"Ftoruracil" kugadzirira: mirayiridzo yekushandiswa, tsanangudzo, kuumbwa, kufanana nekuongorora

Zvirwere zvepachikafu, zvinosuruvarisa, zvino zvave zvakajairika. Zvinonzwisisika, haugone kurega, iwe unoda kurwisa hutano huno. Pasina mhosva iwe unofanira kuzvibata iwe pachako. Pasina rubatsiro rwakakodzera, haugoni kuita. Ichokwadi ndechokuti mamwe mishonga inogona kurongerwa chete nemishonga uye inoshandiswa chete nechirongwa chinogamuchirwa chekugamuchira. Muzviitiko zvakawanda, vanachiremba vanopa mishonga yakadai se "fluorouracil". Mirairo yekushandiswa kwemishonga iyi ichaiswa pasi apa.

General Characteristics

Saka, mishonga inoratidzwa inoshandiswa mu incology, sezvo inoshandiswa zvinopesana. Inogona kuenzaniswa se-anti-metabolites. Ikozvino, iyo inenge iri mumvura inogona kuderedza zvakanyanya metabolism pakati pemasero.

"Fluorouracil" (mirayiridzo yekushandisa nguva dzose inopinda muhomwe nemishonga) inoratidzika nyore. Inosanganisira mvura yakasvibiswa uye caustic soda. Icho chikuru chinoshandiswa zvinoshandiswa ndi fluorouracil.

Mafomu uye zvikamu zvechirwere

Zvinofanira kuonekwa kuti mushonga uyu une maitiro akawanda. Kana uchida "Ftoruracil", mirayiridzo yekushandiswa inotiudza nezvemhando dzayo:

1. Mvura inogadziriswa yehutachiona kana yekusagadzikana. Kazhinji kacho zvinowanzoitika 5% inokonzera inokonzera mumaboules 5 ml. Iko kunewo mhinduro yakanyanyisa, iyo inowanikwa muhombodo ye 10 ml.

2. Mafuta. Inowanzova 5% zvakare. Inoshandiswa kubata chirwere cheganda, somuenzaniso, basal.

Kana iwe wakagoverwa "fluorouracil", mirayiridzo yekushandiswa iine mashoko akadaro pamusoro pezvirongwa zvekugamuchira:

- Tora 0.5 g / m2 zuva nezuva. Kana kuti 12 mg / kg. Nzira yekurapa haisi mazuva anopfuura mashanu. Mushure meizvi, kupera kwemwedzi mumwe kunokosha.

- Kamwe kamwe mumazuva manomwe 0,6 g / m2. Nzira yekurapa inenge mavhiki matanhatu kusvika ku10.

- Mukubatana nedzimwe mishonga inopikisa - pazuva rekutanga uye 8 th yemutambo, 0,6 g / m2.

Zvisinei, mumamiriro ezvinhu ose, kuyerwa kwemaitiro uye nzira yekutora mishonga inogadziriswa. Izvo zvose zvinoenderana nekuoma uye chirwere chechirwere, mamiriro ezvinhu ehurwere, hupenyu hwake, uye chirongwa che chemotherapy.

Iwe unogona kuvhara mvura kana kunyura. Iko kunofanira kutakurwa mupfungwa kuti mamwe mishonga inopiwa kumurwere pamwe chete neiyi, inopa kuderedzwa kwechirwere che fluorouracil ne20-30%.

Pharmacological action nekubatana nemamwe madhiragi

Saka, "Fluorouracil" (mirayiridzo yekushandiswa, tsanangudzo yemishonga inofanira kuverengwa nemurwere) ine simba rinopesana nekuvhiringidza uye inononoka zvakanyanya kuderedza kushandiswa kwemakemikari kunobatsira pakuparadzaniswa kwemasero akaipa. Izvi zvinoreva kuti, chinhu chinovhara kuumbwa kweDNA.

Mushonga wacho unowedzera nokukurumidza zvakakwana, uye kuumbwa kwe fluorouridine monophosphate. Inoparadzaniswa muchiropa kwemaawa anenge makumi maviri. Nhengo dzekuporesa (60-80%) uye itsvo (7-10% muhutende husina kuchinja) dzinobatanidzwa mukushandiswa kwemishonga.

Kana uchida kutora "Ftoruracil", mirayiridzo yekushandiswa (kuumbwa kwemishonga yatakatoongorora) inotaura kuti pane zvimwe zvinhu zvisingagoni kuyananiswa nazvo. Semuenzaniso, sulfonamide zvinodhaka uye phenylbutazone hazvienderani nemukuru wechirwere. Asi alpha-interferon uye cytostatics, zvisinei, kusimbisa chiito che "fluorouracil". Izvi zvinofanira kufungwa nezvazvo pazvinorayiridza dhigiriji.

Cherechedza kuti kupora kwomurwere, nemhaka yehutachiwana hwehutachiona hwakakosha, hunofanira kuitwa pasina makore matatu - gore.

Zviratidzo zvekushandiswa

Kana iwe uchida "Fluorouracil", mirayiridzo yekushandiswa (inowanikwa mutengo wemishonga ndeye 3000-3990 rubles) inotaurira nezvezviratidzo zvakadai zvechiremba:

• Chirwere chetachiona chediki kana rectum, esophagus uye mudumbu. Muchiitiko ichi, mishonga inorayirwa kunyange nechekare isingagoni kushanda kana kuvapo kwemasastases.
• Kansa yepamusoro yeropa.
• Zvirwere zvinosuruvarisa zveguruvladder, mazai, chifuva, chibereki.
• Kanzira yemadonal glands.
• Inecological lesion ye prostate gland.
• Carcinogenesis kana kenza yemupenisi.
• Tumha mumutsipa uye musoro.
• Pre-kenza chimiro, pamwe nemakumbo maduku.

Iyo mishonga inoratidzwa inogona kushandiswa kunyange mune fungal ganda rezvipembenene.

Ndezvipi zvinopesana?

Zvinonzwisisika, hapana kugadziriswa kwemakemikari kunogona kunge kwakakosha kune vose varwere. Uye munyaya iyi chinhu ichocho chinopesana nechokuita.

• Kunyanya kunzwisiswa kwepamusoro kune zvimwe zvikamu zvechirongwa ichi.
• Kuberekwa kana kukwezva. Mushonga uyu unotyisa zvikuru pamucheche. Kana kugamuchirwa kwakatemwa panguva yekuyamwisa, mwana anotorwa kubva pachipfuva.
• Peptic ulcer we duodenum kana dumbu, iri muchiteshi chekuwedzera.
• Kurwisa anemia uye kubuda ropa nguva dzose zvakaoma kana kusingagoni kumira (hemophilia).
• Leukopenia.
• Kuora mwoyo kwehutano hwehisvo kana chiropa.
• Mamiriro ehutano hwehutano, anotangira nehupenyu hwekufa.
• Kunyanya kunetseka kwemuviri.

Mukuwedzera, kune zvimwe zvisingakwanisi. Somuenzaniso, nekuchenjerera mushonga unorayirwa kuvanhu avo vanotambura neye herpes zoster kana chickenpox. Kunyatsoteerera kunofanira kupiwa chinangwa chechirwere ichi kana murwere atotora cytostatics.

Zvinokonzerwa nemigumisiro

Kana iwe uchitarirwa nzira yemishonga yakadai se "Fluorouracil-Lance," mirayiridzo yekushandisa iyi mishonga inenge yakangofanana neyo yakanyorwa kare. Nyaya inofarira varwere vakawanda vane migumisiro. Ichokwadi ndechekuti dzimwe nguva vanogona kunge vakaoma kunzwisisa kupfuura chirwere chacho pachavo. Saka, mushure mokutora chinhu ichocho, migumisiro yakadaro inogona kuonekwa:

• Kuderedza nhamba yeeukocyte uye maplatelets muropa.
• Nasal kubuda ropa, iyo inogona kuva yakaoma kumira.
• Kuvhiringidza kunoonekwa, neuritis yeziso.
• Nausea, iyo inogona kusanganiswa nekurutsira uye chirwere. Muchiitiko ichi, kurapa kunofanira kumiswa kana kuchinjwa.
• Stomach ulcer.
• Stomatitis.
• Iropecia yakasarudzwa kana yakakwana (alopecia).
• Ischemic heart disease, arrhythmia, angina pectoris, mwoyo kusakwanisa, myocardial infarction, cardiomyopathy, thrombophlebitis.
• Kutambudzika uye kupoteredzwa mumusoro, kuwedzera kukuvhundutsa uye kutya kwechiedza, kuora mwoyo muhara, kurasikirwa kwekunzwisisa kwekuziva.
• Dysarthria.
• Kushungurudzwa kwekuravira, kubuda kwepamuviri, kuora mwoyo, kuderedza chido uye chiropa chinoshanda.
• Kupfupika kwemhepo, kukohwa, bronchospasm.
• Kuita zvechisimba muhutano hwekubereka: mumadzimai - kusavapo kwemwedzi, mumarume - azoospermia.
• Hyperpigmentation yeganda, kuoma kwayo uye kuputika.
• Mikoko, ganda rechando, dermatitis.
• Utsi hwakasimba, pamwe nekubatanidzwa kwezvirwere zvezvisikwa zvakasiyana-siyana.

Sezvaunogona kuona, iyo yakagadzirwa mvura kana kuti "Fluorouracil" mafuta, mirayiridzo yekushandiswa kwayo yakatova pachena kwauri, mishonga yakanyanya. Mukuwedzera, zvimwe zvidzidzo zvinoratidza kuvepo kwesimba rinokonzera tsvina uye chirwere chinokonzerwa nemishonga.

Zvinhu zvekuchengetedza zvinhu

Saka, iwe watogamuchira ruzivo rwakanyanya pamusoro pemishonga inowanikwa. Iye zvino tinoda kufunga nezvezvinhu zvayo yekuchengetedza. Kuva mu "Ftoruracil" inofanira kunge iri munzvimbo ine rima. Ichando chokuchengetedza chinofanira kuva 15-25 degrees. Zvinonzwisisika, mishonga inofanirwa kuchengetedzwa kubva kune nzvimbo inowanikwa nevana. Hazvikurudzirwi kusunungura mvura.

Sirifu upenyu hwemishonga ndeye makore maviri. Pashure penguva ino, chigadzirwa hachigoni kugamuchirwa.

Pane zviitiko apo dhidhiyo inowanikwa pasi pechimboule. Izvi zvinoitika panguva yekuchengetedza kwenguva refu. Edza kushandura mvura yacho kusvika kune digirii 60 uye uine simba guru. Zvadaro zvinotonhora chinhu ichocho kusvika kune digrii 35. Kana iyo yakagadziriswa ichiputika uye mvura inenge yava pachena zvakare, iko kugadzirira kwagadzirira kushandiswa.

Drug analogues

Chinonyanya kukosha nezvaunoda kuziva musati watora mishonga "Ftoruratsil" - mirayiridzo yekushandiswa. Mhinduro dzacho dzichavawo dzakashata. Iwe uchadzidza pamusoro pavo gare gare.

Kana murwere asingagoni kuwana mishonga iyi, chiremba anogona kumupa zvakafanana. Vane chinhu chikuru chakashanda-fluorouracil. Iye zvino pane mhando dzakadai dzechirwere ichi:

1. "Fluoro Uracil".

2. Efundex.

3. "Efu-Rix".

4. "Fluoroplex".

5. "Fluracil".

6. "Flouryl".

7. "Queroplex".

8. Timazin.

Ongororo

Zvinofanira kuonekwa kuti ichi chinodhaka chinoshandiswa kakawanda. Varwere vakawanda vanocherechedza kubudirira kwakanyanya kwechirwere mukurwisana nemakumbo.

Kunyange zvakadaro, vanotaura zvakare nezvehuwandu hwemigumisiro yakaipa: kusuruvara, kurutsira, musoro, kuora mwoyo mukati. Izvi hazvishamisi, sezvo mishonga inonyanyisa.

Nokudaro, takapa ruzivo pamusoro pemishonga "Ftoruracil": mirayiridzo yekushandiswa, mutengo, kuongororwa. Yeuka kuti haugoni kutora mushonga uyu iwe pachako. Iva nechokwadi chekuona chiremba. Kana zvisina kudaro, unogona kuzviisa pangozi kukuvadza iwe. Uyezve, muongorori chete anonyatsogona kugadzirisa chirwere chakakodzera mushure mekudzidza kwakakodzera. Iva noutano!