"Mirapex": mirayiridzo kushandiswa, tsananguro, wongororo

Munyaya ino uchadzidza zvose pamusoro gadziriro "mirapex": sei yokutsiva kwezvinodhaka ichi, chii rawo, contraindications, nemishonga, mirayiridzo noruoko rwake. mapiritsi aya unogona kukonzera zvemamiriro maitiro nezvainoita murwere. Saka, asati kutora mushonga uyu "mirapex" mirayiridzo kushandiswa inofanira vainyatsoongorora. Nesuwo kukuudza pamusoro kugarisana kuti mapiritsi aya nevamwe zvinodhaka.

Mazhinji "mirapex": Vhuṱanzi pamusoro zvinodhaka uye zvairatidza kuti kushandiswa

The kushingaira fuma rekugadzirira "mirapex" ndiyo pramipexole. Upiyona zvinoriumba Mahwendefa: povidone, mannitol, starch, aerosil, magnesium stearate.

With kurapa ichi mushonga rinoitwa idiopathic (hwokuzvimirira dzimwe maronda) chirwere kuti "makumbo zororo" uye Parkinson nehosha uyewo mamwe ndarama injini uye extrapyramidal zvirwere.

Product: mapiritsi "mirapex PD" 3 MG, 4.5 MG, 1,5 MG, 0.75 MG, 0,375 MG. Ivo vari kugara mu Maronda akasiyana zvezvimedu 10, uye ipapo mumabhokisi makadhibhokisi.

mapiritsi chena. Vane beveled unopinza uye sandara chimiro kumativi ose, mumwe uyo une zvaunoita ngozi.

Mahwendefa zvinofanira kutorwa nemuromo zvisinei kudya. Idyai mushonga kutenderwa chero nguva. Muchiitiko chino, zvinofanira kusukwa pasi nemvura. Varumbidzwa dose daily rakakamurwa muzvikamu zvitatu.

The mashandiro chiito (pharmacodynamics) "mirapex" Mahwendefa

Inoshanda pramipexole venhumbi unotora kugadzirira "mirapex" zvakananga uye yakakwirira selectivity runogonesa kwaiita subgroup pakati dopamine receptors D2. Pamusana kwaari, ndanyarara hangu nokuda kusarovedza muviri basa kuna Parkinson chirwere. Izvi imhaka activation kuti dopamine receptors vari striatum. Saka pramipexole kunodzivisa ari degeneration pamusoro Tutsinga tunofambisa mashoko utwu kuti kunoitika nokuda neurotoxicity kana ischemia. It kuchititadzisa kana akazoita mwero kwetunhu, muviri, uye kusunungura dopamine. Nemhaka pramipexole Tutsinga tunofambisa mashoko utwu vanodzivirirwa kubva chepfu Migumisiro Anti-Parkinson nevasori "Levodopa". Uyewo nokuda zvainoita zvinoderedza prolactin (dose-kuzvimiririra).

Kana kushandiswa kwenguva yakareba mapiritsi "mirapex" nokuda pakurapa Parkinson nehosha (makore anopfuura matatu) uye chirwere kuti "makumbo zororo" (kupfuura gore) haana kuzivisa kwakaderedza kunyatsoshanda kuti pramipexole.

Nemakemikari pezvakaitwa chokuita kugadzirira "mirapex 'mumuviri womurwere (pharmacokinetics)

Active fuma "mirapex" chinodhaka iri zvachose uye nokukurumidza kunyura pashure nomumukanwa yaitonga. kukwanisa kwake kuitwa (bioavailability) ndiro rinenge mhedziso - vanopfuura 90%. The kunonyanyisa wevasungwa zvinodhaka munyika yeplasma vakachengeta pashure maawa 1-3 mushure kudya. At kudya pramipexole Absorção de Água zvazvingava kunoderedza. Panyaya iyi, uwandu digestible chikafu hakuna kushanduka.

C mapuroteni anosunga pramipexole zvishoma (asingasviki 20%). It ane guru Kuparadzirwa vhoriyamu - 400 litres, izvo zvinoreva kuti wevasungwa muropa yakaderera. Muduku pamwero pachena kuti mushonga muviri rikurumidze. Inenge 90% kuti dose "mirapex" pellets yabudiswa nokuda itsvo, pamwe 80% - kuchinja. The mutsvina yadzo pramipexole inowanikwa imwe mari pe2% of ukaparadza chitsama chezvinodhaka. Zvinyama uye muviri zvinwiwa inocheneswa kubva "mirapex" Mahwendefa panguva neavhareji yevanhu 500 Rine mamiririta / min.

Kushandisa "mirapex" chinodhaka panguva pamuviri

Ndinogona kushandisa panguva "mirapex" Hwendefa pamuviri? Mirayiridzo kushandiswa kwezvinodhaka rinojekesa kuti matambudziko ari zvinodhaka riri kukura ari mudumbu ari mudumbu uye lactation haina kuongororwa.

The zvinobvira mugumisiro pramipexole pamusoro hurongwa uye zviremera anokonzera muchangosangana kwacho akanga akadzidza mu kwakaita mhuka. Hazvina kuratidza kutyorwa fetus panguva yepamuviri mu tsuro uye makonzo.

Excretion kuti pramipexole kupinda mukaka asina kudzidza. Mumwe anogona chete zvokufungidzira kuti nefuma anogona tunodzivisa lactation, sezvo kuchititadzisa kugadzirwa luteotrophic kemikari. Naizvozvo, haufaniri kutora "mirapex" piritsi paanenge achiyamwa.

Panguva pamuviri, mushonga zvinofanira kutorwa chete kana kubatsira kungaita kuti mai kudarika yemberi njodzi kuna azvarwa.

Contraindications pakushandisa mahwendefa 'mirapex "

Drug "mirapex" haigoni kubatwa pakuparwa hypersensitivity kuti pramipexole, uyewo vanhu vakanga vasina asvika makore 18.

With inokosha yambiro inokurudzirwa kushandisa mapiritsi pasi shoma BP uye itsvo kukundikana.

Marwadzo "mirapex" chinodhaka pamusoro tsinga

Kugadzirira "mirapex" - Mahwendefa zvinogona kukonzera tsinga anotevera siyana:

• kuvhiringidzika;
• kunyanya nehavi hope kana kushaiwa yayo;
• zvisipo;
• kukanganwa;
• asthenia;
• dzungu;
• extrapyramidal urwere;
• hypoesthesia;
• tremor;
• myoclonus;
• dystonia;
• kuora mwoyo;
• delirium;
• vachida kuzviuraya;
• hypokinesia;
• ataxia;
• kufunganya;
• neuroleptic akaipa syndrome.

Last kuonekwa muchimiro hyperthermia, nenyonganiso kuti pfungwa uye mafungiro, tsandanyama Rigidity, autonomic lability, akathisia.

Side Migumisiro mapiritsi "mirapex" panorumwe mugadziriro muviri womunhu

Zvetsandanyama nemapfupa Hurongwa anogona kupindura kushandisa mishonga "mirapex" kuratidzwa dzakadaro:

• hypertonic tsandanyama, kugwinha dzavo, twitching;
• panowanikwa arthritis, myasthenia gravis kana bursitis;
• marwadzo ari mubhokisi, mutsipa kana musana (ari lumbosacral).

Vanogonawo kuitika kusiyana mune zvomudumbu ino. Kana izvi zvaitika,

• kurasikirwa havi;
• kupatira;
• svoto;
• dyspepsia;
• flatulence;
• manyoka;
• kurutsa;
• muromo yakaoma;
• achicheka kunzwa mudumbu.

Respiratoria kugamuchira "mirapex" zvinodhaka kungaita kuti kukura sinusitis, pharyngitis, rhinitis, dzihwa-kufanana syndrome. Zvinogonekawo panowanikwa kupfupika mweya, vakawedzera chikosoro uye izwi shanduko.

Chii sei kumwoyo "mirapex" piritsi? Mirayiridzo kushandiswa kwezvinodhaka anoudza pamusoro zvichibvira kukura tachycardia, arrhythmia, angina pectoris, orthostatic hypotension.

Other nemishonga

Kana muchigamuchira zvinodhaka "mirapex" matambudziko akadaro kunogona kuitika munyika urogenital ino, sezvo kakawanda bowel kufamba, hweHIV. Saka kunyange vakafunga kurasikirwa libido uye potency.

Uyezve, unogona kuona chiratidzo kaviri, cataract, conjunctivitis, kuoma pekugara, nezvimwe zvinhu, uye zvakanaka kunzwa, asi intraocular kumanikidzwa.

Other nenjodzi muviri:

• retroperitoneal fibrosis;
• pleural effusion;
• pulmonary infiltration;
• uremu;
• peripheral edema.

Chipimo chemushonga uye Administration "mirapex" Mahwendefa

Kushandisa zvinodhaka unofanira mukati, zuva nezuva 3 nguva. Initial dose "mirapex PD" Mahwendefa - 0,375 MG pazuva. Zvishoma nezvishoma kuwedzera uwandu zvinodhaka zvakafanira (ose 7 days) kuwana zvinodiwa kuchirapa mugumisiro. In nevhiki kurapwa rechipiri ose zuva apere ne 0.75 MG ari wechitatu - kusvika 1,5 MG nokuda wechina - ne 2.25 MG rechishanu vanofanira kunwa mushonga "mirapex" 3 MG zuva nezuva, pazuva rechitanhatu - 3.75 MG, wechinomwe - 4.5 MG.

In chisingaperi renal kukundikana, asi uwandu husingakuvadzi iri kugadziridzwa kwakavakirwa kuita nenhanho creatinine Clearance. The chaiyo zvinodhaka inofanira kugadzwa kuva chiremba.

Migumisiro ovhadhozi piritsi "mirapex"

Kana kushandisa "mirapex" chinodhaka chipimo chemushonga yakatyoka, zviratidzo izvi zvinogona kuitika anofungidzirwa zvisipo, hyperkinesia, kuda kurutsa, kurutsa, kunoderedza BP uye asina kuzvironga.

Nokuti izvi, kuti mushonga hauna kugadzwa. Nyaya zvinodhaka ovhadhozi "mirapex" iri usatsungirira. Varumbidzwa symptomatic kurapa, gastric lavage uye vakagwinya rucherechedzo. Kana pane zviratidzo ovhadhozi pakati excitation ari nechepakati tsinga, zvakakodzera kushandisa kugadzirira, neuroleptics.

Kutaurirana kwavatori Mahwendefa "mirapex" nevamwe zvinodhaka

Pramipexole akabatanidza yeplasma zvishoma uye biotransformation. Naizvozvo, kudyidzana kwayo nedzimwe zvinodhaka kuti chokuita azvaiitwa kashoma.

Zvinodhaka izvo tunodzivisa kana kudzvinyirira kugadzirwa vanoshingaira zvinhu kana cationic samovyvodyaschiesya kuburikidza renal tubules, unogona sei ne mapiritsi "mirapex". Mirayiridzo zvokushandisa inotsanangura kuti iyi nyaya nokukurumidza rutapudzo pachena kuchenesa nzvimbo dzomuviri uye utachiona zvinwiwa kana kubva medicaments kana mumwe wavo.

Kana panguva imwe chete mapiritsi 'mirapex "kushandisa zvinodhaka izvi, unofanira kuteerera zvichibvira zvisipo, dyskinesia, nokusagadzikana. Kana zviratidzo izvi zvichiitika, kuti chipimo chemushonga zvinodhaka anofanira kuderedzwa.

Kugarisana Mahwendefa "mirapex" zvinodhaka "Amantadine" uye "L-dopa"

Chii chinoitika kana kukabatanidzwa mabiko "Levodopa" zvinodhaka uye "selegiline" mapiritsi "mirapex PD"? Instruction inoti kuti pharmacokinetics yezviri mumiririri asingadi kukanganisa wekutanga kana wechipiri. Panguva iyoyo pasi zvizere kuitwa uye excretion zvinodhaka inongoitika nzira "Levodopa" piritsi "mirapex" haana kuzivikanwa.

Pramipexole haana kudzidza kukurukurirana pamusoro zvinodhaka "Amantadine". Asi kugarisana zvichigoneka yokurapa, sezvo vane zvakafanana zvigadziriswe pakati excretion.

Kana dose "mirapex" gadziriro yakawedzera, application mari "Levodopa" ndakarumbidzwa kutapudzwa. Kuwanda zvimwe zvinodhaka antiparkinsonian zvinofanira kuchengetedzwa kugara nenguva chechetere.

Features kugarisana gadziriro "mirapex" nevamwe zvinodhaka

Nokuda mukana tinofanira kugara migumisiro nokungwarira hwakanyanya inokurudzirwa kushandisa mapiritsi "mirapex" akabatana sedatives, doro, uye kushandisa zvinodhaka kuti anobatsira kuwedzera pramipexole wevasungwa muropa (semuenzaniso, mushonga "Cimetidine").

nhungamiro yakananga pakushandisa "mirapex" mahwendefa

Tiri kurondedzera mushonga hauna varumbidzwa kutora pachiimbwa antipsychotics.

Pakurapa dopamine agonist anozivikanwa divi Marwadzo kuvhiringidzika uye fungidziro. Muzviitiko "mirapex" Mahwendefa Rakabatanidzwa zvinodhaka "Levodopa" abnormalities dzakadaro dzaiva kakawanda munguva dzinouya nzendo chirwere pane kumavambo monotherapy.

Chiremba anofanira kuudza murwere ari inobvira panowanikwa zvinhu zvisipo. Izvi divi zvazviri kunokanganisa kugona kudzinga motokari uye zvisarudzo mutoro.

Kusiyana discontinuation mahwendefa kuna Parkinson nehosha vakanga dzakaonekwa chimiro zviratidzo chinoratidza neuroleptic akaipa syndrome.

Anomalous maitiro kushandisa "mirapex" chinodhaka

Varwere uye avo dzinovabatsira, zvakakosha kuziva kuti negashiro dopaminergic zvinodhaka, kusanganisira "mirapex" Mahwendefa (wongororo zvinoratidza ichi), kunowanzokonzera zvemamiriro maitiro murwere. Unogona kuona hyperphagia (nokudyisa muropa), pathological kunotenga (nyanyisa chido kuti yakawanda kutenga), muropa nokubheja uye hypersexuality. Muzviitiko zvakadaro zvakafanira yokuderedza uwandu husingakuvadzi zvinodhaka kana zvishoma nezvishoma kurega kuushandisa.

Kungwarira kushandisa "mirapex" mahwendefa

Medicine "mirapex" apere yambiro varwere kuvapo kwazvo zvirwere kumwoyo. In vachiitisa kurapa pamwe dopaminergic zvinodhaka pane mukana orthostatic hypotension. Saka, mumwe BP vasingazvidzori, kunyanya panguva kutanga kwekupwanyiwa kurapwa.

Kana kutadza kuona zvakanaka zvaanofanira kugara nayo pakarepo pashure kugadzwa mahwendefa "mirapex" uye zvikamu mberi kunorondedzerwa.

Varwere vanofanira kupiwa chokwadi kuti mushonga angava kunyaradza nomugumisiro. Kwave zviitiko pakarepo hope uye kunyanya nehope masikati kusvikira mabasa zuva. Kusanganisira izvi zvingaitika chero nguva iri kurapa kunzwisisa michina kana kutyaira motokari.

Mukana dzichiri melanoma

Somugumisiro epidemiological netsvakurudzo kuti varwere hosha yeParkinson vari pangozi melanoma. Ko chinokonzera chirwere ichi, kana zvimwe zvinhu, zvakadai kushandiswa "mirapex" chinodhaka haina dzatangwa.

Kusimbisa pamusoro urwere pakati "makumbo zororo"

kuti chirwere kuti "kudzikama makumbo" zvinodhaka "mirapex" anoita sei? Testimonials anoratidza kuti dopaminergic zvinodhaka anogona kuwedzera izvozvo. Izvi zvinoonekwa chimiro kwokutanga kutanga zviratidzo manheru chirwere uye dzimwe nguva ari masikati. Panyaya iyi, zviratidzo vakapararira kune dzimwe nemakumbo. The wakaitwa kwevhiki 26 chiremba kudzorwa kudzidza, iyo yakagadzirirwa kudzidza ichi zvazviri, musiyano chinokosha pakati pramipexole uye kurapa kunonyaradza pfungwa nemapoka dzekugonesa zvaidiwa chirwere kunge kuzivikanwa.

Storage mamiriro uye sherefu upenyu

"Mirapex" hwendefa anoreva gadziriro yacho pamazita B. Store vanofanira kuva munzvimbo ine rima. Panyaya iyi mumba tembiricha haafaniri kupfuudza 30 ° C.

Pasherufu-upenyu zvinodhaka - mwedzi 36 (3 years) kubva musi kugadzirwa.

Kushandiswa "mirapex" mahwendefa pauduku uye mamiriro echibvumirano

The mushonga ari contraindicated dzokushandisa vana. Mvumo makapiwa vanhu kugamuchira pamahwendefa, izvo zvasvika nemakore 18. Medicine "mirapex" yakabudiswa muna Pharmacies iri mharidzo mushonga.

Drug analogues "mirapex"

Haukwanisi, nokuti chero chikonzero, kuti vawane hwendefa iri "mirapex"? Chii chinogona kutsiva chinodhaka, unofanira kuudza mishonga kana chiremba. Uye tinopa zvinotevera analogues.

1. "Motopram" mapiritsi. Zvairatidza kuti kushandiswa: chirwere chinonzi Parkinson. It kunogona kuitwa chete kana pamwe mishonga mushonga 'levodopa'. Rinoshandiswawo nokuda kwazvo kana nepakati idiopathic chimiro urwere pakati "makumbo zororo".
2. "Oprimeya" mapiritsi. Chinangwa: antiparkinsonian Mushonga rinodhaka dopaminergic Kupfuudzwa nechepakati tsinga.
3. "Pramipexole" mapiritsi. The kuchirapa mumiririri inoshandiswa Parkinson chirwere. Zvinonzi vaidavira kuti mashandiro chiito kwakabatana zvakananga mano imwe pfuma pramipexole kukurudzira dopamine receptors ari striatum.

Mahwendefa "mirapex" - analogues kana yepakutanga? No kuzvidzora!

Ari pamusoro dzakanyorwa zvigadzirwa, zviri analogues kuti 'mirapex "Mahwendefa. Vane chete nemamwe, dzakawanda dzisiri proprietary zita (kana ATC-Bumbiro), izvo inokurudzirwa ne WHO (World Health Organization).

Kana uchida kuti va- kurapwa vachishandisa mahwendefa "mirapex" analogs rinogonawo kuva nzira huru. Asi usati kutsiva nzira yakatarwa yokurapa, iva nechokwadi kuti kubvunza nyanzvi. Under hapana ezvinhu regai kuzvidzora! Izvi zvinogona kukonzera kusingarapiki zvakaipa kuti utano hwako.

Yambiro! Nyaya Iri tsanangudzo "mirapex" gadziriro iri vaisanganisa uye nyore shanduro yepamutemo mirayiridzo kushandiswa. Drug mashoko anoratidzwa kuti chinangwa kwokudzokorora. Hapana nyaya musashandisa rive anoperekedza dzokuzvirapa.