"Osterepar": mirayiridzo manual, ongororo, mugadziri, analogues

Kuderedza huwandu zvicherwa zviri pfupa rinenge chinokonzera guru yakawanda kuvadza pfupa uye articular midziyo mune vanhu dzemazera akasiyana-siyana. Kazhinji, mapfupa arambe achirema zvinoderedza nokuda vawedzere pfupa kutsemuka - anonzi mapfupa resorption. The normalization kuti vasiri pezvakaitwa pakati kuparadzwa uye pakusika mapfupa - chikuru chinangwa kurapa zvirwere izvi mhando. Mumwe mishonga inoshandiswa Mabatirwo osteoporosis, ndiye "Osterepar". Ngationei zvavanotaura pamusoro "Osterepar" gadziriro mirayiridzo kushandiswa, vanachiremba chaivo uye varwere.

pharmacological characterization

The kushingaira fuma rekugadzirira "Osterepar" riri alendronic acid, uko kunomiririrwa ari chimiro yavaibvisa munyu - yavaibvisa alendronate. The mashandiro chiito yamarudzi ichi haina zvakazara kuongororwa, zvisinei inozivikanwa kuti endpoint pamusoro alendronate yavaibvisa dzokuteerera ndiko kudzorera zvakanaka nepakati pakati kuparadzwa uye kudzorerwa mapfupa tishu. Chikamu ichi muitiro chaitwa ne zvichivhiringidza osteoclasts - specialized pfupa masero anokonzera kuparadzwa kwayo.

Uyezve, zvinozivikanwa kuti rutapudzo pakati plasma karusiyamu kunokonzera kuwanda kwayo pfupa rinenge apo kutora zvinodhaka "Osterepar". Mirayiridzo dzokushandisa inoti zvinosimbisa pfupa marongerwo yekuzvidzivirira mitswe.

The pharmacokinetic zvechadenga

Pasinei chokwadi kuti alendronate yavaibvisa zviri nyore soluble mumvura uye aqueous zvinogadzirisa, zvinodhaka Absorção de Água kubva intestinal lumen haisi kunaka - the Absorção de Água ndiyo chete anenge 25%. Zvinozivikanwa kuti "Osterepar" Kunobatanidza akanaka zvakanaka mapuroteni eplasma (the kunyorerana dhigirii ndiyo 70-75%) havana rinoita mumuviri.

Zvairatidza "Osterepar" gadziriro

Mirayiridzo yokushandisa rinoti mushonga kunoratidzwa nokuda deforming pfupa zvinetso izvo vanozivikanwa se osteoporosis (kusanganisira postmenopausal osteoporosis vakadzi). Alendronate yavaibvisa zvinobudirira kushandiswa pakurapa yakakwirira yeplasma karusiyamu dhigiri varwere nyanyisa kwendangariro.

Contraindications

Official kuti mushonga "Osterepar" Chinyorwa ine yakazara mazita contraindications kusvika mushonga akaronga. Saka, "Osterepar" iri contraindicated kushandiswa mune vana, sezvo yokupedzisira chigadzirwa uye kunyatsoshanda pakati kuchengeteka kushandiswa kwayo hazvisi pachena.

Alendronate yavaibvisa hakuratidzwi panguva paumbwe lactation, zvokudya uye akatakura pamuviri. Uyewo, kuti mushonga wacho contraindicated mu kwakaderedza yeplasma kwevari calcium kushaikwa kusimba uye vhitamini D. Tsaona medicament inofanira kushandiswa varwere kukwana renal excretory ushande.

nemishonga

Musumo kupinda kurapwa tsika alendronate yavaibvisa vasati miviri-bofu, kurapa kunonyaradza pfungwa raitungamirirwa kudzidza. Maererano migumisiro zvidzidzo izvi kakawanda padivi siyana pakati vanhu vachitora alendronate yavaibvisa, akanga zvishoma kuvatumwa kakawanda nenjodzi Varwere kubatwa kurapa kunonyaradza pfungwa.

Pakati nenjodzi anokonzerwa mishonga "Osterepar" varwere akataura zvinetso zviri nemudumbu (dyspepsia, abdominal marwadzo, zvirwere rwecheya ane tsika kupatirwa) uye nechepakati tsinga (nomusoro). Kune rumwe rutivi migumisiro chokuita nokushandiswa "Osterepar" chinodhaka. Mirayiridzo kushandiswa anoratidza kushoma chaizvo neutachiona zvakadai mapundu kana kuvaviwa.

Zvokungwarira

Kutora "Osterepar" mahwendefa vanofanira kunwa mvura vanhuwo kunwa sezvo vamwe zvinwiwa (chicherwa mvura, mukaka, muchero muto) anogona kukanganisa bioavailability nokunonoka Absorção de Água kwayo. Sezvo yavaibvisa alendronate kungava kugumbura rokumusoro zvikamu nemudumbu, hwendefa inofanira kubatwa mvura yakawanda (mukombe uzere). Munguva chinjikira nzvimbo, pane mikana yokuita esophageal maronda pa kugamuchira "Osterepar" chinodhaka. Mirayiridzo dzokushandisa anonyora kuti hazvina kukodzera kanenge hafu yeawa kuti aende kunorara pashure kutora mushonga, uyewo kutora mushonga pamberi mubhedha.

Matanho mushonga waakaudzwa varwere vane mazino zvirwere, kusanganisira bundu Genesisi. Kana hurukuro "Osterepara" inokurudzirwa narwo munhu mazino kuongororwa yakazara uye vaite nokubatanidzwazve yakazara nomumukanwa mhango. mazino nzira inofanira kudziviswa panguva mabiko.

Kana mushonga kwenguva refu (makore anopfuura rimwe nehafu) zvinodhaka kubva boka bisphosphonates, zvingakonzera hudyu mitswe ari proximal chikamu. Panguva chiitiko munhu pakakuvara murwere inokurudzirwa kutumira kuongororwa rechipiri iri femur kuti kuderedza mukana kunenge kutsemuka. Uyezve, "Oseoreparom" kurapa akamira kusvikira ngozi-kubatsira tinyatsonzwisisa kurapwa.

Special kufunga inofanira kugadzwa "Osterepara" Varwere kutora glucocorticoids. mishonga iyi vanokwanisa kuderedza Absorção de Água uye ukuwo, kuti calcium vhitamini D yaunodya mumuviri. In varwere izvi, hypocalcemia anogona kupfeka asymptomatic uye tichiratidza yakanyanya pamberi majini kubatwa. Kuti izvi zvisaitika kuomesa uye nenguva chirwere hypocalcemia yakarumbidza kuona zvakakwana calcium vhitamini D. mutambo

The mushonga haungopiwi varwere pamwe isingawanzowanikwi uye majini akaita zvirwere chokuita lactose kusashivirirana.

The mushonga hakuna zvainoita zvakaitwa mwero uye kukwanisa michina. Zvisinei, tinofanira kuyeuka kuti pane matambudziko uye nenjodzi pashure kutora "Osterepara" zvinogona kukanganisa azvaiitwa.

Drug kwavatori

"Osterepar" kwete pachii kwemajoini Kushandiswa aspirin, kubva asipurini kunowedzera parutivi migumisiro alendronate yavaibvisa (zvikurukuru ayo zvainoita intestinal turakiti). Zvisinei, "Osterepar" zvakanaka akashivirira Varwere kugamuchira mamwe kurapa nevasiri steroidal Anti-anogumbura zvinodhaka. Pasinei chokwadi ichi, mumwe haafaniri zvinodhaka izvi zvikabatanidzwa sezvo Anti-anogumbura zvinodhaka nonsteroidal pachavo vanogona kukonzera chinokosha nemishonga.

Chinangwa alendronic asidhi vakadzi kugamuchira estrogens zvimwe Rakabatanidzwa pamwe progesterone, vakabatsira zvikuru raidudzwa kuwedzera pfupa gobvu ane chinokosha kuderera padanho mapfupa resorption.

Thiazide diuretic kurapa akabatana mutsara rokuti alendronic asidhi kunotungamirira kuti kuderera calcium kurasikirwa uye akazoita mugumisiro "Osterepara".

Chepfu uye zvinodhaka ovhadhozi

Kana muchetura alendronate aona kubva bowel chirwere, richiratidzwa muchimiro kurutsa, chirungurira, esophagitis uye ulceration ari bowel lumen. Pamusoro chikamu skeletal emuviri uye ropa gadziriro zvingakonzera hypocalcemia uye hypophosphatemia.

Kurapa chepfu uye ovhadhozi inoendeswa zvinodhaka tichisunga ari intestinal lumen dzaro inactivation. Unokwanisa kushandisa mukaka, antacids, karusiyamu anotsanangura binders. Self-kunyengedza kurutsa hazvifaniri, nokuti mushonga kunogona kukonzera vasafara uye anopisira pakati yegurokuro. Nokuti gastric lavage zvinokosha kushandisa vachiongorora. Symptomatic kurapa, uye nechinangwa pakudzikamisa ari karusiyamu pamwero muropa plasma.

Reviews vanachiremba uye varwere

On kugadzirira "Osterepar" mhinduro dzaisiyana, asi kunyanya akanaka. By varwere kutora mushonga, kutsamwa anokonzerwa ane irritant mugumisiro zvinodhaka pamusoro mucosa ari intestinal turakiti. Mukuona vanachiremba, zvinodhaka "Osterepar" analogs zvinodhaka ine alendronate yavaibvisa dzinobudirira dziri pakurapa osteoporosis zvakasiyana siyana Genesisi uyewo zvirwere zvetsandanyama nemapfupa hurongwa.

Analogs medicament

Mugore mishonga musika inomiririrwa anoverengeka analogs zvinodhaka ine alendronate yavaibvisa sezvo chinoshingaira chirungiso yakakwana. "Alendronate" "Alendronic asidhi", "Alental", "Strongos" Tevanat ". izvi, uye zvimwe zvinodhaka zvose zvizhinji - analogues zvinodhaka "Osterepar".

Mirayiridzo kushandisa analogues zvinodhaka Zvisinei rinoratidza, kana pane chikamu alendronic asidhi - mushonga zvingashandiswa inonanga nokuda nokurapa osteoporosis.

mhedziso

Osteoporosis - achinyengera chirwere, uye ayo kurapwa yakaoma uye mirefu. How kutaura zvinodhaka "Osterepar 'mirayiridzo kushandiswa, ari mugadziri, varwere uye vanachiremba, kushandiswa pachishandiswa imwe zvainoita skeletal gadziriro rinobatsira, normalizing ari calcium phosphorus muviri uye kudzikira mapfupa resorption.

Zvisinei, panguva yaitonga zvinodhaka, nokuti kunonyanyisa chaizvoizvo unofanira kutevera mashomanana mitemo nyore kuti zvinorondedzerwa muna mirayiridzo kushandiswa, uye kugara kukurukura nachiremba wako kuti vadzivise zvisingadiwi zvinokonzerwa zvinodhaka. Panguva kurapwa, usaregeredza kugadzwa nezvokurara, sezvo ivo vari kiyi abudirire kurapwa uye kunokurumidza kupora.