Lupus anticoagulant - sei nengozi

On kweropa dzingave dzawirwa parameters zhinji, izvo pakutsvaga nokukanganisika kuongorora ropa uye nokudzidza coagulation, asi chero zvakadaro zvinokosha kuyeuka kuti vose zviratidzi vanofanira vaongorore nachiremba uye vanovimba iyi nyaya chete kuongorora chimwe chakarurama, uye pamusoro migumisiro misoro kudzidza. Mune zvimwe zviitiko, ropa coagulation uye anticoagulation gadziriro nokukoshesa ane kuita uye immunological miedzo Somuenzaniso, kuti vape ropa antibodies kuti cardiolipin uye lupus anticoagulant.

Chii chinonzi lupus anticoagulant wayo kukosha mumuviri womunhu

Under kwomuzvarirwo ezvinhu, ropa coagulation uye anticoagulation nehurongwa vari zvakanyatsoenzana, - flowability ropa riri rakaramba napo mumidziyo ropa pasina kukuvadza uye thrombus inotungamirwa ne akuvara uye maronda chero nzvimbo. Nokudaro, kana wevasungwa zvimwe zvinhu zviri muropa serum anofanira ngazviwedzerwe kuripa uye rimwe - chete iyi zvinokwanisika yambiro thrombosis. Asi muviri anogona aripire kuchinja izvi chete kune imwe muganhu, pashure iyo kunouya nguva apo kunyange vaiwanzoti thrombosis kunogona kuva chikonzero ropa - zvinhu mutoro pakugwamba ropa, havana kugara serum. Chinhu fuma chinogona kukonzera coagulation zvinetso zvinosanganisira lupus anticoagulant - rinokosha fuma mapuroteni hunhu, raiva immunoglobulin kwevanhu.

Yakabudiswa antibodies izvi uyewo antibodies kuti cardiolipin uye phospholipids zvavo, pane masero ari zvirwere, uye vazhinji izvi zvinhu muropa yakanga dzakaonekwa nenzira dzakasiyana-siyana autoimmune zvirwere. Asi dambudziko riri pakuti lupus anticoagulant akanaka panguva pamuviri, zvinogona kuva mhosva yematambudziko-siyana chikamu mukadzi pamuviri, uye kubva mudumbu. Zvinofanira kunzwisiswa kuti kuziva miedzo lupus anticoagulant pasina antibodies kuti akasiyana murwere DNA, phospholipids, cardiolipin taura chete zvinoita izvi marwadzo uye kudiwa chenguva yokurapa kutarisira murwere.

Zvinofanira kurangarirwa kuti lupus anticoagulant, inova ndozvakajairwa pamwe neropa serum neeSultan kubva 0,8 kusvika 1,2 zvemasanga dzakabatana, haisi zvakakwana zvakavimbika chakarurama. Naizvozvo, kuti kuonekwa kuti yakakwirira siyana kana kunyange vachizeza mugumisiro kudzidza zvakakodzera kuita kunzwisisa chete coagulation anofanira rinotsanangura D-dimer, coagulation nguva (APTT) uye zvichida yokuwanda zviratidzi kudzidza - kunoenderana ichi wokufembera, uye nzira zvinobvira vabatwe murwere.

Lupus anticoagulant - apo tsvakurudzo kunodiwa

Pakarepo ropa lupus anticoagulant kungadiwa kwete chete kune vakadzi vane pamuviri. Ongororo iyi rinoitwa uye basa varwere asati nemakore 40 akazviratidza arterial uye venous thrombosis upi nzvimbo, thromboembolism, kungoerekana Hemorrhagic kana ischemic sitiroko pasina kuvapo kwezvirwere vari zvinogona kuva chepfungwa kuparadzirwa (chirwere cheBP, atherosclerotic cardio). Zvikurukuru chaikoshawo vakadzi vaduku, uyo muupenyu hwavo hwave zviitiko kufirwa fetus chero pavaipfuura pamuviri pasina masero zvirwere uye fetus chirwere. Chete kuramba zvichiongororwa pamusoro coagulation parameters, coagulate lupus, antibodies kune phospholipids uye cardiolipin anogona kusarudza zvinobudirira kurapwa - chete muchiitiko ichi zvinokwanisika kudzivirira kuchiita ropa zvirwere.