapa.
• Kana kuoma maronda uye subcutaneous hurongwa ganda - 7-21 mazuva.
• In anogumbura pathologies of pelvic zvomukati - mazuva 14.

Kuti uwane mamwe mashoko, rine vasiyana mushonga "Moxifloxacin" mirayiridzo Chinyorwa. Mahwendefa havafaniri kubvumirwa kutsenga. Geza pasi nemvura zvakakodzera mune vhoriyamu duku.

zvomunharaunda kushandiswa

Medicine "Moxifloxacin" (Madonhwe) anogona kupiwa varwere pagore. Practice inoratidza kuti kuvandudzika anouya pazuva rechishanu. Pashure paizvozvo iwe unofanira kuramba kurapwa kwamamwe mazuva 2-3. Varwere vari njodzi ziso vakaroverera kuderedza katatu pazuva. Kana paine achimutsa mubvunzo pamusoro yakarurama yokurapa kana nechirwere hapana zvazvinoita kwemazuva mashanu. Ya kurapwa kunobva bacteriological uye kurapwa mararamiro nekuomarara pamusoro zvokurwara.

Uyezve pane kuti aizomupa mhinduro

Medicament "Moxifloxacin" mirayiridzo Chinyorwa anokurudzira kuti imi mupinde kweawa. The mushonga Saka unogona kuva undiluted kana rakasanganiswa chimiro. The mhinduro inowirirana yavaibvisa chloride 0,9%, mvura jekiseni, dextrose mhinduro pane wevasungwa 10% uye 40%, 20% xylitol, "Ringer". Shandisa zvakajeka chete mvura. Pashure dilution of medicament inoramba akatsiga kwemazuva kamuri tembiricha. Hazvifaniri kuchengeta mufiriji nzira. Kana aizomupa uri kuvaranga nevamwe vamiririri, chimwe nechimwe chinotarisirwa yoga.

nemishonga

Nokuda kurapwa nemishonga "Moxifloxacin" zvichida kutanga fungal zvirwere, leukopenia, kupererwa neropa, thrombocytopenia. Mune zvimwe zviitiko, kurapa pane kuwedzera prothrombin nguva, thromboplastin kuwanda kushandura. Mune vamwe varwere mushonga kunogona kukonzera neutachiona, laryngeal edema, urticaria, anaphylactic kuvhunduka, pruritus, eosinophilia, mapundu. Mune zvisingawanzoitiki kacho pane hyperglycemia, hyperlipidemia, hyperuricemia. In pakurapa fungidzira chirwere chepfungwa. Zvikurukuru, varwere vanogona kuona wokusagadzikana, kufunganya, kuora mwoyo, depersonalization, aone zvinhu zvisipo, pfungwa siyana, achiperekedzwa kuzviuraya. Common nemishonga zvinosanganisira nomusoro, dzungu, chakamira pakunodengenyeka zvine, hope, kuvhiringidzika, kuravira utetsa zvirwere, hope nenyonganiso, nekuvhiri- ngika. Mune zvimwe zviitiko, panguva kurapwa pamwe mishonga kungakanganiswa kufambisa, nezvipusha, achiperekedzwa siyana zvekuchipatara kuratidzwa, hypoesthesia, kukanganisika kunhuhwidza. A nhamba dzevarwere vakanga kuwedzera hwekutaura, kuteerera, peripheral neuropathy, kukanganwa, polyneuropathy. Kana rikashandiswa topically, chiono anogona kuderera kusvikira kurasikirwa kwayo. Zvisinei, yokupedzisira anoonekwa kuva vavanongogara ezvinhu.

Kubatsira Kwavanoita kumwoyo

Part kwaitwa pokushandisa zvinodhaka "Moxifloxacin" ndivo QT-penguva prolongation pavarwere vane hypokalemia, palpitations, vasodilation, tachycardia. Rare nemishonga zvinosanganisira BP uye hypotension, ventricular tachyarrhythmias, syncope. Very kashoma akacherechedza cardiac kusungwa. Kwenguva kunyanya randinenge vanhu mavari rikwanise ischemia, bradycardia (akaora chinokosha).

Impact dzimwe gadziriro uye nhengo

Mune zvimwe zviitiko, mushonga anogona kukonzera kupfupika mweya, kusanganisira asthmatic sepakutanga. A nhamba dzevarwere vakanga vakachengeta zvinetso zviri zvomudumbu turakiti. Kunyanya, tikafunga kurapwa-emergent kuda kurutsa, kurutsa, manyoka, dumbu marwadzo. Vashomanana nemishonga vanoonekwa murombo kudya, dyspepsia, flatulence, gastroenteritis (kunze erosive), kupatira. Vamwe varwere vave kuzivikanwa stomatitis, dysphagia, pseudomembranous colitis. The kurapa zvimwe kuwedzera transaminases, hepatic dysfunction, pave fulminant chiropa, hepatic kukundikana zvichitungamirira upenyu pangozi. Very kashoma kuchengetwa bullous cutaneous siyana (chepfu epidermal necrolysis, Stevens-Johnson urwere). Vamwe varwere noruzivo myalgia, arthralgia, kugwinha, wakawedzera tsandanyama matauriro, tendonitis, tsandanyama simba. mudzira ruptures munogona zvisingawanzoitiki zviitiko, arthritis, gait kunetswa zvichikonzerwa kuvadza zvetsandanyama nemapfupa hurongwa. Varwere ari kurapwa pamwe mishonga inogona kuva akaona nepfungwa nezvezvimwe zvinetso zvedundira. Zvikurukuru, kwakaratidzwa kupera mvura mumuviri (chagumbura manyoka kana kuderera mune mvura vhoriyamu ukapisa), renal dysfunction, insufficiency. Common nemishonga zvinosanganisira vangadikitira, nonspecific marwadzo, zvakawanda zvive. Mugore intravenous kunge thrombophlebitis kana phlebitis.

Asina basa nzira?

In mushonga "Moxifloxacin" contraindications ndeinotevera:

• Mudzira zvokurwara munhau kuti yakatanga somugumisiro yokurapa quinolone inorwisa mabhakitiriya boka.
• Availability elongate QT-penguva (vachiberekwa kana vawana).
• Electrolyte vachivavhiringidza (kunyanya hypokalemia zvaiitika).
• Bradycardia (akaora chinokosha).
• Heart kukundikana pamwe akaderedza ejection basa iri ventricle kuruboshwe.
• Kutyorwa mwoyo mutinhimira (munhau).

Kana lactose kusashivirira, shuga-galactose malabsorption, lactase kushaikwa chiri haana varumbidzwa medicament "Moxifloxacin" (mushonga sezvamunoita unotora lactose, naizvozvo pathologies ataurwa kuiswawo pakati pemazita). Not basa zvinoreva pamuviri kana lactating. Mahwendefa uye mhinduro aibvumirwa kuenda varwere makore 18 okuberekwa. Recommended mushonga pakuparwa hypersensitivity kuna zvinoriumba.

chaiwo zviitiko

Kungwarira inodiwa kugadzwa mushonga varwere vane nechepakati tsinga abnormalities anozoita kuti vabatwe kukudziri- pfari. Boka pangozi zvinosanganisira varwere proarrhythmic inoti. Izvi zvinosanganisira, kunyanya zvinosanganisira rikwanise ischemia, kunyanya mune vakwegura uye vakadzi. Uyewo kuchengeta kungwarira varwere chiropa cirrhosis. chipimo chemushonga kuchinja kungadiwa panguva pamunhu yaizoshanda panguva kurapa zvinoreva achideredza wevasungwa kuti potassium.

Kuti uwane mamwe mashoko,

Practice inoratidza kuti mushonga wacho zvakanaka akashivirira Varwere vazhinji. Nyanzvi kazhinji mishonga yacho sechekushandisa noutachiona maronda. Izvi imhaka yokuti mushonga ane hwakanyatsorwisa yakakwirira kunyatsoshanda mabhakitiriya akawanda. Zvisinei, pane nguva dzose pangozi nemishonga, izvo zvaisanganisira pamwe chigadzirwa inonyevera "Moxifloxacin" mirayiridzo Chinyorwa. Analogs zvinodhaka kana yokushayiwa vanofanira osimudza chiremba nomumwe. Tsiva turusi anogona mishonga yakadai: "Avelox", "Vigamoks", "Rotomoks", "Moksifur", "Moksin" uye vamwe. Kana Migumisiro, rakapinza kudzikira uye panowanikwa zviratidzo havataurwi ari Muchidimbu, unofanira kutsvaka kurapwa nokukurumidza. Kana tichishandisa madonhwe vanofanira usagunzva yakawandisa meso zvinodhaka wacho. Kana izvi zvikaitika, unofanira nokukurumidza sezvinobvira zvakawanda mvura. Kana ovhadhozi enhancement kuti nemishonga.

In mhedziso

The mushonga "Moxifloxacin" vaiona zvakakwana simba antibacterial. Maererano neizvi chaizvo haisi yakarumbidza kutyora chiremba mushonga. Zvikurukuru, izvozvo chokuita nhamba uye kakawanda chikumbiro nzira. Regai kusapfuudza chipimo chemushonga. Intravenous jekiseni chinofanira kuitwa kudzidza chinokosha achishandisa anokwanisa nhengo mudonzvo ndiani achakwanisa kubatsira kana zvakakodzera. Haufaniri kuzvidzora medicate. Pasina migumisiro yokurapa zvinokosha kuona chiremba. Just asati kushandisa zvinodhaka "Moxifloxacin" vanofanira kunyatsoongorora verenga mirayiridzo.