The mushonga "salofalk": analogs uye mirayiridzo kushandiswa

Muviri womunhu kutambura siyana zvirwere, nyore uye kunzwisisa, muupenyu hwake hwose. Kure kuva kupfuura ichangobva kuitwa dzakatevedzana zvoutano kugara anogumbura bowel chirwere. Kurwa navo kukudziridza zvinoverengeka zvakasiyana mishonga yakasiyana nenheyo kuita.

Fuma mesalazine ndiyo rokuti wechikoro ane zvakakwana guru boka mishonga ( "salofalk" analogs) kurwisa chaizvo anogumbura zvirwere bowel.

Zvinoumba "salofalk", pharmacodynamics

Sezvambotaurwa, huru vanoshingaira chirungiso ndiyo mesalazine medicament. Upiyona anopa nhamba yenhengo, zvikurukuru, akadai yavaibvisa carbonate, glycine, povidone, microcrystalline cellulose, silicas, uye titanium, karusiyamu stearate, croscarmellose yavaibvisa, hypromellose chikuru butylmethacrylate copolymer.

"Salofalk" (granules, mapiritsi, suppositories, kuturika) kuchititadzisa (depresses) ari dzinotsanagura neutrophil uye lipoxygenase usage muvanhu prostaglandins uye leukotrienes. The kushingaira fuma kunoderedza mwero kutama, phagocytosis uye degranulation pamusoro neutrophils, akazoita secretion pamusoro lymphocytes. Uyezve, medicament anokwanisa ndichisunga vakasununguka radicals uye zvadaro kuvaparadza, i.e. rinoratidza antioxidant kushanda. Uyewo mesalazine inokwanisa tichisunga rusununguko radicals aumba kubva reactive okisijeni marudzi.

Zvairatidza yokushandisa

Huru panoda akawana kushandiswa "salofalk" - kurapa nokuda maronda colitis uye Crohn chirwere.

chirwere Wokutanga chinhu chirwere kushoma harisati akajekesa hunhu. kukura kwayo kunokonzerwa nezvakaitika kukurukurirana pamusoro masero okutodza uye zvakatipoteredza ezvinhu.

chirwere Crohn kunoita zvinogona inozivikanwa se chisingaperi granulomatous kuzvimba nemudumbu. muitiro uyu anogona kubata nhengo dzose zvomudumbu ezvinhu, zvinokanganisawo akaturikidzana vose zvomudumbu chubhu. Mugumisiro kungava kukura lymphadenitis, ulceration uye scarring kuti bowel rusvingo haisi.

Form zvinodhaka kusunungurwa

Manufacturers kupa vatengi vavo zvinodhaka "salofalk" (zvakafanana neizvi dzingasiyana) mashomanana zvakasiyana siyana kugadzirwa.

In nehwendefa chimiro anogona ine 250 kana 500 MG huru vanoshingaira zvinoriumba - mesalazine. Mune imwe sachet anogona ine 500 MG kana 1 g huru fuma. The medicament muchimiro suppositories (suppositories nokuti rectal Kutarisirwa) rinowanikwa mururimi dosages maviri - 250 uye 500 MG huru zvinoriumba. Uyewo anogona kutengwa Pharmacies uye furo kuturika nokuda rectal yaitonga. Inonyatsobudirira mumwe nomumwe murwere kusunungurwa chimiro ichakubatsira kusarudza kurapa chiremba.

mahwendefa dosing zvaiitwa

Standard chipimo chemushonga nokuti vakuru - katatu pazuva 500 MG. Kana nechirwere chakakomba mwero hosha, kuti kupinda chiremba anekodzero kuwedzera dose kuti 3-4 g pa zuva. Nzira yokurapa agare kubva 2 kusvika 3 months. Kana mishonga chinobviswa kuzvidzivirira nechiyero, izvozvo zvinoitwa mureza zano (1.5 d mu mishonga matatu masikati).

Varwere vaduku 'salofalk "User Application (analogs dzingasiyana-siyana chipimo chemushonga zvaiitwa) rinokurudzira kupa maererano kurema mwana. Babies nomuviri uremu isingadariki makirogiramu 40, chiremba prescribes 250 MG zvinodhaka katatu pazuva. Kana uremu hwomwana kukasapfuura makirogiramu 40, zvinoratidza zvakafanana chipimo chemushonga kana vakuru: 500 MG katatu pazuva.

Mahwendefa zvakanakisisa akatorwa pashure pokupedza kudya, kwete kutsenga uye Inwa mvura (zvimwe mvura).

Zano racho granules

Izvi kusunungurwa chimiro zvinodhaka "salofalk" (granules) anodomwa neMutungamiriri kupinda chiremba kunyanya nomumwe, inobva zvachose kunotoda mufananidzo utano murwere. Kazhinji panguva exacerbation kuti maronda colitis murwere basa kugamuchira dose 500 MG kana 1 g katatu masikati (t. E. The daily Vhoriyamu medicament kubva 1.5 kusvika 3.0 g). Unogona kutora chimwe dose kamwe 3 muhomwe. Kana murwere ari ruregerero, "salofalk" kutora dose pakati 1,5 g pa zuva: unogona kukamurwa kuva 3 mishonga akatorwa kana vose mushonga kamwe.

Kana tiri kutaura pamusoro exacerbation kuti maronda colitis muvana (kubva 6 makore uye vakura), iri kupinda chiremba prescribes mushonga pa mwero 30-50 MG mesalazine pa 1 kg kurema. dose All zvingarerutswa panguva imwe nguva kana akakamurwa 3 mishonga yose zuva.

The granules anofanira kupfeka rurimi uye, pasina dög, pakuparadza. The mushonga anofanira tikanwa zvinwiwa zvakawanda. Kune muviri mugumisiro yakanga nemishonga granules zvinofanira kutorwa nguva uye nguva dzose. Chenjera pavaipfuura maronda colitis kazhinji anofa mukati 2-3 mwedzi, zvimwe zvinogamuchirika zuva dose wakaderedzwa kusvika 1,5 g pa zuva.

Chinangwa uye kwadzinoita kushanda suppositories

"Salofalk" (makenduru) kudzidziswa Chinyorwa anokurudzira munhu chipimo chemushonga 500 MG (1 rectal suppository 500 MG kana 2 - 250 MG) katatu pazuva. Kana hosha iri rikwanise danho, nezuva dose inogona kaviri. Kana murwere basa refu nzira yokurapa kana chipfuro mabiko - evasingatombonamati prophylactic (kuitazve kudzivirira), zvatinosiita dose hazvisi 250 MG (1 kenduru) katatu masikati.

Varwere vaduku chipimo chemushonga inotsamira uremu muviri. Vana yairema makirogiramu asingasviki 40 "salofalk" (makenduru) mirayiridzo kushandiswa inodzora kugadza ½ chipimo chemushonga munhu mukuru, t. E. 250 MG katatu pazuva. Kana uremu hwomwana kukasapfuura makirogiramu 40, zviri basa zvinodhaka chipimo chemushonga sezvo varwere vakuru (katatu pazuva 500 MG).

rectal kuturika

Drug "salofalk" - kuturika inowanika mabhodhoro aivapa rectal yaitonga. The nzira rinoitwa kamwe manheru asati yokurara. Murwere risati kwokubatsira mushonga inokurudzirwa kusunungura ura. The daily chitsama zvinodhaka anosarudzwa inobva murwere uremu (maererano 30-50 MG / kg). Kana chirwere ihuru kana uri muitiro achiwedzerwa, kufadza dose masikati inogona kusvika kusvika 3 years kudzivirira dzokororo nyanzvi kazhinji dzinokurudzira nokutora "salofalk" nomuromo (Mahwendefa). Panyaya iyi dose (daily) vari anopiwawo kurema - 15-30 MG / makirogiramu muviri uremu. All vhoriyamu daily mishonga yose zuva inokurudzirwa kuti rakakamurwa muzvikamu zviviri.

Contraindications kugamuchira "salofalk"

Kushandisa zvinodhaka "salofalk" (analogues - hapana Kunze) iri contraindicated vanhu vane hypersensitivity kune huru uye ebetsero zvinoumba chezvinodhaka. Hazvina kunaka kuti kugadza Mahwendefa vana pasi 3 nemakore, granules - kusvikira makore 6-okuberekwa. Haufaniri kutora mishonga murwere kutambura kubva kwazvo renal kana hepatic insufficiency.

Regai kugadza "salofalk" vanhu vane tsika kutanga ropa siyana hematopoietic zvirwere, maitiro. Kutambura kubva Hemorrhagic diathesis hunhu urikanwi chirwere nemudumbu chero zvakare harifaniri kutora mushonga nokuda mesalazine.

The granules zvisingagamuchirwi medicament raitongwa varwere kutambura kubva phenylketonuria (nhaka chirwere chokuita havachanyatsogoni muviri kuti phenylalanine kunotungamirira kwazvo CNS maronda muchimiro njere urema).

Panyaya vakadzi vane pamuviri uye lactating, kushandisa zvinodhaka ari 3 months pamuviri wokutanga kunofanira takarurama kuzviomesera zvairatidza. Mukati 2-3 trimesters kugadzwa "salofalk" zvinogoneka chete zviitiko apo vanonzi kunobatsirawo hutano mukadzi chitonge zvichibvira ngozi mwana. Maererano uchapupu chete unogamuchirwa kushandisa granules 'salofalk "lactation. Zvisinei, kana mwana ane manyoka, zvakakodzera kusiya achiyamwa. Uye vose, optimally aronga pamberi kutanga pamuviri, kurega kutora "salofalk" kana, kanenge, kuderedza dose yakagamuchirwa.

Possible nemishonga

Side Marwadzo chero mushonga. Pakanga zvagara uye "salofalk" (dzomuzana Russian uyewo). CNS nemishonga zvinokwanisika zviratidzo sezvo musoro, dzungu, chakamira pakunodengenyeka zvine, tinnitus, kuora mwoyo, kugwinha, paraesthesia. Nemudumbu anogona kupindura kushandiswa "salofalk" nemarwadzo mudumbu, bloating, manyoka, kuda kurutsa, kurutsa. Possible kukura hepatitis hepatic transaminase tsika kuchinja. Cardio-vascular hurongwa tigamuchire tachycardia, BP kusiyana-siyana (hyper- kana hypotension), muchipfuva marwadzo, dyspnea.

Mune zvimwe zviitiko, varwere unogona kunzwiwa pave myalgia, arthralgia. Mukuwedzera, mushonga anogona kukonzera kupererwa, leukopenia, thrombocytopenia, anuria, oliguria, hematuria, crystalluria.

Vanoverengeka neutachiona kunobvira kuvaviwa, ganda mapundu, erythema, bronchospasm, pericarditis uye myocarditis. In varwere hypersensitivity kuti mesalazine zvingamuka zvirwere zvakadai interstitial nephritis, nephrotic urwere, rikwanise chokutambudzika pfungwa nomuviri zvemwana asati. Ari oga boka varwere "salofalk" (zvakafanana ake uyewo) kunokonzera zviratidzo zvakafanana urwere pakati chinonzi systemic lupus erythematosus.

Medicines analogues

The "salofalk" yakakwana kwazvo mishonga analogues huru vanoshingaira zvinoriumba. Sei, somuenzaniso, kutsiva "salofalk" - makenduru? Analogues, izvo kazhinji ndivo zvido vatengi uye dzehutano vanogadzwa - iri suppositories "Pentas" uye "Samezil". mishonga izvi chikuru vanoshingaira chirungiso ndiko mesalazine, saka vane yakafanana pharmacological migumisiro pamusoro womunhu.

"Mesakol" - mumwe zvikuru kushandiswa analoginen "salofalk" (mu granules, mahwendefa).

Kunze chinoumba basa analoginen, pane boka guru zvinodhaka zviri zvakafanana kuchirapa chaizvoizvo. zvinodhaka izvi zvinogona zvakachengeteka kutakura "Azathioprine" uye "Alginatol", "hydrocortisone" uye "Dexamethasone" "Diprospan" uye "Irmalaks", "prednisolone" uye "Sulfasalazine". The mazita anoenderera mberi.

chaizvo kurumbidza

Usati watanga kurapwa uye panguva kurapwa uye pashure ayo kugumiswa rinobatsirwa vanokurudzira kutora zvakafanana ropa uye weti nemiedzo. Pamberi kurapwa uye pakuitika zvakafanira kuongorora parameters ari dzichipfekeka mamiriro chiropa. Monitoring yakanakisisa kuitwa pashure pemazuva 14 pashure mharuro yokurapa, uye ipapo mumwe 2-3 nguva zvikamu of 4 mavhiki. Kana pakuongororwa vari mukati kwomuzvarirwo mwero, vachiongorora anoona akaita ose 3 months. Kana pakarepo vamwe kutsauka mhando chichachengetwa muna pachisara zvakakodzera kuita kudzora miedzo pakarepo.

In kugadzwa chero mishonga "salofalk" (makenduru, analogues zvemahwendefa, granules, suspensions) varwere kutambura kubva Árbol asima, chiremba kunodiwa kunyatsoongorora kuongorora mamiriro varwere panguva mushonga. Kana murwere ane nhoroondo rinowanika mukana nemishonga kana achitora "Sulfasalazine" mamiriro eutano vanhu vakadaro vanofanira kuongororwa nokungwarira Paunotanga kurapwa "Salofalk." Kana vanoratidza kusachengeteka kukuru kusashivirirana siyana (kugwinha, abdominal marwadzo, mapundu, muviri), kushandisa zvinodhaka anofanira vakarega pakarepo.

Kana uchityaira kana kuita mabasa kuti zvinoda kumhanya psychomotor siyana, varwere kugamuchira "salofalk", vanofanira kungwarira zvikuru.