The mushonga "Pentas": mirayiridzo kushandiswa, analogs uye wongororo

Mune dose kurapwa waakaudzwa "Pentas"? Mirayiridzo kushandiswa, uye wongororo zvinodhaka inorondedzerwa pazasi. Uyewo zvinhu munyaya anopa mashoko pamusoro siyana kusunungurwa zvinodhaka uye ayo zvivako.

The sezvamunoita, chimiro medicament

Kune dzakawanda kusunungurwa vaiona mishonga yose. We adziise ikozvino.

Kugadzirira "pentasil" - Tablets (500 MG, 100 MG) refu chiito. Vane chena ine grayish tinge, uyewo vakawanda makwapa akasvibirika chiedza mashava, yakarurama kumativi chimiro, pamwe Valium, bevel uye zvakanyorwa kumativi ose.

The vanoshingaira vanzwe mishonga iri mesalazine. Uyewo nzira dziri muchimiro vakaneta zvinhu povidone, ethylcellulose, magnesium stearate, talc, uye microcrystalline cellulose.

In yavakatengesa zvinodhaka "Pentas" (Mahwendefa), mufananidzo iyo chinopiwa munyaya iri yaipiwa mu mhoni packs it vari bepa makatoni.

Zvinofanira kucherechedzwa kuti nyaya medicament inogona kutengwa muchimiro suppositories, kuramba-kusunungurwa granules uye rectal kuturika.

Pharmacology mushonga

Chii mushonga "Pentas"? Mirayiridzo dzokushandisa inotaura kuti mumiririri uyu Anti-anogumbura chiito uye anoshandiswa kurapa maronda colitis uye Crohn chirwere.

Anti-anogumbura ehupfumi zvinodhaka akaratidza chete vemo kushandiswa. Izvi zviri kukonzerwa kwetunhu leukotrienes uye prostaglandins, uyewo chinovhiringidza kuti lipoxygenase basa (neutrophil). Uyezve, chokushandisa anokwanisa kutadzisa kuti secretion kuti immunoglobulin kubudikidza lymphocytes uye kuti inogona kuderedza degranulation, uye phagocytosis kuti neutrophil yokutama.

Kunyanya gastrointestinal yomuchipatara

The medicament "pentasil" (hwendefa), murwiyo icho chaipiwa pamusoro, Exhibits akazivisa antibacterial basa pamusoro vamwe cocci uye Escherichia coli coli. Uyewo ane antioxidant mugumisiro nokuda kukwanisa kwayo kusunga zvinoshingaira chete vakasununguka radicals (okisijeni) uye kuvaparadza.

kushandisa nzira iyi kunoita zvikuru ngozi kuitazve muna Crohn, chirwere kusanganisira vanhu vane ileitis (ane chirwere nguva refu).

Nheyo kushanda zvipatara

Sei mushonga "Pentas"? Mirayiridzo application arikuti kuchirapa mugumisiro zvinodhaka riri pakarepo mushure kukamura uchishandisa mesalazine neVadzidzi intestinal mucosa.

Apinza zvokuudzwa hwendefa zvinoreva pakarepo unoora mu microgranules iyo kuita sezvo yoga siyana uye kwakamutsigira rinoita fuma kusunungurwa - mesalazine. Izvi inopa glamour mushonga kuti pakati 12- kuti mugaranhoko zvachose ph tsika.

Pharmacokinetics zvinoreva

ari Absorção de Água zvinodhaka "Pentas" anoita sei? Mirayiridzo Kushandisa mishumo kuti microgranules ose Zvaparara mahwendefa 12 anosvika duodenum iri maminitsi 60 okutanga.

Inenge 30-50% ane woga chipimo chemushonga zvinodhaka ari ura duku. Communication mesalazine pamwe mapuroteni eplasma ndiyo 43% uye asidhi N-acetyl-shanu-aminosalicylic - 73-85%.

Mesalazine nezvinogadzirwa nomukaka regai zvinopfuura BBB. Tinofanira kugara mushonga ehupfumi zvinozarurwa chete kana uchishandisa yakakwirira mishonga (anenge 1500 MG pazuva).

Acetylation mesalazine iri pachena intestinal mucosa uye chiropa. fuma iyi rinobva weti, mukaka uye mutsvina yadzo.

Zvairatidza kuti kushandisa mishonga

Mune zvimwe zviitiko, mishonga kungaratidzwa "Pentas" (Mahwendefa)? Nyanzvi Guest vanoti mushonga anoita zvakanaka kana:

• maronda colitis;
• chirwere Crohn vake.

Kurambidzwa kushandisa zvinodhaka

Under chii zvinhu havagoni kushandisa chombo akadai "Pentas"? Instructions (Mahwendefa nezvimwe zvinodhaka vane contraindications) inoti zvinotevera inorambidza:

• Hemorrhagic diathesis;
• zvirwere ropa;
• lactation;
• Zvomudumbu turakiti maronda;
• okupedzisira 2-5 mavhiki pamuviri;
• kushayikwa shuga-6-phosphate dehydrogenase;
• makore maviri;
• zvakakomba renal kukundikana;
• hypersensitivity kuti vamiririri Zvinhu;
• zvakakomba hepatic insufficiency.

Special Kutarisirwa vanofanira kunzi munhu akashandiswa trimester pamuviri wokutanga zvinodhaka, uyewo chiropa uye itsvo kukundikana.

Medicament "Pentas": mirayiridzo kushandiswa

Kusarudza chipimo chemushonga chimiro zvinodhaka kunoenderana localization huru pathologic muitiro, uyewo nokureba intestinal maronda.

Suppositories "pentasil" uye kuturika raitongwa panguva distal siyana chirwere (proctosigmoiditis). Panguva iyoyowo makenduru matatu anoshandiswa pazuva 500 MG.

Sei mishonga waingoita "Pentas" (Mahwendefa)? Mirayiridzo dzokushandisa inotaura kuti ichi mhando zvinodhaka inokurudzirwa chete kuti zvakafanana siyana chirwere. Nokuti kudzivirira zvazvo vari Crohn nehosha yacho medicament rinoshandisirwa runa pazuva (1 g mesalazine). Nezveshoko kudzivirira kuitazve pamusoro UC, muchiitiko ichi, mushonga wacho ushandiswe katatu pazuva 500 MG.

Panguva exacerbation weboka chirwere kurapwa vanofanira kugara kwevhiki 8-12. Panguva iyoyowo ose zuva atore 400-800 MG zvinodhaka (katatu daily).

In chirwere chakakomba kungawedzera nezuva chipimo chemushonga pamusoro 3-4 d

Mahwendefa "pentasil" vanofanira kunyanya kutorwa zvakananga pashure zvokudya, mvura kusvinwa vanhuwo mvura.

Zviito ne-hunhu

Mune zvimwe zviitiko, mushonga mu mubvunzo ndiyo zvinotevera nemishonga:

• stomatitis, tremor nhengo dzake, muromo yakaoma, dzungu, kuda kurutsa, kuora mwoyo manzwiro;
• kurasikirwa kudya, kunzwa palpitations, chirungurira, kupfupika mweya panguva kurovedza muviri, kurutsa;
• hematuria, manyoka chirwere, tachycardia, hepatitis, chipfuva kurwadziwa;
• kuwedzera chiropa makemikari, BP nokufamba, pfungwa nomuviri zvemwana asati, polyneuropathy;
• crystalluria, tinnitus, proteinuria (mapuroteni excretion), migraine nomusoro;
• oliguria, leukopenia, anuria (kusavapo weti), thrombocytopenia, inotungamirwa nephrotic urwere ;
• hypoprothrombinemia, agranulocytosis, eosinophilia, kupererwa neropa.

Zvinofanira kucherechedzwa kuti yaunodya zvinodhaka izvi murwere anogona kuonekwa: olisgospermiya, alopecia, photosensitivity, kusimba maoko nemakumbo, lupus-kufanana urwere, akaderedza kugadzirwa lachrymal fluid parotitis.

Ovhadhozi zvinodhaka

Ovhadhozi inotaura nzira kushandisa rakawedzera nehope, kuda kurutsa, gastralgia, kurutsa uye utera yose muviri. Kubvisa zviratidzo izvi zvinoda chiriporipocho gastric lavage uyewo kugadzwa laxatives mishonga uye posindromnoy mishonga.

zvinodhaka kwavatori

The medicament "pentasil" anogona kuderedza mwero Absorção de Água kuti cyanocobalamin. Mesalazine kunowedzerawo kuti kunyatsoshanda kuti uricosuric yomuchipatara (kusanganisira blockers ose tubular secretion).

Tinofanirawo kuziva kuti basa zvinodhaka inowedzera ulzerogennosti glucocorticosteroids akazoita mugumisiro rifampicin uye runogonesa kuti toxicity kuti methotrexate rine hypoglycemic zvazvinoita sulfonylurea nomukaka, spironolactone, furosemide uye sulfonamides.

chaicho mashoko

Panguva kubvuma rimwe dose pamusoro mesalazine Zvinokurudzirwa kuti kutora pamwe zvinotevera kana iri pedyo zvikuru ramangwana. Kana zvaishaikwa ane mishonga shoma, unofanira pakarepo bvunza chiremba wako. It hakubvumidzwi kurega kurapwa pachavo.

Dzimwe pakanyorwa nhau nevasori vari varwere vakachengeta weti aizonyatsovachenesa uye kuonana lenses mu tsvuku-Orange Hue.

Pakurapa mesalazine Zvinoda kuramba kurapwa kutarisira pamusoro basa renal ezvinhu murwere. Uyewo, kuti kuongorora murwere weti uye ropa zvinofanira kugara (yose nzira yokurapa, uyewo yangopedzwa).

The ndingangokuvara panowanikwa nenjodzi Varwere kugamuchira zvinodhaka ichi yakawanda vaya "anononoka acetylators".

With kukura rikwanise chirwere asingashiviriri kune vanoshingaira kuchatibatsira kugadzirira "Pentas" pakarepo Akawisira.

Similar zvinodhaka uye nevatengi wongororo

Unozviziva chii chinogona kunzi kutsiva mishonga? On ichi unofanira kuudza kupinda chiremba. Kazhinji, kuti analogues kuti mudziyo ichi zvinosanganisira zvinotevera zvinodhaka: "Mesakol", "Salozinal" "Salofalk", "Mezavant", "Mesalazin" "Asacol".

Chii vanhu vanoti chokushandisa ichi, vatengi? Maererano mhinduro dzavo, vakati medicament ari nyanzvi mushonga kuti inogona kutengwa chero chemishonga. Varwere vanoti mesalazine ndiwo anoratidza pacharo kwete kurapwa asi kudzivirira Crohn nehosha uye yakanaka chaizvo maronda colitis.