"Chloramphenicol": mirayiridzo kushandiswa. Anosiya "Chloramphenicol"

Chii makemikari remubatanidzwa sezvo chloramphenicol? Mirayiridzo kushandiswa Formulations kwakavakirwa iyi, zvichakurukurwa pazasi. Nesuwo kukuudza pamusoro chii ehupfumi kuti chokushandisa ichi, basa zita, ndiko, kubva icho chinotarisirwa, uye zvichingodaro. D.

tsananguro

Ndezvipi ehupfumi vari kuri kuti nemakemikari zvakadai chloramphenicol? Mirayiridzo yokushandisa nezvembiri kuti mumiririri yakajeka pamusoro boka inorwisa mabhakitiriya amphenicols. Mukuru antibacterial ehupfumi ine laevorotatory isomer.

Akati remubatanidzwa chinhu sekristaro pasina kwakanaka uye ruvara. Zviri havaratidzi soluble nemvura, asi zvikuru soluble mu propylene glycol, pyridine, ethylene glycol uye panyaya iyi. Izvi zvinhu waishandiswa sezvo mushonga unorwisa kwete chete mushonga asi mhuka minda.

Under zita chii inogona kutengwa chemishonga chloramphenicol? zita chishandiso Trade unorira "Chloramphenicol".

Viewed chinoumba yakatanga synthesized muna 1940 kubva muStreptomyces venezuelae. Nhasi, mushonga uyu rinobudiswa kubva styrene noruoko 10-danho usage.

Vaitirei mushonga unoshanda zvakakwana. Zvisinei, hazvina chepfu kwazvo uye kazhinji mhaka nenjodzi.

Medicaments ine chloramphenicol (tradename chaipiwa pamusoro) anobudiswa muchimiro okuzora, anosiya, mhinduro kuti intramuscular uye intravenous Kutarisirwa, uyewo mapiritsi uye capsules.

pharmacodynamics

Sei chloramphenicol? Mirayiridzo yokushandisa mishumo kuti pomutumwa vanokwanisa kuvhiringidza mapuroteni usage kurongedza utachiona kubudikidza zvichivhiringidza imwe enzayemu akadai dioxo-peptidyl transferase. Hatigoni kutaura kuti chloramphenicol ane mavara bacteriostatic kushanda. Ndiye kushingaira streptococci, nemavhairasi makuru, giremu negative utachiona uye stafilokkok. A mamirire kuchiitwa ichi mushonga ndechokuti payo kwakakanganisa inokanganisa okuva husingakwanisi sulfonamides, kuti penicillin uye streptomycin yakawanikwa. Panyaya kushivirira, kuti zvinodhaka vaiona inokudziridza zvishoma nezvishoma.

Pharmacokinetics

Ko chloramphenicol takabatikana? Mirayiridzo yokushandisa inoshuma kuti dzaiita zvokutaurwa yaitonga nefuma yava kunyura kubva nemudumbu zvinodhaka. Kunonyanyisa chloramphenicol wevasungwa kubudirira pashure maawa matatu, uye ayo bioavailability 90%.

Inenge hafu zvinodhaka anosunga kuti mapuroteni eplasma.

Chloramphenicol rinoita chiropa uye yatovapo goho nhatu maawa netsvo, uye pamwe chete bile uye faeces. Zvinofanira kucherechedzwa kuti remubatanidzwa iri hydrolyzed ari dumbu, zvichiguma nokuumbwa basa metabolites.

The dzemo pokushandisa medicament kana ayo neVadzidzi conjunctival zai ine chiduku mwero systemic Absorção de Água. Asi panguva imwe chete asingaurayiwi nayo anosika pamusoro ganda pamusoro kana muziso Urume yakakwana pfungwa kupa bacteriostatic chiito.

zvairatidza

Chinangwa waakaudzwa capsules kana mapiritsi "Chloramphenicol"? Chloramphenicol nokuti zvokuudzwa kushandiswa pakurapa fivha, paratyphoid, salmonellosis mu generalized chimiro, siyana rickettsial zvirwere, brucellosis, tularemia, nemanyoka, pfungwa abscesses uye meningococcal zvirwere.

Uyewo uyu zvinoreva kazhinji Nachiremba varwere vane chlamydia, trachoma, pyogenic vanga utachiona, peritonitis, ehrlichiosis, inguinal lymphogranuloma, siyana utachiona, bile uye Urinary neturakiti utachiona, yersiniosis.

Iyo anobata zvirwere rokunze chloramphenicol? Mafuta nachiremba maronda, ganda zvirwere, mamota, kutsva, venous maronda uye bedsores. Uyewo rinoshandiswa mune makatsemuka pamusoro minyatso roukoti vanamai.

Anosiya "Chloramphenicol" akaisa mukati ari conjunctival zai kubata keratitis, kwemabhakitiriya ziso zvirwere, blepharitis, conjunctivitis, scleritis, uye episcleritis keratoconjunctivitis.

Contraindications medicament

Mishonga, izvo zvinosanganisira chloramphenicol, hauna pachii:

• pauduku (kusvikira mwedzi mumwe);
• zvirwere ropa;
• fungal maronda paganda, psoriasis uye eczema;
• vanhu vane kushayiwa shuga-6-phosphate dehydrogenase, uye chiropa chirwere;
• ekukurerai navakadzi pamuviri;
• kana uri sema kune fuma, kana zvimwe asingaurayiwi yomuchipatara kuva boka iri.

Kunyatsongwarira kunofanira kuonekwa zvirwere zvomwoyo nemidziyo ropa, uyewo pfungwa neutachiona.

"Chloramphenicol": mirayiridzo kushandisa zvinodhaka

Sezvataurwa pamusoro apa, maturusi kwakavakirwa fuma iyi rinoshandiswa intramuscularly, nomutsinga, topically, nomuromo uye conjunctival.

Scheme kurapa chacho nguva kunobva Pfungwa zvinodhaka uye chirwere. Vakatsunga ne nokubata chiremba nomunhu.

Piritsi "Chloramphenicol" zvinofanira kutorwa maminitsi 30 vasati kudya kana awa imwe pashure.

Kana intravenous kana intramuscular jekiseni uye kunanzvana yaitonga varwere mukuru dzavakatumirwa 2 g vanoshingaira chinhu pazuva (muzvikamu 4 zvikamu).

The kunonyanyisa dose kurapwa rino pazuva iri 4 makore With mishonga akawanda kudaro, iva nechokwadi kuti kudzorwa itsvo ropa parameters.

Children ichi mushonga Mushonga Nachiremba Maererano muviri:

• kusvika 3 years - 10-15 MG pa makirogiramu;
• makore 3-8 - 15-20 MG pa makirogiramu;
• vakuru 8 nemakore - 20-30 MG pa makirogiramu.

The kakawanda pokushandisa mhinduro kana mahwendefa vana kwakafanana kuti vakura.

Duration kurapwa pamwe vakati mushonga mazuva 7-11. The kunonyanyisa nguva yokurapa - 2 weeks.

Kana rikashandiswa topically gadziriro yayo rinoshandisirwa zvakakanganisa nzvimbo kakawanda pazuva, uchishandisa gauze. Kana zvakakodzera, zvinoreva anogona kushandiswa pamwe ane occlusive bhandiji. Panyaya iyi, kuti kupfeka ose 3 days kusvikira ronda yakachena uye haazogari.

Panyaya akadonha, kushandiswa muchimiro 0.25 uye 1% kugadzirisa akabatana nevamwe zvinodhaka.

nemishonga

Kushandiswa pasi review, mushonga anogona kukonzera:

• kuvaviwa uye akashatirwa (kana rikashandiswa topically);
• agranulocytosis, thrombocytopenia, aplastic kupererwa neropa, leukopenia;
• goiter;
• delirium, neuritis, siyana zvisipo, nomusoro, kuvhiringidzika, kuora mwoyo;
• gipogemoglobinemiyu, reticulocytopenia;
• Angioedema, urticaria, ganda rashes;
• kuda kurutsa, flatulence, manyoka, nokushatiriswa mumuromo, kurutsa, fufune;
• fungal zvirwere, dermatitis;
• alleviation kunzwa uye zvakaratidzwa, havachanyatsogoni omumwe munuhwi.

In vana kusvikira mwedzi 12 zvingamuka zvemwoyo akawisa.

Price, anoreva zvakafanana uye analogues

Anoreva zvakafanana vanoonekwa rinoreva "Levovinizol", "sintomitsina" "Chloramphenicol" "Chloramphenicol Aktitab", chloramphenicol yavaibvisa succinate, "Chloramphenicol-Lect" nedoro mhinduro "chloramphenicol", chloramphenicol yavaibvisa succinate chena, "Chloramphenicol-Akos".

Zvinofanira kucherechedzwa kuti Pharmacies uye analogues vanogona kusangana zvinodhaka ichi "Levometil", "Levomekol" (chloramphenicol + dioksometiltetragidropirimidin) "Levosin" (sulfadimetoksin dioksometiltetragidropirimidin + + Chloramphenicol + trimekain).

Kana mutengo, zvino anonzi ane mushonga haasi mukuru chaizvo. Chero chimiro zvinodhaka inogona kutengwa nokuda 40-90 rubles.

Reviews emishonga

Pasinei vakawandisa nemishonga uye toxicity zvinodhaka ine chloramphenicol, vari kushandiswa kakawanda. Varwere vakawanda vanokwezvwa low Mari chinodhaka, uyewo kusiyana kwayo chipimo chemushonga siyana.

Maererano unyanzvi, mushonga zvakadaro kazhinji nachiremba kukamura uchishandisa chikumbiro kubvisa mburwa nezvimwe ganda kwemakomo.

Kana unavailability maturusi Kushandiswa anoreva zvakafanana akadai analoginen se "Levomekol" (chloramphenicol + dioksometiltetragidropirimidin). Asi kuita izvozvo chete paakazokurukura chiremba.