Inorwisa mabhakitiriya "zyvox": mirayiridzo kushandiswa, analogs

Mukurapa kwezvirwere zvehutano hwebhakitiriya, chiremba kazhinji anongoronga antibiotics. Iyi mishonga ine nhamba yakawanda yemarudzi. Zvechokwadi, hazvibviri kuziva marudzi ose emishonga yemishonga inorwisa mishonga, asi mamwe mishonga inopesana nehutachiona hwehutachiona inonyanyofarira.

Chimwe chemazuva ano antibiotics, iyo inomiririrwa mumisika yedu yemishonga - ndiyo Zivox. Mirayiridzo yekushandiswa kwechirwere ichi inoratidza kuti iine antimicrobial agent inogadzirwa. Iye ndeyeboka rinokosha - oxazolidinones. Chinhu chikuru chinoshanda chiri linezolid. Zvadaro tichakurukura mashoko anotevera: chiito chechirwere Zivox, mirayiridzo yekushandiswa, mifananidzo, migumisiro uye zvinopesana.

Inogadzirwa sei?

Ichi chemishonga chinowanikwa muzvipimo zviviri zvemadhora:

• Muchimiro chegranules, yakagadzirwa nemuchena kana machena uye ine ruvara rwearangi. Pakati peizvi, chirongwa chekare chinogadzirirwa, nekutarisira kuti 100 mg ye linezolid ichave iri mukati mamiriyoni mashanu ekumiswa kwapera. Iyo mikoko inowanikwa mumudziyo we 150 ml usina kuchena. Uyewo muhomwe pane chiyero chekuyera uye zvikamu (2.5 uye 5 ml yekumiswa).
• Mune mahwendefa ane 600 mg ye linezolid. Mubhokisi pane blister imwe ine mapiritsi gumi mukati.
• Kupindira kwemukana une 2 mg we linezolid / 1 ml, mumapaka 100, 200, 300 ml.

Chii chinokonzerwa nehutachiona hwechirwere?

Kushanda kwezvinhu zvinhu linezolid kunokwanisa kupinda mukati memasero eubhakitiriya, kusunga ribosomes yavo nekudzivirira mapuroteni synthesis. Somugumisiro, microorganisms anofa.

Kurwisana nei microorganisms inobatsira chirwere ichi?

Chirwere ichi "Zivox", murayiridzo wekushandisa kwayo inofambidzana nepasi rimwe nerimwe rine mishonga, rinogunzva zvinokonzerwa nemakoromineki anotevera:

• Gram-positive aerobic bacteria: enterococci, corynebacter, staphylococci, streptococci;
• Gram-negative aerobic mabhakitiriya een genus Pasteurella;
• Gram-positive anaerobic mabhakitiriya: clostridium uye peptostreptococci;
• Gram-negative anaerobic mabhakitiriya emujeri prevotella, bacteroides, chlamydia.

Kusvikira linezolid, mabhakitiriya ejeri moraxella, legionella, mycoplasma anonyatsoona.

Kunewo ma microorganisms anoratidza kurwisana ne linezolid inowanikwa mukugadzirira Zivox. Mirayiridzo yekushandisa inoratidzira zvinotevera zvinorwisana nematambudziko: mabhakitiriya ane hemophilic, uye genera enterobacteriaceae, nizera uye pseudomonas.

Pane zvirwere zvipi mushonga uyu unoratidzwa?

Antibiotic "Zivox" inorayirwa kune zvirwere zvinotevera:

• Zvirwere zvinotapukira uye zvinovhiringidza zvinokonzerwa nemaabhakitiriya anoratidza kuvanzwa kwechirwere ichi.
• Muzviitiko zvechipatara kana munharaunda-inowanikwa pneumonia.
• Nezvipembenene zvinotapukira zveganda uye zvinyoro zvishoma zvemuviri womunhu.
• Muhupo hwezvirwere, avo vanokonzera zvinokonzera iyo inococci, vachiratidza kupikisa vancomycin.

Uyezve, mushonga unorwisa mabhakitiriya "Zivox" unogona kushandiswa sechikamu chechirongwa chekubatana kwehutachiona hunokonzerwa nemaakirita emagiramu.

Pharmacokinetics

Linezolid inozivikanwa nekunyanya kunonoka kubva kune gumbo rekudya kusvika muropa, pasinei nehuwandu hwekusunungurwa kwemuenzi. Sekuve kwemaawa maviri kubva panguva yekutora mishonga, kuiswa kwayo mumaplasma kunosvika pakukwirira kwayo. Linezolid inoratidzika nehuwandu hwebioavailability, uye kugoverwa kwayo kune nhengo uye mishonga zvinokurumidza kusvika. Pasinei nokuti izvo zvinokonzerwa nemishonga inorwisa mabhakitiriya muropa, 31% inosanganiswa nemapuroteni e plasma.

Mumumuviri wemunhu, linezolid inoshandiswa nehuniyidhesi kune zvigadzirwa zviviri zvisingambove nemaitiro antimicrobial. Vanoshamiswa neitsvo (anenge 50%) uye matumbo (kusvika 6%). Kusvika 35% yemishonga inorwisa mabhakitiriya isiri yemabhaibheri yakanyanyiswa pamwe chete nemugini.

Stable pharmacokinetics, inoratidzwa neZivox, inonzi. Mirayiridzo yekushandisa tsanangudzo kusava nekuvimba kwechirevo ichi chemishonga pazera remurwere. Panyaya iyi, vanhu vakwegura haafaniri kuchinja muyero wemiti yemishonga iyi.

Nhamba yechirwere

Zyvox zvinodhaka zvinogona kurongerwa nachiremba kumurwere kuti ashandise mumuromo kana sekuvhiringidzwa kwemukati. Uye murwere anogona kuchinjwa kubva kune imwe mhando yekushandisa zvinodhaka kune imwe pasina kurasikirwa nekubudirira kwehutano.

Chiremba chechirwere, nguva yenguva yacho inorayirwa nechiremba anoenda, uye izvi mamiriro ekurapwa anotsanangurwa nezvimwe zvinotevera:

• Iro rudzi rwebhakitiriya chirwere chakakonzerwa;
• Localization of infection;
• Kuoma kwechirwere;
• Kushanda kwepfungwa yekurapa.

Kana iri streptococcal pneumonia yekunze kwechipatara nechipatara rudzi rwevanhu vakuru nevana vanopfuura makore gumi nemaviri, 600 mg yeZivox inorayirwa. Iyo murayiridzo inoratidza kuti chirwere chechirwere chinofanirwa kutorwa maawa gumi nemaviri, uye nguva yegadziro iri mazuva gumi nemaviri.

Nehutachiona kana zvinyoro zvinyoro zvishoma zvakaoma kana zvisinganzwisisiki, zvakakonzerwa ne staphylococci, streptococci uye vancomycin inopesana nevanococci, kusanganisira diabatic foot syndrome (pasina osteomyelitis), chirwere cheZivox 600 mg chinorayirwa. Iyo mirayiridzo inotiwo kuti nguva iri pakati pemiti inofanira kuva maawa gumi nemaviri. Nzira yerapi inotora mazuva gumi nemaviri, asi inogonawo kupedza kusvika mazuva makumi mana nemakumi mana nematatu maererano nemirairo yechiremba.

Kana murwere ane hosha kukundikana, saka haadi chirongwa chekugadzirisa chirwere. Paanoita nzira ye hemodialysis, linezolid inobviswa panguva iyo nguva yemaawa matatu. Mukusangana nemamiriro ezvinhu aya, mushonga unofanirwa kutorwa mushure mekuchenesa ropa. Varwere vanoonekwa kuti vane chiropa kukundikana havakwanisi kuchinja kuwedzerwa.

Varwere vasati vava nemakore gumi nemaviri vanongorongedzerwa chete maitiro ekuputika eZivox. Mirayiridzo inoshandiswa muzvitsva uye vana inoratidza kuti linezolid inofanira kutorwa pamutengo we 10 mg / kg yehutakadzi hwemwana pane imwe nguva yemaawa masere ose. Nzira yekurapa inobva pamakore gumi kusvika ku14. Iyi miyero yemishonga inobatsira kurapwa mune mharaunda yepamusha uye chipatara pneumonia, zvirwere zvezvinyoro zvinyoro uye ganda, pamwe chete nekudzivirira kwezvirwere zveEcocococcal.

Idziviriro yekudzivirira iyo yakagadzirwa nemashizha inobviswa pakarepo musati wanyungudzwa. Iwe unofanirwa kutarisa purogiramu yekudonha, kuiridzira iyo kweminiti imwe. Kuvhara kusina kuiswa hakukodzeri nekuda kwekusina simba. Nzira yekugadziriswa inogadziriswa panguva ye 30-120 maminitsi.

Application Features

Pane zvimwe zviitiko zvekutora Zivox. Iyo murayiridzo inoratidza kuti kana hutachiona hukakonzerwa nemakirakita e gram-negative, saka zvakakosha kubatanidza mamwe mishonga nemabasa anopesana neboka iri re microorganisms.

Paunotora linezolid, vamwe varwere vanogona kuve nekudzoka kwemyelosuppression. Zvichienderana nehuwandu hwehutano, hunoratidzwa neanemia, leukopenia, thrombocytopenia kana pancytopenia. Kubva pane idzi data, kuongororwa kweropa kunofanirwa kuitwa kune varwere vari pangozi yekubuda ropa. Uyewo, zviyero izvi zvakakodzera kana murwere ane nhoroondo yekutengesa mishonga kana anotora mishonga inoderedza huwandu hweHemoglobin uye maplatelets kana basa ravo. Kuongororwa kwehuwandu hweropa kunobatsirawo kwenguva yakareba yekurapa (mazuva anopfuura 14).

Mune vamwe varwere, kushandiswa kwe linezopa kunogona kuendeswa nehutano hwekudzivirira hutachikiti pseudomembranous nature yemhando dzakasiyana dzekuoma.

Dhairrhea inowanikwa kune vanhu vanotora mishonga inorwisa mabhakitiriya kakawanda. Izvo zviyero zvezvikamu izvi zvinokonzerwa zvinogona kubva kubva kune zvishoma kusvika kune zvakanyanya. Paunenge uchitora Zivox, mapiritsi kana kusimiswa, chirwere chinowanzoitwa mumatumbo chinodzvinyirirwa uye bhakitiriya rejusti Clostridium inopfuura. Muhupenyu hwehupenyu hwavo, iyi microorganism inovanza marwadzo emapoka A uye B, uye inokonzera marwere. Kuwedzera kwehuwandu hwezvinhu izvi kunogona kukonzera rufu kune varwere. Vose varwere vane chirwere chechirwere ichi vanoda kunyatsoongororwa navanachiremba kwemwedzi miviri.

Mune zvimwe zviitiko kune kuwedzera kwekuona kana pachitapwa neZivox. Mirayiridzo yekushandiswa muvana nevakuru inoratidza kuchinja kunogona kuonekwa pakuonekwa kwemavara, kutsvaga kwekutsvaga, kukanganiswa kwemunda, kubhururuka. Mune zviitiko izvi, murwere anoda kubvunzurudzwa nekukurumidza kune an oculist. Kana mushonga uyu uchitorwa nemurwere kwenguva yakareba (inopfuura mwedzi mitatu), saka zvakakosha kuita kutarisa kunooneka pasina. Apo kutaridzika uye kukura kwezvinhu zvakadai seperiipher or optic nerve neuropathy, mubvunzo unomutswa pamusoro pekurega kurapwa kwemishonga kana kubatsirwa kuri kudarika kudarika kwehutano.

Paivawo nematambudziko elactic acidosis neZivoks. Inoratidzika mumhando yekunyunyuta, kurutsira, kusanzwisisiki acidosis kana kuderedza carbonate anions. Ichi chiitiko chinofanirwa kunyatsocherechedzwa nemumwe chiremba wezvokurapa.

Kana murwere ane chido chekutora serotonin reuptake inhibitors pamwe chete neZyvox, iye zvino anofanira kutorwa pasi pekutarisirwa kwehutano kuitira kuti azive serotonin syndrome: kukundikana kwemagariro ekuziva, hyperreflexia, hyperpyrexia, uye kutadza kubatana. Mukuvapo kwechiitiko chinotsanangurwa, kurapwa kunomiswa nemumwe kana kuti mishonga yose. Muchiitiko ichi, kubhurwa kwezino maziso kunowanikwa, iyo inobviswa neunyanzvi hwekuchenesa.

Pane imwe imwe yambiro yekutora Zivox. Mirayiridzo yekushandiswa (mahwendefa kana granules yekugadziriswa kwekumiswa - kwete chinangwa) inoti: mukurapa ne linezolid, hazvikurudzirwi kuendesa motokari, kutarisira midziyo yakananga nemabasa zvinosanganisira ngozi kune hupenyu uye hutano.

Ndezvipi zvinokonzerwa nemishonga?

Kuchinja kusina kunaka kunogona kuitika mumurwere paanotora Zivox 600 mg inorongerwa maererano nehuwandu hwekuratidzwa: kubva pane nguva dzose (10%) kusvika zvisingawanzovi (0.01%).

Kazhinji, semigumisiro mukurapa nemushonga we "Zyvox" mirayiridzo yekushandiswa, sarudzo kana bhetiroti, inoshevedza chiitiko chekunyorova kana kunonotsa. Zvinhu zvinotevera zvinowanzoitika:

• Nausea;
• Diarrhea;
• Headaches.

Vakuru vanogonawo kuvhiringidzika, kurutsira, kurwadziwa mumimba, flatulence, uye zvirwere zvakashata zvemukati.

Kuti zvive nemigumisiro yakaipa kubva mukushandiswa kwemishonga inonzi "Zyvox" mirayiridzo yekushandiswa (kwevana vanopfuura makore gumi nemaviri nevakuru) inoshevedza inoshandura muvara rweruvara rwerurimi.

Kubva pane zvidzidzo zvebhoratori, zvinogona kukonzerwa kuti panguva yekurapa nemishonga iyi inowanzotaridzirwa kuti inonzi thrombocytopenia. Kuwedzera mune zvinyorwa zve triglycerides muropa, kushandiswa kwekunetseka kwechiropa chechiropa cheAIDS, AST, FA, LDH, pamwe chete ne lipase uye amylase, hazvisi sekugara. Ikoko kwaivewo nekuwedzera muhuwandu hwehuwandu hwebilirubin, muumbi uye prolactin.

Mushonga wehutano hwemurwere unogonawo kupindura kune zvinodhaka ne linezolid. Kazhinji izvi zvinoratidzirwa muchezzinesi uye migraine, pamwe nekudengenyeka. Kazhinji zviratidzo zvemigumisiro yemishonga ndeyezviitiko zvekuvhiringidza kunongedza.

Kuchinja kwehutano hwemagetsi ehurumende kunogona kukonzera "Zyvox" (mapiritsi). Iyo mirayiridzo inoratidzira kurara kwevakawanda zvakanyanya kune varwere munguva yekurapa nemugadziriro uyu wemishonga.

Pamusoro pekushanda kwe genitourinary system, kurapwa nekushandiswa kwe "Zyvox" kunogona kuratidzirwa nenzira yechikadzi candidiasis.

Kakawanda kune ganda rinoratidzirwa remishonga ne linezolid nenzira yekumhanya.

Pakati pemimwe migumisiro inogona kunzi fevri uye inokonzerwa nehutachiona hwehutachiona, hunoitika zvisingaiti.

Uyewo, pakubvunzurudza Zivox, paiva nezviitiko zvekuwedzera kweropa, kushungurudza uye kupera.

Mukurapa linezolid yevamwe vechidiki vari kuyaruka kubva pamakore 12 kusvika ku17, zvinotevera zvinoratidzika zvisingadikanwi zvinowanzosangana nazvo:

• Kurwiswa, kurutsa, kuchema, kurwadziwa kwepamuviri;
• Vertigo, migraine;
• Rash;
• Zvirwere zvinotapukira zvepamusoro pekufuridzira kwepamusoro, kukomba, pharyngitis;
• Fever;
• Njodzi, iyo nzvimbo yaunenge ichinetsa kutsanangura.

Izvozvo zvinotevera, zvinoratidzwa nepamusoro pfupi, zvinogonawo kuitika:

• Eosinophilia;
• Kukura kwe triglycerides, ALT, creatine uye lipase;
• Itching.

Muchiedza chekuchipatara, mamwe maitiro emigumisiro akaonekwa akafananidzira Zyvox (sarudzo uye mahwendefa). Izvi zvinosanganisira:

• Myelosuppression inoshandurwa;
• Optic nerve neuropathy;
• Anaphylaxis;
• Angioedema edema;
• Lactic acidosis;
• Peripheral neuropathy;
• Shanduka muvara rezino rejeri;
• Chills;
• Kuwedzera kuneta;
• Serotonin syndrome.

Zivox inoshanda sei nemimwe mishonga?

Kana ichibatanidzwa ne cytochrome isoenzymes, hapana kuchinja mune basa rekupedzisira.

Kana panguva imwechete inobatwa ne linezolid uye monoamine oxidase inhibitors, ipapo zvinoitika zvechipiri zvinowedzera. Pamusoro pechikonzero ichi, madhaji eAdrenomimetics uye dopaminomimetics inofanira kuderedzwa.

Nekubatana kwehutano hweZivox uye zvinorwisa zvinodhaka zvinodzivisa kubatwa kwe serotonin, serotonin syndrome inogona kuitika.

Muchiitiko chekugadzirisa hutano ne "Aztreonam" kana "Gentamycin" pharmacokinetics ye linezolid haina kuonekwa.

Joint reception ne "Rifampicin" inosanganisira kuderera kwepamusoro ye "Zivoks" - kusvika 32%.

Contraindications

Mushonga wacho haugamuchirwi kuti ushandiswe nevarwere vane kukura kwehukuru kune zvakakosha kana zvimwe zvikamu zvinoumba zvakagadzirwa.

Kana murwere ari kutora phenelzine kana isocarboxazide, ipapo linezolid haigoni kutorwa panguva iyi uye mavhiki maviri mushure maro.

Kana pasina nzira yekudzora ropa, saka Zyvox haigamuchirwi mukurapa varwere vane zvirwere zvinotevera:

• Kusagadzikana kwehutano;
• Thyrotoxicosis;
• Pheochromocytoma;
• Uyewo nekubvumirana pamwe neAdrenomimetics uye dopaminomimetics.

Kana iwe usingagoni kunyatsocherechedza varwere vari pangozi ye serotonin syndrome, "Zyvox" haigoni kutarisirwa pasi pemamiriro anotevera:

• Kuvapo kwecarcinoid chirwere;
• Kushandiswa kwezvinodhaka izvo zvinodzivisa reuptake ye serotonin, zvinodzvinyirira zve tricyclic marudzi, triptans, Miperedin uye Buspirone.

Tswendefa reZyvoks rinopesana nevana vari pasi pemakore gumi nemasere nekuda kwekusagona kusarudza dhegi yakakwana.

The mushonga zvinoratidzwa kunorapwa kana kubatsira vaitarisira pazviri pane ngozi zvinotevera nyaya:

• renal uye hepatic insufficiency;
• systemic noutachiona;
• Pamuviri uye lactation.

Aigona kuva mushonga ovhadhozi?

In kurapwa ongororo, uyewo mamwe kushandiswa rekugadzirira "zyvox" muchipatara kana munharaunda vawana chikumbiro ovhadhozi haana dzakaonekwa. Kana izvi zvaitika Zvinokurudzirwa symptomatic kurapa.

Storage uye kusunungurwa

Drug "zyvox" rinowanika Pharmacies kubudikidza mushonga. Ramba kuva panzvimbo, parinoperera unyoro uye yakananga zuva pa tembiricha asina kupfuura 30c, yokurambidza vana kuwana.

analogs

Kana ari unacceptability kurapa "zyvox" analogs akafanana nezvavanofunga vangaendeswa kune huru kurapwa migumisiro yezviri pfuma:

• Kana nemabayo uye bronchitis - "Doxycycline hydrochloride" "Bronhorus" "Arlette".
• Kana bakteialnyh Zvirwere - "Chloramphenicol 0.25 d", "Vankomabol", "Lifakson".
• With Zvirwere ganda - "Benzathine Benzylpenicillin", "Sulfadimetoksin".
• Kana nonhealing Maronda - "Tsifaleksina yavaibvisa munyu", "Liphuzol".

Kuti taurira navo pazvinhu izvi vanofanira chiremba chete, nokuti mumwe mushonga ine zvairatidza, contraindications, uye kunyanya mabiko.