Instructions "Gonal-F." Description rekugadzirira, contraindications, analogs uye wongororo

Mumwe nevakawanda nzira kushaya mbereko kuti havi ovulation. For mazai akawanda yakanakira fertilization, zvakakodzera kuitisa pre-zvinodhaka kurapa chaiyo. "Gonal-F" anonzi imwe inonyatsobudirira zvinodhaka munzvimbo iyi. Instructions "Gonal-F" anokurudzira zvikuru kurapwa pasi kuzviomesera zvokurapa achitarisirwa.

tsanangudzo

Munhu wose anoziva kuti pasina ovulation pamuviri havagoni kuitika. Naizvozvo, vazhinji akanaka pabonde, akatarisana nechinetso zvakaoma kudaro kuti kugadziriswa kuti dzishande uye ezvokunambira kunze kwomuviri waamai muchangosangana. The kupinda Chiremba anofanira kutanga basa pane kuongorora zvokurapa, kunhonga runoenzanirana Zano nzira uye kugadzirira zvakakodzera.

Kupfuura yakachengeteka uye inobudirira zvokushandisa zviri kwakavakirwa follicle nekurukurirano kemikari - FSH (recombinant), ndiro basa kuibvisa ose follicles vakadzi. Instructions "Gonal-F" inoshuma kuti mushonga chomumwe muchikwata ichi, uye mashandiro chiito kwakafanana pedyo yepanyama FSH. Buy mishonga chete chiremba mushonga.

zvairatidza

Drug kudiwa ari gynecological munda uye basa kana kuti Activate kukura follicles. Zvairatidza kuti kushandiswa "Gonal-F" rine zvinotevera:

• Kusavapo ovulation uye kusingagutsi mugumisiro pashure kushandisa "Clomiphene".
• Polycystic ovarian chirwere (zvokurwara chokuita hormone zvinetso kukonzera atadze kushanda zvakanaka pamusoro ovaries).
• Kudiwa kweiyi vakawanda follicles kuti IVF.

Zvakawanda zveBhaibheri dzokurapa yakasimbisa efficacy zvinodhaka kana zvakakodzera kusimudzira vakawanda follicles mu nedanho ovarian hyperstimulation (pehurumende). Rakavakwa kuti yezviri chirungiso inosimudzira kukura follicles, uye nokudaro zvikuru kunoderedza mukana ovarian hyperstimulation.

Application vanhu

Kana asiri zvaidiwa dzinokosha mashandiro ngakuite gonads pakati spermatogenesis kwacho - paumbwe uye kukura dzisingaoneki - runovhuniwa. Follicle anotokonya kemikari zvakakodzera kuti "kutanga" pamusoro muitiro uyu, huchavapo mazuva 75. Wanikidza pathological mamiriro zvinogoneka chete pashure kwemutemo yezvokurapa Diagnostics uye chokuendesa urume.

Kukuchidzira (kana kudzorera) kunowanzoitika inotungamirwa vanhurume gametes dzimwe nguva anotora yakareba kupfuura nemaitirwo vakadzi. Nokuti zvakanaka pamusana kurapwa vanofanira kutevedza zvizere kunenge andrologist. Unofanira ukaramba yakarongerwa zvokudya, kusiya kushandisa doro uye chikakananda. Zviri fanira kugadza gadziriro chaidzo. Instructions "Gonal-F" anoratidza kuti mushonga inogona kushandiswa kuwedzera spermatogenesis varume vane vachiberekwa kana vawana hypogonadism. Zvipatara kunofanira pasi kuramba pokudzora nyanzvi ane ruzivo pakurapa mbereko.

mushonga

Active chezvinonhuwira mushonga anoita follitropin Alfa - imwe fuma kuti kunomutsa kukura follicles vakadzi vane kuvhiringidzika hypothalamic-pituitary hurongwa. The bioavailability zvinodhaka kana raitongwa subcutaneously inenge 70%.

Active chirungiso anotanga kuunganidza ari muviri mushure kutarisira inodzokororwa. Mumwedzi 3 Mazuva okutanga vakachengeta rwakakoshwa kuwedzera zvakanyatsoenzana wevasungwa pamusoro follitropin Alfa, iyo inotanga dzishande rikurumidze.

Ebetsero zvinoriumba zviri mushonga kuti yavaibvisa hydroxide uye rehydrogen phosphate dihydrate, phosphoric acid, methionine, sucrose, polysorbate 20.

kusunungurwa Form

"Gonal F" unobereka wokuItaly mishonga kambani "Industry Farmasyutika Serono Spa". Form kusunungurwa mumiririri - mhinduro kuti subcutaneous jekiseni uye lyophilisates kuti mvura.

The syringes muchimiro mumatanga anokwanisa ane 0.5, 0.75 uye 1.5 Rine mamiririta. Yakadereresa dose akaenzana 22 micrograms pamusoro follitropin Alfa (300 Iu), unosvikirwa - 33 MG kuti basa chirungiso (450 Iu). Kudeuka Huwandu vanoshingaira mumiririri iri 1.5 Rine mamiririta - 66 micrograms ( "Gonal-F 900"). Mutengo zvinodhaka kunoenderana wevasungwa yezviri fuma.

Chinyoreso ane dispenser uye pamwero, inoita kuti kudzora dose. In chimiro ichi mishonga kutenga zvikuru zvinobatsira inobvuma dosages siyana. Zvazvakanakira anogona kunzi, uye pasina kudikanwa kugadzirira mhinduro pamberi nomumwe jekiseni.

Lyophilizate gadziriro mhinduro kuti jekiseni rakasanganiswa mura pamberi mumwe evanhu. The inodiwa chipimo chemushonga the pre-anoti nyanzvi nomumwe nyaya imwe neimwe.

Sei pakurapa "Gonalom-F"?

In kusavapo ovulation mishonga rinotanga muvhiki yokutanga kumwedzi, akapa dzose varikutsika (zvimwe zvinoita Frequency kutsauka). Pfungwa dzishande inofanira chinozoiswa pasi kudzorwa Ultrasound kudzidza, izvo zvinoita kuti kudzora ukuru follicles. Kutanga dose - 0,13-0,25 Rine mamiririta zvinodhaka "Gonal-F 75". Price mhinduro ine 5.5 MG pamusoro follitropin Alfa, ndiye apasi ari kumativi 110 rubles. Kuwedzera dose pamusoro 1-2 vhiki kusvika 225 Iu (kunonyanyisa).

Kana mukati mwedzi mumwe kurapwa haapi nemigumisiro yakanaka, zvinodhaka kurapa zvinofanira vakarega. kwokutanga chipimo chemushonga achawedzerwa mamwe kurapwa.

Kana kudiwa dzinodzorwa ovarian hyperstimulation zvinodhaka chinotarisirwa iri chipimo chemushonga pamusoro 150-225 Iu. Kufadza daily dose haafaniri kupfuudza 450 Iu. Zvipatara kunotanga mazuva 2-3 kumwedzi. Achibatsirwa Ultrasound nyanzvi kuchaita kuongorora kukura follicles. Ya kurapwa zvingava mazuva 5 kusvika 20. Mushure wokupedzisira aizomupa, papera maawa 48, imwe jekiseni evanhu chorionic gonadotropin.

Varume vane matambudziko vane muitiro spermotogenez inoratidzawo dzishande. "Gonal-F" munzvimbo iyi iri ikashandiswa pamwe kwevanhu chorionic gonadotropin. Yekushandisa mishonga zvaiitwa ndiyo subcutaneous jekiseni zvinodhaka katatu pavhiki (dose 150 Iu). Duration yokurapa kunofanira zvinenge 4 months, pashure munhu anofanira aongororwe. With shoma kana kwete kuvandudzika migumisiro kurapwa ingangowedzera kusvika mwedzi 18.

Dosing

The jekiseni zvinodhaka wokutanga kunofanira kuva nyanzvi muchipatara. Zvaakanga arayira, mune ramangwana murwere anogona kushandisa chinyoreso kuita bara, "Gonal-F." Inofanira kutanga kuzivana mirayiridzo kuti zvinodhaka.

Zvinotevera kurumbidza kuti yakazvimirira kushandiswa kwezvinodhaka,

1. Pamberi kubaya, "Gonal-F", vanofanira kugeza maoko avo kwazvo nesipo nemvura uye zvichida mamwe kupatsanurwa akambozvishandisa kuuraya utachiona.
2. Yaora pamusoro yakachena pamusoro raida zvinhu: peni sirinji, chinu upfu uye mvura jekiseni, doro swabs.
3. Zvakakodzera kugadzirira chinyoreso, kubvisa chivharo, kuisa zvinodiwa chipimo chemushonga uye batanidza tsono.
4. Lyophilisate (upfu) rakasanganiswa nemvura kuti jekiseni nokusuma mvura kupinda chinu pamwe pakaoma ane fuma. The rabha pabutiro anofanira ponji tsono kuvhura nehombodo hazvisi zvakakodzera. The mvura inofanira kusumwa zvishoma nezvishoma.
5. It is dhayira mumhepo sirinji kusvikira runodiwa dose, kuisa tsono kupinda chinu ane mhinduro pamusoro (kare husisina kumira), kusuma mhepo uye dhayira zvinodiwa huwandu zvinodhaka.
6. The sirinji inofanira kuva mhepo matema. Kuti kubvisa kwavari, unofanira kuti vawane munwe wako pamusoro pamasvingo sirinji uye matema kuenda kumusoro. Zvino zvakafanira kuti kuvaparadzanisa plunger uye kusunungura zvakawandisa mhepo.
7. Skin anofanira kubatwa akambozvishandisa kuuraya utachiona (doro) panguva jekiseni nzvimbo.
8. The jekiseni zvinoitwa subcutaneously pa 45 kana 90 inegumi. Mavara kuti achizviendesa plunger hakusi zvakakodzera. The mushonga chinofanira kupiwa zvishoma nezvishoma.
9. Nokuti Kutarisirwa kwezvinhu "Gonal-F" Via sirinji matanga rakakwana achizviendesa kutanga bhatani. The tsono ari mudziyo ichi chitete uye diki, saka kurwadziwa nyoro kana hariwanzotaurwa.
10. Mushure jekiseni kune nzvimbo jekiseni kunofanira kuburikidza donje swab zvakakangwa mu akambozvishandisa kuuraya utachiona.
11. Disposable sirinji vachadzingwa pashure nzira.
12. With tsono-sirinji Pazvibato anofanira kubviswa, pfekai chivharo. Akatevera bata zvinokosha kushandisa tsono idzva rinoburuka wakakwana chezvinodhaka.

nemishonga

Kugadzirira "Gonal-F" anogona kukonzera marwadzo panguva kurapwa. Vamwe vakadzi akaona zvinotevera zviratidzo:

• Dzokubereka nadzo - kazhinji kuva ovarian cysts.
• The kunambwa zvinodhaka kunogona kukanganisa nhengo yacho zvomudumbu turakiti. It runoratidzwa nechitarisiko kuda kurutsa, kurutsa, manyoka, kusagadzikana uye kurwadziwa mudumbu.
• The jekiseni Nzvimbo zvingaitika kuzvimba kana akatsvuka ganda.
• zviitiko neutachiona chaizvo zvisingawanzoitiki: mapundu, kuvaviwa, zvakaoma kufema, mapundu.
• Pamusoro chikamu nechepakati tsinga - vanogona kuva kakawanda nomusoro.
• Kuvaduku kazhinji pane zviitiko inokanganisa kumwoyo (thromboembolism).

Instructions "Gonal-F" kunoratidza kuti varume vane mishonga kuonekwe mburwa, zvishoma kwakawedzera muviri uremu. Pane mashoma zviitiko varicocele, gynecomastia.

Contraindications

The mushonga ine simba kukanganisa muviri uye saka haagoni kupiwa pasina risati kurapwa. The rinoita fuma uye mamwe zvinoriumba vane zvimwe zvavasingakwanisi kuita kana kushandiswa. Chiremba anofanira ngaafunge izvi uye kugadziridza kurapwa zvaiitwa.

Instructions "Gonal-F" inonyevera kuti mushonga hakubvumidzwi kushandisa vanhu vane kusashivirirana kana hypersensitivity kuti zvinhu zviri Pfungwa. Muchiitiko chino, anogona kuva zvakakomba sema maitiro kana zvimwe matambudziko. Uyewo Contraindications dzinosanganisira:

• Uterine ropa pamusoro zvisingazivikanwi etiology.
• Oncologic zvokurwara yomunyika sikarudzi.
• Nguva dziri kure ovarian cysts kuti mune pakanyorwa polycystic.
• Pamuviri uye lactation.
• Vachiberekwa abnormalities zvomukati, izvo haawirirani pamuviri.

A Mazvikokota inorangarira vose comorbidities dzinowanikwa murwere nhoroondo. Mune mamwe mamiriro ezvinhu, hapana chikonzero kushandisa maturusi, "Gonal-F." Price kurapwa kunoenderana ya pakurapwa uye chipimo chemushonga zvinodhaka, asi kunyange kurapwa zvinodhura kuuya kutarisirwa kwakaguma pathologies akadai uterine fibroids, magadzirira kubereka, mhingaidzo pamusoro fallopian sepombi.

Zvakakurukurwa kushanda

Usati kurongera mushonga havi ovulation kana spermatogenesis muitiro, chiremba kushandisa kurapa kushaya mbereko, vanofanira kuitisa zvokurapa chirwere vakaroorana, kubatsira ushe kubva kuvapo contraindications uye kudiwa kurapwa. Zvinokoshawo uye chipimo chemushonga vanoronga zvichabviswa iiswe.

Varwere vanosangana dzishande "Gonalom-F" IVF asati kunowedzera mikana kubata pamuviri pemapatya. Chiremba vanosungirwa kuzivisa mukadzi pamberi kutanga kurapwa.

Mawa kushandiswa kwezvinodhaka nedzimwe yomuchipatara kuti itibatsire kukura follicles, kungakonzera kukura hyperstimulation. Mumazana kosi yokurapa zvinokosha kuti kuitisa ultrasonic chirwere uye kuongorora kukura follicles.

"Gonal-F": mutengo uye wongororo

Italian mushonga havi ovulation ane kare kwenguva refu nachiremba kurapa kushaya mbereko mune varume navakadzi nguva. Uyu ndomumwe inonyatsobudirira zvishandiso (vanachiremba vakawanda vanotaura nayo se "inorema atirari"). "Gonal-F" akaratidza nemigumisiro yakanaka kunyange zviitiko apo vamwe kuvazivisa nzira vaiva simba. The inokosha Kutonga kuteverwa nevarwere iri zvizere zvokurapa kudzora muitiro vakwegura follicles uye spermatogenesis,.

In marapirwo chipimo chemushonga hazvingashandurwi mu maduku uye hombe nzira. Mari zvinodhaka zvichisiyana 1,100 rubles. kusvika 16 000 rubles. ( "Gonal-F" 900 Iu). Kuwedzera pakushandisa maturusi zvinodhura, zvinokosha kutevera vamwe anobata kudya uye kubvisa zvachose zvokudya zvisingavaki muviri, Semi-rakapera zvigadzirwa.

Panguva mushonga, vairambidzwa kunwa doro, ine inokanganisa dzisingaoneki kugadzirwa, kukanganisa pituitary shwanu uye hypothalamus, kukanganisa muviri zvepabonde steroids. Yakawedzera aikanganiswa mune urume uye chikakananda.