The mushonga "Torcida" mirayiridzo kushandiswa, description, akafanana uye wongororo. "Torcida": mirayiridzo kushandiswa (mahwendefa)

Mumakore achangopfuura, vanachiremba ano vari kuramba vakatanga taurira avo varwere zvinodhaka ichi se "Torcida". Mirayiridzo yokushandisa kunosanganisira chete dzinokosha Data zvinodiwa kuti munhu wose kutora mushonga, asi zvakawanda vasati watenga kana pashure kuzviwanira kuedza kudzidza zvakawanda pamusoro chokushandisa ichi.

pharmacodynamics

mushonga uyu saluretic. Hazvina basa inofambiswa chinovhiringidza renal reabsorption kuti yavaibvisa uye chloride ions, izvo dziri mune vachikwira chikamu Henle kuti loop, izvo zvairatidza kuti mushonga "torsida" mirayiridzo Chinyorwa.

Pharmacokinetics

Murume, pashure intravenous kwokubatsira mari nokukurumidza anotanga kuratidza diuretic kushanda. Panyaya iyi vakaomerwa kushanda zvinodhaka kunotangira mukati maawa 3 wokutanga uye zvadaro zvakachengetwa kusvikira maawa 12. On pakanyorwa chikumbiro ichi chinoreva diuresis kubatsirwa zvakananga pamusoro dose, iyo Akaratidzawo kuti mushonga "torsida" mirayiridzo Chinyorwa.

Torasemide mwero tichisunga kuti mapuroteni eplasma yakakwirira sezvinoita 99%, izvo zvinoita yakanaka kwazvo, apo metabolites M1, M3 uye M5 zvinesungano azvaitwa pa 86,95 uye 97%. Maximum zvinogoneka zvibviswe hafu-upenyu torasemide aro metabolites siyana mune utano akadzidza, kubvira maawa matatu kusvika mana akaziviswa mukufamba miedzo zvekuchipatara.

Total Clearance of fuma anenge 40 Rine mamiririta / min., Apo renal Clearance mwero anenge 10 Rine mamiririta / min. Metabolite M5 pave pasina diuretic zvazviri, apo ibatanidzo metabolites M3 uye M1 chakaita kuti anenge 10% of pharmacodynamic chiito anokonzerwa pamusoro womunhu.

Features zvinodhaka mune vanhu vane zvirwere zvakasiyana-siyana

Kana murwere akazivisa renal kukundikana, hazvina chokuita zvinonyatsorehwa chokupika Clearance uye hafu youpenyu torasemide, apo kuwedzera nguva nokuti metabolites M5 uye M3. Panguva iyoyowo mumabhatiri zvachose kutanga pharmacodynamic maitiro, asi nguva zvinodhaka chiito renal kukundikana anewo maturo, pasinei kwokuomerwa chirwere.

In avo varwere vanoona chiropa dysfunction, kana vane mwoyo kukundikana, kakawanda zvakawedzera metabolite excretion kuti torasemide uye M5, izvo inoratidzwa kuti mushonga "Torcida" mirayiridzo Chinyorwa.

Huwandu fuma iri weti goho riri zvinenge chose anoenderana huwandu kuti kuchengetwa zviri nevazvipiri utano, maererano nako iye torasemide uye ayo metabolites asingaiti cumulate.

umboo

Kazhinji, zvinobatsira vanoshingaira zvinodhaka anopiwa kuvarapi pakurapa exudates siyana kana edema kuonekwa maererano mwoyo nokukundikana. Zvinofanira kucherechedzwa kuti kune mushonga "Torcida" mirayiridzo kushandiswa (Mahwendefa) kunoratidza kuti ushandiswe, kana zvakakodzera, mureza kurapa.

Contraindications

Pane zvimwe zviitiko umo kushandisa zvinodhaka uyu asiri varumbidzwa kana wairambidza zvachose. Rinovarondedzera vasiyana mushonga "Torcida" mirayiridzo kushandiswa (mahwendefa - vaiona mufananidzo), ndiko kupa vamwe inokosha:

• kuvapo varwere arterial hypotension;
• kunyanya aikanganiswa siyana ebetsero kana basa zvinhu, uyewo mamwe sulfonylureas;
• kwete pachii varwere vanenge itsvo kukundikana pamwe anuria;
• zvakaoma. chiropa mabasa;
• mhando dzose kutyorwa mvura-electrolyte nepakati hurongwa;
• gout;
• kana murwere ari kutambura kubva kwazvo nepfungwa iri Urinary ino;
• nemhando dzose kutyorwa kuri conductive anokudzwa hurongwa pamoyo;
• Kumwe kuchinja kunotanga mu zvizere ropa uye asidhi-chawo mamiriro munhu;
• mhirizhonga munyika kushanda itsvo kukonzerwa nephrotoxic maronda-siyana zvinhu.

Pakati pezvimwe zvinhu, haisi varumbidzwa kushandisa ichi chombo vakadzi vanoramba munguva pamuviri kana lactation.

How rinoshandiswa?

Kana uri kushandisa mvura chimiro, pomutumwa anofanira kuzviita chete nomutsinga uye zvishoma nezvishoma, sezvinoratidzwa zvinodhaka "Torcida" mirayiridzo Chinyorwa. Mutengo chishandiso (kubva rubles mazana mashanu) iri zvakaenzanirana inosvikirika saka vanhu vakawanda hapafaniri kuva matambudziko kuti zvakanaka zvinoenderana zvairatidza kuti kushandiswa kwayo.

Initial kuroorwa dose anenge 10 MG pazuva, i.e. 2 ml gadziriro iyi. Kana paine zvishoma kunotoda tibatsirwe, ipapo dose anogona ngazviwedzerwe kaviri. Asi kana zvisingaiti kuti vawane kunyatsoshanda zvakakodzera, ipapo dose inogona wakawedzera kunyange kaviri, asi mishonga vanofanira kugara kwenguva vaifanira mazuva matatu.

Chenjera pulmonary edema

Kana kushandisa mumiririri uyu anorapa chakasimba pulmonary edema, pokutangira dose ndiyo 20 MG, apo zvichienderana zvachose kunotoda mufananidzo dose ichi chinogona kupiwa hafu yeawa ose. Zvinofanira kucherechedzwa kuti kurapa kwakadaro yose dose haafaniri kupfuudza milligrams 100 pazuva torsemide.

Kuti arambe kurapwa inokurudzirwa senzira kuti vhiki kupfuura, iyo anotarazve kuti mushonga "Torcida" mirayiridzo kushandiswa inogona kushandiswa chinja haadzokorori yaitonga sezvo intravenous harifaniri kushandiswa. Price (Wongororo ngaadarowo) sezvo pahwendefa uye mvura nenhumbi hunowanikwa zhinji, saka zvizere yawapiwa kazhinji kunokonzera chero dambudziko. Chero zvazvingava, kufadza zvinobvira zuva nezuva dose haafaniri kupfuudza 100 MG.

hepatic kukundikana

Kana achishandisa varwere hepatic vanotaura vanofanira kushandisa pamwechete kunonyanyisa kungwarira, sezvo iri mhosva pane mukana wakawedzera kuwanda torasemide ari Kuronga plasma. It rinozivikanwa yoga kuti mushonga "torsida" (10 MG) ari kudzidziswa Chinyorwa (pokunyorera kana mvura chimiro gadziriro - sakosha).

vakwegura

Nokuti kurapa varwere izvi haripi munhu mharidzo dose pakusarudza. Zvinokosha kucherechedza kuti hapana zvikuru nezvidzidzo zvekuchipatara pamusoro fananidzo nzira jaya uye vakwegura vanhu kurapwa haina kuitwa, uye saka nguva dzose nani kubvunza zvimwe chete chiremba pre-vanokwanisa.

A mhinduro jekiseni inofanira zvishoma nezvishoma wakawanda nomutsinga, uye nokudaro zvinofungidzirwa kuzvidzosera kwete intraarterially kuti anosimbisa oga kuti mushonga "torsida" mirayiridzo kushandiswa (ampoules).

nemishonga

Zvinokosha kucherechedza kuti chokwadi kuti nenjodzi kungaita weboka siyana nadzo, saka rimwe nyaya ichakurukurwa yoga:

• Kumwoyo. Muchiitiko chino, apo akatora mushonga anogona kuvapo zvinetso zvakasiyana-siyana Urume uye electrolyte mwero, apo mune dzimwe zvisingawanzoitiki zviitiko rakawedzera metabolic alkalosis. Uyezve, mune dzimwe Mapato wevarwere kuva nenyonganyonga, thrombosis, hypotension, chepfungwa uye cardiac ischemia, chenjera myocardial infarction, angina uye syncope.
• Tsinga. Mune zvisingawanzoitiki Muzviitiko, kunyanya panguva vachiri padanho kurapwa, pangava nemusoro, kunyanya kurukutika, dzungu, uye tsandanyama chinyamunhari chinorwadza.
• The zvomudumbu hurongwa. Mune zvisingawanzoitiki zviitiko, vangave nepfungwa zviri zvomudumbu wemuTesitamende nedanho sei kushandisa mushonga "Torcida". Mirayiridzo yokushandisa inodaro zvinotevera nemishonga: svoto, kushaya kudya, kurutsa, manyoka, dumbu marwadzo. Kungavawo varipo zvakanyanyisa yakakwirira kwevari hepatic makemikari.
• The Urinary hurongwa. Varwere vanoona vachivavhiringidza siyana munyika weti ezvinhu, pane zvakanaka ndichibvunza weti, izvo zvinogona pakupedzisira kutungamirira kunonoka uye simba zvakare tatamuka dundira. Mune zvisingawanzoitiki zviitiko, zvingava kupa mwero inflated pamusoro creatinine uye urea muropa.
• Muviri. Mune zvisingawanzoitiki Muzviitiko, varwere yakanyorwa kuwedzera zvinonakisa kwevari uric acid, lipids uye shuga muropa.
• hurongwa ropa. In zvikuru zvisingawanzoitiki zviitiko, akaderedza uwandu erythrocytes, leukocytes uye maplatelet.
• The rokuzvidzivirira. Mune zvisingawanzoitiki zviitiko, mapundu, photosensitivity, pruritus. By zvinodhaka "torsida" (majekiseni) mirayiridzo kushandiswa kuratidza kuti mune zvimwe zviitiko pashure intravenous Kutarisirwa angatanga kukudziridza rikwanise hypersensitivity siyana apo murwere maximally rubatsiro kutsanya anofanira inopiwa. Mune zvimwe zviitiko, unogona kuona kwazvo ganda zvavaifunga.

Kana isu kutaura pamusoro zvishoma zvinokosha kwechirwere, ari isingawanzowanikwi paraesthesia, uye muromo yakaoma. Uyezve, vainyatsotarisirwa inofanira kubhadharwa kuti chokwadi kuti kushoma chaizvo nyaya muvanhu pane vamwe kutadza kuona zvakanaka, uyewo kwaita tinnitus, kana kurasikirwa kunzwa zvizere.

ovhadhozi

Typical zviratidzo vanenge zvinodhaka ovhadhozi panguva USINGAZIKAMWI. Manual zvinoratidza kuti mune chiitiko ane ovhadhozi anogona kuvapo zvakakwana simba diuresis, uye ngozi huru yokurasikirwa electrolytes uye mvura, hope uye amential syndrome. Pakati pezvimwe zvinhu, imwe ovhadhozi chinoitika zvemwoyo kukundikana, hypotension uye zvirwere-siyana mune zvomudumbu turakiti.

How kurapa?

Chero chairo mushonga nguva haina kuratidzwa. Kazhinji, zviratidzo zvinobva kudhaka, inonyangarika zvachose pashure chipimo chemushonga rutapudzo kana kubviswa kushandiswa kwezvinodhaka ichi rakakwana, uye kana zvakakodzera kuzadzisa marambi electrolytes uye zvinwiwa zvichagoverwa, izvo zvinofanira kuitwa mumamiriro ezvinhu ose kunonyanyisa kuzvidzora. Torasemide hakuna rakabva neropa hemodialysis.

Ndiwo mashoko anokosha chokuita "Torcida" kugadzirira (mirayiridzo kushandiswa, mutengo, wongororo). Analogs ari mudziyo ( "Britomal", "Sutrilneo") kakawanda akasiyana zvakafanana chiito uye marwadzo, asi nzira kuvarapi kazhinji basa somumwe inonyatsobudirira muboka rayo.